IN2014DN10084A - - Google Patents

Info

Publication number: IN2014DN10084A
Authority: IN; India
Prior art keywords: androgen receptor; receptor modulator; trifluoromethylpyridin; diazaspiro; methylbenzamide
Prior art date: 2012-06-07

Application number

Other languages

English (en)

Inventor

Nicholas D Smith

Mark R Herbert

Ouathek Ouerfelli

Anna Dilhas

Original Assignee

Aragon Pharmaceuticals Inc

Sloan Kettering Inst Cancer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-07

Filing date

2013-06-04

Publication date

2015-08-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2014DN10084(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-06-04 Application filed by Aragon Pharmaceuticals Inc, Sloan Kettering Inst Cancer filed Critical Aragon Pharmaceuticals Inc

2015-08-21 Publication of IN2014DN10084A publication Critical patent/IN2014DN10084A/en

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

IN10084DEN2014 2012-06-07 2013-06-04 IN2014DN10084A (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201261656888P	2012-06-07	2012-06-07
PCT/US2013/044116 WO2013184681A1 (en)	2012-06-07	2013-06-04	Crystalline forms of an androgen receptor modulator

Publications (1)

Publication Number	Publication Date
IN2014DN10084A true IN2014DN10084A (sl)	2015-08-21

Family

ID=49712550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IN10084DEN2014 IN2014DN10084A (sl)	2012-06-07	2013-06-04

Country Status (45)

