JP2004189663A - Maillard reaction inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new safe Maillard reaction inhibitor, an external preparation for the skin, and a food and drink. <P>SOLUTION: The Maillard reaction inhibitor contains an extract of a plant selected from Mallotus japonicus Muell. Arg., Diospyros kaki L., Morus alba L., Hypericum perforatum L., Centella asiatica L., Galega officinalis L, Eriodictyon californicum (Hook.et Arn.) Torr and Rosa canina L. Preferably, the plant extract for the Maillard reaction inhibitor is selected from the extracts of the Galega officinalis L and Eriodictyon californicum (Hook. et Arn.) Torr having activities for inhibiting Pentcillin formation. The external preparation for the skin and the food and drink contain them. The plant extract can be utilized as the Maillard reaction inhibitor, and is utilizable for prevention and treatment of various diseases associated with the Maillard reaction such as wrinkles and slack of the skin and complication derived from diabetic. The plant extract imparts gloss and tension to the skin, and can be utilized for prevention of skin aging because of effectiveness to the amelioration of the skin. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

【０１０４】
（試験結果）
表１の通り、本発明のアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップから得られる植物抽出物には、強いメイラード反応阻害作用を有することが確認された。
【０１０５】
（試験２）ペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）生成阻害作用の測定
メイラード反応の終末糖化物質（メイラード反応最終生成物）の一つであるペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）の生成阻害率（％）を比較することにより阻害作用を評価した。
【０１０６】
「試験方法及び評価方法」
ａ．試料
ヤクヨウガレーガ、ヤーバサンタの各乾燥植物１００ｇを５０％エタノール溶液１Ｌに浸漬し、室温にて１週間抽出した後、ろ過して抽出液（乾燥固形分０．１〜２．０重量％）を約１．０ｋｇ得る。これを試験溶液とした。尚、陽性対照としてジメチルスルホキシド、比較対照として１ｍＭと１０ｍＭのアミノグアニジンを同様の条件で調製し、試験に用いた。
ｂ．ペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）の生成阻害作用の測定
試料溶液２５μＬに５００ｍＭ Ｒｉｂｏｓｅ、５００ｍＭ Ｌｙｓｉｎｅ、５００ｍＭ Ａｒｇｉｎｉｎｅ、１００ｍＭ Ｎａ_２ＨＰＯ_４（ｐＨ７．４）、Ｈ_２Ｏを各９５μＬ加え、６０℃、２４時間ヒートブロック上でインキュベートし、反応終了後、反応溶液１００μＬにＨ_２Ｏ ４００μＬを加え、高速液体クロマトグラフィーにてペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）生成量を測定した。
【０１０７】
〈高速液体クロマトグラフィー測定条件〉
溶媒は、アセトニトリル：ＴＦＡ：Ｈ_２Ｏ＝３：０．１：９６．９を使用。流速は１ｍＬ／ｍｉｎ、カラム温度は４０℃、励起波長を３３５ｎｍとし測定波長を３８０ｎｍとする。インジェクション量は１０μＬで行う。尚、ペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）標品は、Ｍｏｎｎｉｅの方法に基づいて調整し、各種機器スペクトルデータにより確認した。それを用いて高速液体クロマトグラム上のピークがペントシジン（ｐｅｎｔｏｓｉｄｉｎｅ）であることを確認した。
【０１０８】
【表２】

【０１０９】
（試験結果）
表２の通り、本発明のヤクヨウガレーガ、ヤーバサンタ抽出物には、アミノグアニジンと同程度のペントシジン生成阻害作用を有することが確認され、メイラード反応阻害剤として使用できる。
【０１１０】
（試験３）安全性試験
（１）皮膚一次刺激性試験
製造例１〜４によって得られたアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップを乾燥固形分濃度が約１．０Ｗ／Ｖ％となるように精製水にて調製し、背部を剪毛した日本白色家兎（雌性，１群３匹，体重２．３ｋｇ前後）の皮膚に適用した。判定は、適用後２４，４８，７２時間に一次刺激性の評点法にて紅斑及び浮腫を指標として行った。その結果は、すべての動物において、何など、紅斑及び浮腫を認めず陰性と判定された。
【０１１１】
（試験４）安全性試験
（２）皮膚累積刺激性試験
同様に製造例１〜４によって得られたアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップを乾燥固形分濃度が約１．０Ｗ／Ｖ％となるように精製水にて調製し、側腹部を剪毛したハートレー系モルモット（雌性，１群３匹，体重３２０ｇ前後）の皮膚に１日１回、週５回，０．５ｍＬ／匹を塗布した。塗布は２週に渡って行い、剪毛は各週の最終塗布日に行った。判定は、各塗布日及び最終塗布日の翌日に一次刺激性の評点法にて紅斑及び浮腫を指標として行った。その結果は、すべての動物において、２週間に渡って何等、紅斑及び浮腫を認めず陰性と判定された。
【０１１２】
（試験５）安全性試験
（３）急性毒性試験
同様に製造例１〜４によって得られたアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップを減圧濃縮・乾燥して得られた粉末（乾燥固形分約１．０Ｗ／Ｖ％）を試験前、４時間絶食させたｄｄｙ系マウス（雄性及び雌性，１群５匹，５週齢）に２，０００ｍｇ／ｋｇ量経口投与し、毒性症状の発現、程度などを経時的に観察した。その結果、すべてのマウスにおいて１４日間何等異状を認めず、又、解剖の結果も異状がなかった。よって、ＬＤ_５０は２，０００ｍｇ／ｋｇ以上と判定された。
【０１１３】
（処方例）メイラード反応阻害剤、皮膚外用剤又は飲食品の製造
上記の評価結果に従い、以下にその処方例を示すが、処方例は各製品の製造における常法により製造したもので良く、配合量のみを示した。又、本発明はこれらに限定されるわけではない。
【０１１４】

【０１１５】

【０１１６】

【０１１７】

【０１１８】

【０１１９】

【０１２０】

【０１２１】

【０１２２】

【０１２３】

【０１２４】

【０１２５】

【０１２６】

【０１２７】

【０１２８】

【０１２９】

【０１３０】

【０１３１】

【０１３２】

【０１３３】

【０１３４】

【０１３５】

【０１３６】

【０１３７】

【０１３８】

【０１３９】

【０１４０】

【０１４１】

【０１４２】
（処方例２９）被覆保護剤
ガーゼ又はリニメント布にヤクヨウガレーガ６０％エタノール抽出液及び抗生物質、抗炎症剤等、適量を混合した処方液を含浸させ、外傷部に添付する。又、これらを直接、局所に散布し、ガーゼ等で被覆しても良い。
【０１４３】

【０１４４】

【０１４５】

【０１４６】

【０１４７】

【０１４８】

【０１４９】

【０１５０】

【０１５１】

【０１５２】

【０１５３】
（試験６）使用効果試験
本発明の皮膚外用剤及び浴用剤を実際に使用した場合の効果について検討を行った。使用テストは皮膚のツヤ・張りがない肌で悩む３０〜６０歳の１０名をパネラーとし、毎日、朝と夜の２回、洗顔後に処方例１の乳液の適量を顔面に３ヶ月に渡って塗布することにより行った。
【０１５４】
更に、処方例２８の浴用剤についても、皮膚のツヤ・張りがない肌で悩む、３０〜６０歳の１０名を対象に、３ヶ月間、必ず１日１回適量の浴用剤を溶解させた浴湯に入浴してもらい、使用テストを実施した。対照には、乳液，浴用剤から浴用剤から本発明の植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表３〜４の通りで表中の数値は人数を表す。尚、使用期間中に皮膚の異常を訴えた者はなかった。
【０１５５】
「皮膚感触改善効果」
有 効：皮膚のツヤ・張りが増し、肌が改善された。
やや有効：皮膚のツヤ・張りがやや増し、肌が改善された。
無 効：使用前と変化なし。
【０１５６】
（試験結果）
表３〜４の結果より、本発明のアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップの各抽出物を含有した乳液及び浴用剤の使用は、皮膚にツヤ・張りを与え、肌が改善されるといった皮膚老化防止作用が確認された。
【０１５７】
【表３】

【０１５８】
【表４】

【０１５９】
（試験７）使用効果試験
本発明の食品を実際に使用した場合の効果について検討を行った。使用テストは皮膚のツヤ・張りがない乾燥肌で悩む３０〜６０歳の１０名をパネラーとし、毎日、朝と夜の２回、処方例３５のパン１個（１回約５０ｇ）を３ヶ月に渡って飲食してもらった。
【０１６０】
対照には、パンから本発明の植物抽出物を除いたものを同様な方法にて処方したものを用いた。又、評価方法は下記の基準にて行い、結果は表５の通りで表中の数値は人数を表す。尚、使用期間中に異常を訴えた者はなかった。
【０１６１】
「皮膚感触改善効果」
有 効：皮膚のツヤ・張りが増し、乾燥肌が改善された。
やや有効：皮膚のツヤ・張りがやや増し、乾燥肌が改善された。
無 効：使用前と変化なし。
【０１６２】
（試験結果）
表５の結果より、本発明のアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップの各抽出物を含有した食品への使用は、皮膚にツヤ・張りを与え、乾燥肌が改善されるといった皮膚老化防止作用が確認された。
【０１６３】
【表５】

