IL134685A - Preparation of nitrogen-saturated mono-unsaturated heterocycles with 5 and 6 atoms in the primary believing ring - Google Patents

Preparation of nitrogen-saturated mono-unsaturated heterocycles with 5 and 6 atoms in the primary believing ring

Info

Publication number: IL134685A
Authority: IL; Israel
Prior art keywords: dox; cytotoxic; analogs; nitrogen; doxorubicin
Prior art date: 1995-11-27

Application number

IL13468596A

Other languages

English (en)

Hebrew (he)

Original Assignee

Zentaris Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-27

Filing date

1996-11-26

Publication date

2002-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24247176&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL134685(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-11-26 Application filed by Zentaris Ag filed Critical Zentaris Ag

2002-12-01 Publication of IL134685A publication Critical patent/IL134685A/en

Links

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KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
230000008685 targeting Effects 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000011285 therapeutic regimen Methods 0.000 description 1
DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical compound OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 description 1
229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
GTZCVFVGUGFEME-UHFFFAOYSA-N trans-aconitic acid Natural products OC(=O)CC(C(O)=O)=CC(O)=O GTZCVFVGUGFEME-UHFFFAOYSA-N 0.000 description 1
125000005270 trialkylamine group Chemical group 0.000 description 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
230000002476 tumorcidal effect Effects 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
230000004580 weight loss Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

IL13468596A 1995-11-27 1996-11-26 Preparation of nitrogen-saturated mono-unsaturated heterocycles with 5 and 6 atoms in the primary believing ring IL134685A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/562,652 US5843903A (en)	1995-11-27	1995-11-27	Targeted cytotoxic anthracycline analogs
IL11969196A IL119691A (en)	1995-11-27	1996-11-26	Analogs of anthracycline cytotoxins intended for the purpose

Publications (1)

Publication Number	Publication Date
IL134685A true IL134685A (en)	2002-12-01

Family

ID=24247176

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL11969196A IL119691A (en)	1995-11-27	1996-11-26	Analogs of anthracycline cytotoxins intended for the purpose
IL13468596A IL134685A (en)	1995-11-27	1996-11-26	Preparation of nitrogen-saturated mono-unsaturated heterocycles with 5 and 6 atoms in the primary believing ring
IL13468500A IL134685A0 (en)	1995-11-27	2000-02-23	Anthracycline analogs and their use

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
IL11969196A IL119691A (en)	1995-11-27	1996-11-26	Analogs of anthracycline cytotoxins intended for the purpose

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL13468500A IL134685A0 (en)	1995-11-27	2000-02-23	Anthracycline analogs and their use

Country Status (27)

Country	Link
US (2)	US5843903A (da)
EP (2)	EP1384710B1 (da)
JP (2)	JP3987575B2 (da)
KR (2)	KR100467899B1 (da)
CN (2)	CN1137136C (da)
AT (2)	ATE251179T1 (da)
AU (1)	AU709539B2 (da)
BR (1)	BR9611647B1 (da)
CA (2)	CA2471775C (da)
CZ (1)	CZ297297B6 (da)
DE (2)	DE69630233T2 (da)
DK (2)	DK0863917T3 (da)
EA (1)	EA001372B1 (da)
ES (2)	ES2205067T3 (da)
HK (2)	HK1017363A1 (da)
HU (1)	HU229870B1 (da)
IL (3)	IL119691A (da)
IS (2)	IS2178B (da)
MX (1)	MX9804119A (da)
NO (2)	NO324035B1 (da)
NZ (1)	NZ322054A (da)
PL (3)	PL187230B1 (da)
PT (2)	PT863917E (da)
SK (2)	SK284392B6 (da)
UA (1)	UA67722C2 (da)
WO (1)	WO1997019954A1 (da)
ZA (1)	ZA969709B (da)

