[go: up one dir, main page]

HUP9902797A2 - Mikrorészecskék - Google Patents

Mikrorészecskék

Info

Publication number
HUP9902797A2
HUP9902797A2 HU9902797A HUP9902797A HUP9902797A2 HU P9902797 A2 HUP9902797 A2 HU P9902797A2 HU 9902797 A HU9902797 A HU 9902797A HU P9902797 A HUP9902797 A HU P9902797A HU P9902797 A2 HUP9902797 A2 HU P9902797A2
Authority
HU
Hungary
Prior art keywords
microparticles
organic solvent
solvent
water
biocompatible
Prior art date
Application number
HU9902797A
Other languages
English (en)
Inventor
Danny H. Lewis
Jean Louis Mesens
J. Michael Ramstack
Michael E. Rickey
Original Assignee
Alkermes Controlled Therapeutics Inc.
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21917114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP9902797(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkermes Controlled Therapeutics Inc., Janssen Pharmaceutica N.V. filed Critical Alkermes Controlled Therapeutics Inc.
Publication of HUP9902797A2 publication Critical patent/HUP9902797A2/hu
Publication of HUP9902797A3 publication Critical patent/HUP9902797A3/hu
Publication of HU223532B1 publication Critical patent/HU223532B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

A találmány tárgya eljárás biődegradálható, biőkőmpatíbilismikrőrészecskék előállítására őly módőn, hőgy a mikrőrészecskéket,amelyek biődegradálható, biőkőmpatíbilis pőlimer matrixőt, ebbenhatóanyagőt és egy szerves őldószert tartalmaznak, egy vizesőldószerrendszerrel érintkeztetnek, miáltal az említettmikrőrészecskékben lévő szerves őldószer mennyiségét 2 tömeg% vagyennél kisebb értékre csökkentik és az őldószerrendszer őlyan, hőgylegalább egy valamely következő feltételt kielégíti (a) emelthőmérsékleten van az idő legalább egy részéig, amelynél amikrőrészecskékkel érintkezésbe kerül és a szerves őldószerhalőgénezett szénhidrőgénektől mentes, és (b) vizet és vízzelelkeverhető, az említett szerves őldószert őldó őldószert tartalmaz,majd a mikrőrészecskéket a vizes őldószerrendszerből kinyerik. Atalálmány vőnatkőzik tővábbá a fentiek szerinti eljárással előállítőttmikrőrészecskékre, valamint ezen mikrőrészecskéket tartalmazógyógyszerkészítményekre is. ŕ
HU9902797A 1996-05-07 1997-05-06 Mikrorészecskék HU223532B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4155196P 1996-05-07 1996-05-07
PCT/EP1997/002431 WO1997041837A2 (en) 1996-05-07 1997-05-06 Microparticles

Publications (3)

Publication Number Publication Date
HUP9902797A2 true HUP9902797A2 (hu) 1999-12-28
HUP9902797A3 HUP9902797A3 (en) 2001-09-28
HU223532B1 HU223532B1 (hu) 2004-08-30

Family

ID=21917114

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902797A HU223532B1 (hu) 1996-05-07 1997-05-06 Mikrorészecskék

Country Status (23)