【０１６４】
【発明の効果】
本発明のアカメガシワ、カキノキ、クワ、セイヨウオトギリソウ、ツボクサ、ヤクヨウガレーガ、ヤーバサンタ、ローズヒップから得られる植物抽出物は、メイラード反応阻害作用を有し、更にこれらのうちヤクヨウガレーガ、ヤーバサンタ抽出物はペントシジン生成阻害作用を有する。さらに、これらはヒト又は動物に対して内用又は外用しても安全なものである。従って、メイラード反応阻害剤としてあらゆる形態の製剤（医薬品類、医薬部外品類、化粧品類、食品類）に応用することができ、皮膚のシワやたるみ、糖尿病由来の合併症などの様々なメイラード反応に関わる疾患の予防及び治療に利用が可能である。更に、皮膚にツヤ・張りを与え、肌の改善に有効的であるため皮膚老化防止用としても利用できる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a novel and safe Maillard reaction inhibitor containing a plant extract or a component thereof, and its application to various skin external preparations or foods and drinks in the field of drugs, quasi-drugs or cosmetics, and aging. The effect of prevention can be expected.
[0002]
It can be used in a wide variety of internal and external preparations (including preparations used for animals), specifically, ampules, capsules, pills, tablets, powders, granules , Solid, liquid, gel or foamed 1) pharmaceuticals, 2) quasi-drugs, 3) foods, 4) topical or systemic skin cosmetics, 5) medicinal products for scalp and hair And / or cosmetic preparations (eg, shampoos, rinses, treatments, permanent solutions, hair dyes, hair styling agents, hair tonics, hair growth / hair restorations, etc.), 6) baths for use in bath water 7) In addition, liquid odor / odor control agents, sanitary articles, sanitary cotton, wet tissues and the like can be mentioned.
[0003]
Foods and drinks include oral compositions (gum, candy, etc.), processed seafood products such as kamaboko and chikuwa, livestock products such as sausage and ham, western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat, etc. Noodles, sauce, soy sauce, sauce, sugar, honey, seasoning such as powdered candy, starch syrup, spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, soy vegetables, sprinkle, or Processed vegetables and fruits such as canned and bottled vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey drinks, soft drinks, beverages such as alcoholic beverages, and other health foods It is used for general foods and drinks.
[0004]
[Prior art]
It is natural that all people age with age, but in recent years factors such as deterioration in environmental conditions, changes in lifestyle, and increased stress due to the complication of social life have led to the promotion of aging. Is increasing. In particular, the importance of living healthy every day has been reconsidered with the increase in the number of elderly people and the prolongation of their lifespan.
[0005]
Aging refers to the deterioration of various functions of the body. When this is considered at the cellular level, various physiological functions in a living body are controlled by proteins. In other words, aging is considered to be a state in which the protein has failed to perform its original function due to some kind of disorder given to this protein, and one of the disorders is non-enzymatic protein saccharification reaction. . This is a reaction that impairs the original function of the protein due to the binding of the reducing sugar to the amino acid or the protein, and is called a Maillard reaction (browning reaction). The reactant in the initial stage of the Maillard reaction is a conjugate of a protein and a sugar called an Amadori compound, and this reaction forms a yellow-green substance having fluorescence through dehydration and polymerization. Become material.
[0006]
In addition, it is presumed that the dysfunction due to the protein saccharification derived from the Maillard reaction causes a complication due to diabetes or the development of senile dementia.
[0007]
In addition, the human skin that comes into contact with the outside world has reduced abrasion and luster of the skin due to aging, and wrinkles and tarmi can be seen. This is because changes in dermis constituents have a large effect, and collagen (collagenous fibrils) and elastin (elastic fibers) crosslink due to protein saccharification by the Maillard reaction. In particular, crosslinking between collagen fibers due to protein saccharification is necessary at the beginning to increase mechanical strength, but gradually increases the number of unnecessary crosslinks, causing a decrease in skin contractility and flexibility, and wrinkles. It is said to cause tarmi. It is also known that browning occurs when a protein is polymerized by the Maillard reaction. This is expected to cause skin browning.
[0008]
BACKGROUND ART Saccharification of proteins that progresses in vivo, which is aging at the cellular level, has attracted attention as a cause of skin aging, diabetic complications, and various cell disorders. However, only a handful of drugs that inhibit it are known, including aminoguanidine (Japanese Patent Laid-Open Nos. 62-142114 and 62-249908), and their inhibitory effects are not so strong. Is the current situation.
[0009]
[Problems to be solved by the invention]
In view of such circumstances, the present inventors have considered that substances having a Maillard reaction inhibitory action, having an excellent physiological aging prevention action, and having no side effects, from natural plants or components contained in plants. We have tried to screen for new plant extracts and studied their novel components and their components.
[0010]
Furthermore, screening was also conducted on a substance that is excellent in inhibiting the production of pentosidine, one of the final products of the Maillard reaction, and that has no side effects.
[0011]
[Means for Solving the Problems]
Therefore, the present inventors have found that a plant extract obtained from red wrinkles, Japanese persimmon, mulberry, St. John's wort, Mulberry, Yakuyo garrega, Yaba santa, and rose hip is highly safe and has a Maillard reaction inhibitory action (amino acid and protein saccharification inhibitory action). It was confirmed.
[0012]
In addition, it was confirmed that Yakuyogarega and Yabasanta also have a pentosidine production inhibitory effect.
[0013]
Furthermore, by using the product of the present invention, the skin and scalp are given a shine and luster, and the skin is improved, and the contraction and softness of the skin such as wrinkles and tarmi on the skin and scalp are reduced, and the skin is browned. Prevention of dullness of the skin or its improvement was confirmed. That is, the present invention has been completed by providing a safe external preparation for skin or a food or drink having an antiaging effect on the skin. Hereinafter, the process leading to the present invention will be described.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
The term "Akamegawiwa" used in the present invention is a plant of the genus Euphorbiaceae, a genus of the genus Mallotus: Mallotus japonicus Muell. Arg. (= Croton japonicum Thumb.) Stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other species such as Kusunohagashiwa (also known as Kamala) (M. philippinensis Muell. Arg.) Are used. You can also.
[0015]
“Kinoki” used in the present invention is a plant of the genus Ekinaceae (Ebenaceae), a genus of Diospyros: Diospyros kaki L., flowers, spikes, pericarp, fruits, stems, leaves, branches, branches and leaves, stems. , Bark, rhizome, root bark, roots, seeds or whole plants can be used, but in addition, the same species of sword (D. discolor Willd.), Swordfish (Diospyros eriantha Champ. Ex Benth.), Black stalk (D. ferrea) (Willd.) Bakh. (= Maba buxifolia Pers.)), Dinosaur (D. lotus L.), Diospyros morrisiana Hance, D. atropurpure Guerke, D.A. conzattii Standl. , D. ebenum Koenig, D.E. virginiana L .; Etc. can also be used.
[0016]
The term “mulberry” used in the present invention refers to a plant of the mulberry family (Moraceae) or mulberry (Morus): a flower of a mulberry (also known as: Karaguwa, Toguwa) (Morus alba L. (= M. Atropurpure Roxb.)), A spike, a pericarp, a fruit, a stem, a leaf, a branch, a branch and a leaf, a stem, a bark, a rhizome, a root bark, a root, a seed, or a whole plant is used, and other species of the same species, M. australis (= M. Acidosa Griff. )), Margwa (M. alba L. var. Multicaulis Loudon), Yamaguchi (M. bombycis koidz. (= M. Alba L. var. Stylosa Bur.) (= M. Japonica b.log.) (Also known as: Rosou, Marbagwa) (M. latifolia) Bur.) Poir.), Moukoguwa (M. mongolia (Bur.) Schneid.), Kuromiguwa (M. nigra L.), can also be used Akamiguwa (M. rubra L.) and the like.
[0017]
The “Hypericum perforatum” used in the present invention is a plant of the family Hypericum (Gutiferae), the genus Hypericum (Hypericum): flowers of St. John's wort (alias: St. John's wort) (Hypericum perforatum L.) Fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but also other species of the same genera, H. erectum Thunberg. H. japoicum Thumb.), H. ascyron L., H. aspyron L. hirsutum L. , H. attenuatum Choisy, Hypericum bellum L., Maruba Byo willow (H. chinense L.), H. eloidedes Choisy, Kinshibai (H. plum). Thunb.), Burgundy gold peach (H. przewalskii Maxim.), Tsukkinukitogi, H. sampsonii Hance, and the like can also be used.
[0018]
The term "Crimsonia" used in the present invention includes plants of the Umbelliferae family and the genus Centella (Centella): flowers, spikelets, pericarp, fruits, stems of Centella asiatica L. (= Hydrocotyleasia asiatica L.). Leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used, but other homologous species can also be used.
[0019]
"Yakuyogarega" used in the present invention includes leguminous plants (Leguminosae) and plants of the genus Galega (Galega): flowers, spikelets, pericarp, fruits, stems, flowers, spikelets, pericarp, fruits, stems, and so on. Leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots, seeds or whole plants are used. officinalis var. albiflora Boiss, G .; officinalis var. hartlandii Hort. Etc. can also be used.
[0020]
The term “Yerba Santa” used in the present invention is a plant of the family “Hyperphyllaceae”, a genus of Eriodiction: Erydictyon californicum (Hook. Et Arn.), A flower of Hook. Et Arn. , Pericarp, fruit, stem, leaf, branch, side-leaf, stem, bark, rhizome, root bark, root, seed or whole plant, but other E. coli species of the same genus. tomentosum Benth. , E .; altissimum, E. angustifomium, E.C. cappitum, E .; crassifolium, E.C. traskiae, E .; tricholyx or the like can also be used.
[0021]
The “rose hip” used in the present invention refers to a plant of the family Rosaceae and the genus Rose (Rosa): Rose hip (also known as: Novara, Inuinoibara, Dogrose, Dogbriar, Kaninabara) (Rosa canina L.). Flowers, spikes, peels, fruits, stems, leaves, branches, branches and leaves, stems, barks, rhizomes, root bark, roots, seeds or whole plants are used, but other congeners of the species Eglan Chinbara (also known as Sweet Briar, Eglan Tine) ( R. eglanteria (= R. Rubiginosa), rosa micranta (R. mitrantha Borrer ex Sm.), Hamanashi (alias: Japanese rose, Turkish stern rose) (R. rugosa Thunb.), Terrihanoi bara (R. ), Neubara (Alternative name: Agetsu) (R. multiflora Thunberg), Yamaha manas (Also known as: Karafutoibara) (R. davrica Pallas (= R. Willdenowii Sprengel)), Naniwaibara (R. laevigita. bella Rehd. Et Wils. , R.A. sweginzowii Koehne, E. Kogane (R. cymosa Tratt.), Sakurako Kin, R. odorata Sweet var. gigantea Rehd. Et Wils. macrophylla Lindl. , Maikai (R. rugosa var. Plena Regel), R. banksiae Ait. Var. Normalis Reg., Kakayanbara (R. brectata Wendl.ac, R. bractata Rendl. ), R. graciliflora Rehd. Et Wils., R. multiflora Thumb. Var. Plaphyphylla Thory, R. omeiensis Rishii, R. omeiensis Rolphie roxburghii Tratt. f. normalis Rehd. et Wils, fine roses (R. seriesa Lindl.), blunt roses (R. se Tata Rolfe, rose (R. hybrida Hort.), centifolia rose (R. centifolia L.), damask rose (R. damascena Miller), gallica rose (R. gallica L.), Moscatabara (R. hamrbara). , Mokkobara (R. banksiae Aiton), R. foetida Herr. (= R. Lutea Mill.), R. gigantea Collett et Hesl., Odratawet a. R. acicularis Lindl.) Can also be used.
[0022]
In addition, the plant extract obtained from Akame-kiwa wrinkles, Japanese persimmon, mulberry, St. John's wort, Mulberry, Yakuga garrega, Yaba santa, and rose hip used in the present invention are various parts of each plant (whole plant, flower, seed, fruit, Leaves, branches, bark, root bark, rhizomes, roots, etc.) or crushed and squeezed. Alternatively, it is extracted with a solvent as it is or after pulverization.
[0023]
Examples of the extraction solvent include water, alcohols (for example, lower alcohols such as methanol, anhydrous ethanol, and ethanol, or polyhydric alcohols such as propylene glycol and 1,3-butylene glycol), ketones such as acetone, diethyl ether, and dioxane. , Acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform, etc., can be used alone or in any combination of two or more kinds, and the respective solvent extracts are combined. It can be used even when it is in the down position.
[0024]
The plant extract obtained from Akamegawiwa, Japanese persimmon, mulberry, St. John's wort, Astragalus, Yakuyogarega, Yaba Santa, and Rosehip is a Maillard reaction inhibitor to be applied, and is further dried, concentrated or concentrated depending on the dosage form and form of the external skin preparation or food or drink. The dilution may be arbitrarily performed and adjusted.
[0025]
In addition, the production method is not particularly limited, but it is usually sufficient if it is in the range of the boiling point of the solvent under normal pressure from normal temperature, and after extraction, filtration or use of an ion exchange resin, adsorption, decolorization, and purification are performed. It may be in the form of a solution, paste, gel, or powder. In many cases, it can be used as it is, but if necessary, further purification treatment such as deodorization and decolorization may be added as long as the effect is not affected. An activated carbon column or the like may be used, and ordinary means generally applied to the extracted substance may be arbitrarily selected.
[0026]
Plant extracts obtained from the red oak wrinkles, oysters, mulberry, St. John's wort, Astragalus, Yakuogarega, Yabasanta, Rosehip, can be used as a Maillard reaction inhibitor as it is, and can be further incorporated into a skin external preparation or food or drink, Although the amount is not particularly specified, it may vary slightly depending on the type, quality, expected degree of action of Maillard reaction inhibitor, skin external preparation or food and drink, but it is usually calculated as solid content in the total amount of the preparation. Therefore, the content is preferably 0.0001% by mass or more (hereinafter, represented by%), and preferably 0.01 to 50.0%. In the case of a bath agent, it may be poured into 200 to 300 L of bath water and the formulation may be considered so that the concentration becomes almost the same.
[0027]
In addition, the Maillard reaction inhibitor of the present invention, a skin external preparation or a food or drink, if necessary, in addition to the above-mentioned essential components, as long as the effects of the present invention are not impaired, pharmaceuticals, quasi-drugs, cosmetics, It can be produced by using components and additives used for pharmaceuticals such as foods and drinks in combination. The content in the pharmaceuticals is not particularly limited, but is usually preferably 0.0001 to 50%.
[0028]
(1) Various fats and oils
Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea Fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard , Squalene, squalane, pristane, hydrogenated products of these oils and fats (hardened oils, etc.) and the like.
[0029]
(2) waxes
Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.
[0030]
(3) Mineral oil
Liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax and the like.
[0031]
(4) Fatty acids
Lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, natural fatty acids such as lanolin fatty acids, Synthetic fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, and isopentanoic acid.
[0032]
(5) Alcohols
Natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, and phenoxyethanol; and synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, and 2-octyldodecanol.
[0033]
(6) Polyhydric alcohols
Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene glycol, 1,3-butylene glycol , Pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.
[0034]
(7) Esters
Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, diethyl phthalate, phthalate, phthalate Dibutyl acid, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.
[0035]
(8) Metal soaps
Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.
[0036]
(9) Gum, sugar or water-soluble polymer compound
Gum arabic, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, fructose, sucrose or esters thereof, trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, Carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan, alkylene (C2-C4) oxide, such as ethylene oxide, low molecular weight chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorus Oxidized chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, potassium Boxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide Or a crosslinked polymer thereof, a carboxyvinyl polymer, polyethyleneimine and the like.
[0037]
(10) Surfactant
Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactants (alkyl amine salt, alkyl quaternary ammonium salt), amphoteric surfactant: carboxylic acid Type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic surfactant) Agent, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing nonionic surfactant), other surfactants (natural surfactant, protein) Derivatives of hydrolysates, polymeric surfactants, surfactants containing titanium and silicon, fluorocarbon surfactants Etc..
[0038]
(11) Various vitamins
Vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), Pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acids, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or derivatives thereof, vitamin D group: ergocalciferol (vitamin D2 ), Cholecalciferol (vitamin D3), dihydrotaxerol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2), menadione (vitamin 3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.
[0039]
(12) Various amino acids
Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine And their amino acids such as sulfates, phosphates, nitrates, citrates, and pyrrolidone carboxylic acids.
[0040]
(13) Various additives derived from plant or animal raw materials
These are processed in a conventional manner according to the type and form of the product to be added (eg, pulverization, milling, washing, hydrolysis, fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization). , Granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc., are arbitrarily selected and combined), and arbitrarily selected from various materials.
[0041]
The solvent used in the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but is usually selected from water, methanol, ethanol, propyl alcohol, isopropyl alcohol, and butanol. , One selected from lower alcohols such as isobutanol or water-containing lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, glycerin or water-containing polyhydric alcohols, acetone and ethyl acetate. Alternatively, it is desirable to use a mixture of two or more. However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.
[0042]
In addition, when an additive derived from a plant or animal-based material is applied to a systemic or topical external preparation or cosmetics, the skin and hair are protected, the moisturizer is improved, the feel / feel is improved, flexibility is imparted, and stimulation is provided. Mitigation, alleviation of stress by aroma, cell activation (prevention of cell aging), suppression of inflammation, improvement of skin and hair quality, prevention and improvement of rough skin, hair growth, hair growth, hair loss prevention, gloss imparting, cleaning effect, In addition to cosmetic effects such as alleviation of fatigue, promotion of blood flow, and warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.
[0043]
In foods and drinks, nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging) and other health and cosmetic effects, improvement of taste, color and aroma, gloss imparting, stabilization, thickening, It can be used for antiseptic purposes. Furthermore, in addition to the above, various cosmetic and pharmacological effects of each raw material known so far are expected, and by combining these, the intended effect can be enhanced or multifunctional. It is also possible to make a product that expects an effect.
[0044]
Specific plants (herbal medicines) as raw materials include, for example, almonds (herring peach), eyes (blue leaves), blue moss (Seifu wisteria), blue oysters (Aoki), blue oysters, or kenashiogiri (Otogi), and blue oysters (Komi) , Aotema, acacia, red ginger (red maize), red crocodile "fruit", red clover, red grape, red akaminoki (logwood), red akameshiwa (red bud), red akamane or rape or madder (akane grass root), red pheasant or pheasant (land yellow), Agi (Awei), Aki larch, Akinire (Lolyu bark), Aguay Guacu, Aguahe (Omiten palm), Akebi (Kidori), Asa (Jinji), Malva Asagao or Asagao (Toshiboshi), Hydrangea (Hydrangea), Ashitaba (morning leaves), Azuki (red azuki bean), Asunaro, Acerola, Acene Ku (Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiurana, Brassica, Abemaki "fruit", Avocado, Ama, Amacha (sweet tea), Amacadul, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Amaranthus, Balsam pear, Hymenoptera, Senninkoku, Sugimorigeito, Hosoaoigato, Aogaito, Haribiyu, Aosuzuran, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish), Aristolomelia (Yurizisen), Arcana (Alcanabo), Alcana , Althea, Arnica, Alpinia or Katsumadai (Sou-zuku), Aloe (lux), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azuka), Yellow sapote, Igakouzolina , Epimedium or Epimedium (Indian kaku), Igusa (Water heart grass), Itadori (Tiger root), Yew (No. 1), Strawberry, Fig (Figurine "fruit, leaf"), Ichihatsu (Primary), Ichibi (Winter Aiko) ), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo "seed, leaves"), Itohimemegi (Enshi), Carob, Inosumanus (Teilexi), Inuyuyu (Honaguinubiyu), Rice "seed, seed coat", Inondo "seed", Ibukijakosou, Nettle, ylang-ylang, iwa tobacco (Iwagashi chi), iwahiba or iwamatsu (makikashi), kidney bean, oolong tea, fennel (feng scent), wheat (chibusanoki), ukiyagara (sanraku), squid "fruit", hime uikyo, turmeric Ukukushi), duckweed (floating), usubasaishin or keirinsaishin or cattle Hyacinthus (spicy), Usbania oyster, Usbenitachiaoi, Uchouran, Utsubogusa (summer hay), Udo or Shisiudo (Qanggai, Independent, Tang Dungyo), Unyadegato (Unkaria, Cat's Claw), Uba tea, Ume (Ume (seed, flesh) )), Vladimir, Elephant's walnut (Kusakomomo), Unshurikan (Chen skin), Eunboku, Estragon, Ezocogi (Ezo Goka), Ezo lily of the valley, Echinashi (Hosobamurasakibarengiku), Enishida, Enokitake (Enotake mushroom), Ebisugusa or Mise ), Elcampre, Elderberry "fruit", Elemi, Eryngii or Pre-Lotus Erinji, Enju (Gooseblossom, Sophora blossom rice), Pea, Ohgi or Kibanaohagi (Ascot radix), Narco lily or Kagikurumabanarukoyuri (Yoshisei), Ohisasanoyuki Is Sasanoyuki, Ouren (Yellow), Ogata Hawken, Ookarasuri (Karokon), Ooguruma (Public engineering incense), Ootsurafuji (Honshu), Oobako (Car forehead, Carmae grass), Obanana thistle (Keju Leak reed, Baekwanda), Toucan (Haruko), Toucan cactus, Obanana okera or Okera (white jujube), Obanassarsuberi (Banaba), Obanayashabushi "fruit", Oohoshigusa (Grain sperm), Oumia catechu, O hawthorn or Hawthorn (mountain sprout), Oomiyashi, Barley ), Oka, okazeri (snake bed), okra "fruit", ogulma (turnover), okururihigotai (Ushu sashimi, indigo sashimi), panax ginseng or horseshoe ginseng (carrot), hypericum or kogomebayotogisiri (brother cutting grass), Odorikosou (intermittent), Onamimomi (blue ears), Onig Mi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tianma), Onyuri or Sasasayuri or Hakatayuri (Yuri), Onoeran, Ononis, Oniyou (Hashiba Yu), Ominaeshi (Shoyu), Oyuco, Dutch mustard (Cresson), Dutch jelly, Dutch beetle, Dutch honeysuckle, olive "fruit, seed, leaf", oregano, orange "fruit, peel", calyxio (ripe ground yellow), cacao "fruit, peel, seed", kagikazura (fishing hook), oyster Or Kantriso (lotus grass), Kakiran, gaku hydrangea, cassia, cassia (Kozomi "fruit"), gajutsu (jajutsu), Kashiwa (Yaki tree, Yuzuha), kascarilla, kascara sagrada, gypsophila, gypsophila, kanikusa ( Kim Sato), Kaniwa, Carnation, Valerian (Kikose), Hippo, Ka Noble or weeping birch (white birch), gerbera, pumpkin, kapok noki "seed", kahoku sansho (shopper), gama (bamboo), chamomile or roman chamomile, chamomile (desert plant), cam cam (camo duck), karagwa or yamaguwa (mulberry straw) , Color, karaksakeman, crow squirrel or cinnamon squirrel (flower melon), crow squirrel (midsummer), mussels, guarana "seed", karahoo (poor), karaya, garyu, karin (mochi), garcinia, kawamidori, kawara saiko Rape, vermilion grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaranjin (Aotoko), Kawamurayogi (In? Ko), Kansui (sweet), Licorice (licorice), Kantarasa, Kandelilla, Kanto, Canna, Kanran, Raspberry (Ezo strawberry, Dutch strawberry, Shrimp strawberry, Nawashiroi strawberry, Maple strawberry, European strawberry), Kiwi "Fruits, leaves", Kikarasuuri (Kuroro root), Kikyo (Kikyo, Kikyo root), Chrysanthemum (Chrysanthemum, Shima kaniku, Daffodilium), Chrysanthemum, Catalpa (Azusa), Giant stalk (Yotei root), Pheasant (Komi), Kizuta, Kidachi aloe, Kidachiha, Kinna , Linden (shincona, red linden), quinoa (quinoa), yellowfin (huangbashi), pigeon pea, gymnema sylvesta, kimmenkaku, cabbage, cabbage "immature fruit", caraway, cucumber, goryuu (Nishikawayanagi, teriyaki), kiraja Saponaria, Kiraya, Kiranso Peanut grass), kumquat "fruit", kinkiju, ginsekai, kimbusen, betel, kinmizukiki (senkaku grass), quinran, ginran, kinryohen, guapeba vermelha, guava "fruit", guayule, quelux infectria (gallicate), kukuinuts , Kugenumaran, wolfberry (Gugi, gugi, gugi leaf, ground bone bark), Sugisugi Kazura (Tenmen Fuyu), Kuzu (Kakkon), camphor tree, gooseberry "fruit", Xining ginseng (Huanghuako), cutiti river, gardenia ( Gardenia), kunugi (bokusou), kupuasu, kubeba, kumazasa, kumamatsura (horse whip grass), clara (bitter scallop), cranberry "fruit", chestnut "seed, fruit, astringent skin", curculigo latifolia "fruit", grapefruit " Fruits and leaves ", buckthorn, black stalk (rescue required) Kameba Hikioko or Kurobana Hikioko or Hikiokoshi (extended life grass), clove (clove, clove), gumbinazuna (sekimei, sekimeishi), kaigai (infestation, infestation spike), cadmium (corolla, cockscomb), gekkavidin, bayberry (laurel tree) Sartorii rose (Tokubukuryo, mountain return), gentian, genoshoko (Oirou grass), Kemponashi (Kigushi), Koukisekikoku, Kishumican (Koji, Tachibana, Obeninican, Fucremican, Sagamikouji, Ponkan, Santara (tachibana)), Koshinbara (Tachibana) Monthly flower), Kosui mentha, Kozo "fruit", Kocha (tea), Kouhone (river bone), Kouhon (straw and kara straw), Kouriang, Kourikyo (Korajang), Cilantro "fruit", Kouren (huohren), Sorghum (Yellow Gon), Cowberry (Koshibachi), coconut "fruit", goshuyu (goshuyu), goshoichigo (covered bunko), pepper (pepper), cosmos, copaiba balsam, coffee "seed, leaf", kobushi or magnolia (spice), burdock (burdock) Burdock, burdock, sesame seeds, sesame, sesame seeds, sesame seeds, sesame seeds, gomeshi, scallop or binankazura or pine bush, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata "Seeds", Cola Vera "Seeds", Coleus Forskoli, Colony Lya, Fenugreek "Fruits", Colombo, Kondulango, Kombu, Konjac, Comfrey (finnari grass), Sisal (Sisal Asa), Saihailan, Sakanelan (Ezosakaneran), Sakisima button or sina button or sap Kura (Oshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura "Leaf, flower, fruit, bark (cherry bark)"), cherry, pomegranate, sasa, sasabagi Sasanqua, Sajiomodaka (Sawahka), Sweet potato, Sugar cane, Sugar beet, Sanebu jujube (Satsumitsujin), Saffron (Safflower, West safflower), Sapodilla, Sapotea mariyo, Pomelo "Fruit", Sabonsou, Salmonberry "Fruit", Sarasin Hemp), saransitou (sand sashimi head), salvia (sage), sawagyoukyo (yamakonasai), sawagumi (yamawalnut), sankaku cactus, sangre degrad (croton), sansouyousou, sanshinjinjin (seven carrots) , Sanshi Yu (Susyuyu), Sansho (Sansho), Sandscon (Yamazone), Shea (Karite), Cyano (fruit), Shiitake (Shitake mushroom), Shion (Shion), Shikaku bean, Dikitaris, Shikunshi (Kimiko), Shiso or Aodiso or Chirimenzo or Katamenziso (Shiyo leaf, Shiso), Rosewood, Linden tree, Chinese pine, Chinese beetle (ream forsythia), Shimeji (Hinshimeji, Shakashimeji, Hatakeshimeji, Oshiiroshimeji, Bunashimeji, Honjimesi, Shirotamotake mushroom) , Potatoes, peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat stalks), ginkgo salmon, sycamore, sakushamitsu (sand vines, sand compaction), juzdama, palm "fruit" , Shunran, palm palm, ginger (raw) Kiang), Japanese hydrangea (Tsuneyama), Shobu (irises, iris root), Shozuku "fruit", Shirazak "seed", Silane (Byancyuu), Shirogoshi butterfly "seed", White clover (clover), White adzuki (chicken bone grass), Shirobanairisu (Small iris), Shirobanatsuta "flower", Shirobanana lupine, Shirominanten (Minami Tenmi), Cinchona sassil Silbra, Jinchouge (Mizuka, Mizuka, Shencho flower), Cinnamon, Cinnammum cassia (Citrus), Watermelon (watermelon), Honeysuckle (gold and silver flowers, Shinobi winter), sorrel (acid pattern), swim berry "fruit", star apple, stevia, strawberry "fruit", suzu psycho (successor lord), horsetail (question), suberhide (horse ken, horse teeth kenko) ), Plum “fruit”, Surugaran (Oran), Scots pine “cone”, European larch, Scots vine, Scots walnut, Scots hawthorn, Scots blossom, Scots dandelion, Scots cypress (Marronnier), Scots pear "fruit", Scots sycamore, Scots stalk (Elder), Scots squirrel (Junipa, swordfish) ), Rose, cornflower, mistletoe, mint or mint, horseradish, horseradish (stone iris), seaweed (seaweed, seaweed, seaweed, seaweed, seaweed) Noseckko (Dendrobium, Ishimasu), Cedron (Bowshukuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Senkyu ( Cucumber), sensin ren (percussion ream), sendan, sennin cactus, senna "fruit, leaf", senninsou (great tate), senburi (medicine), senboku, souka (grass), elegans, shinshinbai, buckwheat "seed" , Somenimo, Broad bean, Rhubarb (Daihuang), Radish, Soybean, Daidai (Orange, Kikomi), Takasagouri Rigogotai (Southeast indigo sashimi), Takasaburo (Dried lotus grass), Takatodai (Daigo), Takagawarabi , Dark sweet cherry "fruit", hollyhock, tachi-kosou (thyme, momoka), hachidokoro (hikari), hollywood, tamarind "seed", onion, tamashiba (spicy), taro tree "fruit, leaf, root bark", tarayou (large leaf) Winter blue, one leaf tea, bitter tea, bitter tea), dahlia (tenjikubotan), tarwi, tankiri bean, tanshiu Chihuahua, Tanjin (Dan ginseng), Dandelion (Gambakoei) or White dandelion or Moko dandelion, Dammar, Cherry "fruit", Tigaya "fruit, root, bud", Chixet ginseng (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Tulip, Choconostay, Artichoke (Artichoke), Artichoke (Ohta), Artichoke (Wuyi), Artemisia (Aoba), Choreimaitake (Irei), Chorogi, Tsukimimiso, Tsukushikaneran, Tsukuritake (mushroom) , Tsuchiakebi, Camellia, Tsumekusa (lacquer lacustrine), Tsujukusa (Duckweed grass), Tsuruazuki (red azuki bean), Tsurutsuchiakebi, Tsurudukudami (What's head crow), Tsuruna (Tankyo), Tsuruninjin (four leaf ginseng), Tsurumame, Tsuwabuki, Deiko, Teuchigurumi, Dubery "Fruits", Tengusa, Tencha (Tencha), Tendai Yaku (Cowflower), Pepper (Winter Gourd), Toukagi Kazura, Pepper (Pan pepper), Touki (Toki), Tokinsenka (Marigold), Toukaichi, Tounabena (River) Cut), corn or corn hair (Nanbaru hair), horned rice mochi (female child), turmeric or Korean gentian (dragon bile), foxtail (wood pirates), dokudami (ten medicines), konkon (sore root), sushi or mamedaoshi or pear squid , Eucommia (Tochu "bark, leaves, roots"), Ash (Qin bark), tomato, tragacanth, triacanthos "seed", lisianthus, tormentilla, dronoki, trolooi, tongue bean, Niseria berry "fruit", potato or yam (mountain) Medicine), Nagikadida (butcher bloom), Nagina octopus Ju, Razuna, Rapeseed, Rapeseed or Haricot Bean (sword bean), Natsumikan, Jujube (daijutsu), Naniwaibara (Kanakurako), Navena (intermittent), Nameko, Peanut (peanut), Nanten (South Tenji), Namban Karamushi ( Ramie), Scented violet, Nigaki (bitter tree), Artemisia (bitter tree), Nikuzuku, Kay or Nikkei or Ceylon Nikkei or Yabunikei (cinnamon bark) or Keishi (Keishi), Gyokubuchidori, Chive (Niriko), Elderberry (Negishi) "Fruits, flowers, stems, leaves"), garlic (garlic), nurde (fivefold), green onion, nemuki or neb or nebi or nemlinoki or digokubana (healing), nozami (daiji), noybara (business fruit), nozenkazura (ryohana) ), Scallop, yarrow, sawdust (maehu), nobara, peach, pineapple "fruit", hibiscus (Bussouge, Furin-Bussouge, Roselle), Hyalindo, Hauchiwa, Pau Dosse, Hakamauraboshi (Bone Crushing), Hakuka Yumatou, Hakusanchidori, Hakusen (ringworm skin), Huckleberry "Fruit", Hakobe (Horiko), Hashibami (Haruko) , Hasiridokoro (Roth Root), Basil, Lotus (Lotus, Lotus, Lotus), Parsley (Netherland Jelly), Naked Wheat, Batata, Hachik or Madake (Bamboo Boiled), Patchouli, Mint (Light-Loaded, Light-Loaded Leaf), Hashime Bean, Adlay (Yokuinin), hanasuge (chimbo), banana, hanamacka, hanabishi (siturishi, shisitsuri), vanilla bins, papaya, striated grass (mouse koji), pahalobobo, hub "whole plant, stem, leaf", paprika, hakakiran, hamago or Honey maggot (vine thorn), hamasuge (kosuke), hamabishi (shi Riko), Hamanas (maikai flower), Hamabofu (beach storm), Hamamelis, palm, rose (rose), balata, balata rubber tree, agaric (aratake, agaricus agaricus, ukisumolinocasa), haran, pariurus (bamboo), Parietaria, orchid kanran Balsamina (Tsurureishi, Nigari), Harnile (Yellow, Yu white skin, Yu leaf), Barbasco, Harindou, Handaikai (Meat large sea), Breadfruit, Hiougi (shadow), Jerusalem ginseng (partisan), Pecan nut, Chestnut (stone) Garlic, beetle, dragonfly, higurumadaria, higotai, hishi (hishomi), pistachio, beet, hitsuba (stone reed), hitszuenishida, daisies (daisy), hinotainokozuchi (cow knee), hinoki bulbul, hinoki, hiba, Castor, sunflower, pepper Japanese apricot (Tamaoi), Japanese cypress (aroma), Japanese apricot mushroom (Kawariharatake, Hiromatsutake), Japanese apricot orchid, Pimenta "fruit", juniper, beaky cucumber, hiyu "fruit", chickpea, Japanese lentil, beloudooi, hirohaokinagusa (white head) "Fruits, leaves, stems", betel nut (large clothing skin, betel nut), Puer tea (pu? Tea), spruce buds (southern rattan), butterflies, butterbur poppies (winter flowers, winter leaves), fujibakama (orchid grass), wisteria beans (flat beans), fujimodoki (butterfly clover, pine flowers), grapes "fruit, peel, seeds, leaves", beech , Fuyumushinatsukutake (Cordyceps sinensis), Brazilian liquorice, Brazilian carrot, Brazilian palm, Brazilian elephant palm, Black currant "fruit", Blackberry, Branjen, Plum "fruit", Flucellaria, Blueberry (Prunus avium), Prune , Floral Blanca, Blond Psyllium, Bundo (Mung Bean), Hazelnut, Loofah, Hetkaran, Safflower (Safflower), Henneken, Belladonna, Berry "Fruit", Persair, Perbianberg, Pereschia Grandifolia, Benkeiiso or Ikuxa (Keiten), Boy Berry “fruit”, squirrel or mulberry or gentian or squirrel or kokia (skin), spinach, balsam (blossoms, acute offspring, osteophyte), potteria sapota, potteria lukma, spinach, spinach, squirrel (toro root) ), Bonito (Japanese magnolia, magnolia), bokeh (gourd), hosoba aburagiku (bitter gourd), hosobaoguruma, hosobananaokera (sojutsu), hosobanokirinsou (Kageten Sanshichi), hosobabarengiku, bodaiju (bodice tree), button ( Peony "flower, leaf, stem, bark"), buttonpi (peony bark), hop, jojoba, borage (ruriichisha), bordeaux, white berry "fruit", hon-onik (meat porcelain, daigei), hon-sekko (iron skin) Stone mackerel, sparrow mountain stone mascara), myzurutennanshaw (Tennan star), maitake (maitake), ephedra (maoh), maca, Cademia nut, Margaret (Mokshungiku), Macri (Martian grass), Magnolia splengeri, Masarambaba, Masaranzuba do Ceara, Masheira de Boi, Masahua (Tamanouzenhallen, Kyukonkinrenka), Matatabi , Matsukasa, pine “leaves, bark, roots”, Matta Olho, Matsuhodo (Bukuryo), Matico (Cordoncillo), Mayorum (Hanahakka), Malvanojadine (Difficult), Mulberry “Fruits”, Quince, Malein (Birudomouzuka) , Mango, mangosteen, mansagna (andesukamitsure), manshu walnut, mandarin "fruit", mannentake (reishi), pheasant (komimi "fruit"), mishimasaiko (saiko), mizuoboba or mizuasagao (dragon tongue), mizokakushi (Hanbe Lotus) , Misohagi (Chikuna), Honey or Eel (Emperor), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit "Fruit", Myrrh, Myrobaran, Mugiwaragiku, Mukunegi, Mukunoki Peel), Munya, purple sap (purple root), purple or purple purple pearl, purple purple corn, purple purple squirrel (Kunming chicken blood Fuji), megakanza opuntica, mehajiki (mass plant), mebogi, Japanese primrose, evening primrose Melissa, melilot, melon "fruit", moko mugwort, moso bamboo, mok giraffe, moje (pepper blossom), mochinoki, mokko (wood incense), maple blossom, peach (peach "leaves, seeds, flowers, fruits"), bean sprouts, morello Cherry "fruit", Moro Ears (burlap), yakawamurasakiimo, yakuchi (masuchi), cornflowers (cornflowers), cornflower mint, yacon, yashabushi (arrow car) or himeyashabushi or giant yashabushi "fruit, peel, fruit ear," yachiyanagi, yatsude (octagonal metal plate) ), Mistletoe (willow parasitism), willow (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, inucoryanagi, kinuyanagi, koryanagi, unryuyanagi, yamayanagi, palm, yamayanagi, obanyanagi, okinawa, ryokusan Stalk ", scotch, scotch (purple beef), tobacco (crane squirrel, Tenmeisei), pokeweed (commercial land), yamahannoki (yamaharu), yamamomo (yellow plum skin), yamayomogi, eucalyptus, yukinoshita (tiger ear grass), Yucca or Flavi Oria, Yuzu "Fruit", Lily, Yorugusa, Artemisia (Aiba), Lygan (Raimaru), Lime "Fruit", Rye, Lacanca "Fruit", Raspberry "Leaf, Fruit", Ratania (Clameria), Rakkyo or Shallot ( Scallop, lavender, longan (longan flesh), agave (Aon agave, fukurin agave), ryocha (green tea), apple "fruit, seeds, leaves, roots", gentian, rubus or suabisimus (sweeten), lurita thistle (urajirohigotai, Xinjiang blue sashimi), litchi (Lichi, Lichi nucleus), lettuce (Chisha), red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia (forsythia), astragalus, waxy ), Wax palm, locon (reed, azu), logan berry "Fruit", rosemary (Rosmarinus officinalis), wasabi, Watafujiutsugi (dense Komuhana), burnet (Chinire), and the like.
[0045]
Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usbaaonori, Sujiaonori, Hiraaonori, Bowaonori, Hosoedaaonori), Anaausa (Aosa) and seaweed [Brown algae] (Macomb, Resiliconbu, Hosomebu, Mitsuikonbu), Wakame, Hirome, Aookame, Giant Kelp (Macrostistis pilifera, Macrocystis integrifolia, Neocitys Luetokeana), Hijiki, Hibamata, Umiuchiwa, Usubaumiuchiwa, Kiribano Sea Prickly Pear, Akabumi Prickly Pear, Konau Prickly Pear, Okinawa Prickly Pear, Usuki Prickly Pear, Ecchi Prickly Pear], Seaweed [Red Algae: Hijirimen, Maxa (Tengusa), Hiracusa, Onixa, Obaku ) Kainori, Yaleus Banori, Kagius Banori, Sujius Banori, Hyus Banori, Akamomininori] and the like.
[0046]
In addition, other algae such as green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Genus kuwanomimo, Volvox: Ohigemawari, Volvox, Palmera, Yotsumemo, Aomidro: Hizaori, Spirogyra, Papilio spp., Hibimidro spp .: Hibimidro spp. Echinacea spp .: Echinacea spp., Iwata spp .: Husaiwata, Sricogulata, Helaiwata, Crocita, Janemo, Mir spp .: Mill, Cromil, Sakibuchimil, Nagamil, Hira Le, Casanori: Casanoli, Jusmo: Futozuzumo, Tamazuzumo, Mizojusmo, Mikazukimo, Korekaete, Tsuzumimo, Kikkogusa: Kikkougusa, Hitoexa Genus: Hitougusa, Hirohanohitengusa, Utsutoegumo, Genus Sumiremo: Sumiremo, Hoshimidoro, Fushinashimidoro etc.).
[0047]
Blue-green algae (Genus L .: L., L., L .: Kawatake, Ishikurage, Hassai, Juremo, L. (spirulina): Spirulina, Trichodesmium (Aiakashio), etc.).
[0048]
Brown algae (Piraella spp .: Piraella spp., Spirogyra spp .: Namiami spp., Isogrape spp .: Isogrape, Isogawara spp .: Isogawara spp. , Genus Sanadagusa: Sanadagusa, Fukurinamiji, common genus: common rush, terrestrial genus: Ezoyahazu, Yahuzugusa, Uraboshiyahazu, genus Genus: jigamigususa, Umiuchiwa genus: Genus genus, genus genus, genus Genus : Nabarimo, Chasoumen: Motsucha-chasomen, Matsumo: Matsumo, Nagamatsumo: Nagamatsumo, Okinawamozuku: Okinawamozuku, fake Genus Tomozuku: Niseftomozuku, Genus Futomozuku: Genus Futomozuku, Genus Genus: Ishimozuku, Genus Cromo: Chromo, Genus Nisemozuku: Nisemozuku, Genus Mozuku: Mozuku, Genus Ishige: Ishige, Genus Genus: Ichimegasa, Callarial spp. Umibos, Urushigusa genus: Urushigusa, Keulushigusa, Tobacco moss, Kombmodoki: Kombudoki, Hambamodoki genus: Havamodoki, Habanori genus: Habanori, Hiranohabanori genus: Habanori, Commonbukuro genus: Commonbukuro, Ezobukurono, Ezobukurono, Ezobukuronozo, genus Genus genus: genus genus: genus kagomenori: genus kagomenori, muralidori: murachidori, sharksugusa genus: sharksugusa, iwahige genus: iwahige, yokojimanori genus: yokojimanori, Genus: Cyperus, Fennel: Fennel, Turmo: Turmo, Anana: Aname, Sujime: Sujime, Miss kelp: Miss kelp, Atsuba Miss kelp, kelp: Gatsugara kelp, Kakisima kelp, Oni kelp, Gohei sorghum, Gohei kelp, Gohei sorghum Genus Oleoptera, Trolocomb: Trolocomb, Antokume: Antokume, Swordfish: Swordfish, Tsurarame, Kurome, Asterina: Asterine, Nesulecomb: Nesirecomb, Kuroshiome: Kuroshiome, Nekoashikame: Acerium, Araumenu Genus: Ainu-Wakame, Chigaiso, Oniwakamezo-Ezoishige: Ezoishige, Yabanemoku: Yabanmoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jo Lomoku, Hiemoku, Hondawara: Tamanamoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Hashimomoku, Haikumokugi, Hawk Mokumoku , Genus genus: genus oleum, genus bulumium: genus bulumium, genus kayamoris: kayamoris, etc.).
[0049]
Red algae (Coleoptera genus: genus oxenori, fenori no moss, Amanori genus: Asakusanori, Susabinori, Uppulinori, Oniamanori, Tasa, Filitasa, Benitasa, Rhodocorton genus: Milnoveni, Akebonomozuku, Agenidae, Genus: Sea elephant, Tsukumonori, Kamogashiranori, Benimozuku: Benimozuku, Hosobenimozuku, Kasamatsu: Casamatsu, Fusanori: Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegaramiragara, Gallaghera Genus: Tamaitadaki, genus genus: genus kaginori, genus chinensis, proboscis genus: scrophularus, scrophium, oobusa, nambugu , Kohira, Yohira, Kinukusa, Hibiroudo: Hibiroudo, Himehibiroudo, Isomemudoki: Isomemudoki, Michigaesou: Michigaesu, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekisuba, Nisekareqaba, Nisekarekubasa Genus Naminohana: Hosobanaminohana, Naminohana, Coralthrum Genus: Garagaramodoki, Shiogosagoromo Genus: Shiogosagoromo, Iwanokawa Genus: Etsukiiwanokawa, Kainokawa Genus: Kainokawa, Kaninote Genus: Kaninote, Kanonomi, Genus, Sagomo, Dessertica Cyanophora, Sakuranori, Nikumukade, Tambanori, Smooth, Fudarak, Malbahudarak, Isonohana: Nuracusa, Ronulaxa, Giant Coleoptera, Hirakintoki: Hirakintoki, Pleurotus genus: Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Komenori, Tosakamatsu, Aimatsumatsu, Fushikintoki, Tsunomukade, Nagakinotoki, Suzumekito, Kakutoitto, Kakutoto Genus Nagaobane: Nagaobane, Funori: Hanafunori, Fukuronori, Makuhnori, Kalexigusa: Kalexigusa, Tosakamokuki: Hosobanotosakamodo, Hirohanotosakamoki, Yatsudegatatosakamoki, Kurotosakanotoka, Japanese moss Tosakamodoki, Nankaitosakamodoki, Himetosakamodoki, Kinuhada: Kinuhada, Ezotosaka: Ezotosaka, Tsukasanori: Enashikarimenia, Otsukasanori, Hana Tacarimenia, genus genus: hornworm, lycaenoid genus: lycopodium, cypress, genus genus: nikhonoo, venicenago genus: venicenago, sukakebeni genus: sukakebeni, okamurasa genus: yamadagusa, mirin genus: mirin, saucaminae spp. , Isomocca: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Rhinoceros, Tachiibara, Kagiibaranori, Kizinoo: Kijinoo, Isosanthus: Isodantsuu, Atsubanori: Atsubanori, Ogononori, Ogonotori, Ogonotori, Mizo-Okonori, Kabanori, Beniogonori, Fukuroshinori, Murasaki Kabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogono Li, Sorbus americana, Cyperus sylvestris, Ligustrum serrata, Lily of the valley, Genus sylvestris, L. Genus: crocodile, saimi, crocodile, lotus spp .: lotus spp. Genus genus goats: genus goatsou, hanasakura, fukuronagi genus: fukurotsunagi, sujikonori, hananoeda genus: hananoeda, hiratagoata genus: hiratagoat, darsu : Darus, masagoshibari, anadarus, webagsa genus: webugsa, Benifukuronori: Benifukuronori, Fushitsunagi: Fushitsunagi, Himefushinagi, Hirohafushinagi, Watsunagisou: Hirawagnagisou, Utsuwagisuigi, Iriomota, Iriomota , Genus Egonori: Egonori, Futogigis, Saeda genus: Saeda, Chrysanthemum genus: Chirimomiji, Konohanoriaceae: Habutaenori, Konohanori, Suzurononori, Usveni genus: Usveni, Genus: Hasuziginu, Nagakonosuginonu Genus: Kagiusbanori, Yaleusbanori, Siusiusbanori, Hyusbanori, Usubanorimodoki genus: Usubanolimodoki, Ayanishiki genus: Ayani Ki, Ayaginu: Ayaginu, Dadia: Enashidazia, Shimadada: Isohagi, Shimadada, Dazimodoki: Dazimomodoki, Itogusa: Moletogusa, Futigusa, Makri: Makuri, Sanaginori: Hanayanagi, Yuna, Yanaginaginamo, Yanaginaginamomori, Yanaginaginomibe, Yanaginaginomibe, and Yanaginaginomibe, Yanaginaginomibe, Yanaginarinamoyana, Yanaginaginoyamo, Yanaginarinamoyana, Yanaginayori, Yanaginayorimo, Yanaginayori, and Yanaginayori-namo-na-yagi-namo-nagi-na-gori , Sasabayanaginori, Sozogenus: Kurosozo, Kobusozo, Hanesozo, Sozonohana, Hanegusa: Hanegusa, Kehanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Genus: Himegoke, Kurohoshigoshi, Hioudoogoshigu Isomegusa, Aspergillus: Aspera, Aspera, Aspera, Aspergillus: Aspera, Aspergillus: Aspergillus, Aspergillus : Kawamozuku, Aokawamozuku, Himekamozuku, Ideyukogome spp .: Ideyukogome, Okichimozuku: Ochichimozuku, Itogusa, Chinorimo: Chinorimo, Chisinori: etc.).
[0050]
Axle algae (Erythra spp., Echinacea spp., Hoshiturimo genus: Hoshiturimo, Lichnotamus genus, Phalaenopsis genus: Himejirabamo, Chaboflavidium, Tripella genus, etc.), yellow algae (Hikarimo genus: Hikarimo etc.) and the like.
[0051]
In addition, as a material derived from animal-based raw materials, a cockscomb extract, a cow or pig, a human placenta extract, a cow or pig stomach, a duodenum, an intestine, an extract of a spleen or a decomposition product thereof, a cow or pig brain tissue Extract, collagen hydrolyzate (acid, alkali, enzyme, etc.) hydrolyzate of bovine / pork or fish, collagen derivative such as water-soluble collagen or acylated collagen, elastin or elastin hydrolyzate of bovine / pork / fish (acid, Alkali or enzyme) or water-soluble elastin derivative, keratin and its degradation product or their derivative, silk protein and its degradation product or their derivative, pig or bovine blood cell protein degradation product (globin peptide), cow or pig hemoglobin Decomposition products (hemin, hematin, heme, protohem, heme iron, etc.), milk, casein and its decomposition products or derivatives thereof, skim milk powder and its decomposition products or it Derivatives, lactoferrin or decomposed product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.
[0052]
In addition, as a material derived from a plant or animal material, any site, cell, tissue, organ, metabolite, or the like derived from a genetically modified product or a cell fusion can be used. Furthermore, for example, undifferentiated cells or cells undergoing differentiation, which are obtained by culturing cells at any site, cell, tissue, organ, or the like, can also be used.
[0053]
(14) Marine components
Seawater such as deep water, for example, seawater salt, dried seawater, inorganic salt obtained from the Dead Sea or the Atlantic or Pacific Ocean (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fungo), for example , Italian fango, German fango, Eifelfango, Freiburgfango, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide , Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintokushi, black pearl stone, etc.
[0054]
(15) Microbial culture metabolite
Yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold or actinomycete metabolite, mold or actinomycete extract, natto metabolite, natto extract, rice fermented extract, rice bran (red bran, white bran) ) Fermented extract, Euglena extract or its decomposition product or water-soluble derivative thereof, trehalose or its derivative, lactic acid fermentation product of raw milk or skim milk powder, lactic acid fermentation product of leguminous plant, lactic acid fermentation product of coconut genus plant, and the like.
[0055]
(16) α-hydroxy acids
Glycolic acid, citric acid, malic acid, tartaric acid, lactic acid, etc.
[0056]
(17) Inorganic pigment
Silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide , Gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, etc.
[0057]
(18) UV absorber / blocker
Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfone Sodium acid, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.) , Methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, octyl paramethoxycinnamate, paramethoxycinnamate 2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, etc., salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, Myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives , Dioxane derivative, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative , Vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, dioxybenzone, octabenzone, slisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, escalol, zinc oxide, Talc, kaolin, etc.
