IL88247A0 - Novel human tissue-type plasminogen activator variant - Google Patents

Novel human tissue-type plasminogen activator variant

Info

Publication number: IL88247A0
Authority: IL; Israel
Prior art keywords: plasminogen activator; human tissue; novel human; type plasminogen; activator variant
Prior art date: 1987-11-06

Application number

IL88247A

Other languages

English (en)

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-11-06

Filing date

1988-10-31

Publication date

1989-06-30

1988-10-31 Application filed by Genentech Inc filed Critical Genentech Inc

1988-10-31 Priority to IL10495388A priority Critical patent/IL104953A/en

1989-06-30 Publication of IL88247A0 publication Critical patent/IL88247A0/xx

1993-03-04 Priority to IL93104953A priority patent/IL104953A0/xx

1994-05-24 Priority to IL10976094A priority patent/IL109760A0/xx

1994-05-24 Priority to IL10975994A priority patent/IL109759A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

IL88247A 1987-11-06 1988-10-31 Novel human tissue-type plasminogen activator variant IL88247A0 (en)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
IL10495388A IL104953A (en)	1987-11-06	1988-10-31	Method for producing tissue-type plasminogen activator by transforming and cultivating a host cell incapable of forming complex glycoproteins
IL93104953A IL104953A0 (en)	1987-11-06	1993-03-04	Method for producing novel human tissue-type plasminogen activator variant
IL10976094A IL109760A0 (en)	1987-11-06	1994-05-24	Modified human tissue-type plasminogen activator which retains its biological activity and is characterized by an increased in vivo hlaf-life
IL10975994A IL109759A0 (en)	1987-11-06	1994-05-24	Human tissue-type plasminogen activator having modified functional carbohydrate residues, which retains its biological activity and is characterized by an increased in vivo half-life

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11809887A	1987-11-06	1987-11-06

Publications (1)

Publication Number	Publication Date
IL88247A0 true IL88247A0 (en)	1989-06-30

Family

ID=22376492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL88247A IL88247A0 (en)	1987-11-06	1988-10-31	Novel human tissue-type plasminogen activator variant

Country Status (18)

Country	Link
EP (2)	EP0387290B1 (pt)
JP (1)	JPH03500843A (pt)
KR (1)	KR920009521B1 (pt)
AT (1)	ATE151812T1 (pt)
AU (2)	AU2804989A (pt)
CA (1)	CA1341609C (pt)
DD (1)	DD286613A5 (pt)
DE (1)	DE3855874T2 (pt)
DK (1)	DK175482B1 (pt)
FI (1)	FI102970B (pt)
HU (1)	HU215230B (pt)
IL (1)	IL88247A0 (pt)
NO (1)	NO307612B1 (pt)
NZ (1)	NZ226829A (pt)
PH (1)	PH30064A (pt)
PT (1)	PT88938B (pt)
WO (1)	WO1989004368A1 (pt)
ZA (1)	ZA888250B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5246850A (en) *	1990-07-31	1993-09-21	Genentech, Inc.	DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
CA2086835C (en) *	1990-07-31	2002-04-02	Bruce A. Keyt	Tissue plasminogen activator variants with decreased clearance
US5242688A (en) *	1990-12-24	1993-09-07	Eli Lilly And Company	Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
EP0643772B1 (en)	1992-06-03	1997-07-23	Genentech, Inc.	Tissue plasminogen activator glycosylation variants with improved therapeutic properties
EP0827751B1 (en) *	1996-09-06	2003-02-26	Juridical Foundation The Chemo-Sero-Therapeutic Research Institute	Medicinal composition containing tissue plasminogen activator and nicotinamide
US7084118B2 (en)	2002-02-22	2006-08-01	Genentech, Inc.	Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1984001786A1 (en) *	1982-10-28	1984-05-10	Beecham Group Plc	Enzyme derivatives and their use in the treatment of thrombosis
DE3789664T3 (de) *	1986-01-31	2004-09-16	Genetics Institute, LLC, Cambridge	Neue thrombolytische proteine.
IE81073B1 (en) *	1986-03-18	2000-01-12	Genentech Inc	Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) *	1987-08-03	1995-07-31	Fujisawa Pharmaceutical Co	Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
DE3888619D1 (de) *	1987-10-09	1994-04-28	Monsanto Co	Modifizierter Gewebeplasminogenaktivator.

