JP2002154922A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new, safe antioxidant having effects for effectively eliminating active oxygen and inhibiting lipid peroxide from generating, and to provide a cosmetic composition capable of improving dry skin, eczema, and chapped skin and further capable of giving gloss and extension to the skin and the hair, by utilizing the antioxidant. SOLUTION: This antioxidant contains essences extracted from one or more kinds of plants selected from Ilex latifolia, Magnoliae Cortex, and Polygonum aviculare. The cosmetic composition contains the antioxidant.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel cosmetic effect of one or more plant extracts selected from tarayou, kouboku, and willow and application to a cosmetic composition based thereon.

[0002] The antioxidant according to the present invention and a cosmetic composition containing the same include pigmentation such as spots and freckles,
It refers to all external preparations for preventing or improving troubles such as rough skin and rough skin.

[0003]

2. Description of the Related Art In recent years, the generation of active oxygen in vivo
Various effects (diseases) caused by it have been reported.
You. Generally, this active oxygen is also called Activated oxygens.
Barred, O _Two ^-, H_TwoO_Two, OH, chemiluminescence,
All have strong bactericidal action and are involved in the self-defense of living organisms
It is considered an important substance. For example, bacteria, virus
External enemies (antigens) such as viruses and foreign substances enter the living body
Then, first, phagocytes in blood, neutrophils, monocytes,
Lophage initiates phagocytosis, then into the phagocytic endoplasmic reticulum
Active oxygen is produced to dissolve engulfed foreign matter
You. This active oxygen affects the dissolution of phagocytic foods, while
Indirectly has a bactericidal action against external enemies such as bacteria and foreign substances
And play a role in protecting the living body from external enemies.

[0004] However, if the active oxygen for self-defense is excessively produced and secreted, even normal cells may be lysed and stimulated, resulting in various disorders.
Recently, many diseases and diseases induced by active oxygen have been reported. For example, fats and oils such as cholesterol in the blood are oxidized by active oxygen, and vascular disorders due to arteriosclerosis in the brain and heart (stroke, myocardial infarction, etc.)
And blood flow impairment due to a thrombus or the like at the time of cerebral trauma, or ischemic state (oxygen deficiency) in blood vessels due to sudden transient atrophy.

In particular, since the skin is an organ that directly contacts the outside world, it is easily affected by external environmental factors such as ultraviolet rays.
It is known that various diseases are caused by the active oxygen generated thereby. For example, if the active oxygen continues to be excessive in the skin due to ultraviolet rays or radiation,
It reacts with the unsaturated fatty acids of the phospholipids of biological membranes to form lipid peroxides, which may cause arteriosclerosis, carcinogenesis, membrane destruction, protein denaturation, skin inflammation, and edema. Is done. In addition, from a cosmetic point of view, a disease caused by an excess of reactive oxygen is only concerned with herpes dermatitis, x-ray dermatitis, burns, trauma, sunshine dermatitis, contact dermatitis, eczema, atopic dermatitis, etc. Instead, it induces an increase in glycosaminoglycan, cross-linkage and reduction of collagen fibers, denaturation of elastic fibers, etc., causing the skin to lose its elasticity, causing external changes such as wrinkles and loosening. It is known that the phenomenon is promoted.

[0006] In order to prevent or ameliorate the above-mentioned diseases, substances such as superoxide dismutase (SOD), catalase, glutathione peroxidase, In addition, tocopherol (vitamin E), oryzanol, plant extract (hamamelis, melissa, emisoso, birch, sage, rosemary, age, basil, ginkgo, psycho, peonies, hange, keihi, taisou, ogong, carrot, licorice, ginger) Its usefulness has been pointed out.

[0007]

However, the active oxygen-scavenging substances mentioned above are poor in stability and solubility in the formulation system, causing off-flavors and coloring due to sedimentation and decomposition, and are not effective at the biological level. Is not enough,
It was not satisfactory in actual use, for example, there were safety problems such as skin irritation.

[0008]

Means for Solving the Problems The present inventors have conducted intensive studies in view of such circumstances, and as a result, have found that Tarayou, Kouboku,
One or more plant extracts selected from the willow tree are excellent in usability and have been confirmed to have an effective active oxygen scavenging (SOD-like) action and a lipid peroxide production inhibitory action to find usefulness as an antioxidant. Successful. Further, by using this, a cosmetic composition which improves dry skin, eczema and rough skin, and gives gloss and shine to the skin and hair has been completed.

[0009] The present invention relates to an antioxidant containing one or more plant extracts selected from tarayou, kokuboku, and willow or a cosmetic composition containing the same.

[0010]

BEST MODE FOR CARRYING OUT THE INVENTION The plants used in the present invention are as follows, and all of them are flowers, spikes, peels, fruits, stems, leaves, branches, branches and leaves, stems, bark, rhizomes, root bark, roots and seeds. Alternatively, whole plants can be used. In addition, those available as crude drugs may be used.

[0011] The "Tarayou" used in the present invention is:
Ilex latifolia Thun (Ilex latifolia Thun), a plant of the genus Aquifoliaceae, genus Ilex
b.), and is also called Ichiyocha, Kuchocha, and Madancha. Other species of the congener, Aohada (Ilex macropoda Mi
q.), red-tailed boxwood (Ilex sugerokii var. brevip
edunculata S. Hu), amami holly (Ilex dimor)
phophylla), American holly (Ilex opaca Ait.),
Dogwood (Ilex crenata var. Crenata (= Ilex crenata
Thunb.)), Ilex vomitori
a), Ilex guayusa (Ilex guayusa), Ushikaba (Kurosoyogo) (Ilex sugerokii Max.), Umedokki (Ilex serrata Thunb.)
lex rotunda Thunb.), Kane boxwood (hair winter blue) (Ilex p
ubescens Hook. et Arm.), fine fruit winter blue (Ilex rotunda T
microcarpa SY Hu), mountain green tea (Hainan winter blue) (Ilex hainanensis Merr.), cinnamon holly (Hiragi mochi, cyst) (Ilex cornutaLindl. et Pax
t.), Holly holly (Ilex aquifolium), Soyogo (Ilex pedunculosa Miq.), Thrips (green cherry peach, fir pine winter blue) (Ilex micrococca Maxim. f. pilosa S.
Y. Hu), vines (Ilex rugosa), long-tailed boxwood (Ilexmaximowicziana), sardines (Pinus serrata, Kashinohamochi, winter blue) (Ilex chinensis Sims (= I. oldha
mii Miq.)), and a golden boxwood (Ilex crenata var. palud)
osa), Ilex geniculata, Yerba mate (Paraguaiacha) (Ilex paraguaiensis A. St. Hil.
(= Ilex paraguayensis St. Hill. = Ilex paraguariens
is)), Manjusei: Ilex aculeolata Nakai,
Beetle (Ilex nipponica), Ilex (Ilex)
integra Thunb.), Gangbai (Umeha winter blue) (Ilex asprella
Champ. Ex Benth.), Ilex kudingcha CJ Tseng, etc. can also be used.

As used herein, “Koroku” refers to a magnoliaceae plant belonging to the genus Magnolia.
Magnolia obovata Thun
b.), Senboku, Kohoku Koboku, Karaho (Magnolia)
officinalis Rehd. et Wils.), Unboku, Unshokuboku (Magnolia officinalis Rehd. et Wils. va
r.biloba Rehd. et Wils.) and other plants commonly referred to as "koboku". Other species of the same genus can also be used.

[0013] The "willow willow" used in the present invention is a plant belonging to the Polygonaceae and Polygonum genus: Polygonum aviculare, and is also referred to as a willow or a hen. In addition, congener species of willow willow (Polygonum aviculare var.vegetum),
Polygonum plebeium, Polygonum polyneuron, Polygonum heterophyl
lum, Polygonum mandshuricum and the like can also be used.

[0014] The one or more plant extracts selected from tarayou, koboku and honeywort used in the present invention are those obtained by extracting various parts of a plant as it is or after crushing. Alternatively, it is extracted with a solvent as it is or after pulverization.

Examples of the extraction solvent include water, alcohols (eg, lower alcohols such as methanol, anhydrous ethanol and ethanol, or polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin), and ketones such as acetone. , Ethyl ether, dioxane, acetonitrile, esters such as ethyl acetate, organic solvents such as xylene, benzene, chloroform, etc. can be used alone or in any combination of two or more. Can also be used in a state where.

These extracts can be arbitrarily prepared by drying, concentrating, diluting, or mixing with other components, depending on the dosage form and form to be applied.

The extraction is usually carried out under normal pressure, and may be heated to increase the efficiency. After the extraction, it is filtered and / or purified using a column such as an ion exchange resin to obtain a solution, paste, gel, or powder. In many cases, the extract can be used as it is, but if necessary, purification treatment such as deodorization and decolorization can be performed as long as the effects of the present invention are not affected. In addition, as a purification treatment means such as deodorization and decolorization, an activated carbon column or the like can be used.

One or more plant extracts of the present invention selected from tarayou, koboku, and willow can be used as an antioxidant or as a raw material to be incorporated into a cosmetic composition. The content thereof varies somewhat depending on the type of the applied dosage form, the method of use, and the expected degree of action, but is usually 0.001% by weight or more (hereinafter expressed as%) as solid content, and preferably about 0.01 to 50%.

The antioxidant or the cosmetic composition according to the present invention is arbitrarily selected from the following essential components and additives and additives as long as the effects of the present invention are not impaired. -Can be manufactured in combination.

(1) Various fats and oils Avocado oil, almond oil, fennel oil, perilla oil,
Olive oil, orange oil, orange luffer oil, sesame oil, cocoa butter, chamomile oil, carrot oil, cucumber oil, tallow fatty acid, kukui nut oil, safflower oil, shea butter, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed Oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, mocro, coconut oil, tallow, lard, or hydrogenated products of these oils (hardened oil, etc.) )Such.

(2) waxes Beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax,
Montan wax, shellac wax, rice wax, squalene, squalane, pristane, etc.

(3) Mineral oils Liquid paraffin, vaseline, paraffin, ozokelide, ceresin, microcrystalline wax and the like.

(4) Fatty acids Natural fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid, isononanoic acid, caproic acid Synthetic fatty acids such as, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) alcohols ethanol, isopropanol, lauryl alcohol,
Natural alcohols such as cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterols, 2-hexyldecanol,
Synthetic alcohols such as isostearyl alcohol and 2-octyldodecanol.

(6) Polyhydric alcohols Ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol , Polypropylene glycol, 1,3-butylene glycol, glycerin, pentaerythritol, sorbitol, mannitol and the like.

(7) Esters Isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyl dodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, Myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate and the like.