[0058]
(19) Whitening agent
Paraaminobenzoic acid derivatives, salicylic acid derivatives, anthranilic acid derivatives, coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives , Nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein , Berberine, placenta extract, ellagic acid, lucinol, etc.
[0059]
(20) Tyrosinase activity inhibitor
Vitamin C or its derivative (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or its derivative (hydroquinone benzyl ether, etc.), kojic acid or its derivative, vitamin E or its derivative, N-acetyltyrosine or its derivative , Glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, gardenia, touki, waremokou, clara, mugwort, honeysuckle, yellowfin, dokudami, matsuhodo, Admiral, bolet, hops, hawthorn, eucalyptus, yarrow, Altea, calyx, mankei, hammeris, caragua or yamaguwa, prolonged life grass, bellflower, toshishi, maizeko, sun dried, mahuang, senkyu, dokkatsu, psycho, Ufuu, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.
[0060]
(21) Melanin pigment reduction / decomposition substance
Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or its derivatives (hydroquinone benzyl ether) and the like.
[0061]
(22) Turnover promoting action / cell activator
Hydroquinone, lactic acid bacterium extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe, ogon, horsetail, gentian, burdock, sicon, carrot, Hamamelis, hops, okinin, edulis, assembly, touki, balsam, amacha, hypericum, cucumber, scotch, mannenrou, parsley) and the like.
[0062]
(23) Astringent
Succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compounds) and the like.
[0063]
(24) Active oxygen scavenger
SOD, catalase, glutathione peroxidase and the like.
[0064]
(25) Antioxidant
Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaseletenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol , Sesamolin, gossypol, propolis etc.
[0065]
(26) Lipid peroxide production inhibitor
β-carotene, plant extracts (sesame cultured cells, amacha, Hypericum perforatum, hamamelis, clove, melissa, emisoso, birch, salvia, mannenrou, Nantenmi, Eijitsu, Ginkgo, green tea) and the like.
[0066]
(27) Anti-inflammatory agent
Icutamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof Salt, licorice extract, sicon extract, age extract, propolis and the like.
[0067]
(28) Antibacterial, disinfectant, disinfectant
Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salami powder, iodine compound, iodoform, sorbin Acid or a salt thereof, propionic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m -Xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phenylphenol, Irgasan CH3565, halocarban, hexachlorophen, chlorohexidi , Ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxyethylene lauryl ether , Polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactants, anionic surfactants (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactants (cetyltrimethylammonium bromide, benza chloride) Ruconium, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, Star Le violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.
[0068]
(29) Moisturizer
Glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprylcaprate, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin or its derivative or chitosan derivative , Pyrrolidonecarboxylic acid or a salt thereof, sodium lactate, urea, sorbitol, amino acid or a derivative thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, Tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine and their sulfates, Acid, nitrate, citrate, or pyrrolidone carboxylic acid), oils and fats such as avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, Cucumber oil, beef tallow fatty acid, quince seed oil, kukuinut oil, safflower oil, shea butter, liquid shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil, sunflower oil, cottonseed oil, Peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mokurou, coconut oil, eucalyptus oil, tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened) Oil) ", waxes (bee wax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin) , Hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, vaseline, paraffin, ozokeride, ceresin, microcrystalline wax), natto metabolite, natto extract, silk fiber extract, plant extract (Akamatsu sap, aloe, kakkon, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or birch sap, assemblage, mulberry bark, biwa leaf, loofah, peony, penguin) and the like.
[0069]
(30) Elastase activity inhibitor
Diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, Mulberry leaf, Calyx, Gennoshoko, Comfrey, Salvia, Agaricus japonicus, Bodaiju, Botanpi), seaweed extract and the like.
[0070]
(31) Hair agent
Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, sodium bromate, thioglycolic acid and the like.
[0071]
(32) Antiandrogen agent
Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.
[0072]
(33) Peripheral vascular blood flow promoter
Vitamin E or its derivatives, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.
[0073]
(34) Stimulant
Pepper tincture, nonyl acid vanillamide, cantaris tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
[0074]
(35) Metabolic activator
Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placental extract, biotin, glyceride pentadecanoate, and the like.
[0075]
(36) Antiseborrheic
Pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.
[0076]
(37) Keratolytic agent
Resorcinol, salicylic acid, lactic acid, urea, etc.
[0077]
(38) Oxidizing agent
Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like.
[0078]
(39) Hair remover
Inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide and calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) etc.
[0079]
(40) Hair swelling agent
Ethanolamine, urea, guanidine, etc.
[0080]
(41) Dye agent
5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenyl acetate Paraphenylenediamine, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol P-nitroorthophenylenediamine, p-phenylenediamine, p-methylaminophenol, picramic acid, sodium piclamate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- ( 2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, sulfuric acid Orthochloroparaphenylenediamine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitrophenol sulfate Tophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcinol , Tannic acid, sodium 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.
[0081]
(42) Fragrance
Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black character Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western mint essential oil, large fragrance essential oil, Tuberose essential oil, T-shaped essential oil, orange flower essential oil, winter green essential oil, Truval sam essential oil, baturi essential oil, rose essential oil, palmarosa essential oil, cypress essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiver essential oil, bergamot essential oil, perl Vegetable flavors such as balsam essential oil, boad rose essential oil, camphor essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannen wax) essential oil, Japanese mint essential oil, etc. Synthetic fragrances, etc.
[0082]
(43) Dyes / colorants
Red cabbage pigment, red rice pigment, Akane pigment, anato pigment, squid pigment, turmeric pigment, endju pigment, krill pigment, persimmon pigment, caramel, gold, silver, gardenia pigment, corn pigment, onion pigment, tamarind pigment, spirulina pigment, Buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.
[0083]
(44) Sweetener
Sugar, sweet tea, fructose, arabinose, galactose, xylose, stevia, mannose, maltose, honey, glucose, miraculin, monelin, licorice extract and the like.
[0084]
(45) Nutrition enhancer
Shell calcined calcium, cyanocorabamine, yeast, wheat germ, egg yolk powder, hemicellulose, heme iron and the like.
[0085]
(46) Dairy products
Milk, cheese, fresh cream, butter, margarine, milk powder, whey, condensed milk, etc.
[0086]
(44) Other
Hormones, sequestering agents, pH adjusters, chelating agents, preservatives / antibiotics, cooling agents, stabilizers, emulsifiers, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products , Animal and plant glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound healing agents, foaming agents, thickening agents, enzymes, purified water (electronic water, small clusters) Etc.), oral agents, deodorants / deodorants, bittering agents, seasonings, etc., and the combination of the Maillard reaction inhibitor of the present invention and a component having a Maillard reaction inhibitor known to date. Can be expected to have an additive or synergistic Maillard reaction inhibitory action.
[0087]
In addition, the dosage form of the Maillard reaction inhibitor of the present invention, further the external preparation for the skin or the food and drink is arbitrary, such as ampule, capsule, powder, granule, pill, tablet, solid, liquid, and gel. It can be used in the form of foams, emulsions, creams, ointments, sheets, etc., pharmaceuticals, quasi-drugs, skin / hair cosmetics, bath agents, foods and drinks.
[0088]
Specifically, for example, internal / external medicinal preparations, lotions, emulsions, creams, ointments, lotions, oils, basic cosmetics such as packs, facial cleansers and skin cleansers, shampoos, rinses, hair treatments, hair creams , Pomade, hair spray, hair styling, perm agent, hair tonic, hair coloring, hair growth and hair restoration, hair cosmetics, foundation, white powder, whitening, lipstick, blush, eyeshadow, eyeliner, mascara, eyebrows, eyelashes, etc. Makeup cosmetics, finishing cosmetics such as beautiful nails, perfumes, bath agents, other toothpastes, mouth fresheners / gargles, liquid odor / deodorant inhibitors, hygiene products, sanitary cotton, wet tissues It can also be used for general foods and drinks.
[0089]
In addition, a Maillard reaction inhibitor containing at least one selected from plant extracts obtained from the red oak wrinkles, oysters, mulberry, St. John's wort, sycamore, Yakuyo garega, Yaba santa, and rose hip of the present invention, and further into a skin external preparation or food and drink May be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.
[0090]
【Example】
Hereinafter, production examples, test examples, and prescription examples will be described, but the present invention is not limited thereto.
[0091]
(Production Example 1)
100 g of each dried plant of Akamega wrinkle, Japanese persimmon, mulberry, St. John's wort, Astragalus, Yakuyo garrega, Yaba Santa, and Rose hip is immersed in 1 L of a 50% ethanol solution, extracted at room temperature for 3 days and nights, and suction filtered to obtain an extract (dry solid). 0.1-2.0%).
[0092]
(Production Example 2)
100 g of each dried plant of Akamega wrinkle, Japanese persimmon, mulberry, St. John's wort, Periwinkle, Yakuyo garega, Yaba Santa, and Rose hip was immersed in a 50% ethanol solution for one day at room temperature, and the solvent was distilled off. It is redissolved in 1 L of a 1,3-butylene glycol solution, and subjected to suction filtration to obtain about 1.0 kg of an extract (dry solid content: 0.1 to 2.0%).
[0093]
(Production Example 3)
100 g of each dried plant of Akamega wrinkle, Japanese persimmon, mulberry, St. John's wort, Periwinkle, Yakuogarega, Yaba Santa, and Rosehip was immersed in 1 L of a 50% 1,3-butylene glycol solution, extracted at room temperature for 3 days and night, and suction filtered. About 1.0 kg of extract (0.1-2.0% dry solids) is obtained.
[0094]
(Production Example 4)
100 g of each dried plant of Akamega wrinkle, Japanese persimmon, mulberry, St. John's wort, Periwinkle, Yakuo garrega, Yaba Santa, and Rose hips was heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solids: About 0.1-2.0%).
[0095]
(Test 1) Measurement of Maillard reaction (terminal glycated substance formation) inhibitory action
The Maillard reaction (browning reaction) is a non-enzymatic protein saccharification reaction. This is a bond between an amino acid or protein controlling various physiological functions in a living body and a reducing sugar, and forms a yellow-brown substance. The initial stage reactant of the Maillard reaction is a protein-sugar conjugate called an Amadori compound. Furthermore, this reaction forms a yellow-green substance having fluorescence through dehydration and polymerization. This is called advanced saccharified substance. This series of reactions is known to impair the function of the protein and to form intra- and intermolecular cross-links of the protein. At present, aminoguanidine is known as a drug that inhibits this reaction. Therefore, by comparing the inhibitory activity with aminoguanidine, it is possible to evaluate the inhibitory effect on this reaction. This test was performed by improving the conventional method.
[0096]
(Test method)
a. sample
The test solution was the extract of the red oak wrinkle, oyster tree, mulberry, St. John's wort, azalea, syrup, yakuyo garega, yaba santa, and rose hip obtained in Production Example 1. A 50% ethanol solvent was used as a positive control.
b. Measurement of inhibitory effect
<Apparent inhibition rate>
To 10 μL of the test solution, 50 μL of 2M glucose, 100 μL of 4 mg / mL bovine serum albumin, 250 μL of 100 mM sodium hydrogen phosphate, and 90 μL of water are added, and reacted at 60 ° C. for 30 hours. To 25 μL of the rosmarinic acid test solution alone, 50 μL of 2M glucose, 100 μL of 0.4% bovine serum albumin, 250 μL of 100 mM sodium hydrogen phosphate, and 75 μL of water were reacted. After the reaction is completed, the tube is taken out of the heat block, placed in a refrigerator at 4 ° C., cooled, stirred by vortex, and then 100 μL of the reacted solution is placed in a new Eppendorf tube. There, 10 μL of a trichloroacetic acid solution is added. The mixture is again vortexed, and then centrifuged by cooling (4 ° C., 15000 rpm, 4 minutes), and the supernatant is removed by suction. Dissolve the precipitate with 400 μL of alkaline phosphate buffer (-). 200 μL is transferred to a 96-well white plate for fluorescence measurement, and the fluorescence is measured at a fluorescence plate reader excitation wavelength of 360 nm and a fluorescence wavelength of 460 nm to calculate the apparent inhibition rate.
[0097]
<Equation 1>
Apparent inhibition rate (%) = 100 − {[(sample−blank) / (positive control−blank)] × 100}
[0098]
<Quenching effect>
Measure how much the sample itself absorbs fluorescence.
Mix 2 μL of the test solution with the positive control reaction solution to make 100 μL. Thereto, 10 μL of a trichloroacetic acid solution was added, and the mixture was stirred by vortexing. After centrifugation under cooling (4 ° C., 15000 rpm, 4 minutes), the supernatant was removed by suction, and 400 μL of an alkaline phosphate buffer (−) was used. Dissolve. 200 μL is transferred to a 96-well white plate for fluorescence measurement, and fluorescence is measured at a fluorescence plate reader excitation wavelength of 360 nm and a fluorescence wavelength of 460 nm to calculate the quenching effect.
[0099]
<Equation 2>
Quenching effect (%) = 100 − {[(positive control−sample) / positive control] × 100}
[0100]
<True inhibition rate>
The true inhibition rate is calculated from the apparent inhibition rate (%) and the quenching effect (%) using the following formula.
[0101]
<Equation 3>
True inhibition (%) = apparent inhibition (%)-quenching effect (%)
[0102]
<Reagent for testing Maillard reaction inhibition action>
-100 mM sodium hydrogen phosphate (pH 7.4): Na ₂ HP0 ₄ ・ 12H ₂ Dissolve 3.6 g with water and adjust to pH 7.4 to bring the total volume to 100 mL.
-2M glucose: Dissolve 18 g of glucose with water to make a total volume of 50 mL.
-4 mg / mL bovine serum albumin: 4 mg / mL aqueous solution of bovine serum albumin. Prepare before use.
-100 mM aminoguanidine: 13.2 mg / mL aqueous solution of aminoguanidine sulfate.
100% (w / v) trichloroacetic acid: Dissolve 100 g of trichloroacetic acid in water to make 100 mL.
-Alkaline phosphate buffer (-): Dilute a 0.25N aqueous sodium hydroxide solution 40-fold with phosphate buffer (-).
[0103]
[Table 1]

