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CY1120393T1 - Κρυσταλλικες μορφες διαμορφωτη υποδοχεα ανδρογονων - Google Patents

Κρυσταλλικες μορφες διαμορφωτη υποδοχεα ανδρογονων

Info

Publication number
CY1120393T1
CY1120393T1 CY20181100712T CY181100712T CY1120393T1 CY 1120393 T1 CY1120393 T1 CY 1120393T1 CY 20181100712 T CY20181100712 T CY 20181100712T CY 181100712 T CY181100712 T CY 181100712T CY 1120393 T1 CY1120393 T1 CY 1120393T1
Authority
CY
Cyprus
Prior art keywords
androgen receptor
androgen
containers
crystal forms
receptor modulator
Prior art date
Application number
CY20181100712T
Other languages
English (en)
Inventor
Nicholas D. Smith
Mark R. Herbert
Ouathek Ouerfelli
Anna Dilhas
Original Assignee
Aragon Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712550&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120393(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aragon Pharmaceuticals, Inc. filed Critical Aragon Pharmaceuticals, Inc.
Publication of CY1120393T1 publication Critical patent/CY1120393T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Στο παρόν περιγράφονται άμορφες και κρυσταλλικές μορφές του διαμορφωτή υποδοχέα ανδρογόνων 4-[7-(6-κυανο-5-τριφθορομεθυλοπυριδιν-3-υλο)-8-οξο-6-θειοξο-5,7-διαζασπιρο[3.4]οκτ-5-υλο]-2-φθορο-Ν-μεθυλοβενζαμίδιο. Επίσης περιγράφονται φαρμακευτικές συνθέσεις κατάλληλες για χορήγηση σε ένα θηλαστικό οι οποίες περιλαμβάνουν το διαμορφωτή υποδοχέα ανδρογόνων, και μέθοδοι χρήσης του διαμορφωτή υποδοχέα ανδρογόνων, μόνου και σε συνδυασμό με άλλες ενώσεις, για την αγωγή νόσων ή παθήσεων που σχετίζονται με την δραστικότητα του υποδοχέα ανδρογόνων.
CY20181100712T 2012-06-07 2018-07-06 Κρυσταλλικες μορφες διαμορφωτη υποδοχεα ανδρογονων CY1120393T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656888P 2012-06-07 2012-06-07
PCT/US2013/044116 WO2013184681A1 (en) 2012-06-07 2013-06-04 Crystalline forms of an androgen receptor modulator

Publications (1)

Publication Number Publication Date
CY1120393T1 true CY1120393T1 (el) 2019-07-10

Family

ID=49712550

Family Applications (4)

Application Number Title Priority Date Filing Date
CY20181100712T CY1120393T1 (el) 2012-06-07 2018-07-06 Κρυσταλλικες μορφες διαμορφωτη υποδοχεα ανδρογονων
CY20201100901T CY1123427T1 (el) 2012-06-07 2020-09-23 Kpyσtaλλikeς mopφeς δiamopφωτη yποδoxea anδpoγonωn
CY20211100595T CY1124831T1 (el) 2012-06-07 2021-07-02 Κρυσταλλiκες μορφες διαμορφωτη υποδοχεα ανδρογονων
CY2021032C CY2021032I2 (el) 2012-06-07 2021-11-04 Κρυσταλλiκες μορφες διαμορφωτη υποδοχεα ανδρογονων

Family Applications After (3)

Application Number Title Priority Date Filing Date
CY20201100901T CY1123427T1 (el) 2012-06-07 2020-09-23 Kpyσtaλλikeς mopφeς δiamopφωτη yποδoxea anδpoγonωn
CY20211100595T CY1124831T1 (el) 2012-06-07 2021-07-02 Κρυσταλλiκες μορφες διαμορφωτη υποδοχεα ανδρογονων
CY2021032C CY2021032I2 (el) 2012-06-07 2021-11-04 Κρυσταλλiκες μορφες διαμορφωτη υποδοχεα ανδρογονων

Country Status (45)

Country Link
US (9) US9481663B2 (el)
EP (4) EP3922629A1 (el)
JP (3) JP6182209B2 (el)
KR (2) KR102195916B1 (el)
CN (3) CN113135892A (el)
AU (3) AU2013271751B2 (el)
BR (1) BR112014030678A2 (el)
CA (4) CA3008345C (el)
CL (1) CL2014003331A1 (el)
CO (1) CO7240407A2 (el)
CR (2) CR20190331A (el)
CY (4) CY1120393T1 (el)
DK (3) DK3533792T3 (el)
EA (3) EA033956B1 (el)
EC (1) ECSP14030098A (el)
ES (3) ES2670683T3 (el)
FR (1) FR21C1050I2 (el)
GT (1) GT201400283A (el)
HK (2) HK1210175A1 (el)
HR (3) HRP20180902T1 (el)
HU (4) HUE038082T2 (el)
IL (4) IL236055A0 (el)
IN (1) IN2014DN10084A (el)
LT (4) LT2858985T (el)
LU (1) LUC00236I2 (el)
ME (2) ME03815B (el)
MX (1) MX356754B (el)
MY (1) MY187500A (el)
NI (1) NI201400142A (el)
NL (1) NL301144I2 (el)
NO (1) NO2021046I1 (el)
NZ (2) NZ702203A (el)
PE (2) PE20150631A1 (el)
PH (2) PH12014502714B1 (el)
PL (3) PL3348553T3 (el)
PT (3) PT3348553T (el)
RS (3) RS57370B1 (el)
SG (3) SG10201610248SA (el)
SI (3) SI2858985T1 (el)
SM (3) SMT201800311T1 (el)
TR (1) TR201808939T4 (el)
TW (1) TWI532732B (el)
UA (2) UA115665C2 (el)
WO (1) WO2013184681A1 (el)
ZA (1) ZA201500076B (el)