(8) Metal soaps Aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

(9) Gum, sugar or water-soluble polymer compound Arabic gum, benzoin gum, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum,
Carob gum, quinseed, agar, casein, lactose,
Fructose, sucrose or its esters, trehalose or its derivatives, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or alkylene such as chitosan, ethylene oxide (C2-C4)
Oxide-added hydroxyalkyl (C2-C
4) chitin or chitosan, low molecular weight chitin or chitosan,
Chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or a salt thereof, hyaluronic acid or a salt thereof, chondroitin sulfate or a salt thereof, heparin, ethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium carboxyethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, Polyethyleneimine and the like.

(10) Surfactants Anionic surfactants (alkyl carboxylate, alkyl sulfonate, alkyl sulfate, alkyl phosphate), cationic surfactants (alkyl amine salt, alkyl quaternary ammonium salt) ), Amphoteric surfactant:
Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (ether type nonionic) Surfactants, ether ester nonionic surfactants, ester nonionic surfactants, block polymer nonionic surfactants, nitrogen-containing nonionic surfactants, and other surfactants (natural surfactants) , Derivatives of protein hydrolysates,
Polymer surfactants, surfactants containing titanium and silicon,
Fluorocarbon surfactants).

(11) Various vitamins Vitamin A group: retinol, retinal (vitamin A
1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1), riboflavin (vitamin B2), pyridoxine (vitamin B)
6), cyanocobalamin (vitamin B12), folic acids,
Nicotinic acids, pantothenic acids, biotins, choline,
Inositols, vitamin C group: vitamin C acid or a derivative thereof, vitamin D group: ergocalciferol (vitamin D2), cholecalciferol (vitamin D3),
Dihydrotaxelol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K
2), menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, γ-oryzanol, orotic acid, vitamin Ps (rutin, eriocitrin, hesperidin), vitamin U Such.

(12) Various amino acids Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid , Hydroxylysine, arginine, ornithine, histidine and the like, and their sulfates, phosphates, nitrates, citrates, and amino acid derivatives such as pyrrolidonecarboxylic acid.

(13) Various additives derived from plant or animal raw materials These are processed in a conventional manner according to the type and form of the product to be added (for example, pulverization, milling, washing, hydrolysis, Fermentation, purification, squeezing, extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decoloration, etc. You can choose to serve.

The solvent used for the extraction may be selected in consideration of the purpose and type of the product to be provided, or the processing to be performed later, but usually, water or a water-soluble organic solvent (eg, ethanol) ,Propylene glycol,
It is preferable to use one or a mixture of two or more selected from among 1,3-butylene glycol). However, when the content of the organic solvent is not preferable depending on the application, only water may be used, or ethanol which is easily removed after extraction may be used, and may be used alone or in an arbitrary mixed solution with water. Exploited extract may be used.

In addition, additives derived from plant or animal raw materials are
When applied to systemic or topical external preparations and cosmetics, including protection of skin and hair, moisturizing, improvement of feel and texture,
Gives flexibility, relieves irritation, relieves stress due to aroma, activates cells (prevents cell aging), suppresses inflammation, improves skin and hair quality, prevents and improves rough skin, hair growth, hair growth, hair loss prevention, gloss Application, cleaning effect, relief of fatigue, promotion of blood flow,
In addition to cosmetic effects such as a warm bath effect, effects such as fragrance, deodorization, thickening, preservation, and buffering can be expected.

In foods and drinks, there are healthy and cosmetic effects such as nutritional supplementation, recovery from fatigue, tonicity, cell activation (prevention of cell aging), etc., improvement of taste, provision of color tone, aroma, gloss and stabilization. It can be used for purposes such as thickening and preservation. Furthermore, in addition to this, various cosmetic and pharmacological effects of each known raw material are expected, and by combining these, the intended effect is enhanced,
Alternatively, it is possible to provide a product that is expected to have a multifunctional effect.