[0104]
(Test results)
As shown in Table 1, it was confirmed that the plant extracts of the present invention obtained from Acacia catechu, Japanese persimmon, mulberry, St. John's wort, Astragalus vulgaris, Yakuyo garrega, Yaba santa, and rose hip have a strong Maillard reaction inhibitory action.
[0105]
(Test 2) Measurement of pentosidine production inhibitory action
The inhibitory effect was evaluated by comparing the production inhibition rate (%) of pentosidine, which is one of the terminal glycated substances of the Maillard reaction (final product of the Maillard reaction).
[0106]
"Test method and evaluation method"
a. sample
100 g of each dried plant of Yakuyo Garega and Yaba Santa is immersed in 1 L of a 50% ethanol solution, extracted for 1 week at room temperature, and then filtered to obtain an extract (dry solid content: 0.1 to 2.0% by weight) of about 1. Get 0 kg. This was used as a test solution. In addition, dimethyl sulfoxide was prepared as a positive control, and 1 mM and 10 mM aminoguanidine were prepared as comparative controls under the same conditions and used for the test.
b. Measurement of pentosidine production inhibition
500 mM Ribose, 500 mM Lysine, 500 mM Arginine, 100 mM Na were added to 25 μL of the sample solution. ₂ HPO ₄ (PH 7.4), H ₂ Add 95 μL of O, incubate on a heat block at 60 ° C. for 24 hours, and after the reaction is completed, add 100 μL of H to the reaction solution. ₂ 400 μL of O was added, and the amount of pentosidine produced was measured by high performance liquid chromatography.
[0107]
<High-performance liquid chromatography measurement conditions>
The solvent is acetonitrile: TFA: H ₂ O = 3: 0.1: 96.9 is used. The flow rate is 1 mL / min, the column temperature is 40 ° C., the excitation wavelength is 335 nm, and the measurement wavelength is 380 nm. The injection volume is 10 μL. In addition, the pentosidine (pentosidine) preparation was adjusted based on the method of Monnie, and confirmed by various instrument spectrum data. It was used to confirm that the peak on the high performance liquid chromatogram was pentosidine.
[0108]
[Table 2]

