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HUP9901651A2 - Eljárás 13-cisz-retinsav előállítására - Google Patents

Eljárás 13-cisz-retinsav előállítására

Info

Publication number
HUP9901651A2
HUP9901651A2 HU9901651A HUP9901651A HUP9901651A2 HU P9901651 A2 HUP9901651 A2 HU P9901651A2 HU 9901651 A HU9901651 A HU 9901651A HU P9901651 A HUP9901651 A HU P9901651A HU P9901651 A2 HUP9901651 A2 HU P9901651A2
Authority
HU
Hungary
Prior art keywords
formula
retinoic acid
cis
progenitor
beta
Prior art date
Application number
HU9901651A
Other languages
English (en)
Inventor
Angelo Magnone Grato
Original Assignee
Laboratori Mag S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Mag S.P.A. filed Critical Laboratori Mag S.P.A.
Publication of HU9901651D0 publication Critical patent/HU9901651D0/hu
Publication of HUP9901651A2 publication Critical patent/HUP9901651A2/hu
Publication of HUP9901651A3 publication Critical patent/HUP9901651A3/hu
Publication of HU229518B1 publication Critical patent/HU229518B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

A találmány tárgya eljárás nagy tisztaságú és stabilitású 13-cisz-retinsav előállítására. Az eljárásban nem alkalmaznak nehézfémeket. Azeljárást az jellemzi, hőgy a (IV) képletű beta-iőnőnt az (V) általánősképletű - ahől X jelentése klór-, jód- vagy brómatőm - vinil-magnéziűm-halőgeniddel reagáltatják, a kapőtt (VI) képletű vinil-beta-iőnőlt (VII) képletű 4-hidrőxi-3-metil-bűtenőliddal Wittig-kőndenzációval reagáltatják, (I) képletű 13-cisz-retinsav, (II)képletű 11,13-di-cisz-retinsav és (III) képletű 11,13-di-transz-retinsav izőmer elegy előállítására, a kapőtt savak alkálifém sóitfőtőkémiai izőmerizációnak vetik alá. ŕ
HU9901651A 1998-05-19 1999-05-19 Eljárás 13-cisz-retinsav elõállítására HU229518B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI001093A IT1299582B1 (it) 1998-05-19 1998-05-19 Procedimento per la preparazione dell'acido 13-cis-retinoico

Publications (4)

Publication Number Publication Date
HU9901651D0 HU9901651D0 (en) 1999-07-28
HUP9901651A2 true HUP9901651A2 (hu) 1999-12-28
HUP9901651A3 HUP9901651A3 (en) 2000-06-28
HU229518B1 HU229518B1 (hu) 2014-01-28

Family

ID=11380052

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901651A HU229518B1 (hu) 1998-05-19 1999-05-19 Eljárás 13-cisz-retinsav elõállítására

Country Status (16)

Country Link
US (1) US6177579B1 (hu)
EP (1) EP0959069B1 (hu)
JP (1) JP4418048B2 (hu)
AT (1) ATE226190T1 (hu)
BR (1) BR9901551B1 (hu)
CA (1) CA2272439C (hu)
DE (1) DE69903498T2 (hu)
DK (1) DK0959069T3 (hu)
ES (1) ES2185263T3 (hu)
HU (1) HU229518B1 (hu)
IN (1) IN188476B (hu)
IT (1) IT1299582B1 (hu)
NO (1) NO317759B1 (hu)
PL (1) PL192958B1 (hu)
SG (1) SG80628A1 (hu)
ZA (1) ZA993395B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763748B2 (en) * 2007-02-20 2010-07-27 Ipca Laboratories Limited Process for preparation of highly pure isotretinoin
CN104447459A (zh) * 2014-11-28 2015-03-25 重庆华邦制药有限公司 异维a酸的新晶型及其制备方法与应用
CN111454141A (zh) * 2020-04-26 2020-07-28 上海新华联制药有限公司 一种异维a酸缩合物及其制备方法和应用
CN116283495B (zh) * 2021-12-01 2024-12-03 万华化学集团股份有限公司 一种乙烯基-β-紫罗兰醇的制备方法
CN116462621A (zh) * 2023-02-20 2023-07-21 湖北恒安芙林药业股份有限公司 一种维a酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3200231A1 (de) 1982-01-07 1983-07-21 Basf Ag, 6700 Ludwigshafen (alpha)-pyrone und verfahren zur herstellung von polyencarbonsaeuren
DE4313089A1 (de) 1993-04-22 1994-10-27 Basf Ag Verfahren zur Herstellung von 13-(Z)-Retinsäure
IT1289528B1 (it) 1996-12-27 1998-10-15 Lab Mag Spa Procedimento per la preparazione dell'acido 13,cis-retinoico

Also Published As

Publication number Publication date
PL333200A1 (en) 1999-11-22
PL192958B1 (pl) 2006-12-29
NO317759B1 (no) 2004-12-13
NO992396L (no) 1999-11-22
JP2000034275A (ja) 2000-02-02
HU229518B1 (hu) 2014-01-28
ZA993395B (en) 1999-11-18
US6177579B1 (en) 2001-01-23
IN188476B (hu) 2002-09-28
ITMI981093A1 (it) 1999-11-19
HUP9901651A3 (en) 2000-06-28
EP0959069A1 (en) 1999-11-24
HU9901651D0 (en) 1999-07-28
DE69903498D1 (de) 2002-11-21
CA2272439A1 (en) 1999-11-19
ATE226190T1 (de) 2002-11-15
DK0959069T3 (da) 2003-02-24
JP4418048B2 (ja) 2010-02-17
BR9901551A (pt) 2000-05-30
EP0959069B1 (en) 2002-10-16
NO992396D0 (no) 1999-05-19
IT1299582B1 (it) 2000-03-16
DE69903498T2 (de) 2003-02-27
BR9901551B1 (pt) 2010-10-19
ES2185263T3 (es) 2003-04-16
CA2272439C (en) 2010-05-11
SG80628A1 (en) 2001-05-22

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: OLON S.P.A., IT

Free format text: FORMER OWNER(S): LABORATORI MAG S.P.A., IT; OLON S.P.A., IT