JP2003238343A - Depressant for melanine production or cosmetic composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new and safety depressant for melanine production or a cosmetic composition. <P>SOLUTION: The depressant for melanine production or cosmetic composition contains more than one kind of plant extracts selected from various plants such as Zea mays, Cuscuta japonica, YABA Santa Claus and Lilium. The depressant significantly depresses the production of melanine dye, has whitening effect, improves spots, freckles and whitens the color of the skin. And improves firmness and gloss of the skin, effective for prevention of aging of the skin and scalp. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to application to a melanin production inhibitor or cosmetic composition containing one or more kinds of plant extracts selected from corn, weevil, yerba santa, and lily.

[0002]

2. Description of the Related Art Factors that determine the color of human skin include the amount of melanin in the epidermis, blood flow in capillaries, food-derived pigment (carotene), and the thickness of the stratum corneum. One of the most important factors is the melanin pigment. So-called liver spots (spots), freckles (freckles), and skin pigmentation after sunburn are caused by the activation of pigment cells in the skin, which markedly enhances the production of melanin pigments. It is one of the major skin problems for women.

This melanin pigment is produced by melanosomes, which are organelles in pigment cells (melanocytes) existing in the basal layer of the epidermis, the root of hair and the outer root sheath. During the process of melanin pigment production, tyrosinase activates tyrosine in the pigment cell (melanocyte) to oxidize tyrosine,
Converted to dopa and dopaquinone, further auto-oxidized, polymerized via dopachrome and 5,6-dihydroxyindole, and finally converted to melanin pigment. The melanin produced is
It is said that it is secreted from the dendrites of pigment cells (melanocytes) to the basal cells, rises as the basal cells divide and become spinous cells, reach the stratum corneum, and then fall off with detachment of the stratum corneum. .

[0004] Therefore, in order to prevent or improve the liver spots (spots), freckles (freckles) and dark skin of the skin, the process of producing melanin is inhibited. Alternatively, it is conceivable to lighten the already generated melanin. Therefore, based on these ideas, various whitening components have been conventionally proposed. For example, kojic acid or a derivative thereof, ascorbic acid or a derivative thereof, tocopherol or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, hydroquinone monobenzyl ether, placenta extract, silk extract or plant extract (Arnica, Artea). , Aloe, sardine, brown grass, chamomile, licorice, gardenia, ginger ginger, shikon, ginger, birch, senkyu,
Genosho, Psycho, Sancha, Toki, Sengoku, Elderberry, safflower, garlic, adlay, litchi, log wood) and the like are known.

[0005]

However, the above-mentioned whitening ingredients have poor stability and solubility in the prescription system, give off an offensive odor and color due to precipitation and decomposition, and are not sufficiently effective at the biological level. However, there was a problem in terms of safety, such as skin irritation, which was not satisfactory.

[0006]

In view of these circumstances, the present inventors have made the development of a useful plant having a melanin production inhibitory effect, and as a result, one or more kinds selected from corn, weevil, yerba santa, and lily. It was confirmed that the plant extract of (1) significantly suppressed the production of melanin pigment and had a whitening effect. Also, to improve skin spots and freckles. Furthermore, the present invention has been completed by providing a highly safe melanin production inhibitor or cosmetic composition capable of improving skin tension and gloss.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The term "corn (also known as jade dragonfly)" used in the present invention means a plant of the family Gramineae, genus Zea: corn (Zea mays L.) flowers and styles. , Male flowers, female flowers and spikes are used, but in addition, pome fruit, pericarp, fruit, stem, leaf, branch, branch, stem, bark, root, rhizome, root bark, seed or whole plant may be used. In addition, Gigantea Quadricolor, Quadricolor, Gracillima Va of the same genus variety
It is also possible to use riegata, Strawberry Corn, or varieties or hybrids thereof.

[0008] Further, the term "Phyllidaceae" used in the present invention means the family Convolvulaceae and the genus Cuspus (Cus).
cuta) plant: Cuscuta japonica Chois.
Flowers, spikes, pericarp, fruits, stems, leaves, branches, foliage, stems, bark, roots, rhizomes, root bark, seeds or whole plants, but other species of the same species (C. australis R. Brown) , Cucurbita chinensis Lam., C. pentagona Engelm., `` C.epillinum Weihe
(= C.major Koch.et Ziz.) ”Or variants or hybrids thereof can also be used.

The term "Yerba Santa" used in the present invention means "Hydrophyllaceae".
ae), a plant of the genus Eriodictyon: Yaba Santa "Eriodictyon californicum (Hook.et Arn.) T
orr. ", (E. tomentosum Benth.) flowers, spikes, fruit ears, pericarps, fruits, stems, leaves, branches, foliage, stems, bark, roots, rhizomes, root bark, seeds or whole plants, but otherwise , Of the same species (E.alt
issimum), (E.angustifolium), (E.capittum), (E.cras
It is also possible to use sifolium), (E.traskiae), (E.trichocalyx), or their variants / crosses.

The "lily (also known as lily)" used in the present invention means a plant of the lily family (Liliaceae) or genus Lilium: lily lancifolium Thunb. (= L. Tigrinum).
Ker-Gawl.) "Flower, spike, head flower or lily of the valley (Lilium au)
ratum Lindl.) flowers, spikes, head flowers, but others,
Pericarp, fruit, stem, tuber, corm, bulb, leaf, branch, branch,
Stem, bark, root, rhizome, root bark, seed or whole plant may be used. In addition, the same genus Hakatayuri (L. brownii FEBr.), (L.
brownii FEBr.var.colchesteri Wils.), Madonna
Lily (L. candidum L.), Himeyuri (L. concolor Salis)
b.), Scorpion lily (L.formosanum Wallace), Sasayuri "L. japonicum thunb. (= L. makinoi)", Kooni lily "L. lei
chtlinii Hook.f.var.tigrinum (Regel) Nichols. (= L.ma
ximowiczii Regel) '', Teppo Yuri (Yuri Muka) (L.longi
florum Thunb.), Iwato lily (L. maculatum Thunb.), Kuruma lily (L. medeoloides A. Gray), Yuri (L. pumiliu)
m), Regal Lily (L.regale Wils.), Otomeyuri
(L. rubellum Baker), Yuri Kanoko (L. speciosum Thun
b.), Itoha lily (L. tenuifolium Fisch.), or their varieties and hybrids can also be used.

The extracts of corn, weevil, yerba santa, and lily used in the present invention mean various parts of each plant (flowers, styles, male flowers, female flowers, spikes, head flowers, berries, pericarps, fruits, stems). , Tubers, corms, bulbs, leaves, branches, branches and leaves, stems, bark, roots, rhizomes, root bark, seeds or whole grass) as they are or after crushing and squeezing. Alternatively, it is extracted with a solvent as it is or after pulverization.

The extraction solvent for the above-mentioned various plant extracts may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, etc.
Water, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol, etc. or hydrous lower alcohols, propylene glycol, 1,3-butylene glycol, polyhydric alcohols such as glycerin, or hydrous polyhydric alcohols, acetone, acetic acid It is desirable to use one or a mixture of two or more selected from various organic solvents such as ethyl. However,
When the content of the organic solvent is not preferable depending on the purpose of use, water alone may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixture with water. You can use the extracted one.
Furthermore, it can be used in a state where each solvent extract is combined.

In addition to the hydrolytic extraction of the above-mentioned various plants by enzymatic decomposition, those obtained by hydrolyzing with acid / alkali can also be used.

The production method is not particularly limited, but it is usually within the range of the boiling point of the solvent at room temperature and atmospheric pressure, and after extraction, filtration or ion exchange resin is used for adsorption / adsorption.
It may be decolorized and purified to form a solution, paste, gel or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added within a range that does not affect the effect, and as a purification treatment means such as deodorization and decolorization. It suffices to use an activated carbon column or the like, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected. It is also possible to add an organic solvent such as ethanol, propylene glycol, 1,3-butylene glycol, or an arbitrary mixed liquid thereof to the extracted liquid after extraction. The obtained extract can be used as it is, but can also be used as a paste or powder by concentrating and drying.

Various plant extracts of corn, weevil, yerba santa, and lily of the present invention can be contained in a melanin production inhibitor or a cosmetic composition, and the content thereof is not particularly limited, and a melanin production inhibitor, Slightly different depending on the type and quality of the cosmetic composition and the expected degree of action.
Mass% or more (hereinafter expressed as%), preferably 0.01 to 5
0.0% is good. Further, in the case of a bath agent, the formulation may be taken into consideration so that it is poured into 200 to 300 L of bath water so as to have the same concentration.

The melanin production inhibitor or cosmetic composition of the present invention may have any dosage form and form, such as capsules, powders,
It can be used by blending it in the form of granules, solids, liquids, gels, bubbles, emulsions, creams, ointments, sheets and the like.

The fields of application thereof are, for example, all kinds of external preparations (including preparations used for animals) in general, and specifically, ampoules, capsules, pills, tablets, powders, granules, solids, Liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (e.g. Basic cosmetics such as water, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, depilatory agents, depilatory agents, shaving treatment agents, aftershave lotions, pre-shows Lotion, shaving cream,
Makeup cosmetics such as foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, nail enamel, nail enamel, nail enamel remover, poultice,
Plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal or / and cosmetic preparations (for example, shampoo, rinse, hair treatment, pre-hair treatment) applied to the scalp and hair. Agents, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair styling agents, hair growth and hair nourishing agents, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 5) For baths to be used Agents, 6) In addition, axillary deodorants, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissues, toothpaste, mouthwash, gargle, dishwasher, etc.

In addition to the above-mentioned essential components, the melanin production inhibitor or cosmetic composition of the present invention may optionally contain the components and additives illustrated below as long as the effects of the present invention are not impaired. The content in the preparation is not particularly specified, but is usually 0.0001 to 50.
% Is preferred.

(1) Various oils and fats Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange lafa oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed Oil, Persic oil, Castor oil, Cottonseed oil, Peanut oil, Turtle oil, Mink oil, Egg yolk oil, Palm oil, Palm kernel oil, Owl, Palm oil, Beef tallow, Lard, Squalene,
Squalane, pristane or hydrogenated products of these oils (hardened oil, etc.), etc.

(2) Waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, etc.

(3) Mineral oil Liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microcrystalline wax, etc.

(4) Fatty acids Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid,
Docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acid, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexane Acids, synthetic fatty acids such as isopentanoic acid.

(5) Alcohols ethanol, isopropyl alcohol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-
Hexyldecanol, isostearyl alcohol, 2-octyldodecanol and other synthetic alcohols.

(6) Polyhydric alcohols ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, etc.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound gum arabic, benzoin gum, dammar gum, guaiac butter, Irish moss, karaya gum, tragacanth gum,
Carob gum, quince seed, agar, casein, lactose,
Fructose, sucrose or its ester, trehalose or its derivative, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) with alkylene (C2-C4) oxide such as ethylene oxide added. )
Chitin or chitosan, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or its salt, hyaluronic acid or its salt, chondroitin sulfate or its salt, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose , Carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylates, polyalkylene oxides such as polyethylene oxide and polypropylene oxide Or its cross-linked polymer, carboxyvinyl polymer, polyethylene N'imin like.

(10) Surfactant Anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), Sulfate ester type amphoteric surfactant, Sulfonic acid type amphoteric surfactant, Phosphate ester type amphoteric surfactant, Nonionic surfactant (ether type nonionic Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, other surfactants (natural surfactants) , Protein hydrolyzate derivatives,
Polymer surfactant, surfactant containing titanium / silicon,
Fluorocarbon type surfactant) etc.