[0109]
(Test results)
As shown in Table 2, it was confirmed that the extracts of Yakuyo garrega and Yaba santa of the present invention have a pentosidine production inhibitory activity comparable to that of aminoguanidine, and can be used as a Maillard reaction inhibitor.
[0110]
(Test 3) Safety test
(1) Skin primary irritation test
The red oak wrinkles, oysters, mulberries, St. John's wort, primrose, yakuyo garega, yaba santa, and rosehip obtained by Production Examples 1 to 4 were prepared with purified water so that the dry solid content concentration was about 1.0 W / V%. It was applied to the skin of Japanese white rabbits (female, 3 per group, body weight around 2.3 kg) whose back was shaved. Judgment was made 24, 48, and 72 hours after application by primary irritation scoring using erythema and edema as indices. The results were negative in all animals without any erythema and edema.
[0111]
(Test 4) Safety test
(2) Skin irritation test
Similarly, red oak wrinkles, oysters, mulberry, hypericum perforatum, azalea, yakuyo garega, yaba santa, and rose hips obtained in Production Examples 1 to 4 were prepared with purified water so that the dry solid content concentration was about 1.0 W / V%. Then, 0.5 mL / animal was applied to the skin of a Hartley-type guinea pig (female, 3 animals per group, body weight of about 320 g) having shaved flank once a day, 5 times a week. Application was performed over two weeks and shaving was performed on the last application day of each week. Judgment was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method as an index of erythema and edema. The results were negative for all animals without any erythema and edema over 2 weeks.
[0112]
(Test 5) Safety test
(3) Acute toxicity test
Similarly, powder obtained by concentrating and drying under reduced pressure the dried red wrinkles, oysters, mulberry, mulberry, St. John's wort, azalea, yakuyo garrega, yaba santa, and rose hip (dry solid content: about 1.0 W / V%) ) Was orally administered to ddy mice (male and female, 5 mice / group, 5 weeks old), which had been fasted for 4 hours before the test, at 2,000 mg / kg, and the appearance and extent of toxic symptoms were observed over time. did. As a result, no abnormalities were observed in all the mice for 14 days, and no abnormalities were observed in the dissection results. Therefore, LD ₅₀ Was determined to be 2,000 mg / kg or more.
[0113]
(Prescription example) Manufacture of Maillard reaction inhibitor, external preparation for skin or food and drink
In accordance with the above evaluation results, formulation examples are shown below, and the formulation examples may be those manufactured by a usual method in the manufacture of each product, and only the compounding amounts are shown. Further, the present invention is not limited to these.
[0114]