1988
- 1988-10-31 IL IL88247A patent/IL88247A0/xx unknown
- 1988-11-02 KR KR1019890701271A patent/KR920009521B1/ko not_active IP Right Cessation
- 1988-11-02 EP EP89900085A patent/EP0387290B1/en not_active Expired - Lifetime
- 1988-11-02 WO PCT/US1988/003901 patent/WO1989004368A1/en active IP Right Grant
- 1988-11-02 HU HU57/89A patent/HU215230B/hu unknown
- 1988-11-02 DE DE3855874T patent/DE3855874T2/de not_active Expired - Lifetime
- 1988-11-02 EP EP96113810A patent/EP0754753A1/en not_active Withdrawn
- 1988-11-02 AU AU28049/89A patent/AU2804989A/en not_active Abandoned
- 1988-11-02 AT AT89900085T patent/ATE151812T1/de not_active IP Right Cessation
- 1988-11-02 JP JP1500176A patent/JPH03500843A/ja active Pending
- 1988-11-03 NZ NZ226829A patent/NZ226829A/en unknown
- 1988-11-03 ZA ZA888250A patent/ZA888250B/xx unknown
- 1988-11-04 PT PT88938A patent/PT88938B/pt not_active IP Right Cessation
- 1988-11-04 PH PH37775A patent/PH30064A/en unknown
- 1988-11-07 DD DD88321544A patent/DD286613A5/de unknown
- 1988-11-07 CA CA582415A patent/CA1341609C/en not_active Expired - Fee Related
1990
- 1990-05-04 NO NO901995A patent/NO307612B1/no not_active IP Right Cessation
- 1990-05-04 FI FI902239A patent/FI102970B/fi not_active IP Right Cessation
- 1990-05-04 DK DK199001122A patent/DK175482B1/da not_active IP Right Cessation
1992
- 1992-08-26 AU AU21317/92A patent/AU658909B2/en not_active Expired

Also Published As

Publication number	Publication date
ZA888250B (en)	1990-07-25
KR920009521B1 (ko)	1992-10-17
DK112290D0 (da)	1990-05-04
ATE151812T1 (de)	1997-05-15
PT88938A (pt)	1989-11-30
AU2804989A (en)	1989-06-01
EP0754753A1 (en)	1997-01-22
NO307612B1 (no)	2000-05-02
NO901995L (no)	1990-07-05
DD286613A5 (de)	1991-01-31
HU215230B (hu)	2000-03-28
EP0387290A1 (en)	1990-09-19
KR890701733A (ko)	1989-12-21
NO901995D0 (no)	1990-05-04
PT88938B (pt)	1993-05-31
PH30064A (en)	1996-11-08
NZ226829A (en)	1991-06-25
CA1341609C (en)	2011-02-01
AU658909B2 (en)	1995-05-04
HUT54209A (en)	1991-01-28
DE3855874D1 (de)	1997-05-22
DK112290A (da)	1990-07-06
FI902239A0 (fi)	1990-05-04
DK175482B1 (da)	2004-11-08
EP0387290B1 (en)	1997-04-16
AU2131792A (en)	1992-11-19
JPH03500843A (ja)	1991-02-28
HU890157D0 (en)	1990-12-28
FI102970B1 (fi)	1999-03-31
FI102970B (fi)	1999-03-31
WO1989004368A1 (en)	1989-05-18
DE3855874T2 (de)	1997-09-11

Publication	Publication Date	Title
GB2189249B (en)	1990-10-31	Modified human tissue-type plasminogen activator and its preparation
IL80659A0 (en)	1987-02-27	Modified tissue plasminogen activators,their preparation and pharmaceutical compositions containing them
AU7090687A (en)	1987-10-08	Modified tissue-type plasminogen activators
ZA888250B (en)	1990-07-25	Human tissue-type plasminogen activator variant
GB8819607D0 (en)	1988-09-21	Novel combination
AU7090587A (en)	1987-10-08	Modified plasminogen activators
NZ223291A (en)	1990-09-26	Modified tissue-type plasminogen activator
ATE119940T1 (de)	1995-04-15	Gewebs-plasminogen-aktivator-derivat.
IL109759A0 (en)	1994-08-26	Human tissue-type plasminogen activator having modified functional carbohydrate residues, which retains its biological activity and is characterized by an increased in vivo half-life
AU608232C (en)	1992-05-07	Modified tissue plasminogen activator
IE870208L (en)	1987-07-29	Modified tissue plasminogen activator
AU7554687A (en)	1988-01-14	Modified tissue plasminogen activator
IE871856L (en)	1988-01-11	"modified tissue plasminogen activator"
IE883342L (en)	1989-05-06	Human tissue-type plasminogen activator variant