HRP20180902T1 - Kristalni oblici modulatora receptora androgena - Google Patents
Kristalni oblici modulatora receptora androgena Download PDFInfo
- Publication number
- HRP20180902T1 HRP20180902T1 HRP20180902TT HRP20180902T HRP20180902T1 HR P20180902 T1 HRP20180902 T1 HR P20180902T1 HR P20180902T T HRP20180902T T HR P20180902TT HR P20180902 T HRP20180902 T HR P20180902T HR P20180902 T1 HRP20180902 T1 HR P20180902T1
- Authority
- HR
- Croatia
- Prior art keywords
- theta
- crystalline form
- prostate cancer
- pharmaceutical preparation
- xrpd
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (15)
1. Kristalni Oblik B 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamida, naznačen time da ima najmanje jedan od:
(a) spektar difrakcije X-zraka praha (XRPD), isti kao što je prikazan na Slici 2;
(b) spektar difrakcije X-zraka praha (XRPD), sa karakterističnim vrhovima na 12.1±0.1° 2-theta, 16.0±0.1° 2-theta, 16.7±0.1° 2-theta, 20.1±0.1° 2-theta, 20.3±0.1° 2-theta;
(c) parametre jedinične ćelije, koji su jednaki sljedećim, na -173°C:
(d) isti spektar difrakcije X-zraka praha (XRPD) kao što su (a) ili (b), poslije barem tjedan dana skladištenja na 40°C i 75% RV; ili
(e) isti spektar difrakcije X-zraka praha (XRPD) kao što su (a) ili (b), poslije 12 dana skladištenja na 25°C i 92% RH.
2. Kristalni oblik prema zahtjevu 1, naznačen time, da ima najmanje jedan od:
(f) termogram DSK, sličan onome koji je prikazan na Slici 11;
(g) termogram termo-gravimetrijske analize (TGA), sličan onome koji je prikazan na Slici 11; ili
(h) termogram DSK s endotermom, koji ima početnu temperaturu na 194°C.
3. Kristalni oblik prema zahtjevu 1 ili zahtjevu 2, naznačen time da navedeni kristalni oblik ima spektar difrakcije X-zraka praha (XRPD), s karakterističnim vrhovima na 12.1±0.1° 2-theta, 16.0±0.1° 2-theta, 16.7±0.1° 2-theta, 20.1±0.1° 2-theta, 20.3±0.1° 2-theta.
4. Kristalni oblik prema bilo kojem od zahtjeva 1-3, naznačen time da navedeni kristalni oblik ima spektar difrakcije X-zraka praha (XRPD) isti kao što je prikazan na Slici 2.
5. Kristalni oblik prema bilo kojem od zahtjeva 1-4, naznačen time da navedeni kristalni oblik ima parametre jedinične ćelije koji su jednaki sljedećim, na -173°C:
6. Kristalni oblik prema bilo kojem od zahtjeva 1-5, da je navedeni kristalni oblik nesolvatiziran.
7. Farmaceutski pripravak koja sadrži 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid i najmanje jedan dodatni sastojak, koji se bira između farmaceutski prihvatljivih nosača, razrjeđivača i ekscipijenata, te pri tome ovaj 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamid u farmaceutskom pripravku se sastoji od kristalnog Oblika B, u skladu s bilo kojim od zahtjeva 1-6.
8. Farmaceutski pripravak prema zahtjevu 7, naznačen time da je navedeni farmaceutski pripravak u obliku pogodnom za oralno davanje sisavcu.
9. Farmaceutski pripravak prema zahtjevu 8, naznačen time da navedeni farmaceutski pripravak predstavlja kruti oblik za oralnog doziranje.
10. Farmaceutski pripravak prema bilo kojem od zahtjeva 7-9, naznačen time da navedeni farmaceutski pripravak sadrži od 0.5 mg do 1000 mg kristalnog 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamida.
11. Farmaceutski pripravak prema bilo kojem od zahtjeva 7-10 naznačen time da je za upotrebu za liječenje raka prostate kod sisavca.
12. Farmaceutski pripravak prema zahtjevu 11, naznačen time da rak prostate predstavlja hormonski senzibilan rak prostate ili hormonski refraktorni rak prostate.
13. Kristalni oblik 4-[7-(6-cijano-5-trifluorometilpiridin-3-il)-8-okso-6-tiokso-5,7-diazaspiro[3.4]okt-5-il]-2-fluoro-N-metilbenzamida za upotrebu prema bilo kojem od zahtjeva 1-6, naznačen time da je za liječenje raka prostate kod humanog subjekta.
14. Kristalni oblik za upotrebu prema zahtjevu 13, naznačen time da rak prostate predstavlja hormonski senzibilan rak prostate ili hormonski refraktorni rak prostate.