Specific plants (crude drugs) as raw materials include
For example, almonds (Hentomo), eye (Aiba), Blue Kazura
(Seifu Fuji), Aoki (Aoki), Aokiri or Kenasia Ogiri
(Otogi), Aotsujirafuji (Kibo), Acacia, Akasho (Akasho), Akasuri `` fruit '', Red clover, Red grape, Akaminoki (Logwood), Akamegawiwa (Red bud), Akaminokane or Akanekane or Akane
(Akane grass root), Acacia elegans or Jiou (Jihuang), Agi (Awei), Aki larch, Akinire (Royu skin), Aguai
Guacu, Aguahe (Omitengu palm), Akebi (Kidori), Asa (Jin Asahi), Malva Asagao or Asagao (Toshibushi), Hydrangea (Hydrangea), Ashitaba (Tomorrow's leaf), Azuki (Red azuki bean), Asunaro, Acerola, Asenyak ( Asenyaku), Achilla (Shokuyoukanna), Anise, Abiu, Abiulana, Brassica, Abemaki `` Fruit '', Avocado, Ama, Amacha (sweet tea), Amachaworu, Amadokoro (Tamatake), Amana (Kojingi), Amaranth (Hiyuyu) , Balsam pear, Papilio xanthus, Senninkoku, Sugimorigeito, Hosoaoigaito, Aougeto, Haribiyu, Amaranthus hippochondriax), Amigasa lily or Bimo (shellfish),
Aristolomelia (Yurizisen), Arcana (Alcanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Souduq), Aloe (Length), Aloe vera, Angelica, Apricot or Hong apricot (Anjin), Ansokkou (Azusa), Yellow sapote , Ikakozorina (ground bile head), Epimedium or Epimedium
(Inyokaku), Igusa (Wicked grass), Knotweed (Tiger root),
Strawberry (first place), strawberry, fig (Fig.
Leaf)), Ichihatsu (first time), Ichibi (Fruit Aoi), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaf ''), Itohimemegi (Enshi), Carob, Inu-zuna (Telelexi), Inubeyu (Sorainubiyu), Rice `` seed, seed coat '', Inondo `` seed '', Ibuki-kusou-so, nettle, ylang-ylang, iwa-tobacco (iwatsuchi-chi), iwahiba or iwamatsu (makikashiwa), oolong tea, wikyo (fenka), wheat (tibusanoki), ukiyagara (miyoko) ), Uguisukagura "fruit",
Himeuikyo, Turmeric (Utsukin), Duckweed (Floating), Usubasaishin or Keirinsaishin or Shousaisaishin (Spicy), Usvenia oi, Usvenitai oi, Utsubogusa (summer dry grass), Udo or Shishiudo (Qang, Independent, Tang Independent) ), Unyadegato (Unkaria, Cat's claw), Uba tea, Ume (Ume `` seed, pulp ''), Urajirogashi, Uwaurushi (Kusakokomomo), Unshu mandarin (Chen skin), Estragon, Ezocogi (Ezogoka), Echinashi (Hosobamurasakikirengiku) , Enishida, Enokitake (Enotake), Ebisugusa or Cassia Tora (Kyoko), Elcampre, Elderberry `` fruit '', Elemi, Elingy or Prelotus elinge, Endu (Solanaceae, Sophoraceae rice), Ogi or Kibanaugi (yellow) Hoki), Ousei (Naruko Yuri, Kagi Kurumabanaruko Yuri), OuHisasa Yuki or Sasanoyuki, Coptis (Coptis), Oogatahouken, giant Karasuuri (Karokon), Ooguruma (civil engineering incense), giant Tsudzurafuji
(Self-defense), plantain (car front child, car front grass), psyllium thistle
(Keju Leak, Hakuto Okina), Toucan (Haruko), Toucan cactus, Oobanokera or Okera (white juku), Oobansarusubari (Banaba), Oobayashibashi "fruit", Ooishigusa (cereal grass), Oumiacatetsu, Omihacateshi or Omihasabi Hawthorn (Yamako), Barley (barley), Oka, Okazeri (Snake bed), Okra `` fruit '', Oguruma (turnover), Oculli higotai (Yushu sashimi, indigo head), Panax ginseng or Ginseng (carrot), St. John's wort or St. John's wort or St. John's wort (St. edulis), St. John's wort (interrupted), Onomimomi (Blue ears), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara
(Tianma), Oni lily or Sasa lily or Hakata lily (Yuri),
Ononis, Halibut (hihayu), Ominaeshi (losing sauce), Oyuco, Dutch mustard (Watercress), Dutch jelly, Dutch biyu, Dutch honeybee, olive `` fruit, seed,
Leaf '', oregano, orange `` fruit, pericarp '', caycaio (ripe yellow), cacao `` fruit, pericarp, seed '', persimmon (persimmon `` leaf ''), kagikazura (fishing hook), persimmon or perilla (loten) Grass), gaku hydrangea, cassia, casino
(Kouzo `` fruits ''), gajutsu (shajutsu), kasiwa (shaki), kasukaira, kascara sagrada, gypsophila, kasensou, kanikusa (kinsato), kaniwa, carnation, kanokosou (kikusone), hippo, Birch or weeping birch (white birch), gerbera, pumpkin, capoknoki `` seed '', kahoku sansho (shopper), tama (bamboo yellow), chamomile or roman chamomile, chamomile (desert plant), cam cam (camo duck), color, karakakeman, crow squirrel or Sinakarasouri (flower melon), rasabisaku (midsummer), oats wheat, guarana `` seed '', karaya, gallyu, karin (mouse), garcinia, kawamidori, kawara psycho
Japanese white grass), Kawazusha, Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (Qumugi, Quumiko), Kawaran Ginseng (Aokko), Kawamuragi (Inchinko), Kansui (Kansai), Licorice (Lucifera), Kantarasa, Candelilla, canto, canna, raspberry (ezo strawberry, dutch strawberry, shrimp strawberry, pear strawberry, maple strawberry,
European Raspberry), Kiwi `` Fruits, Leaves '', Kikarasuuri (Ururone), Kikyo (Kikyo, Kikyo root), Kiku (Chrysanthemum,
Oak, oak, oak, oak, oak, oak, oak, oak, pheasant, oak, kizuta, kidachi aloe, lucky mint, kina, chinoki, quinoa, quinoa, yellowfin, Gymnema Sylvesta, Kimmenkaku, Cabbage,
Cabbage `` immature fruit '', caraway, cucumber, gyoryu (Nishikawayanagi, Ichiyanagi), Kiraja saponaria, Kiraya, Kylansou (acne lacustrine), kumquat `` fruit '', ginseki, kimbusen, betel, kinmizukiki (sengaku grass), Guapeva Vermelha, Guava `` fruits '', guayule, Quercus infectria (gallicate), cucumber nuts, wolfberry (Gugi, gugiko, gugi leaf, skeletal bark), cedar (Tenmen winter), kudzu (kuzuki), camphor tree, goose Berry "fruit", ginseng, cutiti river,
Gardenia (garden), Kunugi (Bokusou), Kupuasu, Kubeba, Kumazasa, Kumatsuzura (horse whip grass), Clara (bitter butter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curculigo latifolia `` fruit '', Grapefruit `` fruits / leaves '', buckthorn, turtle hinoki scorpion or black sap hinoki sprouts or hinoki sprouts (extended life grass), cloves (cloves, cloves), gumbinazu (sekimei, sekimeishi),
Kaigai (Thorndust, Ikutakeho), Celosia (Rooster, Chicken),
Gekkavidin, bay (laurel), Kenashisarutibara (Tsuchukuryo, Yamakiko), gentian, gennoshoko
(Old tongue grass), Kemponashi (Kigushi), Koukisekikoku, Kishumitsukan (Koji, Tachibana, Oveni mikan, Fukuromikan, Sagamikouji, Ponkan, Santara (Tachibana bark)), Koushinbara (Monthly flower), Kosuihakka, Kozo `` Fruit '' , Kocha (tea), Kouhone (river bone), Kohon
(Straw book, Kara straw book), Koryang, Kouryokyo (Kora Kyo), Cilantro `` fruit '', Kourouen (Kohren), Koganebana (yellow gon), Cowberry (Koshibachi), Coco palm `` Fruit '',
Goshuyu (goshuyu), Goshoichigo (covered bonko), pepper
(Pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot spring), burdock (burdock,
Burdock), kobotdur, sesame (sesame), sesame seeds (gensin), garnish (gomiko), sanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran "red bran, white bran", rice oil, cola acuminata " Seeds ", Cola
Vera “seed”, colony lya, fenugreek “fruit”, colombo, conzlango, kelp, konjac, comfrey
(Final barn grass), sisal (sisal asa), saxima button or syna button or cinnamon
Sakura (Ooshimazakura, Yamazakura, Oyamazakura, Edhigashi, Mamezakura, Miyamazakura, Someiyoshino, Takanezakura, Kasumizakura, Kohigan, Satozakura, Kanzakura `` Leaf, flower, fruit, bark (cherry bark) ''), cherry, pomegranate, sasa, sasanqua, Sadomodaka (Sawaka), sweet potato, sugarcane, sugar beet, jujube jujube (acid jujube), saffron (banana flower, west safflower), sapodilla, sapotea marillo, pomelo `` fruit '', sabonso,
Salmon berry `` fruit '', sardine ginger (masa), salamanthus (sand sashimi), salvia (sage), sawagikyo (yamachona), sawagurumi (yamawomo), sankaku cactus,
Sangre degrad (croton), Sansuiyousou, Sansin ginseng (seven carrots), Sanshuyu (sanshuyu), sansho (sanshoyu), sanzukon (Yamazone), shea (carite), cyanoki `` fruit '', shiitake ( Shiitake mushrooms), Shion (Shien), Dikitaris, Shikunshi (Kimiko), Perilla or Aodiso or Chirimenjiso or Katamendiso (Shiso leaf, Shiso), Rosewood,
Linden, linden tree, cinnamonium (forsythia), shimeji (hinshimeji, shakashimeji, hatakeshimeji, oshiraishimeji, bunashimeji, honjimesi, shirotamogitake), shimokren (spicy), shimotsusou, potato,
Peonies (shakuyaku), shajin (shasan), jasmine (matsurika), janohige (wheat gate winter), gypsophila,
Sukushamitsu (sand flakes, shrunk sand), juzdama, palm `` fruit '', ginger (ginger), ginger hydrangea (Tsuneyama), shobu (iris, iris root), shojiku `` fruit '', shirakashi `` seed '', shirogoshi `` seed '' , White clover (clover), white adzuki bean (chicken bone), white iris (small iris), white banana (flower), white banana (flower), white nananten (minamitenmi), cinchona sacsylbra, ginkgo biloba (mizuka, mikaka, shencho), cinnamon, cinnamomu・ Cassia (cinnamon bark), watermelon (watermelon), honeysuckle (gold and silver flowers, Shinobi winter),
Sorrel (acid model), swim berry `` fruit '', star apple, stevia, strawberry `` fruit '', suzu psycho (Xu Chang Lord), horsetail (infestation), purslane (horse dent, horse dent), plum `` fruit '', pear Japanese red pine “cone”, larch, vegetation, walnut, walnut, hawthorn, dandelion, horse chestnut
(Marronnier), pear `` fruits '', snow pears, snow pears, elderflowers (elders), oilseeds (juniper, juniper), yarrow (milfoil), roses, cornflowers, mistletoe, or mint
Horseradish, Sekisho (Iris), Sekkoku (Ishimasu), Cedron (Bowshukuboku), Zeniaoi, Hirohase Nega, Senega, Seri, Celery, Sengoku (Kawakyu), Sengshinren (Shinshinren), Sengdan, Senninsaboten, Senna , Leaves '', Senninsou (great tate), Japanese cabbage (medicinal herb), squid (grass), elephant, buckwheat, buckwheat `` seed seeds '', somenimo, rhubarb (daihuang),
Japanese radish, soybean, Daidai (orange, kikomi), Takasagorurihigotai (Southeast indigo plant), Takasaburo (Dried lotus grass), Takatodai (Daizoku), Takawarabi (Kuzuna), Dark sweet cherry "fruit", Tachiaoi, Tachijakosou (thyme, Momoka), Tachidokoro (Hikari), Tachiyanagi, Tamarind `` seed '', onion, tamashiba (spicy), taro tree `` fruit, leaf, root bark '', dahlia (tenjikubotan), tarwi,
Tanshiniwa, Tanjin (Dan ginseng), Dandelion (Gankoei) or Shirobana dandelion or Moko dandelion, Danmar, Cherry `` fruit '', Tigaya `` fruit, root, bud '', Chixet carrot (Bamboo ginseng), Chicory, Chancapiedra (Kidachiko Mikansou) , Datura (Rhuanghuang), Datura elm (Wuyi), Datura mugwort (Aiba), Choreimaitake (Irei), Chorogi, Tsukimisou, Tsukuritake (mushroom), Camellia, Camellia, Tsumekusa (lacquer primrose), Camellia Ducklings), Tsuruazuki (red azuki bean), Tsurukudami
(Hanshu crow), Tsuruna (Ban apricot), Crucian carrot (Four leaf ginseng), Tsuwabuki, Deiko, Teuchigurumi, Duberry `` Fruit '', Tulip, Chocolate stay, Tengusa, Tencha (Tencha), Tendaiyaku (Wood medicine), Touga (Winter ginger) ), Squash, capsicum (pepper), squid (return), calendula (marigold), tonabena (river cut), corn or corn hair (southern hair), horned beetle (female child), torindo or kosen Gentian,
Tokusa (wood pirates), dokudami (jujutsu), konkon (sore root), sashimi or mamedaoshi or scutellaria, eucommia (mushroom "bark, leaves, roots"), ash (qin bark), tomato, tragacanth, triacanthos "seed", Turkey Kikyo, Tormentilla, Dronoki, Trolo-mallow, Tonen-bean, Niseria berry `` fruit '', Chinese yam or Yamano-imo (herbal medicine),
Naginika (butcher bloom), Naginata Kouju,
Nazuna, oilseed rape, oil bean or sword bean (sword bean), jujube, jujube (daijutsu), nanawaibara (gold cherry blossom), navena
(Intermittent), nameko, narco lily (yellow), peanut (peanut), nanten (minamitenmi), nambangarashi (ramie),
Scented violets, bitter oysters (bitter wood), sagebrush (bitter blue), nutmeg, cay or nikkei or ceylon nikkei or yab nikkei (cinnamon bark) or Keishi (keishi), leek (nirako), elderberry (grafted `` fruit, flower, `` Stalks, leaves ''), garlic (garlic), nulde (fivefold), leek, nemuki or neb or nebi or nemlinoki or digokubana (healing), noa thistle (daiji), noibara (real fruit), nozenkazura (ryohana), nogatei, yarrow , Nodake (maehu), Novara, Nomomo, Pineapple `` fruit '', Hibiscus (Bussouge, Furinbussouge, Roselle), Hirindou, Houchiwa, Pau Dosse, Hakamauraboshi (Bone Crushing), Hakuka Yumato,
Hachsen (ringworm skin), huckleberry `` fruit '', chickweed (red lotus), hazel (haruko), hasiridokoro (roth root), basil, lotus (lotus, lotus, lotus), parsley (holland jellyfish), hadakamugi, batata, hachiku Or Madake (bamboo-boiled), patchouli, mint (lightly loaded, lightly-leaved leaves), barley (yokuinin), hanasuge (chimomo), banana, hanamint, hanabishi (situri, shisitsuri), vanilla bins, papaya, scotweed
(Mouse malt grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, hamago or honeysuckle
(Kazuke), Hamabishi (Situriko), Hamanas (Maikai flower), Hamabo fu (Hama wind), Hamamelis, Palm, Rose (Roses), Ballata, Balata gum tree, Haratake (Haratake, Shirooharatake, Usukimori nokasa), Haran, Paliurus ( (Prunus avium), Parietalia,
Balsamina (Tsurureishi, Nigari), Harunile (Yellow, Yuhakuh, Yuba), Barbasco, Harindou, Handaikai (Greaper Sea), Breadfruit, Hiougi (shadow), Lycopodium ginseng (partisan), Pecan nut, Lycopodium (stone) Hirugaru, Tuzusha Hana, Higurumadaria, Higotai, Hishi (Hisami), Pistachio, Beet, Hitotsuba (Ishire), Hitotsubenienida, Daisies (Daisy), Hinata Kozuchi (cow knees), Hinoki, Hiba, Himashi, Sunflower, bell pepper, Himeuzu (Tamaoi), Himegama (incense blossom), Himematsutake (Kawariharatake, Hiromatsutake), Pimenta `` Fruit '', Juniper, Bjakuyu, Hiyu `` Fruit '', Belodo oyster, Hiroo Okinagusa (Hakuto Okina), Loquat `` Fruit, Leaf, stem ", betel nut (large clothing skin, betel nut), puerh tea (pu-cha), sprout kazura (southern rattan), butterflies, coltsfoot (winter flowers) , Winter leaf), fujibakama (orchid grass), fuji bean (flat beans), fujimoki
(Chowzi zakura, Kirihana), grape `` fruit, peel, seeds,
Leaf '', beech, sycamore mushroom (Cycanoderma), Brazilian liquorice, Brazilian carrot, black currant `` fruit '', blackberry, blagnen, plum `` fruit '', flucellaria, blueberry (Prunus avium), prune, floral blanka, Blond psyllium, bundou (mung beans), hazelnut, loofah, safflower (safflower), henneken, belladonna, berry `` fruit '',
Persea, Perbianberg, Pereschia grandifolia, Benikea or duckweed (Keiten), Boysenberry `` fruit '', Broomweed or Elderweed or Nendow or Hawakigi Kokia (Skinkoshi), Baldwink (Fengxian, acute child, osteophyte) , Potteria sapota, Potteria lukuma, Bohu (windproof), spinach, physalis (Torone), bokeh (mouse), hosobaaburagiku (bitter), hosobaoguruma, hosovanaokera (sojutsu), hosobanokirinso
(Kageten Michichi), Hosobabarengiku, Bodaiju (Bodai tree),
Button (peony `` flower, leaf, stem, bark ''), buttonpi (peony bark), hop, jojoba, borage (ruriichisha), bordeaux, white berry `` fruit '', hon-onik (meat porcelain, large art), hon-sekko ( Iron skin stones, Sparrow mountain stones), Myzuruten Nansha (Tennan star), Maitake (Maitake), Ephedra
(Mao), maca, macadamia nuts, margaret (mokshungiku), macri (sea grass), maguwa (mulberry white bark `` bark,
Leaf)), Magnolia splengheri, Masalampuba,
Masalan Zuba de Ceara, Masheira de Boi, Mashua (Tamanousenhallen, Kyukonkinrenka), Matatabi (Kiten Tate), Matsukasa, Pine `` leaves, bark,
Roots, Matta Oryo, Matsuhodo (Bukuryo), Matico
(Coldon Sillo), Mayorum (Hanamint), Malvanozadin (Difficult), Mulberry `` Fruit '', Quince, Malein (Beloyd Mozuica), Mango, Mangosteen,
Mansagna (Andesukamitsure), Mansugurumi,
Mandarin `` Fruit '', Mannentake (Lingzhi), Pheasant (Kikomi `` Fruit ''), Mishima Psycho (Saiko), Mizuobako or Mizuasagao (Ryungoshi), Mizokakushi (Hanbe Lotus), Misohagi
(Chikuna), Mitsugashiwa, Mitsuba, Midorisapote, Midorihakka, Mimosa, Myoga, Miracle Fruit `` Fruit '', Myrrh, Milobaran, Mugiwaragiku, Mukuge (Mokugeki), Mukunoki, Mukuroji (Extended Life Skin), Munya, Murasaki
(Purple root), purple or purple purple pearl, purple purple corn, purple purple mackerel (Kunming chicken blood wisteria), megakanza opuntica, mehajiki (mother grass), meboki, melaleuca, melissa, melilot,
Melon `` fruit '', sagebrush, moso bamboo, moku giraffe, moje (koshoboku), mock berry (wood incense), maple blossom, peach (peach `` leaves, seeds, flowers, fruits ''), sprouts, morello cherry `` fruits '', Moroheiya (Burlap), yakawamurasakiimo, yakuchi (masuchi), cornflower mackerel (cornflower), cornflower mint, yacon, yashabushi (arrow wheel) or himeyashabushi or ophayashabushi `` fruit,
`` Peel, ears '', willows, yatsude (octagonal gilded), mistletoe (parasitic willow), willows (kawayanagi, tachiyanagi, weeping willow, red willow, pussy willow, dogwood willow,
(Sweet willow, koreanagi, unryuyanagi, yamayamayanagi, palm, yamayanagi, giant willow, tyrichkinuyanagi, fox willow, bonsai), willow `` leaf,
Stalk '', scabbard, savannah koji (purple beef),
(Tsurusui, Tenmei), pokeweed (commercial land), yamanoki (yamaharu), yamamomo (yangmei), yamamugi, eucalyptus, yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, yorigusa , Mugwort (Aiba), reigan (Rainuma), lime "fruit", rye, lakanka "fruit",
Raspberry `` leaves, fruits '', latania (Clameria), Rakkyo or shallots (Shiroi), lavender, longan (longan meat), agave (Aono agave,
Fukurin agave), Ryokucha (green tea), apple `` fruits, seeds, leaves, roots '', gentian, rubus or sabisimus (sweeten), lullama thistle (Urajirohigotai, Xinjiang indigo sashimi), litchi (lichi, lichi nucleus), Lettuce (chisha),
Red currant "fruit", red pitaya, lemon "fruit", lemongrass, forsythia or Chinese forsythia
(Forsythia), astragalus, waxby, wax palm, locust, reed, loganberry `` fruit '', rosemary, mannenwa, rosehip, nobara, wasabi, azalea (Chiyu) and the like.