Country Link
US (9) US5792477A (hu)
EP (1) EP0904063B1 (hu)
JP (2) JP3822909B2 (hu)
KR (1) KR100432677B1 (hu)
CN (1) CN1224380C (hu)
AR (2) AR012820A1 (hu)
AU (1) AU733199B2 (hu)
BG (1) BG64036B1 (hu)
BR (1) BR9709217A (hu)
CA (1) CA2251987C (hu)
CZ (1) CZ293578B6 (hu)
EE (1) EE04540B1 (hu)
HU (1) HU223532B1 (hu)
ID (1) ID17505A (hu)
IL (1) IL126509A (hu)
NO (2) NO323591B1 (hu)
NZ (1) NZ333196A (hu)
PL (1) PL188550B1 (hu)
RU (1) RU2201214C2 (hu)
SK (1) SK283852B6 (hu)
UA (1) UA59361C2 (hu)
WO (1) WO1997041837A2 (hu)
ZA (1) ZA973891B (hu)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU219487B (hu) * 1993-11-19 2001-04-28 Janssen Pharmaceutica Nv. Riszperidont tartalmazó mikrorészecskék, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények és előállításuk
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
US6194006B1 (en) * 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
CN1208090C (zh) * 1999-03-31 2005-06-29 詹森药业有限公司 在控制释放制剂中的预胶凝淀粉
EP1044683A1 (en) * 1999-04-15 2000-10-18 Debio Recherche Pharmaceutique S.A. One-step dispersion method for the microencapsulation of water soluble substances
US6291013B1 (en) * 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
US7030097B1 (en) 1999-07-14 2006-04-18 Cornell Research Foundation, Inc. Controlled nucleic acid delivery systems
FR2797784B1 (fr) * 1999-08-27 2001-11-30 Mainelab Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore
ES2162746B1 (es) * 1999-10-21 2003-02-16 Lipotec Sa Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion.
US6705757B2 (en) * 1999-11-12 2004-03-16 Alkermes Controlled Therapeutics, Inc. Ii Method and apparatus for preparing microparticles using in-line solvent extraction
US6331317B1 (en) 1999-11-12 2001-12-18 Alkermes Controlled Therapeutics Ii Inc. Apparatus and method for preparing microparticles
US6495166B1 (en) 1999-11-12 2002-12-17 Alkermes Controlled Therapeutics Inc. Apparatus and method for preparing microparticles using in-line solvent extraction
GB2356386A (en) 1999-11-17 2001-05-23 Tagra Biotechnologies Ltd Microencapsulation
US7838037B2 (en) * 1999-11-17 2010-11-23 Tagra Biotechnologies Ltd. Method of microencapsulation
CA2403252A1 (en) 2000-03-15 2001-09-20 Wolfgang Sadee Neutral antagonists and use thereof in treating drug abuse
GB0008411D0 (en) * 2000-04-05 2000-05-24 Vectura Ltd Pharmaceutical preparations and their manufacture
IL152360A0 (en) 2000-04-19 2003-05-29 Genentech Inc Sustained release formulations
US6264987B1 (en) * 2000-05-19 2001-07-24 Alkermes Controlled Therapeutics Inc. Ii Method for preparing microparticles having a selected polymer molecular weight
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
CA2419115C (en) * 2000-08-15 2011-03-08 Board Of Trustees Of The University Of Illinois Microparticles, and method and apparatus for forming same
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
US6471995B1 (en) * 2000-09-27 2002-10-29 Alkermes Controlled Therapeutics, Inc. Ii Apparatus and method for preparing microparticles using liquid-liquid extraction
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
WO2002028370A1 (en) * 2000-10-06 2002-04-11 Jagotec Ag Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
EP2316490A3 (en) * 2000-10-31 2012-02-01 PR Pharmaceuticals, Inc. Methods and compositions for enhanced delivery of bioactive molecules
US6899898B2 (en) 2000-12-21 2005-05-31 Nektar Therapeutics Induced phase transition method for the production of microparticles containing hydrophobic active agents