Country	Link
US (9)	US9481663B2 (sl)
EP (4)	EP3533792B1 (sl)
JP (3)	JP6182209B2 (sl)
KR (2)	KR102062024B1 (sl)
CN (3)	CN105693692A (sl)
AU (3)	AU2013271751B2 (sl)
BR (1)	BR112014030678A2 (sl)
CA (4)	CA3008345C (sl)
CL (1)	CL2014003331A1 (sl)
CO (1)	CO7240407A2 (sl)
CR (2)	CR20190331A (sl)
CY (4)	CY1120393T1 (sl)
DK (3)	DK2858985T3 (sl)
EA (3)	EA028791B1 (sl)
EC (1)	ECSP14030098A (sl)
ES (3)	ES2875932T3 (sl)
FR (1)	FR21C1050I2 (sl)
GT (1)	GT201400283A (sl)
HK (2)	HK1210175A1 (sl)
HR (3)	HRP20180902T1 (sl)
HU (4)	HUE050357T2 (sl)
IL (5)	IL320522A (sl)
IN (1)	IN2014DN10084A (sl)
LT (4)	LT2858985T (sl)
LU (1)	LUC00236I2 (sl)
ME (2)	ME03815B (sl)
MX (1)	MX356754B (sl)
MY (1)	MY187500A (sl)
NI (1)	NI201400142A (sl)
NL (1)	NL301144I2 (sl)
NO (1)	NO2021046I1 (sl)
NZ (2)	NZ717683A (sl)
PE (3)	PE20150631A1 (sl)
PH (2)	PH12014502714A1 (sl)
PL (3)	PL3533792T3 (sl)
PT (3)	PT2858985T (sl)
RS (3)	RS57370B1 (sl)
SG (3)	SG11201408140QA (sl)
SI (3)	SI3533792T1 (sl)
SM (3)	SMT202100355T1 (sl)
TR (1)	TR201808939T4 (sl)
TW (1)	TWI532732B (sl)
UA (2)	UA123142C2 (sl)
WO (1)	WO2013184681A1 (sl)
ZA (1)	ZA201500076B (sl)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8461343B2 (en)	2007-03-27	2013-06-11	Sloan-Kettering Institute For Cancer Research	Synthesis of thiohydantoins
CA2857061A1 (en)	2011-12-16	2013-06-20	Olema Pharmaceuticals, Inc.	Novel benzopyran compounds, compositions and uses thereof
RS57370B1 (sr)	2012-06-07	2018-08-31	Aragon Pharmaceuticals Inc	Kristalni oblici modulatora receptora androgena
CN105358535B (zh)	2012-09-11	2019-01-04	麦迪威森前列腺医疗有限责任公司	恩杂鲁胺制剂
SG10201902568YA (en)	2012-09-26	2019-04-29	Aragon Pharmaceuticals Inc	Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
JOP20200097A1 (ar)	2013-01-15	2017-06-16	Aragon Pharmaceuticals Inc	معدل مستقبل أندروجين واستخداماته
JP2017525727A (ja) *	2014-08-26	2017-09-07	アスターバイオテックリミテッドライアビリティカンパニー	プロテインキナーゼ阻害剤
MD3226841T2 (ro)	2014-12-05	2025-06-30	Aragon Pharmaceuticals Inc	Compoziții anticancerigene
WO2016090105A1 (en)	2014-12-05	2016-06-09	Aragon Pharmaceuticals, Inc.	Anticancer compositions
PL3226842T3 (pl)	2014-12-05	2021-07-12	Aragon Pharmaceuticals, Inc.	Kompozycje przeciwnowotworowe
US9888543B2 (en)	2014-12-19	2018-02-06	Lutron Electronics Co, Inc.	Multi-channel lighting fixture having multiple light-emitting diode drivers
WO2017209939A1 (en)	2016-06-03	2017-12-07	Aragon Pharmaceuticals, Inc.	Anticancer compositions
WO2018112001A1 (en)	2016-12-13	2018-06-21	Watson Laboratories Inc.	Solid state forms of apalutamide
EP4438126A3 (en)	2017-10-16	2025-01-01	Aragon Pharmaceuticals, Inc.	Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
WO2019135254A1 (en)	2018-01-02	2019-07-11	Mylan Laboratories Limited	Apalutamide polymorphs and their preparation thereof
US20200270226A1 (en) *	2018-06-20	2020-08-27	Crystal Pharmaceutical (Suzhou) Co., Ltd.	Crystalline forms of arn-509, preparation method and use thereof
WO2020049598A2 (en)	2018-09-08	2020-03-12	Cipla Limited	Apalutamide polymorphs
IT201900003839A1 (it)	2019-03-15	2020-09-15	Olon Spa	Sintesi di apalutamide amorfa stabile
WO2020234817A1 (en) *	2019-05-21	2020-11-26	Laurus Labs Limited	Polymorphic forms of apalutamide and its preparation thereof
IT201900010593A1 (it)	2019-07-01	2021-01-01	Dipharma Francis Srl	Forma cristallina di un inibitore di recettori degli androgeni
WO2021033098A1 (en) *	2019-08-22	2021-02-25	Dr. Reddy’S Laboratories Limited	Process for the preparation of apalutamide
IT201900015974A1 (it)	2019-09-10	2021-03-10	Olon Spa	Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
CN110590740A (zh) *	2019-09-20	2019-12-20	武汉大学	一种阿帕鲁胺化合物及其药物制剂
WO2022049265A1 (en)	2020-09-04	2022-03-10	Synthon B.V.	Improved process for preparation of apalutamide
CN112679468A (zh) *	2021-01-05	2021-04-20	四川科伦药物研究院有限公司	阿帕他胺的晶体形式、制备方法和用途
WO2023143090A1 (zh) *	2022-01-25	2023-08-03	成都苑东生物制药股份有限公司	一种阿帕他胺溶剂化物新晶型及其制备方法
CN115536634B (zh) *	2022-10-17	2024-06-11	上海博悦生物科技有限公司	一种阿帕他胺的合成方法
CN116332907A (zh) *	2023-03-16	2023-06-27	奥锐特药业股份有限公司	一种无定形阿帕他胺的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5323907A (en)	1992-06-23	1994-06-28	Multi-Comp, Inc.	Child resistant package assembly for dispensing pharmaceutical medications
US7709517B2 (en)	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
CN101032483B (zh)	2006-03-09	2011-05-04	陈德桂	调节雄激素受体活性的乙内酰脲衍生物及其应用
ES2588606T3 (es)	2006-03-27	2016-11-03	The Regents Of The University Of California	Modulador del receptor de andrógenos para el tratamiento del cáncer de próstata y enfermedades asociadas con el receptor de andrógenos
SG10201408699TA (en) *	2006-03-29	2015-02-27	Univ California	Diarylthiohydantoin compounds
US8461343B2 (en)	2007-03-27	2013-06-11	Sloan-Kettering Institute For Cancer Research	Synthesis of thiohydantoins
CN102884057B (zh) *	2010-02-16	2016-09-14	亚拉冈制药公司	雄激素受体调节剂及其用途
RS57370B1 (sr)	2012-06-07	2018-08-31	Aragon Pharmaceuticals Inc	Kristalni oblici modulatora receptora androgena
US20200270226A1 (en)	2018-06-20	2020-08-27	Crystal Pharmaceutical (Suzhou) Co., Ltd.	Crystalline forms of arn-509, preparation method and use thereof