In addition, other seawaters, for example, seawater salt, dried seawater, inorganic salts obtained from the Dead Sea or the Atlantic or Pacific Ocean (such as sodium chloride, magnesium chloride, potassium chloride), sea mud or mud (fango) Species, for example, sea mud or mud in various places such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango, etc. (Ingredients:
Silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese,
Arsenic, water), Shotoku stone, etc.

Examples of the seaweeds include seaweeds [green algae: Chlorella vulgaris, Chlorella pyrenoidsa, Chlorella ellipsoidia, Aonori (Usubaa nori, Susiaonori, Hiraaonori, Bouaonori, Hosoedaaonori), Anaoausa (Aosa algae), Algae algae [Aosa algae] Kinds: Kombu (macomb, risicombu, hosomekombu, mishitsembo), wakame, hirome, blue sea turtle, giant kelp (macrocystis pilifera, macrocystis integrifolia, neocitys luetokeana), hijiki, hibamata, umiuchiwa, usubaumiuchiwa Klebanoumi prickly pear, Akaba prickly pear, Kona prickly pear, Okina prickly pear, Usuyuki prickly pear, Echinoki prickly pear], algae , Obakusa, Kataobakusa,
Yatabegusa, Yuikiri, Shimatengusa, Tosakanori, Togekirinsai, Akumasakirinsai, Kirinsai, Juniperus giraffe, Tsunomata, Obatsunomata, Tochaka (Yahatsunonomata), Ezotsunomata, Togetsunomata, Hirakotonota, Kotojita, Kotojita
Jareus Banori, Kagius Banori, Siusius Banori, Hyus Banori, Akamomininori] and the like.

In addition, other algae, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus: Chlorococcus, Kwanomimo: Kwanomimo, Volvox: Ohikawawari, Volvox, Palmera, Yotsumemo, Spirogyra: Hizaori, Spirogyra, Tsurugimidro, Hibimidoro: Hibimidoro, Aosa: Anaoasa, Amiosa, Nagaosa, Kawanori: Kawanori,
Genus Fricciella, genus genus: boletus japonicus, asamidorigusuga, kawashiogusa, marimo, baronia genus: tamagobaronia, tamabaronia, magnum: agatamagu, iwata: husaiwata, suricogita, heraiwata, crocodile, crocus Sakibuchimil, Nagamir, Hiramil, and Casanori:
Casanori, Jusmo: Fusuzumo, Tamazumi,
Species of the genus Mizudzumo, genus Genus genus, genus Colecaete, genus genus tsutsumo, genus cynomolgus genus: genus primrose, genus genus: human enthusiasts, genus phyllo, enthusiastic genus, mothine enthusiast, genus Genus, genus genus, sumiremo, etc.

Blue-green algae (Genus Papilio xylophila: Lynthia spp., Phyllophora spp.
(Hassai, Yuremo, Racenmo (Spirulina) genus: Spirulina, Trichodesmium (Aiakashio), etc.).

Brown algae (Piraella spp .: Piraella spp., Shiomidoro spp .: Naganami spp., Isogrape spp .: Isogrape,
Isogawara genus: Isogawara, Kurogashira genus: Gunsenkurogashira, Kashirazaki genus: Kashirazaki, Muchimo genus: Muchimo, Hiramutimo, Kebelligsa, Amidigusa genus: Amidigsa, Sakibiroamiji, Sanadagusa: Sanadagusa, Fukuromamiji, Common genus, Common genus Artemisia spp.
Genus genus: genus pine, genus genus: agamatsu, genus okinawa, genus okinawazuku, genus nov., Genus genus: nov. Ishige, Irolo, Icmegasa: Ichimegasa, Keyari: Keyari, Umibos: Umibos, Urushigusa: Ursigusa,
Betula genus, Tobacco moss, Laminaria spp. Genus Kagomenori: Kagomenori, Muraridori: Murachidori, Shakuganusa: Shakuganusa,
Genus Genus: Genus Genus, Genus Genus: Genus Genus: Genus Genus, Genus Kayamonori, Genus Kayamono, Genus Genus: Fennel, Turmo Genus: Turmo, Aname Genus: Aname, Genus Ligustrum: Sujime, Genus Missiscoma: Genus Ligustrum, Genus L. , Oni-kombu, Gohei-kombu, Naga-kombu, Pea-kombu, Ochidumi-kombu, Toro-kombu genus: Toro-kombu, Antokume genus: Antokume, Kajime genus: Kajime, Tsuruarame, Kurome, Kikuishicombe genus: Kikuishicomb, Nejirekombu: Nekorecome, Kuroshiomeko genus : Nekoshikonbu,
Alame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakameezoishige: Ezoishige, Yabanemoku: Yanemoku, Rapamoku: Rapamoku, Jiromoku: Uganomok, Jiromoku, Hiemomoku, Hamawara, Tamamomoku Akamoku, Shidamoku, Hondawara, Nejimoku, Narasamo, Mametarawara, Tatsukuri, Yasumatamoku, Umitoranoo, Oobamoku, Fushizushimoku, Hahakimoku, Togemoku, Jolemoku, Saw-moku, Ooban-moku, Genus genus:
Bulukimo, genus cynomolgus: cynomolgus etc.).