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6869617B2 (en) 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20020114843A1 (en) * 2000-12-27 2002-08-22 Ramstack J. Michael Preparation of microparticles having improved flowability
WO2002058671A1 (en) * 2001-01-26 2002-08-01 Debio Recherche Pharmaceutique S.A. Burst free pharmaceutical microparticules
WO2002067991A1 (en) * 2001-02-23 2002-09-06 Genentech, Inc. Erodible polymers for injection
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
PT1397155E (pt) * 2001-06-21 2015-12-07 Genentech Inc Formulação de libertação sustentada
US6730772B2 (en) 2001-06-22 2004-05-04 Venkatram P. Shastri Degradable polymers from derivatized ring-opened epoxides
WO2003002100A1 (en) * 2001-06-26 2003-01-09 Farrell John J Tamper-proof narcotic delivery system
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
EP1455593B1 (en) 2001-10-06 2013-07-24 Merial Limited Methods and compositions for promoting growth and innate immunity in young animals
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
SE0201599D0 (sv) * 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
JP2006503004A (ja) * 2002-07-31 2006-01-26 アルザ・コーポレーション 射出可能なデポ組成物及びその使用
US6800663B2 (en) * 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
WO2004064752A2 (en) * 2003-01-22 2004-08-05 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
US7736391B2 (en) 2003-02-06 2010-06-15 Tonaba Healthscience Ii, Llc Cosmetic and reconstructive prostheses with a microencapsulated biologically compatible rupture indicator for sustained release and methods of detecting compromise of a prosthesis
US6908484B2 (en) * 2003-03-06 2005-06-21 Spinecore, Inc. Cervical disc replacement
US20070207211A1 (en) * 2003-04-10 2007-09-06 Pr Pharmaceuticals, Inc. Emulsion-based microparticles and methods for the production thereof
BRPI0409032A (pt) * 2003-04-10 2006-05-02 Pr Pharmaceuticals método para a produção de micropartìculas à base de emulsão
WO2004108792A2 (en) * 2003-04-10 2004-12-16 Vinod Chintamani Malshe Novel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof
CA2527994C (en) * 2003-06-03 2014-11-18 Santen Pharmaceutical Co., Ltd. Process for producing microparticles
US7279579B2 (en) * 2003-06-04 2007-10-09 Alkermes, Inc. Polymorphic forms of naltrexone
ES2600554T3 (es) 2003-07-18 2017-02-09 Oakwood Laboratories L.L.C. Prevención de la reducción del peso molecular del polímero, de la formación de impurezas y de la gelificación en composiciones poliméricas
US8900636B2 (en) 2003-07-23 2014-12-02 Evonik Corporation Controlled release compositions
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
WO2005015160A2 (en) * 2003-08-07 2005-02-17 The Children's Hospital Of Philadelphia Functionalized polymeric colloids
US7309500B2 (en) * 2003-12-04 2007-12-18 The Board Of Trustees Of The University Of Illinois Microparticles
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2005070332A1 (en) * 2004-01-12 2005-08-04 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
JP2007517912A (ja) * 2004-01-13 2007-07-05 バソジェニックス ファーマシューティカルズ， インコーポレイテッド 心脈管および腎臓の適応症のための制御放出ｃｇｒｐ送達組成物
EP1703916A2 (en) * 2004-01-13 2006-09-27 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by calcitonin gene related peptide and compositions containing the same
WO2005070444A2 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by calcitonin gene related peptide and compositions containing the same
US20050245461A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US20050245541A1 (en) * 2004-03-19 2005-11-03 Elliot Ehrich Methods for treating alcoholism
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