2013
- 2013-06-04 RS RS20180680A patent/RS57370B1/sr unknown
- 2013-06-04 EP EP19169275.5A patent/EP3533792B1/en active Active
- 2013-06-04 EP EP13800681.2A patent/EP2858985B1/en active Active
- 2013-06-04 DK DK13800681.2T patent/DK2858985T3/en active
- 2013-06-04 WO PCT/US2013/044116 patent/WO2013184681A1/en active Application Filing
- 2013-06-04 CA CA3008345A patent/CA3008345C/en active Active
- 2013-06-04 SI SI201331894T patent/SI3533792T1/sl unknown
- 2013-06-04 CA CA2875767A patent/CA2875767C/en active Active
- 2013-06-04 LT LTEP13800681.2T patent/LT2858985T/lt unknown
- 2013-06-04 CN CN201610202980.2A patent/CN105693692A/zh active Pending
- 2013-06-04 EA EA201492272A patent/EA028791B1/ru unknown
- 2013-06-04 CA CA3114726A patent/CA3114726A1/en active Pending
- 2013-06-04 US US14/406,520 patent/US9481663B2/en active Active
- 2013-06-04 CN CN202110417935.XA patent/CN113135892A/zh active Pending
- 2013-06-04 HR HRP20180902TT patent/HRP20180902T1/hr unknown
- 2013-06-04 KR KR1020157000266A patent/KR102062024B1/ko active Active
- 2013-06-04 LT LTEP18157435.1T patent/LT3348553T/lt unknown
- 2013-06-04 BR BR112014030678A patent/BR112014030678A2/pt not_active Application Discontinuation
- 2013-06-04 PL PL19169275T patent/PL3533792T3/pl unknown
- 2013-06-04 NZ NZ717683A patent/NZ717683A/en unknown
- 2013-06-04 ME MEP-2020-163A patent/ME03815B/me unknown
- 2013-06-04 ES ES19169275T patent/ES2875932T3/es active Active
- 2013-06-04 SI SI201331010T patent/SI2858985T1/sl unknown
- 2013-06-04 DK DK19169275.5T patent/DK3533792T3/da active
- 2013-06-04 AU AU2013271751A patent/AU2013271751B2/en active Active
- 2013-06-04 MX MX2014015005A patent/MX356754B/es active IP Right Grant
- 2013-06-04 SM SM20210355T patent/SMT202100355T1/it unknown
- 2013-06-04 PE PE2014002383A patent/PE20150631A1/es active IP Right Grant
- 2013-06-04 RS RS20200913A patent/RS60617B1/sr unknown
- 2013-06-04 CR CR20190331A patent/CR20190331A/es unknown
- 2013-06-04 SG SG11201408140QA patent/SG11201408140QA/en unknown
- 2013-06-04 SM SM20200496T patent/SMT202000496T1/it unknown
- 2013-06-04 PL PL13800681T patent/PL2858985T3/pl unknown
- 2013-06-04 SM SM20180311T patent/SMT201800311T1/it unknown
- 2013-06-04 LT LTEP19169275.5T patent/LT3533792T/lt unknown
- 2013-06-04 EA EA201791592A patent/EA033956B1/ru unknown
- 2013-06-04 TR TR2018/08939T patent/TR201808939T4/tr unknown
- 2013-06-04 HU HUE18157435A patent/HUE050357T2/hu unknown
- 2013-06-04 PL PL18157435T patent/PL3348553T3/pl unknown
- 2013-06-04 ES ES18157435T patent/ES2809738T3/es active Active
- 2013-06-04 HK HK15111086.5A patent/HK1210175A1/xx unknown
- 2013-06-04 PE PE2020000234A patent/PE20200795A1/es unknown
- 2013-06-04 UA UAA201702779A patent/UA123142C2/uk unknown
- 2013-06-04 SI SI201331788T patent/SI3348553T1/sl unknown
- 2013-06-04 SG SG10201610248SA patent/SG10201610248SA/en unknown
- 2013-06-04 IL IL320522A patent/IL320522A/en unknown
- 2013-06-04 HU HUE13800681A patent/HUE038082T2/hu unknown
- 2013-06-04 PE PE2019002096A patent/PE20200725A1/es unknown
- 2013-06-04 RS RS20210739A patent/RS61988B1/sr unknown
- 2013-06-04 EP EP18157435.1A patent/EP3348553B1/en not_active Revoked
- 2013-06-04 ME MEP-2018-158A patent/ME03081B/me unknown
- 2013-06-04 CA CA3055660A patent/CA3055660A1/en not_active Abandoned
- 2013-06-04 IN IN10084DEN2014 patent/IN2014DN10084A/en unknown
- 2013-06-04 EP EP21171579.2A patent/EP3922629A1/en active Pending
- 2013-06-04 EA EA201992010A patent/EA201992010A1/ru unknown
- 2013-06-04 TW TW102119817A patent/TWI532732B/zh active
- 2013-06-04 HU HUE19169275A patent/HUE054595T2/hu unknown
