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DK175482B1 - Human vævsplasminogenaktivator-variant - Google Patents

Human vævsplasminogenaktivator-variant Download PDF

Info

Publication number
DK175482B1
DK175482B1 DK199001122A DK112290A DK175482B1 DK 175482 B1 DK175482 B1 DK 175482B1 DK 199001122 A DK199001122 A DK 199001122A DK 112290 A DK112290 A DK 112290A DK 175482 B1 DK175482 B1 DK 175482B1
Authority
DK
Denmark
Prior art keywords
human tissue
plasminogen activator
type plasminogen
amino acid
tissue type
Prior art date
Application number
DK199001122A
Other languages
Danish (da)
English (en)
Other versions
DK112290D0 (da
DK112290A (da
Inventor
Adair J Hotchkiss
John V O'conner
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK112290D0 publication Critical patent/DK112290D0/da
Publication of DK112290A publication Critical patent/DK112290A/da
Application granted granted Critical
Publication of DK175482B1 publication Critical patent/DK175482B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK199001122A 1987-11-06 1990-05-04 Human vævsplasminogenaktivator-variant DK175482B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11809887A 1987-11-06 1987-11-06
US11809887 1987-11-06
PCT/US1988/003901 WO1989004368A1 (en) 1987-11-06 1988-11-02 Novel human tissue-type plasminogen activator variant
US8803901 1988-11-02

Publications (3)

Publication Number Publication Date
DK112290D0 DK112290D0 (da) 1990-05-04
DK112290A DK112290A (da) 1990-07-06
DK175482B1 true DK175482B1 (da) 2004-11-08

Family

ID=22376492

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001122A DK175482B1 (da) 1987-11-06 1990-05-04 Human vævsplasminogenaktivator-variant

Country Status (18)

Country Link
EP (2) EP0387290B1 (pt)
JP (1) JPH03500843A (pt)
KR (1) KR920009521B1 (pt)
AT (1) ATE151812T1 (pt)
AU (2) AU2804989A (pt)
CA (1) CA1341609C (pt)
DD (1) DD286613A5 (pt)
DE (1) DE3855874T2 (pt)
DK (1) DK175482B1 (pt)
FI (1) FI102970B (pt)
HU (1) HU215230B (pt)
IL (1) IL88247A0 (pt)
NO (1) NO307612B1 (pt)
NZ (1) NZ226829A (pt)
PH (1) PH30064A (pt)
PT (1) PT88938B (pt)
WO (1) WO1989004368A1 (pt)
ZA (1) ZA888250B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246850A (en) * 1990-07-31 1993-09-21 Genentech, Inc. DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells
CA2086835C (en) * 1990-07-31 2002-04-02 Bruce A. Keyt Tissue plasminogen activator variants with decreased clearance
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
EP0643772B1 (en) 1992-06-03 1997-07-23 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
EP0827751B1 (en) * 1996-09-06 2003-02-26 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Medicinal composition containing tissue plasminogen activator and nicotinamide
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
DE3789664T3 (de) * 1986-01-31 2004-09-16 Genetics Institute, LLC, Cambridge Neue thrombolytische proteine.
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
IL87276A (en) * 1987-08-03 1995-07-31 Fujisawa Pharmaceutical Co Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same
DE3888619D1 (de) * 1987-10-09 1994-04-28 Monsanto Co Modifizierter Gewebeplasminogenaktivator.

Also Published As

Publication number Publication date
IL88247A0 (en) 1989-06-30
ZA888250B (en) 1990-07-25
KR920009521B1 (ko) 1992-10-17
DK112290D0 (da) 1990-05-04
ATE151812T1 (de) 1997-05-15
PT88938A (pt) 1989-11-30
AU2804989A (en) 1989-06-01
EP0754753A1 (en) 1997-01-22
NO307612B1 (no) 2000-05-02
NO901995L (no) 1990-07-05
DD286613A5 (de) 1991-01-31
HU215230B (hu) 2000-03-28
EP0387290A1 (en) 1990-09-19
KR890701733A (ko) 1989-12-21
NO901995D0 (no) 1990-05-04
PT88938B (pt) 1993-05-31
PH30064A (en) 1996-11-08
NZ226829A (en) 1991-06-25
CA1341609C (en) 2011-02-01
AU658909B2 (en) 1995-05-04
HUT54209A (en) 1991-01-28
DE3855874D1 (de) 1997-05-22
DK112290A (da) 1990-07-06
FI902239A0 (fi) 1990-05-04
EP0387290B1 (en) 1997-04-16
AU2131792A (en) 1992-11-19
JPH03500843A (ja) 1991-02-28
HU890157D0 (en) 1990-12-28
FI102970B1 (fi) 1999-03-31
FI102970B (fi) 1999-03-31
WO1989004368A1 (en) 1989-05-18
DE3855874T2 (de) 1997-09-11

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