15. Farmaceutska kompozicija prema zahtjevu 8, naznačen time da sisavca predstavlja ljudsko biće.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656888P | 2012-06-07 | 2012-06-07 | |
| EP13800681.2A EP2858985B1 (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
| PCT/US2013/044116 WO2013184681A1 (en) | 2012-06-07 | 2013-06-04 | Crystalline forms of an androgen receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180902T1 true HRP20180902T1 (hr) | 2018-08-24 |
Family
ID=49712550
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180902TT HRP20180902T1 (hr) | 2012-06-07 | 2013-06-04 | Kristalni oblici modulatora receptora androgena |
| HRP20201387TT HRP20201387T1 (hr) | 2012-06-07 | 2020-08-31 | Kristalni oblici modulatora receptora androgena |
| HRP20210909TT HRP20210909T1 (hr) | 2012-06-07 | 2021-06-08 | Kristalni oblici modulatora androgenih receptora |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201387TT HRP20201387T1 (hr) | 2012-06-07 | 2020-08-31 | Kristalni oblici modulatora receptora androgena |
| HRP20210909TT HRP20210909T1 (hr) | 2012-06-07 | 2021-06-08 | Kristalni oblici modulatora androgenih receptora |
Country Status (45)
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| SG11201402564QA (en) | 2011-12-16 | 2014-09-26 | Olema Pharmaceuticals Inc | Novel benzopyran compounds, compositions and uses thereof |
| PE20200725A1 (es) | 2012-06-07 | 2020-07-21 | Aragon Pharmaceuticals Inc | Formas cristalinas del modulador receptor de androgeno: 4-[7-(6-ciano-5-trifluorometilpiridin-3-il)-8-oxo-6-tioxo-5,7-diazaespiro[3,4]oct-5-il]-2-fluoro-n-metilbenzamida) (apalutamida) |
| CA2884795C (en) | 2012-09-11 | 2023-10-17 | Medivation Prostate Therapeutics, Inc. | Formulations of enzalutamide |
| MX371020B (es) | 2012-09-26 | 2020-01-13 | Aragon Pharmaceuticals Inc | Antiandrógenos para el tratamiento del cáncer de próstata resistente a la castración no metastásico. |
| JOP20200097A1 (ar) * | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
| WO2016029776A1 (en) * | 2014-08-26 | 2016-03-03 | Astar Biotech Llc | Protein kinase inhibitors |
| CA2969661C (en) | 2014-12-05 | 2023-04-25 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
| US20170360754A1 (en) | 2014-12-05 | 2017-12-21 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
| KR102387089B1 (ko) | 2014-12-05 | 2022-04-14 | 아라곤 파마슈티컬스, 인코포레이티드 | 항암 조성물 |
| MX2017008050A (es) | 2014-12-19 | 2018-01-18 | Lutron Electronics Co | Accesorio de iluminacion multicanal que tiene controladores de diodo emisor de luz. |
| JP2019517497A (ja) | 2016-06-03 | 2019-06-24 | アラゴン ファーマシューティカルズ，インコーポレイテッド | 抗癌性組成物 |
| EP3555061B1 (en) | 2016-12-13 | 2023-06-07 | Watson Laboratories Inc. | Solid state forms of apalutamide |
| SG11202003402QA (en) | 2017-10-16 | 2020-05-28 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
| WO2019135254A1 (en) * | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Apalutamide polymorphs and their preparation thereof |
| CN111344283B (zh) * | 2018-06-20 | 2022-08-12 | 苏州科睿思制药有限公司 | Arn-509的晶型及其制备方法和用途 |
| WO2020049598A2 (en) | 2018-09-08 | 2020-03-12 | Cipla Limited | Apalutamide polymorphs |
| IT201900003839A1 (it) | 2019-03-15 | 2020-09-15 | Olon Spa | Sintesi di apalutamide amorfa stabile |
| WO2020234817A1 (en) * | 2019-05-21 | 2020-11-26 | Laurus Labs Limited | Polymorphic forms of apalutamide and its preparation thereof |
| IT201900010593A1 (it) * | 2019-07-01 | 2021-01-01 | Dipharma Francis Srl | Forma cristallina di un inibitore di recettori degli androgeni |
| US20220281836A1 (en) * | 2019-08-22 | 2022-09-08 | Dr. Reddy's Laboratories Limited | Process for the preparation of apalutamide |
| IT201900015974A1 (it) | 2019-09-10 | 2021-03-10 | Olon Spa | Apalutamide cristallina stabile in forma pura e processo per la sua preparazione |
| CN110590740A (zh) * | 2019-09-20 | 2019-12-20 | 武汉大学 | 一种阿帕鲁胺化合物及其药物制剂 |
| EP4541786A3 (en) | 2020-09-04 | 2025-08-06 | Synthon B.V. | Improved process for preparation of apalutamide |
| CN112679468A (zh) * | 2021-01-05 | 2021-04-20 | 四川科伦药物研究院有限公司 | 阿帕他胺的晶体形式、制备方法和用途 |
| WO2023143090A1 (zh) * | 2022-01-25 | 2023-08-03 | 成都苑东生物制药股份有限公司 | 一种阿帕他胺溶剂化物新晶型及其制备方法 |
| CN115536634B (zh) * | 2022-10-17 | 2024-06-11 | 上海博悦生物科技有限公司 | 一种阿帕他胺的合成方法 |
| CN116332907A (zh) * | 2023-03-16 | 2023-06-27 | 奥锐特药业股份有限公司 | 一种无定形阿帕他胺的制备方法 |
| WO2025153768A1 (en) * | 2024-01-18 | 2025-07-24 | Nanoform Finland Oyj | Composition comprising crystalline nanosized apalutamide |
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| DK2004181T6 (da) | 2006-03-27 | 2023-08-21 | Univ California | Androgen receptormodulator til behandling af prostatacancer og androgen receptor-associerede sygdomme |
| JP5350217B2 (ja) * | 2006-03-29 | 2013-11-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ジアリールチオヒダントイン化合物 |
| WO2008119015A2 (en) | 2007-03-27 | 2008-10-02 | Sloan-Kettering Institute For Cancer Research | Synthesis of thiohydantoins |
| EA028869B1 (ru) * | 2010-02-16 | 2018-01-31 | Арагон Фармасьютикалс, Инк. | Модуляторы рецептора андрогенов и их применение |
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| CN111344283B (zh) | 2018-06-20 | 2022-08-12 | 苏州科睿思制药有限公司 | Arn-509的晶型及其制备方法和用途 |
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2014
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2015
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2016
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2024
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