Red algae (Russia genus: Ushikenori, Funorinoushike, Amanori: Asakusanori, Susabinori,
Genus Upirinori, Onimanori, Tasa, Filitasa, Benitasa, Rhodocorton: Milnoveni, Akebonomozuku: Akebonomozuku, Konahada: Haikonahada, Yogorekonahada, Aokonahada, Sea Species: Acacia sylvestris, Ochryllus : Larch, Fusanori: Fusanori, Nisefusanori: Nisefusanori,
Sodegarami: Sodegarami, rattle genus: rattle, hiragaragara, hirohatamatamaki genus: hirohatamaitadaki, tamayitadaki Genus: hibiroudo, himehibiroudo,
Genus Isomomedogi: Genus Isomomedo, Genus genus: Genus medusa, Ryumonsou: Ryumonsou, Hera Ryumon, Nisekarekigusa genus: Nisekarekigusa, Okitsubara genus: Oba-okitsubara, Akaba: Akaba, Malva-acaba, Naminohanamina
Naminohana, coral genus: rattle, mushroom, shiogosagoromo, iwanokawa: etsukiiwanokawa, kainokawa: kainokawa, kaninote: kaninote, coral genus: coral, coral, moss, moss , Tambanori, slippery,
Fudarak, Malbahudarak, Isonohana: Nuracusa,
Cranouraxa, Stinging skull, Hunting genus: Hunting ibis, Hunting genus: Hunting sword, Hunting genus: Chabokintoki, Hunting ibis, Matsunori, Komenori, Tosakamatsu, Aedes pine, Fushikintoki, Tsunomukade, Nagakinotoki, Suzukito, Fukutokite, Fukutokite Nagaobabane: Nagaobabane,
Genus Funori: Hanafunori, Fukuronori, Makuhnori, Karenikusa genus: Kalexigusa, Tosakamaki Genus: Hosobanotosakamakiki, Hirohanokasakamukido, Yatsudegatatosakamokiki, Kurosakamokado, Nezashinotokamukado, Yukasakanokado, Hana Modoki,
Genus genus, genus genus: quinohada, genus esculenta: esoteka, tsukasanori genus: enashikarimenia, ootsukasanori, hanagatakarimenia, hohono genus: honoo, lycopodium genus: lycopodium, genus genus, nikunobenigo Susqueke Beni, Okamuragusa:
Yamadakusa, Mirin genus: Mirin, Hosobamilin, Tosakanori genus: Kikutosaka, Ezonameshi: Ezonameshi, Isomokka: Isomocca, Yukari: Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiinobori, Kijino-io Isanthus, Atsubanori: Atsubanori,
Ogonori: Ogonori, Tsurushiramo, Shiramo, Ogogonori, Mizookonori, Kabanori, Beniogonori, Fucresinori, Murasakikabanori, Shinkaikabanori, Togekabanori, Kataogonori, Ryukyuogonori, Ryukyuogonori, Ryokyuogonori, Ryokyuogonori , Genus Amanita: Hachijoenaga, Fushikenori genus: Fushikunori, Namiiwatake genus: Namiiwatake, scorpion genus: Scorpion genus, Occidental genus: Okutsunori, Saimi genus: Itanisa, Saimi, Harigane, Lotus japonicus:
Lotus spiders, genus genus: Ikanoashi, Hosoibonori,
Nobonori, Black Snapper: Black Snapper, Red Snapper: Red Snapper, Hishbukuro: Hishiburokuro, Madaragusa: Pleurotus terrestris, Echinacea purpurea, Taoyagousou: Genus Taoyanagi, Hanasakura, Asperidae , Hirata goat: Hirata goat, Darus: Darus, Masagoshibari, Anadalus, Uebagsa: Uebagsa, Benifukuronori: Benifukuronori, Fushigusa: Fushitsunagi, Himefushinagi,
Species of the genus Hirohafushi, Snapdragons: Snapdragons, Snapdragons, Species: igis, keiigis, crickets, nigiri, amixa, egonori:
Egonori, Futogigis, Saeda: Saeda, Chrysanthemum Genus: Chrysanthemum, Konohanori Family: Habutaenori, Konohanori, Suzushironori, Usveni: Usveni, Hasuginu: Hasuginu, Nagakonohori: Nagakonosugino, Sugisugina, Genus Yareusbanori, Sujiusbanori, Hyusbanori, Usubanorimodoki: Usubanorimodoki, Ayanishiki: Ayanishiki, Ayaginu:
Ayaginu, Dassia: Enashidazia, Shimadada: Isohagi, Shimadada, Dazimodoki: Dazimomodoki, Itogusa: Moleutogusa, Futonigusa, Makuri: Makuri, Yanaginori: Hanayanagi, Yuna, Yanaginori, Motsurenagina, Rabbitum : Kurozozo, Kobusoso, Hanezozo, Sozonohana, Hanegusa: Hanegusa, Kanegusa, Kozanemo: Kozanemo, Isomurasaki, Hosokozanemo, Himegoge: Himegoke, Kurohimegoke, Hiodoshigu, Hoshigusa Suginasugusa, Isobasho Genus: Isobasho, Fujimatsumo Genus: Fujimatsumo, Sawwort: Genus Hakezakinokawa, Kawamozuku: Kawamozuku, A Kawamozuku, Himekawamozuku,
Ideyugogome: Ideyugogome, Okitimozuku: Okitimozuku, Itogusa, Chinorimo: Chinorimo, Chisginori: Chisinori, etc.).

Wheel algae (Charus spider, Shiratamamo,
Hossiturimo: Hossiturimo, Lichnotumnus, Flassica: Himegrass, Chaboflas, Tripera, etc., Yellow algae (Hikarimo: Hikarimo, etc.) and the like.

Examples of the material derived from animal raw materials include a cockscomb extract, a cow or human placenta extract, a pig or cow extract of the stomach, duodenum or intestine or a decomposition product thereof, and a pig or cow spleen extract. Product or its degradation product, extract of pig or cow brain tissue, water-soluble collagen, collagen derivative such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its decomposition product Or a derivative thereof, a silk protein and its degradation product or a derivative thereof, a pig or bovine blood cell protein degradation product (globin peptide), a pig or bovine hemoglobin degradation product (hemin, hematin, heme, protohem, heme iron, etc.),
Cow milk, casein and its decomposition products or their derivatives, skim milk powder and its decomposition products or their derivatives, lactoferrin or its decomposition products, chicken egg components, fish meat decomposition products and the like.

(14) Microbial culture metabolite Yeast metabolite, yeast extract, natto metabolite, natto extract, rice ferment extract, rice bran (red bran, white bran) ferment extract, euglena extract, raw milk or skim milk powder Lactic acid fermentation products and trehalose or derivatives thereof.

(15) α-hydroxy acids glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.

(16) Inorganic pigments Silicic anhydride, magnesium silicate, talc, kaolin,
Bentonite, mica, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide,
Titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, red iron oxide, black iron oxide, gunjou, chromium oxide,
Chromium hydroxide, carbon black, calamine, etc.

(17) UV absorber / blocker Benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium salt, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), p-
Aminobenzoic acid derivatives (such as paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate), and methoxycinnamic acid derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, paramethoxycinnamic acid
2-ethoxyethyl, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono
Glyceryl-2-ethylhexanoate, etc.), salicylic acid derivatives (octyl salicylate, salicylphenyl, homomenthyl salicylate, dipropylene glycol salicylate, ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (methyl anthranilate, etc.), urocanin Acid derivatives (such as urocanic acid and ethyl urocanate), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, Nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, sinoxate, oxybenzone, diamine Kishibenzon, Okutabenzon, sulisobenzone, benzo resorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, Neo Heliopan, ESKA roll,
Zinc oxide, talc, kaolin, etc.

(18) Whitening agent p-aminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound,
Benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives,
Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives,
Vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, placenta extract , Ellagic acid, lucinol and so on.

(19) Tyrosinase activity inhibitor Vitamin C or a derivative thereof (such as magnesium phosphate of vitamin C and vitamin C glucoside), hydroquinone or a derivative thereof (such as hydroquinone benzyl ether), kojic acid or a derivative thereof, vitamin E or Derivatives thereof, N-acetyltyrosine or derivatives thereof, glutathione, hydrogen peroxide, zinc peroxide, placental extract, ellagic acid, arbutin, rucinol, silk extract, plant extract (chamomile, mulberry, corn, waremokou, clara, mugwort, Honeysuckle, yellowfin, amberjack, matsuhodo, adlay, dragonflies, hops, hawthorn, eucalyptus, achillea millefolium, althea, calyx, mankeishi, hamamelis, yamaguwa, enmeisou, bellflower, toshishi, seizoko, sun dried, mao, senkyu Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(20) Melanin pigment reduction / decomposition substance Phenylmercury hexachlorophene, mercuric oxide, mercurous chloride, aqueous hydrogen peroxide, zinc peroxide, hydroquinone or a derivative thereof (hydroquinone benzyl ether) and the like.

(21) Turnover promoting action / cell activator hydroquinone, lactic acid bacteria extract, placenta extract, reishi extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (Aloe, Ogon, horsetail, gentian, burdock,
Sicon, carrot, hamamelis, hop, yokunin,
Odrich, Assemble, Touki, Calendula officinalis, Amacha, Hypericum perforatum, Cucumber, Periwinkle,
Rosemary, parsley).

(22) Astringent succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcinol, ferric chloride, tannic acid (including catechin compound) Such.

(23) Active oxygen scavenger SOD, catalase, glutathione peroxidase and the like.

(24) Antioxidants Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydroguaselethenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, Parahydroxyanisole, propyl gallate, sesamol,
Sesamolin, gossypol, etc.

(25) Lipid peroxide production inhibitor β-carotene, plant extract (cultured sesame cells, amateur,
Hypericum, Hamamelis, Clover, Melissa, Emmeso, Birch, Sage, Rosemary, Minami Minami,
Ages, ginkgo, green tea) etc.

(26) Anti-inflammatory agent Ictamole, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor,
dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or a salt thereof, glycyrrhetinic acid or a salt thereof, licorice extract, sicon extract, age extract and the like.

(27) Antibacterial, bactericidal and disinfecting agents acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof, alkyl diaminoethyl glycine chloride solution, triclosan, sodium hypochlorite, Chloramine T, salad powder, iodine compound,
Iodoform, sorbic acid or a salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophen, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, phenoxyethanol, chlorobutanol, Isopropyl methyl phenol, nonionic surfactants (polyoxyethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene Octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde , Hexamine, brilliant green, malachite green,
Crystal Violet, Jamal, Photosensitizer 101
No. 201, Photosensitizer No. 401, N-long-chain acyl basic amino acid derivatives and their acid addition salts, zinc oxide, hinokitiol, kudin and the like.

(28) Humidifier Glycerin, propylene glycol, 1,3-butylene glycol, hyaluronic acid or its salt, polyethylene glycol, chondroitin sulfate or its salt, water-soluble chitin or chitosan derivative, pyrrolidone carboxylic acid or its salt, lactic acid Sodium, Mini Sasanishiki extract, Bacillus natto metabolite, Bacillus natto extract, Loofah water, Birch (birch) or Akamatsu sap

(29) Elastase activity inhibitor diisopropyl fluorophosphate, plant extracts (Ougon, Hypericum perforatum, Clara, mulberry leaves, calyx, gennoshoko, comfrey, sage, western elderberry, bollige, buttonpi), seaweed extract and the like.

(30) Hair preparations Selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castal tincture, ginger tincture, capsicum tincture, quinine hydrochloride, strong aqueous ammonia, potassium bromate, bromate Sodium, thioglycolic acid and the like.

(31) Antiandrogens Estrogen (estrone, estradiol, ethinylestradiol, etc.), isoflavones, oxendrone, etc.

(32) Peripheral blood flow promoter Vitamin E or a derivative thereof, assembly extract, garlic extract, ginseng extract, aloe extract, gentian extract, touki extract, cepharanthin, carpronium chloride, minoxidil and the like.

(33) Stimulant Pepper tincture, vanylamide nonylate, tincture tincture, tincture tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.

(34) Metabolic activators Photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, glyceride pentadecanoate and the like.

(35) Antiseborrheic agents Pyridoxine or its derivatives, sulfur, vitamin B6 and the like.

(36) Keratolytic agent Resorcin, salicylic acid, lactic acid and the like.

(37) Oxidizing agent Hydrogen peroxide water, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, pyrroline peroxide Sodium acid, sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.

(38) Hair remover Strontium sulfate, sodium sulfide, barium sulfide,
Inorganic reducing agents such as calcium sulfide; thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate) and the like.