DK1734971T3 (da) 2004-04-15 2012-02-13 Alkermes Pharma Ireland Ltd Indretning på polymerbasis med forsinket frigivelse
US7919499B2 (en) 2004-04-22 2011-04-05 Alkermes, Inc. Naltrexone long acting formulations and methods of use
US20050260272A1 (en) * 2004-05-05 2005-11-24 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
US7748343B2 (en) 2004-11-22 2010-07-06 The Board Of Trustees Of The University Of Illinois Electrohydrodynamic spraying system
EP1679065A1 (en) * 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
EP1838305A1 (en) * 2005-01-21 2007-10-03 Richard H. Matthews Radiosensitizer formulations comprising nitrohistidine derivatives
US20080213593A1 (en) * 2005-01-21 2008-09-04 President And Fellows Of Harvard College Systems And Methods For Forming Fluidic Droplets Encapsulated In Particles Such As Colloidal Particles
US8598092B2 (en) 2005-02-02 2013-12-03 Halliburton Energy Services, Inc. Methods of preparing degradable materials and methods of use in subterranean formations
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
CN103637977A (zh) * 2005-07-18 2014-03-19 宾夕法尼亚大学理事会 含药植入物及其使用方法
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US7669732B2 (en) * 2005-10-25 2010-03-02 Imi Cornelius Inc. Cup lid dispenser
WO2007076462A2 (en) * 2005-12-22 2007-07-05 Oakwood Laboratories, Llc Sublimable sustained release delivery system and method of making same
US8747870B2 (en) 2006-04-20 2014-06-10 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
WO2007124132A2 (en) * 2006-04-20 2007-11-01 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
KR100781604B1 (ko) * 2006-06-13 2007-12-03 한불화장품주식회사 다가 알코올을 이용한 난용성 활성 성분 함유 중공형 다중마이크로캡슐의 제조 방법 및 이를 함유하는 화장료 조성물
PT2359808E (pt) 2006-08-09 2013-08-28 Intarcia Therapeutics Inc Sistemas de entrega osmótica e montagens de pistão
US8202524B2 (en) 2006-08-31 2012-06-19 Sk Chemicals Co., Ltd. Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby
US20090263346A1 (en) * 2006-12-05 2009-10-22 David Taft Systems and methods for delivery of drugs
EP2101745A4 (en) * 2006-12-05 2009-12-30 Landec Corp ADMINISTRATION OF MEDICINES
WO2008084093A2 (en) * 2007-01-11 2008-07-17 Novozymes A/S Particles comprising active compounds
AU2008231093A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
PL2157967T3 (pl) 2007-04-23 2013-06-28 Intarcia Therapeutics Inc Formulacje zawiesinowe peptydów insulinotropowych i ich zastosowania
MX337286B (es) 2007-05-25 2016-02-22 Indivior Uk Ltd Formulaciones de transferencia sostenida de compuestos de risperidona.
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
US8748448B2 (en) 2007-10-18 2014-06-10 Aiko Biotechnology Combination analgesic employing opioid agonist and neutral antagonist
WO2009051824A2 (en) 2007-10-18 2009-04-23 Aiko Biotechnology Combination analgesic employing opioid and neutral antagonist
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
BRPI0906754A2 (pt) * 2008-02-04 2015-07-07 Torrent Pharmaceuticals Ltd Formulário de dosage prolongado da libertação de paliperidone
AU2009212367B2 (en) * 2008-02-08 2013-08-01 Foresee Pharmaceuticals Co., Ltd. Composition for sustained release delivery of proteins or peptides
CA2726861C (en) 2008-02-13 2014-05-27 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
HUE047004T2 (hu) 2008-06-16 2020-04-28 Pfizer Hatóanyaggal töltött polimer nanorészecskék és eljárások elõállításukra és alkalmazásukra
JP2012501966A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド ビンカアルカロイド含有治療用ポリマーナノ粒子並びにその製造方法及び使用方法
WO2010030763A2 (en) * 2008-09-10 2010-03-18 Bind Biosciences, Inc. High throughput fabrication of nanoparticles