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acid,
Nicotinic acid, Pantothenic acid, Biotin, Choline,
Inositols, vitamin C group: vitamin C acid or its derivative, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K)
2), menadione (vitamin K3), menadiol (vitamin K4), other, essential fatty acid (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U etc.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine, etc., and their sulfates, phosphates, nitrates, citrates,
Alternatively, amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant- or animal-based raw materials. These are processes (for example, crushing, milling, washing, hydrolysis, etc.) which are conventionally carried out depending on the product type and form to be added. Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, powderization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are selected and combined), and various materials are selected. You can select it and use it.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, the processing to be performed later, etc., but usually water, methanol, ethanol, propyl alcohol, isopropyl is used. Alcohol, lower alcohol such as butanol, isobutanol or hydrous lower alcohol, polyhydric alcohol such as propylene glycol, 1,3-butylene glycol, glycerin or hydrous polyhydric alcohol, various organic solvents such as acetone, ethyl acetate, etc. It is desirable to use one or a mixture of two or more of them. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol that is easy to remove after extraction may be used and used alone or in any mixed solution with water, or Exploited extract may be used.

Additives derived from plant or animal raw materials are
When used as a systemic or topical external preparation, cosmetics, including protection of skin and hair, moisturizing, improvement of touch and texture,
Giving flexibility, reducing irritation, relieving stress caused by fragrance, activating cells (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, hair growth, hair growth, hair loss prevention, gloss , Cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as warm bath effect, fragrance, deodorant, thickening,
The effects of antiseptic and buffer can be expected.