(39) Hair swelling agent Ethanolamine, urea, guanidine and the like.

(40) Dyes 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol ,
2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, ortho Aminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-
Diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol,
Picramic acid, sodium picramate, N, N'-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenyl Paraphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorthocresol sulfate, 2-amino-5-nitrophenol sulfate,
Orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-sulfate
Diamine, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin, tannic acid, 2-hydroxy
Sodium 5-5-nitro-2 ', 4'-diaminoazobenzene-5'-sulfonate, hematein and the like.

(41) Flavors Natural animal flavors such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang-ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, Guayakwood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, ginger grass essential oil, cedar essential oil, spearmint essential oil, western Mentha essential oil, Fengqiang essential oil, Tuberose essential oil, T-shaped essential oil, Orange flower essential oil, Winter green essential oil, Truval sam essential oil, Batuuri essential oil, Rose essential oil, Palmarosa essential oil, Cypress essential oil, Hiba essential oil,
Sandalwood essential oil, Petit glen essential oil, Bay essential oil, Vetiva essential oil, Bergamot essential oil, Peruvian balsam essential oil, Boad rose essential oil, Camphor essential oil, Mandarin essential oil, Eucalyptus essential oil, Lime essential oil, Lavender essential oil, Linaloe essential oil, Lemongrass essential oil, Lemon essential oil, Rosemary Vegetable flavors such as essential oils, Japanese peppermint essential oils, and other synthetic flavors.

(42) Dyes / Colorants Red cabbage dye, red rice dye, madder dye, anato dye, squid dye, turmeric dye, ende dye, krill dye, persimmon dye, caramel, gold, silver, gardenia dye, corn dye , Onion pigment, tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin, etc.

In addition, humectants, hormones, sequestering agents, pH adjusters, chelating agents, preservatives / anti-binders, fresheners, stabilizers, emulsifiers, animal and vegetable proteins and their decomposed products, animal and vegetable Vegetable polysaccharides and their degradation products, animal and vegetable glycoproteins and their degradation products, blood flow enhancers, anti-inflammatory and antiallergic agents, cell activators, keratolytic agents, wound healing agents, foam enhancers, thickeners Agents, oral preparations, deodorants / deodorants, bittering agents, seasonings, enzymes, and the like can be used, and when used in combination therewith, various additive and synergistic effects can be expected.

The dosage form of the antioxidant or cosmetic composition of the present invention is arbitrary, and may be in the form of capsules, powders, granules, solids, liquids, gels, air bubbles, emulsions, creams, ointments, sheets and the like. can do.

Specifically, for example, external preparations such as medicinal preparations, lotions, emulsions, creams, ointments, lotions, oils, packs, and other basic cosmetics, facial cleansers and skin cleansers, depilatory agents, depilatory agents, aftershave lotions , Pre-show lotion, shaving cream, shampoo, rinse,
Hair treatments, hair styling products, perm agents, hair tonics, hair dyes, hair growth and hair growth products, etc., makeup cosmetics such as foundation, lipstick, blusher, eyeshadow, eyeliner, mascara, perfumes, bath agents , Other, toothpaste, mouth freshener / gargle, deodorant,
Various products such as deodorants, sanitary cotton, and wet tissues can be used, and can be blended into general foods and drinks.

The method of adding to the antioxidant or the cosmetic composition of the present invention may be added in advance or during the production, and may be appropriately selected in consideration of workability. good.

[0078]

EXAMPLES The present invention will now be described with reference to Production Examples, Test Examples and Formulation Examples, but the present invention is not limited thereto.

(Production Example 1) 100 g of each dried product of tarayou, koboku, and green willow was heated and extracted with purified water (about 80 ° C.) for about 5 hours, filtered and extracted (dry solid content: about 0.1 to 3.0%).
%) Of about 1.0-3.0 kg.

(Production Example 2) 100 g of each dried product of tarayou, kouboku and honeywort were immersed in a 50% ethanol solution, extracted at room temperature for 5 days and nights, and then filtered to obtain an extract (dry solid content: about 0.1 to 3.0). %) Of about 1.0-3.0 kg.

(Production Example 3) 100 g of each dried product of tarayou, kouboku and beet willow at 50 ° C. in a mixed solution of an equal amount of a 30% propylene glycol solution and a 30% 1,3-butylene glycol solution.
And slowly extract with warming for 6 hours, and suction-filter to obtain about 1.0-3.0 kg of extract (dry solid content: 0.2-3.5%).

(Production Example 4) 100 g of each dried product of tarayou, kouboku, and green willow was added to a 30% ethanol solution or 50% 1,3-
After immersion in a butylene glycol solution or a 50% propylene glycol solution, or purified water (about 30 ° C.), and extraction at room temperature for 5 days and nights, filtration and extraction of the extract (dry solid content: about 0.1 to
2.5%) from about 1.0 to 3.0 kg.

(Test 1) Active oxygen elimination (SOD-like activity)
Action Test In recent years, many diseases and diseases induced by active oxygen have been reported, and it has been pointed out that removal and elimination of active oxygen leads to prevention of tissue damage. In this test,
The active ingredient of the present invention obtained in Production Example 2 was evaluated for its ability to eliminate active oxygen generated by the xanthine-xanthine oxidase system using the nitro blue tetrazolium method (Lipid peroxide experiment method, p. Publishing Co., Ltd.)
It was examined by.

"Testing method and evaluation method" [0100] In 2.5 mL of 0.05 M sodium carbonate buffer (pH 10.2) containing 1.0 mM xanthine and 3.0 mM disodium ethylenediaminetetraacetate, 0.2%
Add 75 mM nitro blue tetrazolium, 0.15 W / V% bovine serum albumin, and 0.1 mL of each sample solution, and leave at 25 ° C. for 10 minutes. There is a xanthine oxidase aqueous solution 0.1m which was adjusted so that the absorbance change was about 0.3 / 20 minutes in advance.
After L was added and left at 25 ° C. for 20 minutes, the reaction was stopped with a 6 mM CuCl solution, and the absorbance at 560 nm was measured. In addition, the results obtained by determining the inhibition rate by Equation 1 with the group containing the reaction stop solution before the addition of xanthine oxidase as a blank for each sample and the control, in which the solvent of the sample solution was added instead of the sample as a control. As shown in FIG.

"Sample" A sample was prepared by adjusting the product of the present invention obtained in Production Example 2 so that the solid content concentration was 0.1%, and then subjected to a test. . As a control, extracts extracted from peonies and hops which are known to have active oxygen scavenging ability by the same production method were used for the test.

<Equation 1> Active oxygen scavenging rate (%) = {1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD value)} ×
100

(Test Results) As shown in FIG. 1, the product of the present invention exhibited a stronger active oxygen scavenging ability than the control. Therefore, the product of the present invention is considered to be useful as an active oxygen scavenger.

(Test 2) Lipid Peroxide Production Inhibition Test Lipid peroxide is a product obtained by oxidizing unsaturated fatty acids, which damages cell membranes in vivo, inactivates various enzymes, and denatures biological proteins. And so on. As a result, it is said that various harmful effects on living tissues, such as acceleration of aging and cancerous changes are caused. In the skin, for example, the accumulation of lipid peroxides caused by the peroxidation of sebum causes changes in the cell membrane and mitochondrial functions of the skin,
It is said to not only induce symptoms such as melasma, primary irritant dermatitis, and atopic dermatitis, but also promote skin aging such as rough skin, wrinkles, and senile pigmentation. Suppression is regarded as important in dermatology. In this test, the amount of peroxide of linolenic acid generated by ultraviolet rays was measured by using the TBA method (Analytical, Biochemistry. Vol. 95, pp. 351-358 (1979)) and obtained in Production Example 2. The antioxidant effect of the active ingredient of the present invention was examined.

"Test method and evaluation method" A solution in which 0.1% linolene was dissolved in 0.8% sodium lauryl sulfate 4.
To 9 mL, add 0.1 mL of the test sample and irradiate with ultraviolet light for 1 hour. 1 mL of this reaction solution is placed in a centrifuge tube containing dibutylhydroxytoluene as a reaction terminator, 1 mL of thiobarbituric acid solution is added thereto, and the mixture is heated at 95 ° C. for 1 hour. After cooling, 4 mL of a butanol solution was added, shaken well, centrifuged, and the absorbance of the butanol layer at 532 nm was measured.
In addition, the solvent to which the solvent was added was used as a control, and a blank which was not irradiated with ultraviolet rays was set for each sample and the control. The results are shown in FIG. "Sample" A sample was prepared by adjusting the product of the present invention obtained in Production Example 2 so as to have a solid content concentration of 0.1%, and subjected to a test. As a comparative sample, dl-α-tocopherol 0.05 manufactured by Kishida Chemical Co., Ltd.
% Was used for the test.

<Equation 2> Lipid peroxide production inhibition rate (%) = ｛1− (sample OD value−blank (sample) OD value) / (control OD value−blank (control) OD)
Value)} × 100

(Test Results) As shown in FIG. 2, the product of the present invention was found to have a strong inhibitory effect on lipid peroxide production. Therefore, the product of the present invention is considered to be useful as an antioxidant.

(Test 3) Safety test (1) Skin primary irritation test The product of the present invention obtained in Production Examples 1 to 4 was prepared in purified water so that the dry solid concentration was about 1.0%. It was applied to the skin of Japanese white rabbits (female, 3 per group, weighing around 2.3 kg) whose back was shaved. The judgment was made 24, 48, and 72 hours after application by the primary irritation scoring method using erythema and edema as indices. The result was negative in all animals without any erythema and edema.

(Test 4) Safety Test (2) Skin Cumulative Irritation Test Similarly, the product of the present invention obtained in Production Examples 1 to 4 was prepared with purified water so that the dry solid content was about 1.0%. Hartley guinea pig (female, 3 per group)
Once a day, 5 times a week, 0.5 mL
/ Animal was applied. Application was performed over two weeks and shaving was performed on the last application day of each week. The determination was made on the day following each application day and the day after the last application day by using the primary irritancy scoring method with erythema and edema as indices. The result is 2 in all animals.
No erythema and edema were observed over the course of the week, and the test was judged negative.

(Test 5) Safety test (3) Acute toxicity test Similarly, the powder of the present invention obtained in Production Examples 1 to 4 was concentrated under reduced pressure and dried (dry solid content: about 1.0%). Before the test, ddy mice fasted for 4 hours (male and female,
2,000 mg / kg was orally administered to a group (5 animals, 5 weeks old) at a dose of 2,000 mg / kg. as a result,
No abnormalities were observed in all mice for 14 days,
The dissection was not abnormal. Therefore, LD50 is 2,000mg
/ Kg or more.

(Formulation Examples) Production of Various Cosmetic Compositions The following formulation examples are shown in accordance with the above evaluation results. Was.