JP5757872B2 (ja) * 2008-09-11 2015-08-05 エボニック コーポレイションＥｖｏｎｉｋ Ｃｏｒｐｏｒａｔｉｏｎ 調整可能な抽出速度を有する溶媒抽出マイクロカプセル化
WO2010033776A1 (en) * 2008-09-18 2010-03-25 Surmodics Pharmaceuticals, Inc. Microencapsulation process with solvent and salt
CA2743600C (en) * 2008-11-14 2016-11-08 Ewha University-Industry Collaboration Foundation Method for preparing microspheres and microspheres produced thereby
US20100143479A1 (en) * 2008-12-04 2010-06-10 Oakwood Laboratories, Llc Method of making sustained release microparticles
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
JP2012512175A (ja) 2008-12-15 2012-05-31 バインド バイオサイエンシズ インコーポレイテッド 治療薬を徐放するための長時間循環性ナノ粒子
ES2319158B1 (es) * 2008-12-23 2010-01-26 Grifols, S.A Composicion de microparticulas biocompatibles de acido alginico para la liberacion controlada de principios activos por via intravenosa.
CA2749993C (en) * 2009-01-23 2016-12-20 Surmodics Pharmaceuticals, Inc. Continuous double emulsion process for making microparticles
US20100196436A1 (en) * 2009-01-30 2010-08-05 Gooberman Lance L Implants containing disulfiram and an anti-inflammatory agent
US8791093B2 (en) * 2009-05-29 2014-07-29 Lance L. Gooberman Pharmaceutical delivery systems for treatment of substance abuse and other addictions
HUE035862T2 (hu) 2009-09-28 2018-05-28 Intarcia Therapeutics Inc Lényegében állandósult gyógyszeradagolás gyors kialakítása és/vagy befejezése
US8641900B2 (en) * 2009-11-05 2014-02-04 Taiwan Biotech Co., Ltd Method and device for continuously preparing microspheres, and collection unit thereof
JP5891175B2 (ja) 2009-12-11 2016-03-22 バインド セラピューティックス インコーポレイテッド 治療用粒子の凍結乾燥に対する安定製剤
EA201290499A1 (ru) 2009-12-15 2013-01-30 Байнд Байосайенсиз, Инк. Композиции терапевтических полимерных наночастиц с высокой температурой стеклования и высокомолекулярными сополимерами
US8207290B2 (en) 2010-03-26 2012-06-26 Cerulean Pharma Inc. Methods and systems for generating nanoparticles
WO2011143226A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
KR20120011344A (ko) * 2010-07-21 2012-02-08 에스케이케미칼주식회사 고분자 미립구의 제조방법 및 그 방법에 의해 제조된 고분자 미립구
CA2813302A1 (en) * 2010-09-30 2012-04-05 Evonik Corporation Emulsion method for preparing low residual solvent microparticles
US20120082731A1 (en) * 2010-09-30 2012-04-05 Adrian Raiche Method For Removing Residual Organic Solvent From Microparticles
EP3257498B1 (en) * 2010-12-29 2019-04-24 Medincell Biodegradable drug delivery compositions
US8546521B2 (en) 2011-01-28 2013-10-01 Cerulean Pharma Inc. Method for fabricating nanoparticles
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
KR101481859B1 (ko) * 2011-05-20 2015-01-14 에스케이케미칼주식회사 초기 약물 방출이 감소된 고분자 미립자의 제조방법 및 그 방법에 의해 제조된 고분자 미립자
KR101265955B1 (ko) 2011-09-07 2013-05-22 한불화장품주식회사 혼합 생약 추출발효물을 배합시킨 마이크로캡슐을 포함하는 화장료 조성물
JP6356678B2 (ja) 2012-09-17 2018-07-11 ファイザー・インク 治療用ナノ粒子を製造する方法
CN103834054B (zh) * 2012-11-27 2018-05-11 东丽先端材料研究开发（中国）有限公司 聚乳酸中空微球的制备方法
HUE036141T2 (hu) * 2013-06-20 2018-06-28 Pharmathen Sa Szigmoid kibocsátási profillal bíró polilaktid-poliglikolid mikrorészecskék elõállítása
SMT201700494T1 (it) 2013-06-20 2018-01-11 Pharmathen Sa Preparazione di microparticelle di polilattide-poliglicolide aventi un profilo di rilascio sigmoidale
WO2015020240A1 (ko) 2013-08-06 2015-02-12 동국제약 주식회사 엔테카비어 미립구 및 이를 포함하는 비경구투여용 약제학적 조성물
JP6505705B2 (ja) * 2013-12-05 2019-04-24 アルライズ バイオシステムズ ゲゼルシャフト ミット ベシュレンクテル ハフツング 経口投与用製剤の製造方法
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
PE20170312A1 (es) 2014-03-14 2017-03-30 Pfizer Nanoparticulas terapeuticas que comprenden un agente terapeutico, y metodos para su elaboracion y uso