- 2013-06-04 IL IL267608A patent/IL267608B1/en unknown
- 2013-06-04 PT PT138006812T patent/PT2858985T/pt unknown
- 2013-06-04 JP JP2015516121A patent/JP6182209B2/ja active Active
- 2013-06-04 PT PT191692755T patent/PT3533792T/pt unknown
- 2013-06-04 NZ NZ702203A patent/NZ702203A/en unknown
- 2013-06-04 KR KR1020197033592A patent/KR102195916B1/ko active Active
- 2013-06-04 CN CN201380041652.3A patent/CN104619692A/zh active Pending
- 2013-06-04 PT PT181574351T patent/PT3348553T/pt unknown
- 2013-06-04 MY MYPI2014703627A patent/MY187500A/en unknown
- 2013-06-04 SG SG10201610249TA patent/SG10201610249TA/en unknown
- 2013-06-04 DK DK18157435.1T patent/DK3348553T3/da active
- 2013-06-04 ES ES13800681.2T patent/ES2670683T3/es active Active
- 2013-06-04 UA UAA201500086A patent/UA115665C2/uk unknown
2014
- 2014-12-01 CR CR20140549A patent/CR20140549A/es unknown
- 2014-12-04 PH PH12014502714A patent/PH12014502714A1/en unknown
- 2014-12-04 NI NI201400142A patent/NI201400142A/es unknown
- 2014-12-04 IL IL236055A patent/IL236055A0/en unknown
- 2014-12-05 CL CL2014003331A patent/CL2014003331A1/es unknown
- 2014-12-05 GT GT201400283A patent/GT201400283A/es unknown
- 2014-12-05 EC ECIEPI201430098A patent/ECSP14030098A/es unknown
- 2014-12-09 CO CO14270612A patent/CO7240407A2/es unknown
2015
- 2015-01-06 ZA ZA2015/00076A patent/ZA201500076B/en unknown
2016
- 2016-07-26 PH PH12016501470A patent/PH12016501470B1/en unknown
- 2016-09-12 US US15/262,522 patent/US9994545B2/en active Active
- 2016-12-19 HK HK16114389.2A patent/HK1226066A1/zh unknown
2017
- 2017-01-17 AU AU2017200298A patent/AU2017200298B2/en active Active
- 2017-02-15 JP JP2017025746A patent/JP6345821B2/ja active Active
- 2017-12-22 AU AU2017279807A patent/AU2017279807B2/en active Active
2018
- 2018-05-09 US US15/975,449 patent/US10308630B2/en active Active
- 2018-05-23 JP JP2018098638A patent/JP2018141009A/ja active Pending
- 2018-05-31 IL IL259738A patent/IL259738B/en active IP Right Grant
- 2018-07-06 CY CY20181100712T patent/CY1120393T1/el unknown
2019
- 2019-04-15 US US16/384,002 patent/US10526310B2/en active Active
- 2019-07-10 US US16/507,780 patent/US10556882B2/en active Active
- 2019-12-11 US US16/710,785 patent/US10766875B2/en active Active
2020
- 2020-06-15 IL IL275413A patent/IL275413A/en unknown
- 2020-07-29 US US16/942,069 patent/US10934271B2/en active Active
- 2020-08-31 HR HRP20201387TT patent/HRP20201387T1/hr unknown
- 2020-09-23 CY CY20201100901T patent/CY1123427T1/el unknown
2021
- 2021-01-26 US US17/158,806 patent/US12018008B2/en active Active
- 2021-06-08 HR HRP20210909TT patent/HRP20210909T1/hr unknown
- 2021-07-02 CY CY20211100595T patent/CY1124831T1/el unknown
- 2021-11-02 LU LU00236C patent/LUC00236I2/fr unknown
- 2021-11-02 NO NO2021046C patent/NO2021046I1/no unknown
- 2021-11-03 NL NL301144C patent/NL301144I2/nl unknown
- 2021-11-03 FR FR21C1050C patent/FR21C1050I2/fr active Active
- 2021-11-03 LT LTPA2021525C patent/LTPA2021525I1/lt unknown
- 2021-11-04 HU HUS2100047C patent/HUS2100047I1/hu unknown
- 2021-11-04 CY CY2021032C patent/CY2021032I2/el unknown
2024
- 2024-05-13 US US18/662,345 patent/US20250092011A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP6182209B2 (ja)	2017-08-16
RS57370B1 (sr)	2018-08-31
SI2858985T1 (sl)	2018-12-31
PH12016501470B1 (en)	2021-12-10
LTPA2021525I1 (sl)	2021-11-25
EP3533792B1 (en)	2021-05-05
CN104619692A (zh)	2015-05-13
IL236055A0 (en)	2015-02-01
PL3533792T3 (pl)	2021-11-29
JP2018141009A (ja)	2018-09-13
CR20190331A (es)	2019-11-12
CA2875767C (en)	2018-08-14
CY1120393T1 (el)	2019-07-10