As a concrete plant (crude drug) used as a raw material,
For example, almonds, ai, blue vines
(Seifufuji), Aoki (Aoki), Aogiri or Kenashiaogiri
(Goji paulownia), Aotsutsurafuji (Kibo), Aotenma, Acacia, Red capsicum (Akasoma), Redcurrant `` fruit '', Red clover, Red grapes, Red amber (Logwood), Red algae (Red bud), Red pine or Red madder or Red madder (Akane) (Grassroots), Akagia jiou or jiou (ground yellow),
Agi (A Wei), Aki Larch, Akinire (Resin), Aguay Gua Su, Aguahe (Omi Tenguyashi), Akebei
(Ki-dori), Asa (Asakojin), Malva Morning Glory or Morning Glory
(Dagushi), Hydrangea (hydrangea), Ashitaba (tomorrow leaf), Azuki (red azuki bean), Asunaro, Acerola, Asenyak (Asenyaku), Athira (Sakuyoukanna), anise, abiu, abiulana, canola, abemaki "fruit" ,Avocado,
Ama, Amacha (sweet tea), Amachatsuru, Amadokoro (Tamatake), Amana (Kokoji), Amaranthus (Hiyu, Hagatetow, Himegateto, Senninkoku, Sugimorigateto,
Hosoaogatetou, Aogatetou, Haribiyu, Aozulan, Amaranthus hippocondriacus), Amigasa lily or Fritillaria (shellfish), Aristromelia (Yurizuisen), Arcana (Arcanna), Algarrobo (Cabbage), Artea, Arnica, Alpinia or Katsumadai
(Souzuku), aloe (蘆 薆), aloe vera, angelica, apricot or hon apricot (apricot kernel), ansokkou (benzoin), yellow sapote, igakoukousrina (geijutsu), sardine or chinensis (indian cabbage), rush
(Wicked grass), Japanese knotweed (Kojo root), yew (first place), strawberry,
Fig (flowerless "fruits and leaves"), figs (first), hibiscus (winter aoi), Ichiyakuso (one medicinal herb), ginkgo (ginkgo biloba "seed, leaves"), Itohimehagi (distant), locust bean, Inunazuna (Taylexi) , Inubiyu (Honagainubiyu), rice "seed, seed coat", inondo "seed", Echinochloa japonica, nettle, ylang-ylang, iwatobacco (Iwabaki),
Iwahiba or Iwamatsu (wind roll), common bean, oolong tea, fennel (incense), wheat (Chibana), ukiyagara (Sanryo), Uguisukagura "fruit", Himeyokiou, turmeric (Yukin), duckweed (Ukiwa), Usubasaishin Or Keirin saishin or Sengoku saishin (spicy), mussels mallow, mung bean mallow, medusa orchid, nemophilus (summer hay), udo or shishido (invigoration, independence, indonesia), unyadegat (unkalia, cat's claw),
Uba Tea, Ume (Ume "seed, fruit pulp"), Vladimir Ogashira, Argentine (Rawberry), Unshu Mikan (Chenhide), Umboku, Estragon, Ezo-kogi (Ezo Goka), Ezo Suzuran, Echinashi (Hosobamurasakibareniku, Echinashi), Enishi Mushrooms), Ebisugusa or Cassia tora (Keiko), El Campre, Elderberry "fruit",
Elemi, Eryngii or Pre-Lotus erynge, Enju (Sophorae, Sophorae rice), Pea, Ougi or Kibanana
(Yellow radish), Naruco lily or Kagi Kurumabanaruko Yuri (Yellow), Ohihisasanoyuki or Sasanoyuki, Ouren (Yellow), Ogata Houken, Ookarasuri (Calocon),
Plantain (Civil engineering incense), Giant tsuboji (Self-defense), Plantain
(Carmaco, Carophyllum), Milk thistle (Yuzhou Leopard, Bald Ear), Toucan Hazel (Haruko), Toucan Cactus, Obana Ochera or Ochera (White Sprout), Obana Sarsberg (Banaba), Ooba Yashaboshi "Fruit", "Fruit" Grains), Oomiacatetsu, Omihawthorn or Hawthorn
(Yamashiko), Omiyashi, Barley (barley), Oka, Okazeri (Heiwako), Okra "fruit", Oguruma (overturning), Oklurihigotai (Banzhou Leopard, Indigo Spin), Panax ginseng or Panax ginseng (carrot) , Hypericum perforatum or Hypericum perforatum or Hypericum perforatum (younger brother cut grass), Odorikosou (intermittent), Onami (blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninogagara
(Tianma), Onoelan, Ononis, halibut (Ryaku-yu), Ominaeshi (soy sauce), Oyuco, Dutch mustard (cresson), Dutch jelly, Dutch biu, Dutch honeywort,
Olive "fruits, seeds, leaves", oregano, orange "fruits, pericarps", scallops (ripe yellow), cacao "fruits,"
`` Pericarp, seed '', oyster (persimmon `` leaf ''), oyster vine (fishing hook), oyster duck or citrus root (rensenzo), oyster, hydrangea, cassia, casino oyster (cow fruit `` fruit ''),
Baidutsu (muddle), oak wrinkle (camellia tree, camellia leaf), Cascarilla, cascara sagrada, gypsophila, Kasenso, crabweed
(Kin Sato), kaniwa, carnation, valerian (Yoshikusa), hippopotamus, birch or birch (birch), gerbera, pumpkin, kapok cypress `` seed '', kahoksansho (pepper), gama (ginger yellow), chamomile or roman chamomile , Kamiyatsude (grazing), Kamkamu (duck), Karagua or Yamaguchi (Mulberry), color, larvae, crow cucumber or Cinna crow (Gourd melon), crow bishaku (half summer), oats, guarana "seed", karahoo (kobushi),
Karaya, Gallu, Karin (Cucurbita), Garcinia, Kawamidori, Kawara Psycho (Jourensai, White-floured grass), Kawajisha, Kawaratake, Kawara Nadeshiko (Ishitake) or Ezokawaranadeshiko (Eggs, Red-breasted mackerel) (Aoi and garlic), Kansu (sweetening), Kanzo (licorice), Cantara, candelilla, canto, canna, kanran, raspberry (ezo strawberry, Dutch strawberry, shrimp strawberry, nawairo strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '' , Cichlid melon (melon root), kyokyo (kikyo, bellflower), chrysanthemum (chrysanthemum, chrysanthemum, chrysanthemum, chrysanthemum), kikutanigiku, kisage (梓 fruit), cypress (cowroot), pheasant (kuri), kizuta, kidachiaroe Yellow mint, quinnah, quinanoki (sinkona, red quinoa), quinoa (quinoa), yellowfin (yellow oak) , Kimame,
Gymnema Sylvester, Kimenkaku, cabbage, cabbage "unripe fruit", caraway, cucumber, goryu
(Nishikawayanagi, Teyanagi), Kiraja Saponaria, Kiraya, Kiransu (Kenshi Kousa), Kumquat "fruit", Kinkju,
Ginsekai, Kimbusen, betel, Kinmizuki (Senkusakusa), Quinlan, Ginran, Kinryohen, Guapeva Vermelha, Guava "fruit", Guayule, Quercus infectria (gallic child), Kukui nuts,
Kugenumaran, Cuco (Dragon, Marlin, Marbled Leaf, Crustacea),
Black whale (Tenmon winter), Japanese kudzu (Kudzu root), camphor tree, gooseberry "fruit", Ginseng (yellow flower), Kutiti river, gardenia (Yamashiko), Kunugi (Kusou), Kupuasu, Kubeba, Kumazasa, and Kumadura (horse whip) Grass), Clara
(Bitter ginseng), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit "fruit / leaf", buckthorn, black anemone
(Need to rescue), Kamehiba Hikokoshi or Kurobana Hikiokoshi or Hikiokoshi (Enmei grass), Cloves (cloves, cloves), Gumbai nazuna (sekimei, sekimeishi), Kaigai (peelworm, sagebrush), keito (cowflower, chicken cob, garlic beetle), gecko Bay (Laurel), Kensai Sartori Ibara (Tsukuryo,
Mountain return), Gentian, Gennoshoko (Old bird), Kemponashi (Kurushi), Kokishikoku, Kishikankan (Koji, Tachibana, Ovenimikan, Fukuromican, Sagamikoji, Ponkan, Santara (Tachibana peel)), Koshinbara
(Monthly flowers), Kosui mint, Kozo `` fruit '', Kocha
(Black tea), Kouhone (River bone), Kouhon (Straw book, Karamoto book), Kouryan, Kouryokyo (Kora ginger), Cilantro `` fruit '', Coleoptera (Huang Huang Ren), Scutellaria (yellow gon), Bilberry (overtachibana), Coco palm "Fruit", Goshuyu (Wu 茱萸), Gosho strawberry (Okubonko), Pepper (Pepper), Cosmos, Copaiba balsam, Coffee "seed, leaf", Kobushi or Magnolia (Spicy), Burdock (burdock, burdock root), Kobotsunuru, Sesame (sesame), sesame seedless (gentle), trash (schisandra), rapeseed or vinacanthus or pine wilt, wheat (wheat),
Rice or rice bran "Aka bran, Shiranuka", rice oil, cola acminata "seed", cola vera "seed", colony lya, fenugreek "fruit", colombo, conzulango, konbu, konjac, konfrey (final grass), Sisal (Sisal Asa), Saihairan, Sakaneran (Ezosakaneran), Sakishima Button Crane or Shina Button Crane or Shina Senninsou (Gaisen), Sakura (Oshima Sakura, Yamazakura,
Oyama Prunus, Ed Higashi, Mame Prunus, Miyama Prunus, Somei Yoshino, Takane Prunus, Kasumi Prunus, Cohigan, Sato Prunus, Kanzakura "Leaf, Flower, Fruit, Bark"
(Sakura) ''), cherry, pomegranate, Sasa, Sasabaginran, Sasanka, Sageomodaka (Sawarai), sweet potato, sugar cane, sugar beet, rapeseed (Satsumejin), saffron (Safflower, west safflower), Sapodilla, Sapote mariyo,
Pomelo "fruits", sapons, salmon berry "fruits", salicinosa (mamari), salan citrus (sand indigo head), salvia (sage), kawasakikyo (mountain spinach), sour walnuts (mountain walnuts), sankaku cactus, sangrede Grado, Crocodile, Hyacinthus, Carrot
(37 ginseng), Sanshuyu (Yamatake mushroom), Sansho (Japanese pepper),
Sandscon (wild bean root), shea (carite), cyanoki `` fruit '', shiitake (shiitake mushroom), zion (purple garden), shikakumame, digitalis, shikunshi (messenger), perilla or blue-throated foxtail, or chimenjiso or katamenjizo (shiso leaf, shiso-ko) ), Rosewood, linden, cypress, syringa (ream),
Shimeji (Hinjimeji, Shakamejime, Hatake Shimeji, Oshiroijimeji, Beech Shimeji, Honjimeshi, Shimotake Mushroom), Shimokuren (Spicy), Apiaceae, Potato,
Peonies (peony), shajin (samseng), jasmine (matsuryka), january beard (barley winter), juvenile cowpea, gypsophila, shukshamitsu (sand kernel, curd sand), juzdama, palm "fruit", shunlan, Palm oil palm, ginger (ginger), hydrangea hydrangea (tsuneyama), ginger (iris, iris root), shozuku "fruit", white oak "seed", silane (butterfly), white-billed butterfly "seed",
White clover (white clover), White Azuki (chicken bone grass),
White squirrel (Small squirrel), White vine, "Flower",
White lupine, Shirominanten (southern Tenmi), Cinchona Succibula, Jinchoge (Mizuka, Mizukaka, Shichohana),
Cinnamon, Cinnamomum cassia, watermelon
(Watermelon), honeysuckle (gold and silver flower, Shinobi winter), sorrel (acidic), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', Suzuko (Lord Xu), horsetail (question), purslane (horse toothpaste,) Horse tooth Kenko), plum "fruit", sulgalan (orang), red pine "cone", Japanese larch, western quintet, walnut, hawthorn, hornbill, dandelion, horse chestnut (malonie), pear "fruit" ], Natsumiyukiso, Sambucus nigra
(Elder), Pacific jelly (Juniper, Juniper), Yarrow (Millfoil), Rose, Astragalus vulgaris, Mistletoe, Peppermint or Peppermint, Horseradish, Budgerigar
(Ishikon), Ginkgo (Cherry Blossom, Kouki Ginkgo, Oanabashi Ginkgo, Okinawa Ginkgo, Hon Ginkgo, Ginkgo Ginkgo, Shikaku Ginkgo, Kibanano Ginkgo) (Dendrobium, Ishibuchi), Cedron (Boshishuboku), Henasei, Henosei, Henosei, Henosei, Heisei Oise, Hire Celery, senkyu (river kyu), senshinren (shinshinren), sendan, sennin cactus, senna "fruit, leaves", ninninsou (daiba), senburi (this medicine), senboku, souka
(Grass fruit), elephant chow, buckwheat syrup, buckwheat "seed seed", some potatoes, broad bean, rhubarb (daikon), radish, soybean, daidai (orange peel, drought), takasagogorurihigotai (south indigo indigo head), takasaburo (drought lotus) ), Takatodai
(Ohji), Takawarabi (in Japanese), dark sweet cherry "fruit", hollyhocks, pearl oysters (thyme, lily scent), tadikoro (hikai), tachinyanagi, tamarind "seed", onion, tamshiba (spicy), taranoki "fruit" , Leaf, root bark ", tarayo (Oba winter blue, one leaf tea, bitcho tea, bitter tea), dahlia (tenjiku button), tarui, tankimimame, tanchiuchiwa, tanjin (danshen), dandelion
(Kamahide) or white dandelion or moco dandelion, danmar, cherry "fruit", chigaya "fruit, root, bud",
Ginseng carrot (Chicken ginseng), chicory, chanka piedra (Kidachi-kansou), tulip, choconostay, artichoke (artichoke), ginseng (daikon), ginseng (garden), ginseng (agar leaf), chorei Maitake (boiled boar), Chorogi, Tsukimiso, Tsukusakaneran, Tsukuritake (mushrooms), Tsuchiakebi, camellia, Centella asiatica, Tsumekusa (lacquer grass), Tsuyakusa (Duck sedge), Tsuzuki adzuki beans, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami, Tsurutsudachi Ami. Tsuruna (Apricot radix), Ginseng (Folia ginseng), Glycine soja, Tsuwabuki, Deiko, Ganoderma lucidum, Duberry "fruit", agar beetle, tencha
(Japanese tea), Tendaiyaku (crow), Toga (winter gourd), Tokagi quail, Capsicum (Pepper), Touki (Toki), Sugar beet (Marigold), Toukikachi, Tounabena
(River-free), Sciurus mochi (Sadako), Scented gentian or Ginseng (dragon gall), Horse chestnut (tree bandit), Dokdami (ten drugs), Tokon (root), Eucommia vulgaris (Musaka `` bark, leaves,
Roots), ash (Hind skin), tomatoes, tragacanth, triacanthus "seed", eustoma, tormentilla, doronoki, trolley mallow, dragonfly, nigeria berry "fruit", Chinese yam or yam (mountain drug), swordfish
(Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Soiled Bean or Tatehaki (Sword Bean), Natsumikan, Natume (Otsuki), Naniwaibara (Kinsakurako), Navena (Intermittent), Nameko, Peanut (peanut), Nanten (South Tenten) Fruits), Nanban Karamushi (Cara hemp), Nioisumire, Nigaki (Bitterwood), Sagebrush (Bitterwood), Chrysanthemum, Kay or Nikkei or Ceylon Nikkei or Yab Nikkei (Keikin) or Keishi (Keishi),
Black-throated Plover, Chinese chive (Nishiko), Elderberry (Oscullet tree `` fruit, flower, stem, leaf ''), garlic (large garlic), Nurude (quintet), leek, nectar or nebu or nevi or nemoki or digobana (hymn), thistle (Oyagi), Neubara (Fruit), Nostoc communis (Ryohaku), Nogetou, Yarrow, Nodake (Former Hu), Novara, Peach, Pineapple `` fruit '', Hibiscus (Bushouge, Furinbusouge, Roselle), Hyelindo, Houssewa, Peach, , Hakamaurabosi (bone fracture), Hakukayutomu, Chinese cabbage, Chinese cabbage (tinea bark), Huckleberry "fruits", chickweed (harsh), hazel (harbor), hasilidokoro
(Roth root), basil, lotus (lotus, lotus meat, lotus root), parsley
(Netherlands jelly), hadakamugi, batata, bee weed, or bamboo shoots (boiled bamboo), patchouli, mint (light load, light load leaf), hassho beans, pearl barley (Yokuinin), hanasuge (knowledge mother), banana, hanahakka, hanabishi (shitsuri, shitsuri) , Vanilla vins, papayas, yellow squirrels (mouse koji), pahalobobo, hub "whole grass, stems, leaves", paprika, stilts,
Hamago or Mitsuba Hamago (vine vine), Hamasuge (Kafuzi), Hamabishi (Shitsuriko), Hamanasu (maikai flower), Hamaboufu (hama windbreak), Hamamelis, palm, rose (rose), balata, balata, aratake mushroom,
White-bellied agaric, Usukimorinokasa), Haran, Pariurus (Rhododendron japonicum), Parietaria, Harkanran, Balsamina (Tsurureishi, Nigauri), Harunire
(Insect skin, Elm skin, Insect leaf), Barbasco, Harlindo, Handaikai (Katsu Omi), Panoki, Hyogi (Hikari), Pea nuts, Carrots
(Gypsum, Liu Singh), Higulmadaria, Higotai, Hishi
(Hishimi), pistachio, beet, tsutsumi (Ishidashi), hibiscus edulis, daisies (daisies), Hinako no Kozuchi
(Cow knee), Hydrangea cypress, cypress, hiba, castor, sunflower, bell pepper, Himeuzu (Aoi), himemagama (garlic), Himematsutake (Kawariharatake, Hiromatsutake), Himemuyoran, Pimenta "fruits", juniper, Japanese juniper, Japanese juniper "Fruit", chickpeas, lentils, biloba mallow,
Broadbrush (Bald-headed), loquat "fruit, leaf, stem", betel nut (daiskin skin, calyx), Pu'er tea (Fu-cha), Futokazura (nantan), butterbur, butterbur dandelion (submarine winter flower, subordinate winter leaf), Wisteria mackerel (Orchid grass), Wisteria bean (Foliar beans), Wisteria
(Chrysanthemum cherry, Fuyuhana), grape "fruit, peel, seed,
Leaves, Beech, Fuyusuminatsutake (Coleoptera: Cordyceps), Brazilian licorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "Fruits", Blackberries, Branjen, Plums "Fruits", Frucellaria, Blueberries Cypress), prune, floral blanka, blond psyllium, bundou (mung bean), hazelnut, loofah, hetkaran, safflower
(Safflower), Henneken, Belladonna, Berry “fruit”, Persear, Perbianberg, Pereschia grandifolia, Benchisou or Duckweed (Keiten), Boysenberry “fruit”, Broomwood or Eldera or Nendou or Hakidoki kokia (ground silkworm) ), Hosairan, Haoutenga
(Fengxian, acute child, skeleton grass), Pouteria sapota, Pouteria lucuma, honoki, spinach, physalis (Torone), honoki (Japanese thicket, magnolia), bokeh (wood melon), hollyhock (Bokuyoku), hosoba Ogura, Hosobana okera
(Sosou), Rhododendron japonicum (Keiten Sanchi), Rhododendron japonicum, Bodaiju (Bodhi tree), Button (peony `` flower, leaf,
Stem, bark "), button pie (peony skin), hop, jojoba, bourgei (Ruricha), Bordeaux, white berry" fruit ", Hongonik (Meat Juyo, Daiei), Hongsekoku (Sekiseki Suzu, Suzuyama Ishihasu) , Maizuru Tennan Show (Tiannansei), Maitake (Maitake), Maou (Mako), Maca, Macadamia nuts, Margaret (Mokshungiku), Makuri (Seagrass), Magwa (Mulberry bark "bark, leaf"), Magnolia・ Sprengheri, Masarunzuba, Masalanzuuba de Ceara, Masheira de Boi, Mashua (Tamanouzenhallen, Kyukonkinrenka), Matatabi (Matsukasa), Matsukasa, pine "leaf, bark, root", Matta Orho, Matsuhodo (boiled peony), Matico (Cordon sillo), Mayoram (Hanajaca), Marvanojazin (Ginseng), Mulberry "fruit", quince, Malein (Bilroadmou) Zuica), mango, mangosteen, mansagna (Andes chamomile), manshugurumi, mandarin "fruit",
Ganoderma lucidum (Ganoderma lucidum), Pheasant (Gourmet `` Fruit ''), Mishima Psycho (Saiko), Water plantain or Water morning glory (Rhinoglossus),
Mizokukushi (Half-sided lotus), Misohagi (Senkyaku), Michiyanagi or Niwayanagi (Henji), Mitsugashiwa, Mitsuba, Midori Zapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "fruits", Myrrh, Myrobalan, Mugiwaragiku, Mukuge , Mukunoki, Mukuroji (prolonged skin), Munya, purple (purple root), purple syrup or purple syrup
(Purple), Purple fuji wisteria (Kunming chicken blood wisteria), Mega Kansa
Opuntika, swordfish (beneficial herb), barley, evening primrose (evening primrose), melaleuca, melissa, meliloth,
Melon "fruit", Mokoyomogi, Moso bamboo, Mokugirin, Moje (pepper), Mochinoki, Mokko (tree incense), Japanese maple, Peach (peaches "leaves, seeds, flowers, fruits"), coconut, morello cherry "fruit" , Moroheiya
(Burlap), yakawamurasaki yak, yakchi (maschi), cornflower (cornflower), cornflower, yacon, yashabushi (arrow wheel) or Himeyashabushi or Obayashishabushi "fruit, fruit skin, fruit ear", yam willow, yam depot (octagonal metal plate) , Mistletoe (willow parasitism), willow (Kiyanagi, Tachiyanagi, weeping willow, red willow, cat willow, dog cory willow, willow willow, cory willow, unryow willow, willow willow, palm, willow willow, willow willow,
(Tailuku nuyanagi, fox willow, doronoki), willow tree "leaf, stem", porcupine, yam koji (purple gold cattle),
Yab Tobacco (Tsuru, Tenmei), Yamabobo (Shokuryoku), Yamanoki (Yamaharu), Yamamomo (Yangume), Yamamogomi, Eucalyptus, Yukinoshita (Tiger's ear grass), Yucca or Flavifolia, Yuzu `` fruit '', lily, Yellow primrose, mugwort (moth leaf),
Rigan (Thunder maru), lime "fruit", rye, swingle "fruit", raspberry "leaves, fruits", latania (clamellia), rakkyo or shallot (caucasian white), lavender, longan (longan meat), agave lantern (aono agave, fukurin). Agave, green tea, apple "fruit, seeds, leaves, roots", gentian, lubas or Suavesimus (Violet), thistle (Valentillo higotai, Xinjiang indigo head), litchi (lunch, litter branch), lettuce (Chisha), Red currant "fruit", Red pitaya, Lemon "fruit", Lemongrass, Forsythia or Forsythia (Forsythia), Astragalus, Rhizome, Waus palm, Locon (Reed, root), Logan berry "Fruit" ,, rosemary (mannenrou), rosehip (novara), wasabi, cottonweed (Japanese flower), Remokou
(Jiju) and the like.