US9439864B2 (en) * 2014-07-07 2016-09-13 Antriabio, Inc. Solvent extraction from biodegradable microparticles
KR101738127B1 (ko) * 2014-08-08 2017-05-22 (주)비씨월드제약 약물 함유 서방성 미립자의 제조 방법
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3215223B1 (en) 2014-11-07 2020-07-01 Indivior UK Limited Buprenorphine dosing regimens
MX2017015504A (es) 2015-06-03 2018-05-15 Intarcia Therapeutics Inc Sistemas de colocacion y remoción de implante.
WO2016198113A1 (en) 2015-06-11 2016-12-15 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
PT3377041T (pt) 2015-11-16 2023-12-15 Maria Pereira Da Cruz Alves Garcia Método para morcelação e/ou direcionamento de princípios farmaceuticamente ativos ao tecido sinovial
CA3024479A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
WO2018178973A1 (en) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
CN109718212A (zh) * 2017-10-30 2019-05-07 浙江圣兆药物科技股份有限公司 一种减少利培酮微球中低挥发溶剂苯甲醇的方法
CN109718209B (zh) * 2017-10-30 2021-03-05 浙江圣兆药物科技股份有限公司 一种低乙醇残留的利培酮微球冻干方法
KR101862197B1 (ko) * 2018-02-02 2018-05-29 이상운 빗물 고임 방지구조를 갖는 안내판 고정장치
CN111714442B (zh) * 2019-03-04 2024-04-12 广州铂思雅生物医药科技有限公司 植入剂的制备
GR1009870B (el) * 2019-07-09 2020-11-12 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει ενα ατυπο αντιψυχωσικο φαρμακο και μεθοδος παρασκευης αυτου
CN110407652B (zh) * 2019-08-19 2021-02-02 安徽雷鸣科化有限责任公司 一种水胶炸药的混装设备及其控制方法
CN113116830B (zh) * 2019-12-31 2024-07-02 广州铂思雅生物医药科技有限公司 缓释颗粒的制备
EP4125823A1 (en) * 2020-03-30 2023-02-08 Biological E Limited Risperidone microspheres, process for their prepartion and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634668A (hu) * 1962-07-11
BE744162A (fr) * 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd Procede d'encapsulage
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
DE2010115A1 (de) * 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von Mikrogranulaten
JPS523342B2 (hu) * 1972-01-26 1977-01-27
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
JPS523653A (en) * 1975-06-27 1977-01-12 Fuji Photo Film Co Ltd Process for producing fine polymer particles
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4530840A (en) * 1982-07-29 1985-07-23 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
WO1989003678A1 (en) * 1987-10-30 1989-05-05 Stolle Research & Development Corporation Low residual solvent microspheres and microencapsulation process
DE8812411U1 (de) 1988-09-29 1990-02-08 Siemens AG, 1000 Berlin und 8000 München Behälter einer gasisolierten Mittelspannungs-Lastschaltanlage
IL92344A0 (en) * 1989-01-04 1990-07-26 Gist Brocades Nv Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules
CA2050911C (en) * 1989-05-04 1997-07-15 Thomas R. Tice Encapsulation process and products therefrom
US5478564A (en) * 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
HU222501B1 (hu) * 1991-06-28 2003-07-28 Endorecherche Inc. MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására
CA2148823C (en) * 1992-11-17 1999-03-09 Welfide Corporation Sustained release microsphere preparation containing antipsychotic drug and production process thereof
EP1649850A1 (en) * 1993-11-19 2006-04-26 Alkermes Controlled Therapeutics Inc. II Preparation of biodegradable microparticles containing a biologically active agent
HU219487B (hu) * 1993-11-19 2001-04-28 Janssen Pharmaceutica Nv. Riszperidont tartalmazó mikrorészecskék, eljárás előállításukra, alkalmazásuk és ezeket tartalmazó gyógyászati készítmények és előállításuk
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
US5945126A (en) 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process

