FR21C1050I1 - Formes cristallines d'un modulateur de récepteur d'androgène - Google Patents

Formes cristallines d'un modulateur de récepteur d'androgène

Info

Publication number: FR21C1050I1
Authority: FR; France
Prior art keywords: androgen receptor; crystalline forms; receptor modulator; modulator; androgen
Prior art date: 2012-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

FR21C1050C

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Memorial Sloan Kettering Cancer Center

Aragon Pharmaceuticals Inc

Original Assignee

Memorial Sloan Kettering Cancer Center

Aragon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-07

Filing date

2021-11-03

Publication date

2021-12-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR21C1050(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2021-11-03 Application filed by Memorial Sloan Kettering Cancer Center, Aragon Pharmaceuticals Inc filed Critical Memorial Sloan Kettering Cancer Center

2021-12-10 Publication of FR21C1050I1 publication Critical patent/FR21C1050I1/fr

2024-05-24 Application granted granted Critical

2024-05-24 Publication of FR21C1050I2 publication Critical patent/FR21C1050I2/fr

Status Active legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

FR21C1050C 2012-06-07 2021-11-03 Formes cristallines d'un modulateur de récepteur d'androgène Active FR21C1050I2 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201261656888P	2012-06-07	2012-06-07
EP13800681.2A EP2858985B1 (fr)	2012-06-07	2013-06-04	Formes cristallines d'un modulateur du récepteur des androgènes
EP18157435.1A EP3348553B1 (fr)	2012-06-07	2013-06-04	Formes cristallines d'un modulateur de récepteur d'androgène
PCT/US2013/044116 WO2013184681A1 (fr)	2012-06-07	2013-06-04	Formes cristallines d'un modulateur du récepteur des androgènes

Publications (2)

Publication Number	Publication Date
FR21C1050I1 true FR21C1050I1 (fr)	2021-12-10
FR21C1050I2 FR21C1050I2 (fr)	2024-05-24

Family

ID=49712550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR21C1050C Active FR21C1050I2 (fr)	2012-06-07	2021-11-03	Formes cristallines d'un modulateur de récepteur d'androgène

Country Status (45)

Country	Link
US (9)	US9481663B2 (fr)
EP (4)	EP3922629A1 (fr)
JP (3)	JP6182209B2 (fr)
KR (2)	KR102195916B1 (fr)
CN (3)	CN113135892A (fr)
AU (3)	AU2013271751B2 (fr)
BR (1)	BR112014030678A2 (fr)
CA (4)	CA3008345C (fr)
CL (1)	CL2014003331A1 (fr)
CO (1)	CO7240407A2 (fr)
CR (2)	CR20190331A (fr)
CY (4)	CY1120393T1 (fr)
DK (3)	DK3533792T3 (fr)
EA (3)	EA033956B1 (fr)
EC (1)	ECSP14030098A (fr)
ES (3)	ES2670683T3 (fr)
FR (1)	FR21C1050I2 (fr)
GT (1)	GT201400283A (fr)
HK (2)	HK1210175A1 (fr)
HR (3)	HRP20180902T1 (fr)
HU (4)	HUE038082T2 (fr)
IL (4)	IL236055A0 (fr)
IN (1)	IN2014DN10084A (fr)
LT (4)	LT2858985T (fr)
LU (1)	LUC00236I2 (fr)
ME (2)	ME03815B (fr)
MX (1)	MX356754B (fr)
MY (1)	MY187500A (fr)
NI (1)	NI201400142A (fr)
NL (1)	NL301144I2 (fr)
NO (1)	NO2021046I1 (fr)
NZ (2)	NZ702203A (fr)
PE (2)	PE20150631A1 (fr)
PH (2)	PH12014502714B1 (fr)
PL (3)	PL3348553T3 (fr)
PT (3)	PT3348553T (fr)
RS (3)	RS57370B1 (fr)
SG (3)	SG10201610248SA (fr)
SI (3)	SI2858985T1 (fr)
SM (3)	SMT201800311T1 (fr)
TR (1)	TR201808939T4 (fr)
TW (1)	TWI532732B (fr)
UA (2)	UA115665C2 (fr)
WO (1)	WO2013184681A1 (fr)
ZA (1)	ZA201500076B (fr)