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1995
- 1995-11-27 US US08/562,652 patent/US5843903A/en not_active Expired - Lifetime
1996
- 1996-11-14 HU HU9903771A patent/HU229870B1/hu unknown
- 1996-11-14 PT PT96938216T patent/PT863917E/pt unknown
- 1996-11-14 SK SK628-98A patent/SK284392B6/sk unknown
- 1996-11-14 EP EP03010988A patent/EP1384710B1/en not_active Expired - Lifetime
- 1996-11-14 AT AT96938216T patent/ATE251179T1/de active
- 1996-11-14 EA EA199800492A patent/EA001372B1/ru not_active IP Right Cessation
- 1996-11-14 AU AU75722/96A patent/AU709539B2/en not_active Expired
- 1996-11-14 ES ES96938216T patent/ES2205067T3/es not_active Expired - Lifetime
- 1996-11-14 DE DE69630233T patent/DE69630233T2/de not_active Expired - Lifetime
- 1996-11-14 AT AT03010988T patent/ATE401305T1/de active
- 1996-11-14 JP JP52012397A patent/JP3987575B2/ja not_active Expired - Lifetime
- 1996-11-14 DE DE69637604T patent/DE69637604D1/de not_active Expired - Lifetime
- 1996-11-14 UA UA98063318A patent/UA67722C2/uk unknown
- 1996-11-14 PL PL96326865A patent/PL187230B1/pl unknown
- 1996-11-14 CA CA002471775A patent/CA2471775C/en not_active Expired - Lifetime
- 1996-11-14 PL PL96358646A patent/PL188786B1/pl unknown
- 1996-11-14 WO PCT/EP1996/005029 patent/WO1997019954A1/en active IP Right Grant
- 1996-11-14 DK DK96938216T patent/DK0863917T3/da active
- 1996-11-14 KR KR10-2004-7004548A patent/KR100467899B1/ko active IP Right Grant
- 1996-11-14 NZ NZ322054A patent/NZ322054A/en not_active IP Right Cessation
- 1996-11-14 DK DK03010988T patent/DK1384710T3/da active
- 1996-11-14 CN CNB961986050A patent/CN1137136C/zh not_active Expired - Lifetime
- 1996-11-14 PT PT03010988T patent/PT1384710E/pt unknown
- 1996-11-14 CA CA002238574A patent/CA2238574C/en not_active Expired - Lifetime
- 1996-11-14 BR BRPI9611647-1A patent/BR9611647B1/pt not_active IP Right Cessation
- 1996-11-14 EP EP96938216A patent/EP0863917B1/en not_active Expired - Lifetime
- 1996-11-14 CN CNB021439192A patent/CN1166597C/zh not_active Expired - Lifetime
- 1996-11-14 PL PL358737A patent/PL191781B1/pl unknown
- 1996-11-14 KR KR10-1998-0703948A patent/KR100445754B1/ko active IP Right Grant
- 1996-11-14 SK SK341-2004A patent/SK284672B6/sk not_active IP Right Cessation
- 1996-11-14 ES ES03010988T patent/ES2310222T3/es not_active Expired - Lifetime
- 1996-11-14 CZ CZ0135798A patent/CZ297297B6/cs not_active IP Right Cessation
- 1996-11-20 ZA ZA9609709A patent/ZA969709B/xx unknown
- 1996-11-26 IL IL11969196A patent/IL119691A/en not_active IP Right Cessation
- 1996-11-26 IL IL13468596A patent/IL134685A/en not_active IP Right Cessation
1998
- 1998-05-05 IS IS4734A patent/IS2178B/is unknown
- 1998-05-15 NO NO19982252A patent/NO324035B1/no not_active IP Right Cessation
- 1998-05-25 MX MX9804119A patent/MX9804119A/es unknown
- 1998-07-15 US US09/116,125 patent/US6184374B1/en not_active Expired - Lifetime
1999
- 1999-05-24 HK HK99102273A patent/HK1017363A1/xx not_active IP Right Cessation
2000
- 2000-02-23 IL IL13468500A patent/IL134685A0/xx unknown
2003
- 2003-07-09 HK HK03104934.8A patent/HK1052920B/zh not_active IP Right Cessation
2005
- 2005-03-01 NO NO20051111A patent/NO20051111L/no not_active Application Discontinuation
2006
- 2006-11-09 IS IS8567A patent/IS2634B/is unknown
- 2006-11-15 JP JP2006309698A patent/JP4778405B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2000502055A (ja)	2000-02-22
JP4778405B2 (ja)	2011-09-21
DE69630233D1 (de)	2003-11-06
PT863917E (pt)	2004-02-27
CN1137136C (zh)	2004-02-04
PL187230B1 (pl)	2004-06-30
CZ135798A3 (cs)	1998-10-14
JP2007045845A (ja)	2007-02-22
IL119691A0 (en)	1997-02-18
PL188786B1 (pl)	2005-04-29
IS8567A (is)	2006-11-09
WO1997019954A1 (en)	1997-06-05
BR9611647A (pt)	1999-02-23
IS2634B (is)	2010-06-15
NO982252D0 (no)	1998-05-15
JP3987575B2 (ja)	2007-10-10
IS2178B (is)	2006-12-15
EA199800492A1 (ru)	1998-12-24
ES2205067T3 (es)	2004-05-01
IL119691A (en)	2002-02-10
HUP9903771A2 (hu)	2000-02-28
ATE251179T1 (de)	2003-10-15
HK1052920A1 (en)	2003-10-03
NO20051111L (no)	2005-03-01
KR20040037176A (ko)	2004-05-04
UA67722C2 (en)	2004-07-15
BR9611647B1 (pt)	2010-03-09
CN1405127A (zh)	2003-03-26
CA2471775A1 (en)	1997-06-05
PT1384710E (pt)	2008-10-08
HK1052920B (zh)	2005-03-04
NZ322054A (en)	1999-04-29
US5843903A (en)	1998-12-01
AU709539B2 (en)	1999-09-02
HU229870B1 (en)	2014-10-28
KR100467899B1 (ko)	2005-01-24
PL191781B1 (pl)	2006-07-31
IS4734A (is)	1998-05-05
SK62898A3 (en)	1999-06-11
DK1384710T3 (da)	2008-11-17
CA2238574C (en)	2004-10-19
CA2238574A1 (en)	1997-06-05
CN1202903A (zh)	1998-12-23
HK1017363A1 (en)	1999-11-19
EP0863917B1 (en)	2003-10-01
EP1384710B1 (en)	2008-07-16
ZA969709B (en)	1997-08-25
CA2471775C (en)	2008-01-29
EP1384710A1 (en)	2004-01-28
PL326865A1 (en)	1998-10-26
DE69630233T2 (de)	2004-08-05
AU7572296A (en)	1997-06-19
EA001372B1 (ru)	2001-02-26
IL134685A0 (en)	2001-04-30
DE69637604D1 (de)	2008-08-28
CZ297297B6 (cs)	2006-11-15
SK284392B6 (sk)	2005-03-04
KR19990071672A (ko)	1999-09-27
ES2310222T3 (es)	2009-01-01
NO982252L (no)	1998-05-15
NO324035B1 (no)	2007-07-30
KR100445754B1 (ko)	2004-12-08
DK0863917T3 (da)	2004-01-19
HUP9903771A3 (en)	2000-07-28
ATE401305T1 (de)	2008-08-15
EP0863917A1 (en)	1998-09-16
US6184374B1 (en)	2001-02-06
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CN1166597C (zh)	2004-09-15

Publication	Publication Date	Title
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Manea et al.	2013	lGnRH-III-a promising candidate for anticancer drug development
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