(Formulation Example 1) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Cetyl alcohol 1.5 4. Glycerin monostearate 2.0 5. Polyoxyethylene (20) cetyl ether 3.0 6. Polyoxyethylene (20 ) Sorbitan monooleate 2.0 7.1,3-butylene glycol 1.0 8. Glycerin 2.0 9. A: 50% ethanol extract of Tarayou B: 50% ethanol extract of Kokuboku C: 50% ethanol extract of green willow * A to C Extract or components of the product 5.0 10. Preservative (paraoxybenzoate) qs 11. spices qs 12. Purified water 100

(Formulation Example 2) Emulsion weight% 1. Squalane 8.0 2. Jojoba oil 7.0 3. Glyceryl paraaminobenzoate 1.0 4. Ethyl urocanate 1.0 5. Magnesium salt of vitamin C phosphate ester 1.0 6. Cetyl alcohol 1.5 7. Glycerin monostearate 2.0 8. Polyoxyethylene (20) cetyl ether 3.0 9. Polyoxyethylene (20) soorbitan monooleate 2.0 10.1,3-butylene glycol 1.0 11. Glycerin 2.0 12. Tarayou extract of Production Example 3 3.0 13. Kokuboku hot water extract 3.0 14. Appropriate amount of preservative (para-oxybenzoate) 15. Residual amount of purified water 100

(Prescription Example 3) Cosmetic oil weight% 1. Liquid paraffin 30.0 2. Squalane 20.0 3. Olive oil 20.0 4. Isopropyl palmitate 10.0 5. Grapefruit fruit or leaf hot water extract 3.0 6. Tarayou 30% glycerin extraction Liquid 3.0 7. Kokuboku 30% glycerin extract 3.0 8. Olive oil 1.0 9. Shea fat 1.0 10. Butylhydroxyanisole 0.1 11. Vitamin E derivative 0.1 12. Preservative (benzalkonium chloride) qs 13. Fragrance (Mugaria water) Appropriate amount 14.Residual water to be 100

(Formulation Example 4) Flexible lotion weight% 1. Glycerin 5.0 2.1,3-butylene glycol 5.0 3. Polyoxyethylene sorbitan monolaurate (20E.O) 1.0 4. Ethanol 15.0 5. Tarayou 30% ethanol extraction Liquid 1.0 6. Kokuboku 30% ethanol extract 1.0 7. Honey willow 50% ethanol extract 1.0 8. Ilex guayusa 50% ethanol extract 1.0 9. Antibacterial and preservative (lactoferrin solution) qs 10. Perfume (Western thin water) Appropriate amount 11.Purified water 100 residue

(Prescription Example 5) Astringent lotion weight% 1. Sorvitol 2.0 2. POE (20) oleyl alcohol 1.0 3. Ethanol 15.0 4. Tarayou 50% 1,3-butylene glycol extract 2.0 5. Koboku 50% ethanol Extract 1.0 6. Salix 50% ethanol extract 1.0 7. Allantoin 0.2 8. Astringent (zinc sulfocarbonate) 0.2 9. Antibacterial and preservative (thiamine lauryl sulfate) qs 10. Aroma (lavender water) qs 11. Purification Water 100 and the rest

(Formulation Example 6) Two-layer lotion (liquid to liquid type) wt% 1. squalane 8.0 2. POE sorbitan tetraoleate 0.3 3. sorbit 1.0 4. ethanol 15.0 5. 30% ethanol extract of tarayou 2.0 6. Kokuboku 30% glycerin extract 1.0 7. Willow 30% glycerin extract 1.0 8. Ascorbic acid 0.2 9. Astringent (calamine) 0.1 10. Preservative (phenoxyethanol) qs 11. Fragrance (lemon water) qs 12. Purification Water 100 and the rest

(Formulation Example 7) Carmine lotion (liquid to solid) wt% 1. Glycerin 3.0 2.1,3-butylene glycol 5.0 3. Ethanol 15.0 4. Iron oxide (Bengara) 0.2 5. Zinc oxide 0.5 6. Kaolin 2.0 7.Tarayou 50% propylene glycol extract 2.0 8. Kokuboku 50% propylene glycol extract 2.0 9. Rose willow 50% propylene glycol extract 1.0 10. Placenta extract 1.0 11. Camphor 0.2 12. Phenol 0.03 13. Preservative (photosensitizer No. 201 & 401) Suitable amount 14.Fragrance (Bodhi tree water) Suitable amount 15.Residual amount to be 100 purified water

(Formulation Example 8) Pack weight% 1. Polyvinyl alcohol 15.0 2. Carboxymethylcellulose sodium 5.0 3. Propylene glycol 3.0 4. Ethanol 10.0 5. Tarayou 50% ethanol extract 1.0 6. Koboku 50% ethanol extract 1.0 7 . Willow willow 50% ethanol extract 1.0 8. Preservative (paraoxybenzoate) qs 9. Fragrance (Tokisui) qs 10. Purified water 100

(Formulation Example 9) Peel-off pack% by weight 1. Glycerin 5.0 2. Propylene glycol 4.0 3. Polyvinyl alcohol 15.0 4. Ethanol 8.0 5. Polyoxyethylene glycol 1.0 6. Pantothenyl ethyl ether 1.0 7. Tarayou 30% ethanol Extract 2.0 8. Kokuboku 50% ethanol extract 2.0 9. Rose willow 50% ethanol extract 2.0 10. Preservative (paraoxybenzoate) qs 11. perfume (cypress water) qs 12. Purified water 100

(Formulation Example 10) Cold cream weight% 1. Salicone beeswax 11.0 2. Liquid paraffin 22.0 3. Lanolin 10.0 4. Olive oil 5.0 5. Chamomile oil 5.0 6. Palm oil 5.0 7. Borax 0.5 8. Tarayou extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 9.Kokuboku extract 2.0 (ethanol: 1,3-butylene glycol = 1: 1 extraction solvent) 10.Salix extract 2.0 (ethanol: 1, ethanol 3-butylene glycol = 1: 1 extraction solvent) 11. Liquid shea butter 1.0 12. Preservative (acrinol) 0.1 13. Perfume (sage water) Appropriate amount 14. Purified water 100

(Formulation Example 11) Emollient cream% by weight 1. Stearic acid 2.0 2. Stearyl alcohol 7.0 3. Reduced lanolin 2.0 4. Squalane 5.0 5. Octyl dodecanol 6.0 6. Polyoxyethylene cetyl ether (25E.O.) 3.0 7. Lipophilic glyceryl monostearate 2.0 8. Propylene glycol 5.0 9. Hot-water extract of tarayou 3.0 10. Kokuboku 10% 1,3-butylene glycol extract 3.0 11. Beet willow 30% 1,3-butylene glycol extract 3.0 12. Tarayou 50% 1,3-butylene glycol extract 2.0 13. Preservative (paraben) appropriate amount 14. Fragrance (cinch water) appropriate amount 15. Purified water 100 residue

(Formulation Example 12) Face Wash Cream% by Weight 1. Myristic acid 25.0 2. Stearic acid 5.0 3. Tallow fatty acid 5.0 4. Propylene glycol 10.0 5. Potassium hydroxide 6.0 6. Coconut oil fatty acid diethanolamide 6.0 7. Tarayou extraction Liquid 2.0 (ethanol: 1,3-butylene glycol = 1: 2 extraction solvent) 8. Kokuboku hot water extract 2.0 9. Luffa fruit or stem 50% 1,3-butylene glycol extract 2.0 10. Dipotassium glycyrrhetinate 1.0 11 .Preservative (salicylic acid) 0.1 12.Perfume (sage water) appropriate amount 13.Purified water 100 residue

(Formulation Example 13) Face wash cream weight% 1. stearic acid 10.0 2. palmitic acid 10.0 3. myristic acid 12.0 4. lauric acid 4.0 5. oleyl alcohol 1.5 6. lanolin derivative (EO adduct) 1.0 7. glycerin 18.0 8. Potassium hydroxide 6.0 9. Tarayou extract of Production Example 3 5.0 10. Kokuboku extract 1.0 (Ethanol: 1,3-butylene glycol = 1: 1 extract) 11. Glycyrrhetinic acid 1.0 12. Preservative (salicylic acid) 0.1 0.1 13. Perfume (Tokisui) Appropriate amount 14. Purified water 100 residue

(Formulation Example 14) Body soap weight% 1. Potassium laurate 15.0 2. Potassium myristate 5.0 3. Propylene glycol 5.0 4. Whey 1.5 5. 70% tarayou 1,3-butylene glycol extract 1.0 6. Kokuboku 70% 1,3-butylene glycol extract 0.5 7. Rosewood 70% 1,3-butylene glycol extract 0.5 8. Polyethylene powder 0.5 9. Hydroxypropyl chitosan solution 0.5 10. Amino acids (glycine, glutamine, etc.) 0.5 11. Preservative (undecylenic acid, phenol) qs 12. pH adjuster qs 13. Flavor (lavender water) qs 14. Purified water 100

(Formulation Example 15) Sunscreen cosmetics (O / W type)% by weight 1. Oxybenzone 2.0 2. Octyl paramethoxycinnamate 5.0 3. Squalane 10.0 4. Vaseline 5.0 5. Stearyl alcohol 3.0 6. Stearic acid 3.0 7. Glyceryl monostearate 2.0 8. Ethyl polyacrylate 1.0 9.1,3-butylene glycol 6.0 10. Disodium edetate 0.1 11. Triethanolamine 1.0 12. Titanium dioxide 5.0 13. 50% tarayou dipropylene glycol extract 0.5 14. Kokuboku 50% dipropylene glycol extract 0.5 15. Willow 50% dipropylene glycol extract 0.5 16. Mulberry bark 50% dipropylene glycol extract 0.5 17. Purple root 50% dipropylene glycol extract 0.5 18. Preservative (Paraben) Appropriate amount 19.Fragrance (apple water) Appropriate amount 20.Remaining to make purified water 100

(Formulation Example 16) Sunscreen cosmetics (oil type)% by weight 1. Liquid paraffin 70.0 2. Ethyl paraaminobenzoate 1.0 3. Tetrahydroxybenzophenone 1.0 4. Cetyl octanoate 25.0 5. Tarayou 30% 1,3 -Butylene glycol extract 1.0 6. Koboku 10% 1,3-butylene glycol extract 1.0 7. Rose willow 50% 1,3-butylene glycol extract 0.5 8. Yukinoshita whole plant 30% 1,3-butylene glycol extract 0.5 9. Whole barley whole plant 50% 1,3-butylene glycol extract 0.5 10. Fencil fruit 30% 1,3-butylene glycol extract 2.0 11. Appropriate amount of antioxidant (butylhydroxytoluene) 12. Appropriate amount of fragrance (body oil water)