Examples of seaweeds include seaweed [green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, aonori (usubaaonori, sujiaonori, hiraaonori, bowaonori, hosoedaonori), anaosaa (sea algae), Kind: kelp (Macombus, liquorice, Hosomekonbu, Mitsuishikonbu), wakame, hirome, aowakame, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitrus ruetokeana), hijiki, hibamata, sea uchiwa, usubaumiu Kirebanoumiuchi, Akabatumiuchi, Konaumiuchiwa, Okuchiuchiwa, Usuyukiuchiwa, Echiukiumiuchiwa], Seaweed [Red algae: Hijirimen, Hakusa, Hirakusa, Onik , Obakusa, Kataobakusa,
Yatabegusa, Yukigiri, Amanita, Tosakanori, Togekirinsai, Amaxakirinsai, Giraffe, Jakushinkirinsai, Tsunomata, Obatatsunomata, Tochaka (Nyakuzuna-no-Tomashita), Ezotsunomatsuta, Togenomata, Hirasakonotoma, Kotobuki, Kotobuki, Kotobushi
[Yaleus Banori, Kagious Banori, Suzius Banori, Haius Banori, Akamomijinori] and the like.

In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Qualmomim: Quanonimo, Volvox: Ohigewawari, Volbox, Palmera, Yotsumeu, Genus Aomizu: Hizaori, Ao-shiro, Tsurugi-Midoro, Hibi-Midoro: Hibi-Midoro, Aosa Genus: Anaaosa, Amiosa, Nagahaosa, Kawanori: Kawanori,
Fruicula genus, Shiogusa genus: Oenothera genus, Asamidoriushigusa, Kawashiogusa, Marimo, Baronia genus: Tamagobalonia, Tamabaronia, Magatagum genus: Magata, Iwachia genus: Fusaiwaduta, Black squirrel, Mildewer, Black millet, Nematoda, Hagemonia, Nematoda. Sakibutimir, Nagamir, Hiramiru, and Kasanori:
Casanori, genus genus: Futozuzumo, Tamazuzumo,
(Mizujuzumo, Mikadzuki genus, Colecaete genus, Tsudumimo genus, Kikkokusa genus: Kikkokusa, Astragalus genus: Hitogusa, Hirohanohitohegusa, Usutoegusa, Motukihitoe, Sayamidoro, etc.

Blue-green algae (genus Suizenjinori: genus Suizenjinori, genus Algae, genus Nostoc: Kawatake, Nostoc commune,
Hassai, genus Yuremo, racenmo (spirulina) genus: spirulina, trichodesmium (aiacacio), etc.).

Brown algae (Pyraera: Pyraera, Shiomidoro: Nagamisio Midoro, Isogrape: Isogrape,
Genus Isogawara: Isogawara, Kurogashira: Gunsen Kurogashira, Kasakizaki: Kazakizaki, Muchimo: Muchimo, Hiramuchimo, Keperigusa, Astragalus: Astragalus, Sakibirohajiza, Sanyuhajihadosa, Azagusa saga: Common sage: Common clover, Common clover Prickly squirrel, Ulaboshihaha, Symphalida: Symphologus, Cyperus genus: Cyperus cypress, Konaumi uchiwa, Akabayumi uchiwa, Namikura genus: Prunus chinensis, Somexaceae genus: Somenaceae
Pinus genus: Matsumo, Nagamatsu genus: Nagamatsu moth, Okinawa mozuku genus: Okinawa mozuku, Niceft mozuku genus: Physcomit genus, Physmozuku genus: Physcomitum genus: Genus mosquito: Genus mosquito: Genus moss, Genus moss Isige, Iroro, Ichimegasa: Ichimegasa, Calligraphy: Calli, Umibosu: Umibosu, Urushigusa: Urushigusa,
Black cypress, Tobacco bug, Genus: Haemorium, Haberdoki: Haberodoki, Havanori: Havanori, Habernori: Hazelnut, Common genus: Common butterbur, Ezoburo genus: Nematode: Nephila, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Rhizophora, Pleurotus vulgaris Genus Kagomenori: genus Kagomenori, genus Muralis: murachidori, genus Phalaenopsis: shark
Sardine: Sardine, Asclepias: Asclepias, Kayamonori: Kayamonori, Fennel genus: Fennel, Tsurumo: Tsurumo, Anata: Squirrel, Susume: Aedes albopictus, Missus konjac, Miscanthus, Aedes radisculent, konjac beetle, konjac beetle, scutella conserved , Onikonbu, Goheikonbu, Nagakombu, Pea kombi, Otojijimokubu, Tororokonbu genus: Tororocombu, Antocume: Antokume, Kajime: Kajime, Tsuruarame, Kurume, Chrysanthemum genus: Chrysanthemum genus: Necrochamus genus, Black konjac genus, Black locust, Black civet, : Catfish,
Genus Alame: Alame, Ainu Wakame, Ainu Wakame, Chigaiso, Oniwaka Ezo Ishige: Ezo Ishige, Yabanemoku: Yabanemoku, Rappamok: Rappamok, Jolomok: Ugananomoku, Jolomok, Hiemoku, Honduramaku, Isamanidae, Tamanashira Akamoku, Shidamok, Hondawara, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yasumatamok, Umitranano, Obamamok, Fushizushimok, Hahamok, Togemoku, Yoremoku, Sugimurakoku, Sugimurakoku, Sugimurakoku, Sugimoku, Sugimoku, Sugimoku
Burukkimo, genus Kayamonori: Kayamonori, etc.).

[0039] Red algae (genus: Kensuke Nori, Funori Nousuke, genus Magnolia: Asakusanori, Susabinori,
Upruinori, Onia manori, Tasa, Fuiritha, Benitasa, Rhodocorton: Milnobeni, Akebono Mozuku: Akebono Mozuku, Konahada genus: Hikonahada, Yogorekonahazukuni Azukuniboku, Azusa konjac, Azusa konjac, Azurus chinensis, Azurus chinensis, Azulina serrata, Azurus serrata, Scorpionaceae. : Pine pine, Fusanori genus: Fusanori, False genus: False genus,
Genus Sodegari: Sodegarami, Rattle Genus: Rattle, Rattle, Hilotatamaidae: Hirohatamai Taki, Tamai Taki: Tamai Tadaki, Kagenokiri: Kagaminori, Kaburi, Hibachi, Hibachi, Hibachi, Hibachi, Hitenagao, Hitengusa, Hitenagasa, Hitenagasa, Hitenagai Genus: Hihibiroud, Hibihibiroud,
Pteridophytes: Pleurotus, Pleurotus: Pleurotus: Rumex, Ryumonsou: Ryumonsou, Hera Ryumon, Nymphalaceae: Nisekarekigusa: Okitsubara genus: Psyllium syllabus: Acacia
Naminohana, Coral Spodoptera: Rattlefish, Shiogusagoromo: Shiogusagoromo, Ivanoka genus: Etsukiiwanokawa, Kainokawa: Kainokawa, Kanitonote: Kaninote, Corydalis, Dendrobium, Scutellaria, Dioscorea, Rhizophorus, Scutellaria, Saccharomyces , Tambanori, slippery,
Fudaraku, Maruba Hudarak, Isonohana: Nurakusa,
Black knuckle, Ginkgo biloba, Japanese quince: Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese quince, Japanese pine tree, Japanese pine tree Nagaobane genus: Nagaobane,
Genus: Hanafunori, Fukurofunori, Mafunori, Kaligukisa: Pachydermia japonicum, Podocarpus genus: Hosobanotokaomodoki, Hirohanotosakadoki, Yatsudegatatokadoki, Kurotosakatodoki, Katodoki, Katodoki, Katodoki, Katodoki Doki,
Himetosakadoki, Kinuhada genus: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hanagatakarimenia, Honoo: Honoo, Hichinagenasu, Nihonbunio, Nihonburonoo Pleurotus cornucopia, Okamuragusa:
Yamadagusa, Mirin: Mirin, Hosobamirin, Tosakanori: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomokka, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kadikio Nori, Phytophthora alba Spodoptera litura, genus Astragalus: Astragalus,
Genus Ogonori: Ogonori, Cranegrass, Shiramo, Ozonori, Mizookonori, Cabana Nori, Beniogonori, Fukuroshinonori, Muranosakinogoonori, Scorpionaceae, Scutellariae, Scorpionoris , Amanita genus: Nectaria vulgaris, Fushiklenori genus: Fushiklenori, Namibia genus: Pleurotus cornucopiae, Cyprinidae: Pleurotus genus, Periwinkle genus: Periwinkle, Prunus genus: Pleurotus genus: Simi, Hedgehog, Lotus japonicus
Lotus japonicus, Scutellaria: squid reeds,
Novonori, Black-headed genus: Black-headed ginsou, Red-headed genus: Red-headed ginsou, Rhizoma genus: Hishibukuro, Madaragusa: Scutellaria, Etsukimadara, Taogo-nagien: Taogosou, Hanasakura, Haduna, sugi , Hiratao goat genus: Hiratao goat, dalus genus: dalus, scorpionfish, anadalus, weebagsa genus: weebagsa, benifukuronori genus: benifukuronori, fushuna genus: fushunagi, himefusutsunagi,
Broadbill, Salix genus: Spodoptera cinerea, Usbawa vulgaris, squid genus: squid, caygis, squid squid, haneigis, axusa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chirimomimushi: Chirimomiji, Konohanori family: Hatabenoori, Konohanori, Suzuronori, Usubini: Usbeni, Hasugiginu: Hasujiginu, Nagausaginohagi, Hausaginohagi, Hausaginohaji, Niusakonohaji, sugi-nosagi, sugi, sugi Yaleus Banori, Suzius Banori, Haius Banori, Usbanorimodoki: Usbanorimodoki, Ayanishiki: Ayanishiki, Agianu:
Ayaginu, Dasia genus: Enashidasia, Shimadsia genus: Isohagi, Shimadaia, Dagimodi: Dagimodoki, Itogusa: Moroitogusa, Futoigusa, Makuri: Makuri, Yanaginori genus: Hana-yanagia, sagiyunayunayunayunayunayunayunayunabenyi, benna : Crosozo, Cobosozo, Hanesoso, Sozonohana, Amaranthus: Ranunculaceae, Raponica, Cozanemo: Cozanemo, Imurasaki, Hosocozanemo, Genus: Mesothraceae, Black-spotted dragonfly, Anemoneaceae, Anemoneaceae, Anemoneaceae, Anemoneaceae, Angustiaceae, Angustiaceae, Angustiformes Astragalus, Rhizophora: Rhizopus, Fujimatsumo: Fujimatsumo, Sawtooth genus: Toothbrush Mushrooms, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome genus: Ideyukogome, Ochiimozuku genus: Ochiimozuku, Otomogusa, Chichinorimo: Chinorimo, Chisujinori: Chisujinori and the like).