[0115]

[0116]

[0117]

[0118]

[0119]

[0120]

[0121]

[0122]

[0123]

[0124]

[0125]

[0126]

[0127]

[0128]

[0129]

[0130]

[0131]

[0132]

[0133]

[0134]

[0135]

[0136]

[0137]

[0138]

[0139]

[0140]

[0141]

[0142]
(Formulation Example 29) Coating protective agent
A gauze or liniment cloth is impregnated with a 60% ethanol extract solution of Yakuyo garrega and a formulation solution containing an appropriate amount of an antibiotic, an anti-inflammatory agent, etc., and attached to the wound. Alternatively, these may be directly sprayed locally and covered with gauze or the like.
[0143]

[0144]

[0145]

[0146]

[0147]

[0148]

[0149]

[0150]

[0151]

[0152]

[0153]
(Test 6) Use effect test
The effect when the skin external preparation and bath agent of the present invention were actually used was examined. The use test was conducted by a panel of 10 people aged 30 to 60 who were worried about skin with no shiny or firm skin, and applied the appropriate amount of the emulsion of Formulation Example 1 to the face twice a day, morning and night, and after washing the face for 3 months. It was performed by coating.
[0154]
Furthermore, as for the bath preparation of Prescription Example 28, an appropriate amount of bath preparation was always dissolved once a day for 10 months for 10 persons aged 30 to 60 who were worried about skin without gloss and tension. We had you take a bath and performed use test. As a control, an emulsion or a bath preparation prepared by removing the plant extract of the present invention from the bath preparation by the same method was used. The evaluation was performed according to the following criteria. The results are as shown in Tables 3 and 4, and the numbers in the table represent the number of persons. No one complained of abnormal skin during the use period.
[0155]
"Skin feel improvement effect"
Effective: Skin gloss / tension increased and skin improved.
Slightly effective: The gloss and tension of the skin increased slightly, and the skin was improved.
Ineffective: No change from before use.
[0156]
(Test results)
From the results of Tables 3 and 4, the use of the latex and bath agent containing the extracts of the red wrinkles, oysters, mulberry, St. John's wort, azalea, yakuyo garega, yaba santa and rose hip of the present invention gives the skin a gloss and tension. In addition, the effect of preventing skin aging such as improving the skin was confirmed.
[0157]
[Table 3]

[0158]
[Table 4]

[0159]
(Test 7) Use effect test
The effect when the food of the present invention was actually used was examined. The usage test was for 10 panelists of 30 to 60 years old suffering from dry skin with no gloss and firmness of the skin. Over to eat and drink.
[0160]
A control prepared by removing the plant extract of the present invention from bread in the same manner was used as a control. The evaluation was performed according to the following criteria. The results are as shown in Table 5, and the numerical values in the table represent the number of persons. No one complained during the period of use.
[0161]
"Skin feel improvement effect"
Effective: Skin gloss / tension increased, dry skin improved.
Slightly effective: Skin gloss and tension increased slightly, and dry skin improved.
Ineffective: No change from before use.
[0162]
(Test results)
From the results in Table 5, it can be seen that the use of the present invention in foods containing the extracts of the red wrinkles, oysters, mulberry, St. John's wort, St. John's wort, Yakuyo garega, Yaba santa, and rose hip gives the skin a glossy and firm skin, The effect of preventing skin aging, such as improvement, was confirmed.
[0163]
[Table 5]

[0164]
【The invention's effect】
The plant extracts obtained from the red oak wrinkles, oysters, mulberry, St. John's wort, Hypericum perforatum, Yakuyo garega, Yaba santa, and rose hips have a Maillard reaction inhibitory action. Having. Furthermore, they are safe for internal or external use for humans or animals. Therefore, it can be applied as a Maillard reaction inhibitor to various forms of pharmaceuticals (medicines, quasi-drugs, cosmetics, foods), and various Maillard reactions such as skin wrinkles and sagging, and complications derived from diabetes. It can be used for the prevention and treatment of diseases related to. Furthermore, it gives gloss and tension to the skin and is effective for improving the skin, so that it can be used for preventing skin aging.

Claims (5)

A Maillard reaction inhibitor comprising one or two or more plant extracts selected from Akamegawiwa, Japanese persimmon, mulberry, St. John's wort, Astragalus, Yakuogarega, Yabasanta, and Rosehip. 2. The Maillard reaction inhibitor according to claim 1, wherein the plant extract is an extract from Yakuyo garrega and / or Yaba santa. 3. The Maillard reaction inhibitor according to claim 2, which has a pentosidine production inhibitory action. An external preparation for skin, comprising the Maillard reaction inhibitor according to claim 1. A food or drink comprising the Maillard reaction inhibitor according to claim 1.