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AR108489A1 (es) 2016-06-03 2018-08-29 Aragon Pharmaceuticals Inc Composiciones antineoplásicas
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IT201900015974A1 (it) 2019-09-10 2021-03-10 Olon Spa Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
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CN115536634B (zh) * 2022-10-17 2024-06-11 上海博悦生物科技有限公司 一种阿帕他胺的合成方法
CN116332907A (zh) * 2023-03-16 2023-06-27 奥锐特药业股份有限公司 一种无定形阿帕他胺的制备方法

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BR112012020558B1 (pt) * 2010-02-16 2020-11-03 Aragon Pharmaceuticals, Inc moduladores do receptor de androgênio, suas composições farmacêuticas, e seus usos
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CN111344283B (zh) 2018-06-20 2022-08-12 苏州科睿思制药有限公司 Arn-509的晶型及其制备方法和用途

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PH12016501470A1 (en) 2017-07-10
US10556882B2 (en) 2020-02-11
CN104619692A (zh) 2015-05-13
US20150133481A1 (en) 2015-05-14
PL3348553T3 (pl) 2021-02-08
CR20140549A (es) 2015-04-06
PE20150631A1 (es) 2015-05-11
TR201808939T4 (tr) 2018-07-23
EP3533792B1 (en) 2021-05-05
IL275413A (en) 2020-07-30
ES2670683T3 (es) 2018-05-31
HUE050357T2 (hu) 2020-11-30
DK2858985T3 (en) 2018-05-28
ES2875932T3 (es) 2021-11-11
KR102062024B1 (ko) 2020-01-03
SMT202000496T1 (it) 2020-11-10
EP3922629A1 (en) 2021-12-15
US9994545B2 (en) 2018-06-12
CA2875767A1 (en) 2013-12-12
EP2858985A1 (en) 2015-04-15
SI2858985T1 (sl) 2018-12-31
MX2014015005A (es) 2015-09-04
TW201402561A (zh) 2014-01-16
CA3008345C (en) 2019-10-22
BR112014030678A2 (pt) 2017-06-27
HUE038082T2 (hu) 2018-09-28
FR21C1050I1 (fr) 2021-12-10
UA115665C2 (uk) 2017-12-11
CA2875767C (en) 2018-08-14
PL3533792T3 (pl) 2021-11-29
CY1124831T1 (el) 2022-03-24
US20190241539A1 (en) 2019-08-08
SMT202100355T1 (it) 2021-07-12
AU2013271751B2 (en) 2017-02-23
SG10201610248SA (en) 2017-02-27
IL259738B (en) 2021-06-30
ZA201500076B (en) 2016-10-26
PH12016501470B1 (en) 2021-12-10
SI3348553T1 (sl) 2020-11-30
ME03815B (me) 2021-04-20
JP6182209B2 (ja) 2017-08-16
US12018008B2 (en) 2024-06-25
NO2021046I1 (no) 2021-11-02
JP2017178923A (ja) 2017-10-05
PT3533792T (pt) 2021-06-07
ECSP14030098A (es) 2016-01-29
EA201791592A1 (ru) 2018-01-31
LT3533792T (lt) 2021-07-26
US10308630B2 (en) 2019-06-04
CN113135892A (zh) 2021-07-20
US20200354335A1 (en) 2020-11-12
CR20190331A (es) 2019-11-12
NZ702203A (en) 2016-09-30
PL2858985T3 (pl) 2018-09-28
HK1210175A1 (en) 2016-04-15
MY187500A (en) 2021-09-24
PH12014502714A1 (en) 2015-02-02
HRP20210909T1 (hr) 2021-09-03
IL267608A (en) 2019-08-29
EA028791B1 (ru) 2017-12-29
US9481663B2 (en) 2016-11-01
US20250092011A1 (en) 2025-03-20
CA3114726A1 (en) 2013-12-12
EP2858985B1 (en) 2018-04-18
HK1226066A1 (zh) 2017-09-22
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AU2017279807B2 (en) 2018-11-08
CY2021032I2 (el) 2022-03-24
JP2015518890A (ja) 2015-07-06
JP6345821B2 (ja) 2018-06-20
LUC00236I2 (el) 2025-02-03
CL2014003331A1 (es) 2016-03-04
HRP20180902T1 (hr) 2018-08-24
JP2018141009A (ja) 2018-09-13
CY1123427T1 (el) 2021-12-31
US20190330182A1 (en) 2019-10-31
HRP20201387T1 (hr) 2020-11-27
SG10201610249TA (en) 2017-02-27
AU2013271751A1 (en) 2014-12-18
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HUS2100047I1 (hu) 2021-11-29
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US20180258067A1 (en) 2018-09-13
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US10526310B2 (en) 2020-01-07
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EP2858985A4 (en) 2016-05-25
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LT3348553T (lt) 2020-09-25

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