Axis algae (genus Chara, genus Citra,
The genus Rhizopus: Rhizophyllum, the genus Lichnotamnus, the genus Flamus: Himaflamus, Chaboflamus, Tripera, etc.), the yellow algae (Genus Hikarimo: Hikarimo, etc.), etc.

Materials derived from animal-derived materials include poultry extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposed product thereof, cow or pig. Brain tissue extract, hydrolyzed collagen hydrolyzate (acid, alkali, enzyme, etc.) of cattle, pigs or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin of cattle or pigs or elastin hydrolyzate (acid , Alkali, enzyme, etc.) or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or bovine blood cell protein degradation product (globin peptide), to cow or pig Degradation products of hemoglobin (hemin, hematin, heme, protoheme, heme iron, etc.),
Milk, casein and its degradation products or their derivatives, skim milk powder and its degradation products or their derivatives, lactoferrin or its degradation products, chicken egg components, fish meat degradation products, nucleic acid-related substances (ribonucleic acid, deoxyribonucleic acid), etc.

As the material derived from plant or animal raw materials, any site derived from a gene recombinant or a cell fusion,
Cells, tissues, organs, metabolites, etc. can also be used.
Furthermore, for example, an undifferentiated cell group, a cell group in the process of differentiation, or the like obtained by culturing an arbitrary site, cell, tissue, organ or the like can be used.

(14) Marine components Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salts (sodium chloride, magnesium chloride, potassium chloride, etc.) obtained from the Dead Sea or the Atlantic or Pacific oceans, sea mud Or mud (fango), for example, sea mud or mud of various places such as Italian fango, German fango, Eifelfango, and Freiburgfango (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, Potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), Seitoku stone, Kurodaite, etc.

(15) Microorganism culture metabolite Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, Fermented rice extract,
Fermented rice bran (red bran, white bran) extract, euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermented product of raw milk or skim milk powder, fermented product of lactic acid bacterium of legumes, lactic acid bacterium of coconut plant Fermented material, etc.

(16) α-hydroxy acids Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.

(17) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, Gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(18) Ultraviolet absorbing / blocking agent Benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone-sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), para-aminobenzoic acid derivative ( Paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc., methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate,
Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, mono-2-diparamethoxycinnamate
Glyceryl ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate,
Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline Derivative, pyrimidine derivative,
Dioxane derivative, camphor derivative, furan derivative,
Pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, vitamin B6 derivative, umbelliferone, esculin, benzyl cinnamate, cinoxate, oxybenzone, dioxybenzone, octabenzone, thrisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, Baicalein, berberine, neoheliopan, escarol, zinc oxide,
Talc, kaolin, etc.

(19) Whitening agent Para-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative,
Nucleic acid derivative, allantoin derivative, nicotinic acid derivative,
Vitamin C or its derivatives (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or its derivatives, kojic acid or its derivatives, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract. , Ellagic acid, lucinol, etc.

(20) Tyrosinase activity inhibitor Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or Derivatives thereof, N-acetyltyrosine or a derivative thereof, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou,
Clara, mugwort, honeysuckle, yellowfin, duckweed, matsuhod, pearl barley, duckweed, hops, hawthorn, eucalyptus, yarrow, altea, keihi, mankeishi, hamamelis, karaguawa or yamgua, meicho, bellflower, succulent, yellow-dried, hemp dry, hemp. (Senkyu, Dokatsu, Psycho, Boufu, Hamabofu, Ougon, Peony skin, Peony, Gennoshoko, Kakkon, Licorice, Quintuple, Aloe, Shouma, Safflower, Green tea, Black tea, Asakuyaku)
etc.

(21) Melanin dye reducing / decomposing substance Phenyl mercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide solution, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether)
etc.

(22) Turnover promoting action / cell activating substance Hydroquinone, lactic acid bacterium extract, placenta extract, ganoderma lucidum extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, dragonfly, horsetail, gentian, burdock,
Sikon, carrot, hamamelis, hop, yokinin,
Odori Koso, Assemblies, Touki, Daffodil, Amacha, Hypericum, Cucumber, Prickly Pear,
Mannenrou, parsley) etc.

(23) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound), etc. .

(24) Active oxygen scavenger SOD, catalase, glutathione peroxidase, etc.

(25) Antioxidant Vitamin C or salt thereof, stearic acid ester, vitamin E or derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Para-hydroxyanisole, propyl gallate, sesamol,
Sesamorin, Gossypol, Propolis etc.

(26) Lipid Peroxide Production Inhibitor β-Carotene, Plant Extract (Sesame Cultured Cells, Armature,
Hypericum, Hamamelis, Clove, Melissa, Crassulaceae, Birch, Salvia, Mannenrow, Nantenmi, Ages, Ginkgo, green tea) etc.

(27) Anti-inflammatory agent Ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, chamazulen, chlorpheniramine maleate, glycyrrhizic acid or its salt, glycyrrhetinic acid or its salt, licorice extract, shikon extract, agets extract, propolis and the like.

(28) Antibacterial / sterilizing / disinfectant acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercury chrome, lactoferrin or its hydrolyzate, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, porridge powder, iodine compound,
Iodoform, sorbic acid or its salt, propionic acid or its salt, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p- Chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565,
Halocarbane, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant Agents (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (odor Trimethylammonium chloride, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, yellowtail Ant Green, Malachite Green, Crystal Violet, Jermal, Photosensitizer No. 101, Photosensitizer No. 201, Photosensitizer No. 401, N-long chain acyl basic amino acid derivative and its acid addition salt, zinc oxide, hinokitiol, kujin, propolis, etc. .

(29) Moisturizer Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid),
Hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative, pyrrolidonecarboxylic acid or its salt, sodium lactate, urea, sorbitol, amino acid or its derivative (valine, leucine, isoleucine, threonine, methionine). , Phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine,
Cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, their sulfates, phosphates, nitrates, citrates or pyrrolidonecarboxylic acid), oils and fats " Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange lafer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, quince seed oil, kukui nut oil, safflower oil, shea Fat, liquid shea butter, soybean oil, camellia oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil , Mokurou, coconut oil, eucalyptus oil, beef tallow, lard Squalene, squalane, pristane or hydrogenated product thereof fats and oils (hydrogenated oils) ", waxes (beeswax, carnauba wax, spermaceti, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax),
Mineral oil (liquid paraffin, petrolatum, paraffin, ozokeride, ceresin, microchristine wax),
Bacillus natto metabolite, natto extract, silk fiber extract, plant extract (red pine sap, aloe, kudzu root, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, white birch or birch sap, senburi, mulberry bark, biwa Leaves, loofah, peony skin, peony) etc.

(30) Elastase activity inhibitor diisopropyl fluorophosphate, plant extract (salmon, Hypericum, Clara, mulberry leaf, cinnamon, ginger ginger, comfrey, salvia, elderberry, bodige, button pipi), seaweed extract and the like.

(31) Hair agent Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thiantol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid, etc.

(32) Antiandrogens Estrogen (estron, estradiol, ethinyl estradiol, etc.), isoflavone, oxendron, etc.

(33) Peripheral blood flow promoter Vitamin E or a derivative thereof, cucumber extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(34) Stimulants Capsicum tincture, nonyl acid vanilamide, cantharis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(35) Metabolic activator Photosensitizer No. 301, hinokitiol, pantothenic acid or its derivatives, allantoin, placenta extract, biotin, pentadecanoic acid glyceride, etc.

(36) Antiseborrheic agent pyridoxine or its derivative, sulfur, vitamin B6
etc.

(37) Keratolytic agent Resorcin, salicylic acid, lactic acid, urea, etc.

(38) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium peroxytripolyphosphate, sodium bromate, potassium bromate, pyroline peroxide Sodium acid salt, sodium peroxyorthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution,
Mushroom extract, etc.

(39) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(40) Hair swelling agent Ethanolamine, urea, guanidine, etc.

(41) Dyeing agent 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
-5-Nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein, etc.

(42) Fragrances Natural animal fragrances such as musk, civet, catrium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black character essential oil, cinnamon essential oil, ginnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mint essential oil, large scented essential oil, tuberose essential oil, clove essential oil, orange essential oil, winter green essential oil, true balsam essential oil, butchery essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil,
Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Vetiver Essential Oil, Bergamot Essential Oil, Peruvian Balsam Essential Oil, Boad Rose Essential Oil, Homou Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil, Lime Essential Oil, Lavender Essential Oil, Linaloe Essential Oil, Lemongrass Essential Oil, Lemon Essential Oil, Rosemary Essential Oil (Mannen wax) Essential oils, vegetable flavors such as Japanese peppermint essential oil, and other synthetic flavors.

(43) Dye / Colorant Red cabbage dye, red rice dye, madder dye, annatto dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, whole buckwheat pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

(44) Other hormones, sequestering agents, pH adjusting agents, chelating agents, antiseptic / antifungal agents, cooling agents, stabilizers, emulsifiers, kinetic agents
Vegetable protein and its degradation product, animal / vegetable polysaccharide and its degradation product, animal / vegetable glycoprotein and its degradation product, blood flow promoter, anti-inflammatory / anti-inflammatory / anti-allergic agent, wound healing agent, A foaming agent, a thickening agent, an enzyme, purified water (electronic water, small clusters, etc.), an oral preparation, a deodorant / deodorant, a bittering agent, etc. can be used. Additive or synergistic improvements in other cosmetic effects can be expected.

The method of adding the melanin production inhibitor or the cosmetic composition of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability. Good.

[0075]

EXAMPLES The present invention will be described below with reference to production examples, test examples, and formulation examples, but the present invention is not limited thereto.

(Manufacturing Example 1) 100 g of various dried plants of corn, weevil, yerba santa, and lily were heated and extracted with purified water (about 80 ° C.) for about 5 hours and filtered to extract (dry solid content: about 0.1). ~ 6.0%) about 1.0 kg.

(Production Example 2) 100 g of various dried plants of corn, weevil, yerba santa, and lily were dipped in a 50% ethanol solution, extracted at room temperature for 5 days and night, and then filtered to obtain an extract (dry solid content: about 0.1). ~ 6.0%) about 1.0 kg.

(Production Example 3) 100 g of various dried plants of corn stalks, weevil seeds, yerba santa leaves, lily flowers, 70% ethanol solution or 70% 1,3-butylene glycol solution, or 60% propylene glycol solution Or, soak in purified water (about 30 ° C), extract at room temperature for 5 days, then filter to extract (dry solids: about 0.1-6.0%)
You get 1.0kg.