TW201402561A (zh)	2014-01-16
CR20140549A (es)	2015-04-06
CY2021032I1 (sl)	2022-03-24
CN113135892A (zh)	2021-07-20
CL2014003331A1 (es)	2016-03-04
NZ702203A (en)	2016-09-30
EA201992010A1 (ru)	2020-01-24
MX2014015005A (es)	2015-09-04
FR21C1050I1 (fr)	2021-12-10
UA115665C2 (uk)	2017-12-11
ES2809738T3 (es)	2021-03-05
KR20150021993A (ko)	2015-03-03
SMT202000496T1 (it)	2020-11-10
CN105693692A (zh)	2016-06-22
PE20200795A1 (es)	2020-08-10
AU2017279807B2 (en)	2018-11-08
HRP20201387T1 (hr)	2020-11-27
EA033956B1 (ru)	2019-12-13
SMT202100355T1 (it)	2021-07-12
EP2858985B1 (en)	2018-04-18
AU2017279807A1 (en)	2018-01-25
JP2015518890A (ja)	2015-07-06
RS60617B1 (sr)	2020-09-30
PT3348553T (pt)	2020-09-28
IL259738A (en)	2018-07-31
IL267608B1 (en)	2025-06-01
SMT201800311T1 (it)	2018-07-17
US20210163441A1 (en)	2021-06-03
ES2875932T3 (es)	2021-11-11
LUC00236I2 (sl)	2025-02-03
NZ717683A (en)	2018-04-27
US20250092011A1 (en)	2025-03-20
ES2670683T3 (es)	2018-05-31
HUE050357T2 (hu)	2020-11-30
HK1210175A1 (en)	2016-04-15
UA123142C2 (uk)	2021-02-24
HUE038082T2 (hu)	2018-09-28
NO2021046I1 (no)	2021-11-02
CY1124831T1 (el)	2022-03-24
EP3533792A1 (en)	2019-09-04
ME03815B (me)	2021-04-20
EP2858985A1 (en)	2015-04-15
EA201791592A1 (ru)	2018-01-31
DK3348553T3 (da)	2020-07-27
US10308630B2 (en)	2019-06-04
CA3055660A1 (en)	2013-12-12
HRP20210909T1 (hr)	2021-09-03
TWI532732B (zh)	2016-05-11
PH12014502714B1 (en)	2015-02-02
KR20190132543A (ko)	2019-11-27
CA3008345A1 (en)	2013-12-12
GT201400283A (es)	2017-07-03
TR201808939T4 (tr)	2018-07-23
US12018008B2 (en)	2024-06-25
SG11201408140QA (en)	2015-01-29
HK1226066A1 (zh)	2017-09-22
CO7240407A2 (es)	2015-04-17
US20190330182A1 (en)	2019-10-31
PT3533792T (pt)	2021-06-07
PE20150631A1 (es)	2015-05-11
CA3114726A1 (en)	2013-12-12
AU2017200298B2 (en)	2017-09-28
US20200115361A1 (en)	2020-04-16
MY187500A (en)	2021-09-24
LT2858985T (lt)	2018-09-25
EP3348553B1 (en)	2020-07-08
AU2013271751B2 (en)	2017-02-23
US20180258067A1 (en)	2018-09-13
AU2017200298A1 (en)	2017-02-02
US10526310B2 (en)	2020-01-07
PE20200725A1 (es)	2020-07-21
KR102062024B1 (ko)	2020-01-03
DK2858985T3 (en)	2018-05-28
IL267608A (en)	2019-08-29
HUS2100047I1 (hu)	2021-11-29
US10556882B2 (en)	2020-02-11
NL301144I2 (nl)	2025-03-20
RS61988B1 (sr)	2021-07-30
PT2858985T (pt)	2018-07-10
SG10201610248SA (en)	2017-02-27
EP2858985A4 (en)	2016-05-25
US20150133481A1 (en)	2015-05-14
JP6345821B2 (ja)	2018-06-20
PH12014502714A1 (en)	2015-02-02
JP2017178923A (ja)	2017-10-05
ME03081B (me)	2019-01-20
WO2013184681A1 (en)	2013-12-12
US10766875B2 (en)	2020-09-08
SI3348553T1 (sl)	2020-11-30
US9994545B2 (en)	2018-06-12
IL320522A (en)	2025-06-01
US20170001977A1 (en)	2017-01-05
LT3348553T (lt)	2020-09-25
DK3533792T3 (da)	2021-06-28
IL259738B (en)	2021-06-30
PL2858985T3 (pl)	2018-09-28
PH12016501470A1 (en)	2017-07-10
EP3348553A1 (en)	2018-07-18
SG10201610249TA (en)	2017-02-27
FR21C1050I2 (fr)	2024-05-24
US20200354335A1 (en)	2020-11-12
SI3533792T1 (sl)	2021-11-30
US20190241539A1 (en)	2019-08-08
NI201400142A (es)	2016-12-02
US10934271B2 (en)	2021-03-02
HRP20180902T1 (hr)	2018-08-24
IL275413A (en)	2020-07-30
MX356754B (es)	2018-06-11
EA201492272A1 (ru)	2015-05-29
BR112014030678A2 (pt)	2017-06-27
LT3533792T (lt)	2021-07-26
EA028791B1 (ru)	2017-12-29
ZA201500076B (en)	2016-10-26
EP3922629A1 (en)	2021-12-15
HUE054595T2 (hu)	2021-09-28
ECSP14030098A (es)	2016-01-29
CA2875767A1 (en)	2013-12-12
KR102195916B1 (ko)	2020-12-30
PL3348553T3 (pl)	2021-02-08
CY2021032I2 (el)	2022-03-24
CA3008345C (en)	2019-10-22
CY1123427T1 (el)	2021-12-31
AU2013271751A1 (en)	2014-12-18
US9481663B2 (en)	2016-11-01