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US8461343B2 (en)	2007-03-27	2013-06-11	Sloan-Kettering Institute For Cancer Research	Synthesis of thiohydantoins
US9574043B2 (en)	2009-01-12	2017-02-21	University Of Massachusetts Lowell	Polyisobutylene-based polyurethanes
AU2012353660A1 (en)	2011-12-16	2014-06-12	Olema Pharmaceuticals, Inc.	Novel benzopyran compounds, compositions and uses thereof
JP6182209B2 (ja)	2012-06-07	2017-08-16	アラゴンファーマシューティカルズ，インコーポレイテッド	アンドロゲン受容体変調剤の結晶質形態
CN105358535B (zh)	2012-09-11	2019-01-04	麦迪威森前列腺医疗有限责任公司	恩杂鲁胺制剂
EA037806B1 (ru)	2012-09-26	2021-05-24	Арагон Фармасьютикалз, Инк.	Способ лечения неметастатического кастрационно-резистентного рака простаты
WO2014081916A2 (fr)	2012-11-21	2014-05-30	University Of Massachusetts	Polyuréthane polyisobutylène à résistance élevée
JOP20200097A1 (ar) *	2013-01-15	2017-06-16	Aragon Pharmaceuticals Inc	معدل مستقبل أندروجين واستخداماته
JP2017525727A (ja) *	2014-08-26	2017-09-07	アスターバイオテックリミテッドライアビリティカンパニー	プロテインキナーゼ阻害剤
WO2016090105A1 (fr)	2014-12-05	2016-06-09	Aragon Pharmaceuticals, Inc.	Compositions anticancéreuses
SG11201704267VA (en)	2014-12-05	2017-06-29	Aragon Pharmaceuticals Inc	Anticancer compositions
MA41108B1 (fr)	2014-12-05	2021-03-31	Aragon Pharmaceuticals Inc	Compositions anticancéreuses
CN107113952B (zh)	2014-12-19	2019-08-27	路创技术有限责任公司	具有多个发光二极管驱动器的多通道照明器具
AR108489A1 (es)	2016-06-03	2018-08-29	Aragon Pharmaceuticals Inc	Composiciones antineoplásicas
ES2952770T3 (es)	2016-12-13	2023-11-06	Watson Lab Inc	Formas de estado sólido de apalutamida
US10526429B2 (en)	2017-03-07	2020-01-07	Cardiac Pacemakers, Inc.	Hydroboration/oxidation of allyl-terminated polyisobutylene
US10835638B2 (en)	2017-08-17	2020-11-17	Cardiac Pacemakers, Inc.	Photocrosslinked polymers for enhanced durability
SG11202003402QA (en)	2017-10-16	2020-05-28	Aragon Pharmaceuticals Inc	Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
WO2019135254A1 (fr)	2018-01-02	2019-07-11	Mylan Laboratories Limited	Polymorphes d'apalutamide et leur préparation
WO2019143629A1 (fr)	2018-01-17	2019-07-25	Cardiac Pacemakers, Inc.	Polyuréthane polyisobutylène à extrémité coiffée
CN111344283B (zh) *	2018-06-20	2022-08-12	苏州科睿思制药有限公司	Arn-509的晶型及其制备方法和用途
WO2020049598A2 (fr)	2018-09-08	2020-03-12	Cipla Limited	Polymorphes d'apalutamide
IT201900003839A1 (it)	2019-03-15	2020-09-15	Olon Spa	Sintesi di apalutamide amorfa stabile
WO2020234817A1 (fr) *	2019-05-21	2020-11-26	Laurus Labs Limited	Formes polymorphes d'apalutamide et leur préparation
IT201900010593A1 (it)	2019-07-01	2021-01-01	Dipharma Francis Srl	Forma cristallina di un inibitore di recettori degli androgeni
EP4017848A1 (fr) *	2019-08-22	2022-06-29	Dr. Reddy's Laboratories Ltd.	Procédé pour la préparation d'apalutamide
IT201900015974A1 (it)	2019-09-10	2021-03-10	Olon Spa	Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
CN110590740A (zh) *	2019-09-20	2019-12-20	武汉大学	一种阿帕鲁胺化合物及其药物制剂
US20230312507A1 (en)	2020-09-04	2023-10-05	Synthon B.V.	Improved process for preparation of apalutamide
WO2023143090A1 (fr) *	2022-01-25	2023-08-03	成都苑东生物制药股份有限公司	Nouvelle forme cristalline de solvate d'apalutamide et son procédé de préparation
CN115536634B (zh) *	2022-10-17	2024-06-11	上海博悦生物科技有限公司	一种阿帕他胺的合成方法
CN116332907A (zh) *	2023-03-16	2023-06-27	奥锐特药业股份有限公司	一种无定形阿帕他胺的制备方法

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US5323907A (en)	1992-06-23	1994-06-28	Multi-Comp, Inc.	Child resistant package assembly for dispensing pharmaceutical medications
US7709517B2 (en) *	2005-05-13	2010-05-04	The Regents Of The University Of California	Diarylhydantoin compounds
CN101032483B (zh)	2006-03-09	2011-05-04	陈德桂	调节雄激素受体活性的乙内酰脲衍生物及其应用
EP2656842B1 (fr)	2006-03-27	2016-08-10	The Regents of The University of California	Modulateur de récepteur androgène pour le traitement du cancer de la prostate et de maladies associées au récepteur androgène
CN102755318B (zh) *	2006-03-29	2014-09-10	加利福尼亚大学董事会	二芳基硫代乙内酰脲化合物
US8461343B2 (en)	2007-03-27	2013-06-11	Sloan-Kettering Institute For Cancer Research	Synthesis of thiohydantoins
BR112012020558B1 (pt) *	2010-02-16	2020-11-03	Aragon Pharmaceuticals, Inc	moduladores do receptor de androgênio, suas composições farmacêuticas, e seus usos
JP6182209B2 (ja) *	2012-06-07	2017-08-16	アラゴンファーマシューティカルズ，インコーポレイテッド	アンドロゲン受容体変調剤の結晶質形態
CN111344283B (zh)	2018-06-20	2022-08-12	苏州科睿思制药有限公司	Arn-509的晶型及其制备方法和用途