(Test 1) Melanin production inhibition test "Test method and evaluation method" B16 melanoma cells were cultured for 24 hours, and this culture solution was replaced with a culture solution containing a sample. At this time, purified water was added to the blank. After culturing for 3 days, the cells were treated with trypsin and 10% DM
It was heated and dissolved in a 1N-NaOH solution containing SO and the absorbance at 420 nm was measured. At the same time, the MTT reduction method (Tim Mosmann; Jou
rnal of Immunological Methods p55-63 (1983) reference), and after confirming that there is no difference in the number of viable cells between the blank group and the sample addition group, the inhibition rate for the amount of melanin production in the blank cells (%) Was calculated by the equation 1. The results are shown in Fig. 1. "Sample" The sample of the melanin production inhibition test was a variety of plant extracts (solid content concentration: 0.00) obtained in Production Example 2 of the present invention.
(Adjusted to 25%) was used for the test. As a comparative sample, arbutin (manufactured by Sigma) was prepared under the same conditions,
Used for the test.

<Equation 1> Melanin production suppression rate (%) = {1- (sample melanin amount / blank melanin amount)} × 100

(Test Results) As shown in FIG. 1, it was confirmed that the various plant extracts of corn, weevil, yerba santa, and lily of the present invention have almost the same melanin production-inhibitory action as compared with arbutin. Can be used as

(Test 2) Safety test (1) Primary skin irritation test Various plant extracts obtained in Production Examples 1 to 3 were prepared so that the solid content concentration was about 1.0%, and this was placed on the back. Shaved Hartley guinea pig (female, 3 per group, weight 300-350)
0.03 mL was applied per 2 × 2 cm ² square of the skin of g).
Judgment was performed 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indexes. As a result, in all animals, no erythema or edema was observed, and it was determined to be negative.

(Test 3) Safety test (2) Cumulative skin irritation test The various plant extracts obtained in Production Examples 1 to 3 were prepared so that the solid concentration was about 1.0%, and the flanks were prepared. Shears (2x
4 cm ² ) Hartley guinea pigs (female, 3 per group,
Skin (body weight: about 320 g) was applied once a day, 5 times a week, at 0.5 mL / animal. The application was carried out for 2 weeks, and the shearing was performed on the last application day of each week. Judgment was performed on the day after each application day and the day after the last application day, using erythema and edema as indexes by the primary irritation scoring method. As a result, in all animals,
Neither erythema nor edema was observed for 2 weeks after the application, and it was judged to be negative.

(Test 4) Safety test (3) Single dose toxicity test Various plant extracts obtained in Production Examples 1 to 3 were adjusted with purified water to a concentration of 12.5%, and 16 mL / mouse / kg amount,
Before the test, ddy mice (male and female, 5 mice per group, 5 weeks old) that had been fasted for 16 hours were orally administered with a sonde, and the onset and extent of toxic symptoms were observed over time. As a result, no abnormality was observed in all mice for 14 days, and the results of autopsy were also abnormal. Therefore, LD ₅₀ is 2,000
It was judged to be a safe substance since it is 0 mg / kg or more.

(Formulation Example) Manufacture of Melanin Production Inhibitor and Cosmetic Composition According to the above-mentioned evaluation results, the formulation examples are shown below. Each formulation example may be one produced by a conventional method in the production of each product. , Only the blending amount is shown. Further, the present invention is not limited to these.

[0086] (Prescription example 1) Emulsion mass%     1. Squalane 5.0     2. Olive oil 5.0     3. Jojoba oil 5.0     4. Cetyl alcohol 1.5     5. Glycerin monostearate 2.0     6. Polyoxyethylene (20) cetyl ether 3.0     7. Polyoxyethylene (20) soorbitan monooleate 2.0     8.1,3-butylene glycol 1.0     9. Glycerin 2.0    10.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0    11. Preservative (paraoxybenzoate) Suitable amount    12. Perfume proper amount    13. Residue to make purified water 100

[0087] (Prescription example 2) Emulsion mass%     1. Squalane 8.0     2. Jojoba oil 7.0     3. Glyceryl p-aminobenzoate 1.0     4. Ethyl urocanate 1.0     5. Vitamin C phosphate magnesium salt 1.0     6. Cetyl alcohol 1.5     7. Glycerin monostearate 2.0     8. Polyoxyethylene (20) cetyl ether 3.0     9. Polyoxyethylene (20) soorbitan monooleate 2.0    10.1,3-butylene glycol 1.0    11. Glycerin 2.0    12.1,2-Pentanediol 3.0    13. Corn Extract 2.0 of Production Example 1    14. Pomegranate extract of Production Example 1 2.0    15. Yarba Santa Extract 2.0 of Production Example 1    16. Ivy leaf or stem 70% ethanol extract 1.0    17. Hypericum leaf or stem 70% ethanol extract 1.0    18. Purple Root 50% propylene glycol extract 1.0    19. Silk protein enzymatic degradation solution 1.0    20. Pork placenta water extract 1.0    21. Antibacterial and antiseptic (paraoxybenzoic acid ester)    22. Residue of purified water 100

[0088] (Prescription example 3) Cosmetic oil mass%     1. Liquid paraffin 30.0     2. Squalane 20.0     3. Olive oil 20.0     4. Isopropyl palmitate 10.0     5. Lily Extract 3.0 of Production Example 1     6. Pomegranate extract of Production Example 1 3.0     7. Grapefruit fruit or leaf hot water extract 1.0     8. Mulberry leaf or bark hot water extract 1.0     9. Soybean seed hot water extract 1.0    10. Olive oil 1.0    11. Shea butter 1.0    12.Butyl hydroxyanisole 0.1    13. Vitamin E derivative 0.1    14. Antibacterial / antiseptic (benzalkonium chloride)    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0089] (Formulation Example 4) Flexible lotion mass%     1. Glycerin 5.0     2.1,3-butylene glycol 5.0     3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0     4. Ethanol 15.0     5. Corn style 60% ethanol extract 2.0     6. Ivy leaf or root 60% 1,3-butylene glycol extract 1.0     7. Chamomile whole plant 60% 1,2-pentanediol extract 1.0     8. Bodhi flower or fruit 50% 1,3-butylene glycol extract 1.0     9. Yuzu fruit 30% ethanol extract 1.0    10. Ginger fruit or root 30% 1,2-pentanediol extract 1.0    11. Kiwi fruit 50% ethanol extract 1.0    12. Antibacterial (lactoferrin solution) appropriate amount    13. Antibacterial and antiseptic (paraoxybenzoic acid ester)    14. Perfume (Western light water) Suitable amount    15. Residue to make purified water 100

[0090] (Prescription example 5) Astringent lotion mass%     1. Sorbit 2.0     2.POE (20) oleyl alcohol 1.0     3. Ethanol 15.0     4.1,2-Pentanediol 3.0     5. Pomegranate seeds or whole plant 30% ethanol extract 3.0     6. Kobodzu leaf or fruit 50% propylene glycol extract 2.0     7. Clove flower or bud 30% ethanol extract 2.0     8. Soaproot leaves 50% 1,3-butylene glycol extract 2.0     9. Gentian whole plant 50% ethanol extract 2.0    10. Hamamelis leaf or bark 50% 1,3-butylene glycol extract 1.0    11. Sansho peel or fruit 30% ethanol extract 1.0    12. Yeast 50% 1,3-butylene glycol extract 1.0    13. Allantoin 0.2    14. Astringent (zinc sulfocarbonate) 0.2    15. Antibacterial and antiseptic (thiamin lauryl sulfate)    16. Perfume (lavender water) Suitable amount    17. Residue to make purified water 100

[0091] (Prescription example 6) Two-layer type lotion (liquid-liquid type) mass%     1. Squalane 8.0     2. POE sorbitan tetraoleate 0.3     3. Sorbitol 1.0     4. Ethanol 15.0     5. Yaba Santa leaf or root 70% propylene glycol extract 3.0     6. Lily flower or head flower 70% 1,2-Pentanediol extract 3.0     7. Scutellaria rhizome or root bark 60% 1,2-pentanediol extract 2.0     8. Oolong tea leaf or stem 70% ethanol extract 2.0     9. Avocado fruit or root 50% propylene glycol extract 2.0    10. Coffee beans or seeds 50% 1,3-butylene glycol extract 2.0    11. Sage whole plant 50% ethanol extract 1.0    12. Western Bodhi flower or fruit 30% ethanol extract 1.0    13. Ascorbic acid glucoside 0.2    14. Astringent (calamine) 0.1    15. Antibacterial and antiseptic (phenoxyethanol)    16. Perfume (Chamomile water) Suitable amount    17. Residue to make purified water 100

[0092] (Prescription example 7) Carmine lotion (liquid to solid) mass%     1. Glycerin 3.0     2.1,3-butylene glycol 5.0     3. Ethanol 15.0     4. Iron oxide (red iron oxide) 0.2     5. Zinc oxide 0.5     6. Kaolin 2.0     7. Yaba Santa whole plant 30% propylene glycol extract 3.0     8. Lily flower 50% propylene glycol extract 3.0     9. Kobotsudzu seed 50% propylene glycol extract 2.0    10. Peony root 50% propylene glycol extract 2.0    11. Mulberry flowers or leaves 50% propylene glycol extract 2.0    12. Barley seed or fruit 50% propylene glycol extract 2.0    13. Comfrey leaf and stem 50% ethanol extract 1.0    14. Coltsfoot flower or leaf 50% 1,3-butylene glycol extract 1.0    15. Pig placenta enzyme decomposition solution 1.0    16. Silk protein alkaline solution 2.0    17. Camphor 0.2    18. Phenol 0.03    19. Antibacterial / preservative (photosensitive element 201 & 401)    20. Perfume (bodhi tree water) appropriate amount    21. Residue to make purified water 100

[0093] (Prescription example 8) Pack mass%     1. Polyvinyl alcohol 15.0     2. Carboxymethyl cellulose sodium 5.0     3. Propylene glycol 3.0     4. Ethanol 10.0     5.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     6. Panax ginseng root 30% ethanol extract 1.0     7. Grape stem or leaf 30% ethanol extract 1.0     8.Wenzhou mandarin orange peel 50% 1,3-butylene glycol extract 1.0     9. Green tea leaf or stem hot water extract 1.0    10. Peach leaf or stem hot water extract 1.0    11. Yeast 50% 1,3-butylene glycol extract 1.0    12. Pork placenta hot water extract 1.0    13. Antibacterial and antiseptic (paraoxybenzoic acid ester)    14. Perfume (Rose water) Appropriate amount    15. Residue to make purified water 100

[0094] (Prescription example 9) Peel-off pack mass%     1. Glycerin 5.0     2. Propylene glycol 4.0     3. Polyvinyl alcohol 15.0     4. Ethanol 8.0     5. Polyoxyethylene glycol 1.0     6. Pantothenyl ethyl ether 1.0     7. Corn style 50% 1,2-butylene glycol extract 3.0     8. Pomegranate 50% glycerin extract 3.0     9. Safflower whole plant 50% ethanol extract 1.0    10. Dutch jelly (parsley) leaf or stem 50% ethanol extract 1.0    11. Eucalyptus leaf or stem 30% ethanol extract 1.0    12. Royal jelly 50% ethanol extract 1.0    13. Trehalose solution 1.0    14. Antibacterial and antiseptic (paraoxybenzoic acid ester)    15. Perfume (Karashi water) Suitable amount    16. Residue to make purified water 100

[0095] (Prescription example 10) Cold cream mass%     1. White beeswax 11.0     2. Liquid paraffin 22.0     3. Lanolin 10.0     4. Olive oil 5.0     5. Ylang Ylang oil 5.0     6. Palm oil 5.0     7. Borax 0.5     8.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     9. Achillea millefolium extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    10. White birch bark extract 2.0       (Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)    11. Ginseng root 50% propylene glycol extract 2.0    12. Matsuhodo sclerotium 50% 1,2-butylene glycol extract 1.0    13. Soybean seed water extract 1.0    14. Zinc yeast 50% 1,3-butylene glycol extract 1.0    15. Liquid shea fat 1.0    16. Dipotassium glycyrrhizinate 0.1    17. Antibacterial and antiseptic (acrinol) 0.1    18. Perfume (Ylang-Ylang water) Suitable amount    19. Residue to make purified water 100