Publication	Publication Date	Title
IN2014DN10084A (sl)	2015-08-21
TN2012000126A1 (en)	2013-09-19	Polycyclic compounds as lysophosphatidic acid receptor antagonists
MX2013006040A (es)	2013-08-26	Antagonistas del receptor de acido lisofosfatidico y su uso en el tratamiento de fibrosis.
MY163055A (en)	2017-08-15	Polycyclic antagonists of lysophosphatidic acid receptors
NZ702663A (en)	2017-03-31	Nuclear transport modulators and uses thereof
IN2012DN02735A (sl)	2015-09-11
IN2012DN00754A (sl)	2015-06-19
NZ630805A (en)	2016-01-29	Pharmaceutical combinations comprising a thionucleotide analog
WO2014070991A3 (en)	2014-07-17	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
UA107334C2 (ru)	2014-12-25	Производные аминоэфиров алкалоидов и их лекарственные композиции
MX2015007051A (es)	2016-01-12	Diazol lactamas.
MX353331B (es)	2018-01-09	Formas solidas de clorhidrato de (1r,4r)-6´-fluoro-n,n-dimetil-4-f enil-4´,9´-dihidro-3´h-espiro-[ciclohexano-1,1´-pirano[3,4,b]indo l]-4-amina.
MX2015012043A (es)	2016-03-17	Agonistas muscarinicos.
WO2015079415A9 (en)	2015-08-27	Amorphous cobicistat solid dispersion
UA115310C2 (uk)	2017-10-25	СПІРОЦИКЛІЧНІ СПОЛУКИ НА ОСНОВІ ПОХІДНИХ 2-ОКСІНДОЛУ, ЯКІ МІСТЯТЬ ЯДРО СПІРО[ІНДОЛО-3,1'-ПІРОЛО[3,4-c]ПІРОЛУ] ТА ЗАЛИШКИ БІОГЕННИХ СІРКОВМІСНИХ АМІНОКИСЛОТ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНІ КОМПОЗИЦІЇ НА ЇХ ОСНОВІ
TN2011000063A1 (en)	2012-09-05	Quinuclidine carbonate derivatives and medicinal composition thereof