(Formulation Example 17) Cream foundation (O / W type) weight% 1. stearic acid 4.0 2. glyceryl monostearate 3.0 3. cetanol 1.5 4. isopropyl myristate 7.0 5. liquid paraffin 10.0 6. salami beeswax 3.0 7. Triethanolamine 1.5 8. Glycerin 3.0 9. Bentonite 1.0 10. Titanium oxide 8.0 11.2,4-Dihydroxybenzophenone 8.0 12. Kaolin 3.0 13. Talc 3.0 14. Color pigment (iron iron oxide) 1.0 15. Hot water extraction with tarayou Dry powder 0.2 16. Kokuboku hot water extraction dry powder 0.2 17. Preservative (paraben) proper amount 18. Fragrance (rose water) proper amount 19. Purified water 100 residue

(Prescription Example 18) Shampoo wt% 1. Triethanolamine lauryl sulfate 5.0 2. Sodium polyoxyethylene lauryl ether sulfate 12.0 3.1,3-butylene glycol 4.0 4. Diethanolamide laurate 2.0 5. Disodium edetate 0.1 6.Tarayou 20% 2,3-butylene glycol extract 2.0 7. Koboku 10% 1,4-butylene glycol extract 2.0 8. Hydroxypropyl chitosan solution 2.0 9. Mucopolysaccharide solution 1.0 10. Antibacterial and preservative (photosensitive No. 101) Appropriate amount 11. Appropriate amount of pH adjuster 12. Appropriate amount of fragrance (sandalwood water) 13. Residue to 100 purified water

(Formulation Example 19) Rinse weight% 1. Stearyltrimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Tarayou 50% 1,2-butylene glycol extract 1.0 6. Koboku 50% 1,2-butylene glycol extract 1.0 7. Rose willow 50% 1,2-butylene glycol extract 1.0 8. Futandanpopo 50% 1,3-butylene glycol extract 1.0 9. Hydroxyethyl chitosan solution 1.0 10. Trehalose solution 1.0 11. Hydrolyzed silk solution 1.0 12. Appropriate amount of antibacterial and preservative (benzalkonium chloride) 13. Appropriate amount of fragrance (lavender water) 14. Residual amount of purified water 100

(Formulation Example 20) Rinse weight% 1. Stearyl trimethylammonium chloride 2.0 2. Cetostearyl alcohol 2.0 3. Polyoxyethylene lanolin ether 3.0 4. Propylene glycol 5.0 5. Ethylene glycol 3.0 6. Tarayou 50% ethylene glycol extraction Solution 1.0 7. Kokuboku 50% 1,3-butylene glycol extract 1.0 8. Green willow 30% ethanol extract 1.0 9. Trehalose solution 1.0 10. Hydrolyzed keratin solution 1.0 11. Antibacterial and preservative (benzalkonium chloride) Proper amount 12.Perfume (chamois water) Proper amount 13.Residual water to be 100

(Formulation Example 21) Hair liquid% by weight 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Yuzu hot water extract 2.0 6. Tarayou 50% ethanol extract 2.0 7. Matsufudo sclerotium 50% ethanol extract 1.0 8. Melissa whole plant 50% ethanol extract 1.0 9. Panax ginseng root 50% ethanol extract 1.0 10. Carpronium chloride 0.3 11. Hinokitiol 0.5 12. Keratin Decomposition solution 1.0 13. Antibacterial and preservative (paraben, benzalkonium chloride) proper amount 14. Fragrance (senkyu water) proper amount 15. Purified water 100 residue

(Formulation Example 22) Hair liquid weight% 1. Ethanol 29.0 2. Polyoxypropylene butyl ether phosphoric acid 10.0 3. Polyoxypropylene monobutyl ether 5.0 4. Triethanolamine 1.0 5. Trimethylene glycol 5.0 6. Koboku 50% Ethanol extract 1.0 7. Parsley whole plant 50% 1,3-butylene glycol extract 0.5 8. Loquat leaf 30% ethanol extract 1.0 9. Azulene 1.0 10. Antibacterial and preservative (paraben, benzalkonium chloride) qs 11 .Perfume (Touki water) Appropriate amount 12. Residual water with 100 purified water

(Formulation Example 23) Hair tonic wt% 1. Ethanol 40.0 2. Ethyl oleate 1.0 3. Polyoxyethylene (40) hydrogenated castor oil 2.0 4. Hot water extract of willow willow 5.0 5. Peony peel 50% ethanol extraction Liquid 3.0 6. Yuzu leaf or fruit 50% ethanol extract 3.0 7. Preservative (paraben) suitable amount 8. Purified water 100 residue

(Formulation Example 24) Hair tonic weight% 1. l-menthol 0.2 2. ethanol 32.5 3. polyoxyethylene hydrogenated castor oil 0.5 4. propylene glycol 5.0 5. diphenhydramine hydrochloride 0.3 6. yuzu hot water extract 2.0 7 Tarayou 50% ethanol extract 1.0 8. Kokuboku 50% ethanol extract 1.0 9. Carboxymethyl chitin solution 1.0 10. Vitamin E derivative 0.5 11. Antibacterial and preservative (paraben) 0.1 12. Flavor (sage water) qs 13. Residue with 100 purified water

(Formulation Example 25) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Salix 50% propylene glycol extract 5.0 3. Panax ginseng root 50% propylene glycol extract 2.0 4. Artemisia leaf or stem 50% 1,3- Butylene glycol extract 1.0 5. 50% nuts 1,3 butylene glycol extract 1.0 6. Vitamin E derivative 0.5 7. Pepper tincture 0.5 8. Resorcin 0.5 9. Dipotassium glycyrrhizinate 0.5 10. Carboxymethyl chitin solution 0.5 11 Beef hematin solution 0.5 12. Mucin solution 0.5 13. Amino acids (glycine, glutamine, etc.) 0.5 14. Antibacterial and preservative (paraben) 0.1 15. Perfume (rosemary water) qs 16. Purified water 100

(Formulation Example 26) Hair restorer / hair restorer weight% 1. Ethanol 60.0 2. Tarayou 50% 1,3-butylene glycol extract 1.0 3. Rosewood 50% 1,3-butylene glycol extract 1.0 4. Assembly Drugs) Whole plant 60% ethanol extract 1.0 5. Canthari tincture 0.5 6. Pantothenic acid derivative 0.5 7. Glycyrrhizic acid 0.5 8. Resorcinol 0.5 9. Salicylic acid 0.5 10. Hydroxyethyl chitosan solution 0.5 11. Elastin hydrolyzate 0.5 12 .Antibacterial and preservative (paraben) 0.1 13.Perfume (lavender water) Suitable amount 14.Purified water 100 residue

(Formulation Example 27) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 2.0 4. Dry powder extracted with hot water of Tarayou 5.0 5. Dry powder extracted with hot water of Willow tree 5.0 6. Dye (Gunjo green)

(Formulation Example 28) Granule bath agent weight% 1. Sodium bicarbonate 58.0 2. Anhydrous sodium sulfate 30.0 3. Borax 4.0 4. Dry powder extracted with hot water of tarayo 2.0 5. Dry powder extracted with hot water of hot water 1.0 6. Willow willow 50% ethanol extracted dry powder 1.0 7. Fine wintering 70% ethanol extracted dry powder 1.0 8. Iris leaf or root 70% ethanol extracted dry powder 1.0 9. Apple juice powder 1.0 10. Pigment (Gunjo, chromium hydroxide) 11. Suitable amount of fragrance (grape water)

(Formulation Example 17) Coating Protecting Agent A gauze or liniment cloth is impregnated with a prescription liquid obtained by mixing a 20% ethanol extract of tarayou, an appropriate amount of an antibiotic and anti-inflammation, etc., to prepare a clothing protecting agent to be attached to the wound. Alternatively, the water extract of the willow willow may be directly applied locally and covered with gauze or the like.

(Test 6) Use effect test The effect when the cosmetic composition of the present invention was actually used was examined. Use test was conducted by panelists for those who are worried about spots, freckles, dark and dark (34 to 41 years old, 10 people) and those who are worried about dry skin or skin without luster (26 to 47 years old, 10 people). And twice a night after washing the face, an appropriate amount of the emulsion of Formulation Example 1 was applied to the face for 3 months.
In addition, what was prescribed similarly except for the product of the present invention was used as a control. The evaluation was performed according to the following criteria. The results are shown in Tables 1 and 2, and the numerical values in the table represent the number of persons. No one complained of skin abnormalities during the use period.

"Stain, freckles, skin color improving effect" Efficacy: Blemish, freckles, and skin blackness were less noticeable (improved) than before. Slightly effective: spots, freckles, and skin darkness were slightly reduced. Ineffective: No change from before use.

[0127]

"Effect of improving skin feel" Efficacy: Gloss and firmness of the skin increased, and dry skin and rough skin were improved. Slightly effective: slightly increased skin gloss and tension, and improved dry skin and rough skin. Ineffective: No change from before use.

[0129]

(Test Results) As shown in Tables 1 and 2, the emulsion containing the product of the present invention is effective for significantly improving dry skin, giving the skin a gloss and firmness, and reducing stains and freckles. It was confirmed. In addition, there was a case that it was effective in reducing eczema.

[0131]

The antioxidant according to the present invention, which contains one or more plant extracts selected from tarayou, kokuboku and honeywillow, has an excellent active oxygen scavenging effect and an excellent inhibitory effect on lipid peroxide production. It was confirmed that it had. Further, the cosmetic composition containing them has an effect of improving spots, freckles, skin color, an effect of improving dry skin, eczema, and rough skin, and a beautiful skin effect of giving gloss and tension to skin and hair, and an antiaging effect.

[Brief description of the drawings]

FIG. 1 is a diagram showing the results of an active oxygen elimination test of a product of the present invention.

FIG. 2 is a graph showing the results of a lipid peroxide production inhibition test of the product of the present invention.

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[Procedure amendment]

[Submission date] February 22, 2001 (2001.2.2)
2)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0019

[Correction method] Change

[Correction contents]

The antioxidant or the cosmetic composition of the present invention may contain, in addition to the above-mentioned essential extract, any of the following components and additives as needed, as long as the effects of the present invention are not impaired. The content in the preparation is not particularly limited, but is usually preferably 0.0001 to 50%.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/48 A61K 7/48 7/50 7/50 35/78 35/78 CE A61P 17/16 A61P 17/16 F term (reference) 4C083 AA072 AA082 AA111 AA112 AA122 AB032 AB152 AB212 AB232 AB242 AB312 AB432 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC352 AC422 AC432 AC442 AC472 AC482 AC542 AC582 AC642 AC692 AC782 AC792 AD022 AD112 AD 272 AD642 AD662 BB41 CC05 CC07 CC12 CC23 CC25 CC38 CC39 EE12 FF01 4C088 AB12 AB43 AB65 BA08 MA17 MA28 MA63 ZA89

Claims (2)

[Claims] 1. An antioxidant comprising an extract of at least one plant selected from tarayou, koboku, and willow. 2. A cosmetic composition comprising the antioxidant according to claim 1.