[0096] (Formulation example 11) Emollient cream mass%     1. Stearic acid 2.0     2. Stearyl alcohol 7.0     3. Reduced lanolin 2.0     4. Squalane 5.0     5. Octyldodecanol 6.0     6. Polyoxyethylene cetyl ether (25E.O.) 3.0     7. Lipophilic glyceryl monostearate 2.0     8. Propylene glycol 2.0     9.1,2-Pentanediol 2.0    10. Pomegranate seed or leaf 50% propylene glycol extract 2.0    11. Corn flower 50% dipropylene glycol extract 2.0    12. Shiso leaf 50% propylene glycol extract 2.0    13. Purple root 50% propylene glycol extract 2.0    14. Soybean seed fermented soybeans 1.0    15. Glycyrrhetinic acid 0.1    16. Pig placenta enzyme decomposition solution 1.0    17. Antibacterial (lactoferrin solution) 0.5    18. Antibacterial and antiseptic (Zinc pyridione)    19. Perfume (Mugwort water) Suitable amount    20. Residue of purified water 100

[0097] (Prescription example 12) Face wash cream Mass%     1. Myristic acid 25.0     2. Stearic acid 5.0     3. Beef tallow fatty acid 5.0     4. Propylene glycol 10.0     5. Potassium hydroxide 6.0     6. Coconut oil fatty acid diethanolamide 6.0     7. Yaba Santa Extract 2.0 of Production Example 1     8. Corn extract 2.0 of Production Example 1     9. Lily Extract 2.0 of Production Example 1    10. Apple fruit 20% 1,3-butylene glycol extract 1.0    11. Rosehip fruit 30% ethanol extract 1.0    12.Kakkon hot water extract 1.0    13. Burdock root 50% 1,3-butylene glycol extract 1.0    14. Glycyrrhizic acid 1.0    15. Apricot kernel 0.1    16. Walnut shell grain 0.1    17. Antibacterial and antiseptic (2-phenoxyethanol) 0.1    18. Perfume (tokimizu) Appropriate amount    19. Residue to make purified water 100

[0098] (Prescription example 13) Face-wash cream mass%     1. Stearic acid 10.0     2. Palmitic acid 10.0     3. Myristic acid 12.0     4. Lauric acid 4.0     5. Glycerin 18.0     6. Sodium dl-pyrrolidonecarboxylate 1.0     7. Dioctyl adipate 1.0     8. Cetostearyl alcohol 3.0     9. Triethanolamine 3.0    10. Ergocalciferol 1.0    11. Oleyl alcohol 1.5    12. Lanolin derivative (EO adduct) 1.0    13. Potassium hydroxide 6.0    14.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0    15. Royal Jelly Extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    16. Oil-soluble licorice root or rhizome extract 1.0       (Ethanol: 1,3-butylene glycol = 1: 1 extract)    17. Edetate 1.0    18. Glycyrrhetinic acid 1.0    19. Walnut walnut shell grain 0.1    20. Antibacterial and antiseptic (photosensitive element 401) 0.1    21. Perfume (Mugwort water)    22. Residue of purified water 100

[0099] (Prescription example 14) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Alkanediol 1.0     5. Yaba Santa whole plant 50% dipropylene glycol extract 4.0     6. Seaweed and kelp 70% 1,3-butylene glycol extract 0.5     7. Armchair leaf or stem 70% 1,3-butylene glycol extract 0.5     8. Soybean seed fermented natto fermentation liquid 0.5     9. Loquat leaf 50% dipropylene glycol extract 0.5    10. Altea whole plant 60% dipropylene glycol extract 0.5    11. Mackerel clover leaf 20% 2,3-butylene glycol extract 0.5    12. Aloe pulp end 1.0    13. Polyethylene powder 0.5    14. Hydroxypropyl chitosan solution 0.5    15. Amino acids (arginine, glycine, glutamine, etc.) 0.5    16. Monoammonium glycyrrhizinate 0.1    17. Antibacterial / antiseptic (undecylenic acid, phenol)    18. pH adjuster    19. Fragrance (Lavender water) Suitable amount    20. Residue of purified water 100

[0100] (Prescription example 15) Body soap mass%     1. Potassium laurate 15.0     2. Potassium myristate 5.0     3. Propylene glycol 5.0     4. Lily head flower 70% 2,3-butylene glycol extract 3.0     5. Corn flower 70% 2,3-butylene glycol extract 3.0     6. Toki rhizome 70% 2,3-butylene glycol extract 0.5     7.Kakkon 70% 1,3-butylene glycol extract 0.5     8. Nettle 70% 1,3-butylene glycol extract 0.5     9. Hydrolyzed collagen solution derived from fish (salmon or flounder, sea bream) 0.5    10. Psyllium whole plant 50% ethanol extract 0.5    11. Amino acids (glutamine, proline, lysine, etc.) 0.5    12. Monoammonium glycyrrhizinate 0.1    13. Antibacterial and antiseptic (undecylenic acid, phenoxyethanol)    14. pH adjusting agent    15. Perfume (orange water)    16. Residue to make purified water 100

[0101] (Prescription example 16) Sunscreen cosmetics (O / W type) Mass%     1. Oxybenzone 2.0     2. Octyl para methoxycinnamate 5.0     3.Dihydroxymethoxybenzophenone 0.2     4. Squalane 10.0     5. Vaseline 5.0     6. Stearyl alcohol 3.0     7. Stearic acid 3.0     8. Glyceryl monostearate 2.0     9. Polyethyl acrylate 1.0    10.1,3-butylene glycol 6.0    11. Disodium edetate 0.1    12. Triethanolamine 1.0    13. Titanium dioxide 5.0    14. Yaba Santa seed or root 50% ethanol extract 3.0    15. Corn style or spike 50% ethanol extract 3.0    16. Gentian whole plant 50% ethanol extract 1.0    17. White birch bark 70% dipropylene glycol extract 1.0    18. Cornflower leaf 50% propylene glycol extract 0.5    19. Kakkon 50% propylene glycol extract 0.5    20. Yuzu fruit 50% dipropylene glycol extract 0.5    21. Antibacterial and antiseptic (benzyl paraoxybenzoate)    22. Perfume (jasmine water) Suitable amount    23. Residue to make purified water 100

[0102] (Prescription example 17) Sunscreen cosmetics (oil type) Mass%     1. Liquid paraffin 70.0     2. Tetrahydroxybenzophenone 1.0     3. Cetyl octanoate 23.8     4.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     5. Orange peel or fruit 10% 1,3-butylene glycol extract 0.5     6. Burdock root hot water extract 0.5     7. Horse chestnut whole plant 30% 1,3-butylene glycol extract 0.5     8. Mallow flower or leaf 50% propyl alcohol extract 0.5     9. Whole pearl barley 50% 1,3-butylene glycol extract 0.5    10. Peony root or leaf hot water extract 0.5    11. Merilito flower or leaf 70% 1,3-butylene glycol extract 0.5    12.Ethyl paraaminobenzoate 0.2    13. Antioxidant (Butylhydroxytoluene) Suitable amount    14. Perfume (Mixed perfume)

[0103] (Prescription example 18) Cream foundation (O / W type) Mass%     1. Stearic acid 4.0     2. Glycerin monostearate 3.0     3. Cetanol 1.5     4.Isopropyl myristate 7.0     5. Liquid paraffin 10.0     6. White beeswax 3.0     7. Triethanolamine 1.5     8. Glycerin 3.0     9. Bentonite 1.0    10.Titanium oxide 8.0    11.2,4-Dihydroxybenzophenone 8.0    12. Kaolin 3.0    13. Talc 3.0    14. Coloring pigment (yellow iron oxide) 1.0    15. Pomegranate flower or seed 70% 2,3-butylene glycol extract 1.0    16. Lily flower 70% 1,2-Pentanediol extract 1.0    17. Dokudami leaf hot water extract dry powder 0.3    18. Yukinoshita whole plant hot water extract dry powder 0.3    19. Rhizophora rhizome or root bark 50% ethanol extract 0.3    20. Antibacterial and antiseptic (phenoxyethanol) 0.1    21. Perfume (Rose water) Suitable amount    22. Residue of purified water 100

[0104] (Prescription example 19) Shampoo mass%     1. Lauryl sulfate triethanolamine 5.0     2. Sodium polyoxyethylene lauryl ether sulfate 12.0     3.1,3-butylene glycol 4.0     4. Lauric acid diethanolamide 2.0     5. Disodium edetate 0.1     6.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     7. Mackerel clover 20% 2,3-butylene glycol extract 2.0     8. Hot water extract of root bark or rhizome 2.0     9. Iris flowers or rhizome 30% 1,4-butylene glycol extract 2.0    10. Toki root 30% 1,4-butylene glycol extract 2.0    11. Hot water extract of tomato fruit 1.0    12. Hydroxypropyl chitosan solution 1.0    13. Hyaluronic acid solution 1.0    14. Dipotassium glycyrrhizinate 0.1    15. Antibacterial and antiseptic (photosensitive element 101)    16. pH adjuster    17. Perfume (grape water) Suitable amount    18. Purified water

[0105] (Prescription example 20) Rinse mass%     1. Stearyl trimethyl ammonium chloride 3.0     2. cetostearyl alcohol 3.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5.1,2-Pentanediol 2.0     6. Corn stylus or spike 50% 1,2-pentanediol extract 3.0     7. Pomegranate leaf or stem 50% 2,3-butylene glycol extract 3.0     8. Yaba Santa Fruit 50% 1,2-Pentanediol Extract 1.0     9. Scented flower 50% 1,3-butylene glycol extract 1.0    10. Mackerel fruit 30% 1,2-butylene glycol extract 1.0    11. Yellow rhizome 50% 1,3-butylene glycol extract 1.0    12. Cherry fruit or flower 50% 1,3-butylene glycol extract 1.0    13. Soybean seed fermented soybeans 0.5    14. Hydroxyethyl chitosan solution 0.5    15. Hydrolyzed collagen solution derived from fish (salmon or tuna, sea bream, sole) 0.5    16. Trehalose solution 0.5    17. Hydrolyzed silk solution 0.5    18. Antibacterial / antiseptic (benzalkonium chloride)    19. Fragrance (salvia water) Suitable amount    20. Residue of purified water 100

[0106] (Prescription example 21) Rinse mass%     1. Stearyl trimethyl ammonium chloride 2.0     2. cetostearyl alcohol 2.0     3. Polyoxyethylene lanolin ether 3.0     4. Propylene glycol 5.0     5. Ethylene glycol 3.0     6. Lily flower 50% 1,2-Pentanediol extract 3.0     7. Kobodzu crane whole plant 50% 1,2-pentanediol extract 3.0     8. Western bodhi flower or fruit 50% 1,4-butylene glycol extract 1.0     9. Olive leaf 50% 1,2-butylene glycol extract 1.0    10. Centipede fruit or flower 50% 1,3-butylene glycol extract 1.0    11. Sweet green tea 50% glycerin extract 1.0    12. Bifidobacterium fermentation liquid 1.0    13. Sodium alginate 1.0    14. Trehalose solution 1.0    15. Hydrolyzed keratin solution 1.0    16. Antibacterial / antiseptic (benzalkonium chloride)    17. Perfume (Hamamelis water) Suitable amount    18. Residue to make purified water 100