Also Published As

Publication number Publication date
CA2251987C (en) 2005-05-10
US20020028249A1 (en) 2002-03-07
WO1997041837A2 (en) 1997-11-13
US6403114B1 (en) 2002-06-11
RU2201214C2 (ru) 2003-03-27
KR100432677B1 (ko) 2004-09-13
JP4769119B2 (ja) 2011-09-07
PL188550B1 (pl) 2005-02-28
KR20000010697A (ko) 2000-02-25
CA2251987A1 (en) 1997-11-13
BG102854A (bg) 1999-05-31
JP3822909B2 (ja) 2006-09-20
JP2000503663A (ja) 2000-03-28
IL126509A0 (en) 1999-08-17
EP0904063A2 (en) 1999-03-31
AR046034A2 (es) 2005-11-23
US5792477A (en) 1998-08-11
AU733199B2 (en) 2001-05-10
AU2897297A (en) 1997-11-26
NO984808D0 (no) 1998-10-15
CZ293578B6 (cs) 2004-06-16
UA59361C2 (uk) 2003-09-15
NO984808L (no) 1999-01-06
CN1224380C (zh) 2005-10-26
US20020146457A1 (en) 2002-10-10
ZA973891B (en) 1997-11-07
US5916598A (en) 1999-06-29
NZ333196A (en) 2000-02-28
AR012820A1 (es) 2000-11-22
SK154198A3 (en) 1999-05-07
NO20065995L (no) 1999-01-06
ID17505A (id) 1998-01-08
EE9800383A (et) 1999-04-15
US6110503A (en) 2000-08-29
EP0904063B1 (en) 2002-09-04
US20050276859A1 (en) 2005-12-15
IL126509A (en) 2004-08-31
SK283852B6 (sk) 2004-03-02
HU223532B1 (hu) 2004-08-30
JP2006249440A (ja) 2006-09-21
BR9709217A (pt) 1999-08-10
HUP9902797A3 (en) 2001-09-28
US20030129249A1 (en) 2003-07-10
CZ359198A3 (cs) 1999-03-17
US20040197417A1 (en) 2004-10-07
EE04540B1 (et) 2005-10-17
PL329720A1 (en) 1999-04-12
BG64036B1 (bg) 2003-11-28
WO1997041837A3 (en) 1998-02-26
NO323591B1 (no) 2007-06-11
CN1226821A (zh) 1999-08-25
US6290983B1 (en) 2001-09-18

Similar Documents

Publication Publication Date Title
HUP9902797A2 (hu) Mikrorészecskék
MY118174A (en) Process for the preparation of microparticles
DE69622006D1 (de) Herstellung von Microspheren
AU6070694A (en) Process for preparing a dehydrogenation catalyst
AU8142594A (en) Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
TW284813B (hu)
NO962874L (no) Preparering av ben for transplantasjon
GR3026338T3 (en) High release solid preparation, preparation and use thereof
CA2252607A1 (en) Medical devices with improved elastic response
FR2619391B1 (fr) Procede de reduction d'un catalyseur de raffinage avant sa mise en oeuvre
EP0922451A3 (en) Microcapsules containing seminal material for artificial insemination in pigs
GB8829539D0 (en) Granules based on hydrophilic polymers on which an aqueous formulation,containing one or more active principles,is absorbed
AU4285697A (en) Aqueous local anaesthetic solution, method for improving solubility of local anaesthetic, local anaesthetic agent with decreased neurotoxicity and method for decreasing neurotoxicity of local anaesthetic agent
CA2004050A1 (en) Oxygen removal with carbon catalyzed erythorbate or ascorbate
WO2001047339A3 (en) Anchoring device for a threaded member
GB9817805D0 (en) Use of a composition
CA2006825A1 (en) Method for the destruction of halogenated organic compounds in a contaminated medium
EP1611908A3 (en) Absorbent for removing substances related to malady in body fluid, method for removing the same, device for body fluid purification and system for body fluid purification
RU94010864A (ru) Способ получения инсулинсодержащих полимерных гидрогелей
EP0798284A3 (en) Method for treating a solution of organic compound
FR2700240B1 (fr) Procédé de destruction notamment d'algues marines telles que la Caulerpa Taxifolia, et installation pour la mise en Óoeuvre du procédé.
EP0793235A3 (en) Single-chip memory system having a decoder for pulse word line method
MX220674B (en) Process for hydrolysis of adiponitrile and prodn. of nylon 6,6 utilizing low catalyst levels
ES2077091T3 (es) 7-(difenilmetil)oxi-9a-metoximitosano y su obtencion y uso.
EDWINKIESTER JR What We Know Now About Melatonin

Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20040526