2013
- 2013-06-04 JP JP2015516121A patent/JP6182209B2/ja active Active
- 2013-06-04 HU HUE13800681A patent/HUE038082T2/hu unknown
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- 2013-06-04 CN CN202110417935.XA patent/CN113135892A/zh active Pending
- 2013-06-04 DK DK19169275.5T patent/DK3533792T3/da active
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- 2013-06-04 PT PT181574351T patent/PT3348553T/pt unknown
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- 2013-06-04 EP EP19169275.5A patent/EP3533792B1/fr active Active
- 2013-06-04 PE PE2014002383A patent/PE20150631A1/es active IP Right Grant
- 2013-06-04 EP EP13800681.2A patent/EP2858985B1/fr active Active
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- 2013-06-04 BR BR112014030678A patent/BR112014030678A2/pt not_active Application Discontinuation
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- 2013-06-04 EP EP18157435.1A patent/EP3348553B1/fr not_active Revoked
- 2013-06-04 NZ NZ717683A patent/NZ717683A/en unknown
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- 2013-06-04 KR KR1020197033592A patent/KR102195916B1/ko active Active
- 2013-06-04 SI SI201331894T patent/SI3533792T1/sl unknown
- 2013-06-04 WO PCT/US2013/044116 patent/WO2013184681A1/fr active Application Filing
- 2013-06-04 SI SI201331788T patent/SI3348553T1/sl unknown
- 2013-06-04 DK DK13800681.2T patent/DK2858985T3/en active
- 2013-06-04 TW TW102119817A patent/TWI532732B/zh active
- 2013-06-04 CN CN201380041652.3A patent/CN104619692A/zh active Pending
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- 2013-06-04 RS RS20210739A patent/RS61988B1/sr unknown
- 2013-06-04 DK DK18157435.1T patent/DK3348553T3/da active
- 2013-06-04 KR KR1020157000266A patent/KR102062024B1/ko active Active
- 2013-06-04 PL PL13800681T patent/PL2858985T3/pl unknown
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- 2013-06-04 CA CA3055660A patent/CA3055660A1/fr not_active Abandoned
- 2013-06-04 HU HUE19169275A patent/HUE054595T2/hu unknown
- 2013-06-04 EA EA201992010A patent/EA201992010A1/ru unknown
2014
- 2014-12-01 CR CR20140549A patent/CR20140549A/es unknown
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- 2014-12-09 CO CO14270612A patent/CO7240407A2/es unknown
2015
- 2015-01-06 ZA ZA2015/00076A patent/ZA201500076B/en unknown
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2016
- 2016-07-26 PH PH12016501470A patent/PH12016501470B1/en unknown
- 2016-09-12 US US15/262,522 patent/US9994545B2/en active Active
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2017
- 2017-01-17 AU AU2017200298A patent/AU2017200298B2/en active Active
- 2017-02-15 JP JP2017025746A patent/JP6345821B2/ja active Active
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2018
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- 2018-05-23 JP JP2018098638A patent/JP2018141009A/ja active Pending
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- 2018-07-06 CY CY20181100712T patent/CY1120393T1/el unknown
2019
- 2019-04-15 US US16/384,002 patent/US10526310B2/en active Active
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2020
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2021
- 2021-01-26 US US17/158,806 patent/US12018008B2/en active Active
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- 2021-11-02 LU LU00236C patent/LUC00236I2/fr unknown
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- 2021-11-03 FR FR21C1050C patent/FR21C1050I2/fr active Active
- 2021-11-03 LT LTPA2021525C patent/LTPA2021525I1/lt unknown
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2024
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CN104619692A (zh)	2015-05-13
US20150133481A1 (en)	2015-05-14
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ZA201500076B (en)	2016-10-26
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GT201400283A (es)	2017-07-03
FR21C1050I2 (fr)	2024-05-24
LT3348553T (lt)	2020-09-25

Publication	Publication Date	Title
FR21C1050I2 (fr)	2024-05-24	Formes cristallines d'un modulateur de récepteur d'androgène
LTPA2020514I1 (lt)	2020-07-27	Androgeno receptorių moduliuojantys junginiai
EP2906226A4 (fr)	2016-06-08	Modulation de l'expression de récepteur d'androgène
EP2911666A4 (fr)	2016-10-12	Modulateurs du récepteur des androgènes androgéno-résistant
SMT201600139B (it)	2016-07-01	Composti anticancro
RS56810B1 (sr)	2018-04-30	Indolkarbonitrili kao selektivni modulatori androgen receptora