[0107] (Formulation Example 22) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5. Pomegranate fruit or seed 50% 1,3-butylene glycol extract 3.0     6. Apricot fruit 50% glycerin extract 1.0     7. Hop female spike 50% ethanol extract 1.0     8. Melissa whole plant 50% ethanol extract 1.0     9. Usubasaicin rhizome 30% ethanol extract 1.0    10. White birch sap 1.0    11. Carpronium chloride 0.3    12. Hinokitiol 0.5    13. Keratin decomposition solution 0.5    14. Stearyl glycyrrhetinate 0.1    15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    16. Perfume (Rosehip water) Suitable amount    17. Residue to make purified water 100

[0108] (Formulation Example 23) Hair liquid mass%     1. Ethanol 29.0     2. Polyoxypropylene butyl ether phosphoric acid 10.0     3. Polyoxypropylene monobutyl ether 5.0     4. Triethanolamine 1.0     5.1,2-hexanediol 1.0     6. Yaba Santa leaf or stem 50% 1,3-butylene glycol extract 3.0     7. Chamomile flowers or fruits 50% 1,2-butylene glycol extract 1.0     8. Assembly leaf or stem 50% 1,2-butylene glycol extract 1.0     9. Ginseng root hot water extract 1.0    10. Apple fruit 30% ethanol extract 1.0    11. Sesamorin 0.3    12. Azulene 1.0    13. Antibacterial / antiseptic (paraben, benzalkonium chloride) appropriate amount    14. Perfume (orange water) Suitable amount    15. Residue to make purified water 100

[0109] (Formulation Example 24) Hair liquid mass%     1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     5. Comfrey leaf or stem 50% ethanol extract 1.0     6. Peach fruit or leaf 50% ethanol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Hamamelis leaf or stem hot water extract 1.0     9. Comfrey leaf or stem 50% ethanol extract 1.0    10. Lettuce leaf 50% ethanol extract 1.0    11. Carpronium chloride 0.3    12. Pantethine solution 0.3    13. Amino acids or their derivatives 3.0     (Lysine, alanine, pyrrolidone carboxylic acid, etc.)    14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount    15. Perfume (Rose water) Appropriate amount    16. Residue to make purified water 100

[0110] (Prescription example 25) Heartonic mass%           1.Ethanol 40.0     2. Ethyl oleate 1.0     3. Polyoxyethylene (40) hydrogenated castor oil 2.0     4. Lily flower 30% ethanol extract 3.0     5. Yashabushi fruit or seed 30% ethanol extract 1.0     6. Antibacterial / antiseptic (propyl paraoxybenzoate) 0.2     7. Residue to make purified water 100

[0111] (Prescription example 26) Heartonic mass%     1.l-menthol 0.2     2. Ethanol 32.5     3. Polyoxyethylene hydrogenated castor oil 0.5     4. Propylene glycol 5.0     5. Diphenhydramine hydrochloride 0.3     6.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 5.0     7. Hypericum perforatum fruit or pericarp hot water extract 1.0     8. Western Bodhi flower or leaf 50% propylene glycol extract 1.0     9. Lavender flower or flower spike hot water extract 1.0    10. Bildo Aoi rhizome or root bark 50% ethanol extract 1.0    11. Auregon rhizome or root bark 50% ethanol extract 1.0    12. Soybean seed hot water extract 1.0    13. Carboxymethyl chitin solution 1.0    14. Chicken comb extract solution 0.2    15. Pantethine solution 0.2    16. Antibacterial / antiseptic (phenoxyethanol)    17. Fragrance (lemon water) Suitable amount    18. Residue to make purified water 100

[0112] (Prescription example 27) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2. Lily head flower or spike 50% glycerin extract 5.0     3. 50% Propylene Glycol Extract Liquid     4. Vitamin E derivative 0.5     5. Capsicum tincture 0.5     6. Resorcin 0.5     7.Dipotassium glycyrrhizinate 0.5     8. Carboxymethyl chitin solution 0.5     9. Collagen protein enzymatic degradation solution 1.0    10. Pig hematin solution 0.5    11. Pork mucin solution 0.5    12. Amino acids (arginine, glycine, glutamine, etc.) 0.5    13. Antibacterial and antiseptic (paraben) 0.1    14. Perfume (rosemary water) Suitable amount    15. Residue to make purified water 100

[0113] (Prescription example 28) Hair growth and hair nourishing agent% by mass     1.Ethanol 60.0     2.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 3.0     3. Aloe stem or mesophyll hot water extract 3.0     4. Whole plant 60% ethanol extract 3.0     5. Peony rhizome or root bark 60% ethanol extract 3.0     6. Artemisia leaf or stem 50% 1,3-butylene glycol extract 1.0     7. Soybean seed natto fermented liquid 1.0     8. Whole clover 20% 2,3-butylene glycol extract 1.0     9. Pepper fruit hot water extract 1.0    10. Cantharis tincture 0.5    11. Pantothenic acid derivative 0.2    12.β-glycyrrhetinic acid 0.2    13. Resorcin 0.2    14. Hydroxyethyl chitosan solution 0.2    15. Elastin hydrolyzate 0.2    16.Keratin protein enzymatic degradation solution 0.2    17. Preservative (paraben) 0.1    18. Perfume (Bergamot water) Suitable amount    19. Residue to make purified water 100

[0114] (Prescription example 29) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 5.0     4.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 4.0     5. Sorbitol 1.0     6. Peach leaf or stem 70% ethanol extract dry powder 1.0     7. Black tea leaf or stem 30% ethanol extract dry powder 1.0     8. Dye (Gunjo green)

[0115] (Formulation example 30) Granule bath agent mass%     1. Sodium hydrogen carbonate 58.0     2. Anhydrous sodium sulfate 30.0     3. Borax 3.0     4. Hyaluronic acid powder 3.0     5. Corn style or flower spike hot water extract dry powder 1.0     6. Pomegranate seed hot water extract dry powder 1.0     7. Yaba Santa whole grass hot water extract dry powder 1.0     8. Lily flower hot water extract dry powder 1.0     9. Orange peel 50% ethanol extract 1.0    10. Apple juice powder 1.0    11. Dye (Gunjou, Chromium hydroxide) Appropriate amount    12. Perfume (grape water) Suitable amount

(Formulation Example 31) Coating protective agent A gauze or liniment cloth is impregnated with a formulation solution in which an appropriate amount of corn style, whole weevil or whole Yaba Santa or lily flower hot water extract, antibiotics, anti-inflammatory agents, etc. is mixed. And attach it to the wound. Alternatively, the corn style, the whole weevil, the whole yerba santa or the lily flower hot water extract may be directly and locally sprayed and covered with gauze or the like.

[0117] (Prescription example 32) Toothpaste mass%     1. Silicic anhydride 20.0     2.Sorbit solution 50.0     3. Glycerin 10.0     4. Pomegranate fruit or seed hot water extract 5.0     5. Yaba Santa Fruit or Seed Hot Water Extract 5.0     6. Sodium lauryl sulfate 2.0     7. Saccharin sodium 0.05     8. Sodium carboxymethyl cellulose 1.5     9. Fragrance (cardamom water)    10. Appropriate amount of colorant    11. Purified water

[0118] (Prescription example 33) Oral cooling agent Mass%     1. Ethanol 20.0     2. Glycerin 15.0     3. Polyoxyethylene hydrogenated castor oil 1.0     4. Saccharin 0.2     5.Chlorhexidine 0.01     6.A: Corn extract of Production Example 2       B: Pomegranate extract of Production Example 2       C: Yabasanta extract of Production Example 2       D: Lily extract of Production Example 2       * Any one of A to D extract 3.0     7. Hypericum leaf or stem hot water extract 1.0     8. Grapefruit fruit or leaf hot water extract 1.0     9. Green tea leaf or stem hot water extract dry powder 0.1    10. Dye (Gunzhou Green) Appropriate amount    11. Residue to make purified water 100

[0119] (Prescription example 34) Dish detergent for mass%     1. Alkyl (C12) glucoside 20.0     2. Polyoxyethylene (3) dodecyl ether sulfate Na 10.0     3. Glycerin 2.0     4. Ethanol 5.0     5. Yaba Santa whole grass hot water extract 3.0     6. All safflower hot water extract dried powder 1.5     7. Sandalwood whole plant 50% dipropylene glycol extract 0.5     8. Residue to make purified water 100

(Test 5) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. The usage test was conducted by 20 people aged 30 to 60 years old who are suffering from dark spots and freckles, from the age of 30 to 60, and applied twice daily in the morning and at night and after washing the face with an appropriate amount of the emulsion of Prescription Example 1 on the face for 3 months. It was done by doing. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. The evaluation method was carried out according to the following criteria, and the results are shown in Table 1 and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Blemish freckles & skin color improving effect] Effective: Blemish freckles and skin color were white and improved. Slightly effective: The spots, freckles, and skin color were white, and were slightly improved. Ineffective: No change from before use.

[0122]

[Table 1]

(Test Results) As shown in Table 1, the cosmetic composition of the present invention containing various plant extracts of corn, weevil, yerba santa, and lily significantly improved spots and freckles, and improved skin color. It can be confirmed to whiten and can be used as a whitening agent.

(Test 6) Use effect test The effect of actually using the cosmetic composition of the present invention was examined. Use test for healthy women 25-50
Twenty 20-year-old panelists were used twice daily in the morning and evening, and after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months. As a control, an emulsion prepared by removing various plant extracts of the present invention and formulated by the same method was used. In addition, the evaluation method is based on the following criteria,
The results are shown in Table 2, and the numerical values in the table represent the number of people. No one complained of skin abnormality during the period of use.

[Effect of improving skin tension and gloss] Effective: Improves skin tension and gloss. Slightly effective: Skin tension and luster improved slightly. Ineffective: No change from before use.

[0126]

[Table 2]

(Test Results) As shown in Table 2, the cosmetic composition containing various plant extracts of corn, weevil, yerba santa, and lily of the present invention can significantly improve skin tension and gloss. It could be confirmed.

[0128]

[Effects of the Invention] Corn of the present invention
It was confirmed that the melanin production inhibitor or cosmetic composition containing one or more plant extracts selected from Yaba Santa and lily significantly suppressed the production of melanin pigment and had a whitening effect. And improve the spots and freckles on the skin,
To improve the skin color to white. Furthermore, the tension and gloss of the skin can be improved. Therefore, it is effective in preventing aging of the skin and scalp.
It can also be used for other general foods and drinks.

[Brief description of drawings]

FIG. 1 is a graph showing the inhibitory rate against the amount of melanin produced by various plant extracts of corn, weevil, yerba santa, and lily of the present invention.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 7/00 A61K 7/00 X 7/021 7/021 7/06 7/06 7/075 7/075 7/08 7/08 7/11 7/11 7/16 7/16 7/42 7/42 7/48 7/48 7/50 7/50 F term (reference) 4C083 AA032 AA072 AA111 AA112 AA122 AB032 AB152 AB232 AB242 AB442 AC012 AC022 AC072 AC092 AC102 AC112 AC122 AC132 AC152 AC212 AC242 AC352 AC422 AC442 AC472 AC482 AC532 AC542 AC582 AC612 AC642 AC792 AC932 AD022 AD042 AD452 AD512 AD532 AD642 AD662 CC04 CC05 CC06 CC07 CC12 CC19 CC23 CC25 CC32 CC33 CC37 CC01 DD23 CC41 CC31 EE06 EE07 EE10 EE12 EE22 EE31 EE41

Claims (2)

[Claims] 1. A melanin production inhibitor comprising one or more kinds of plant extracts selected from corn, weevil, yerba santa, and lily. 2. A cosmetic composition comprising the melanin production inhibitor according to claim 1.