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HRP20171472T1 - Optimizirana monoklonska protutijela protiv inhibitora puta tkivnog faktora (tfpi) - Google Patents

Optimizirana monoklonska protutijela protiv inhibitora puta tkivnog faktora (tfpi) Download PDF

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Publication number
HRP20171472T1
HRP20171472T1 HRP20171472TT HRP20171472T HRP20171472T1 HR P20171472 T1 HRP20171472 T1 HR P20171472T1 HR P20171472T T HRP20171472T T HR P20171472TT HR P20171472 T HRP20171472 T HR P20171472T HR P20171472 T1 HRP20171472 T1 HR P20171472T1
Authority
HR
Croatia
Prior art keywords
seq
residues
amino acid
acid sequence
substitution
Prior art date
Application number
HRP20171472TT
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English (en)
Inventor
Peter Scholz
Zhuozhi Wang
Junliang Pan
Joanna Grudzinska
Christian Votsmeier
Jan Tebbe
Jörg BIRKENFELD
Nina Wobst
Simone BRÜCKNER
Susanne Steinig
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44542552&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20171472(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of HRP20171472T1 publication Critical patent/HRP20171472T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Filtering Materials (AREA)

Claims (3)

1. Ljudsko monoklonsko IgG protutijelo koje se specifično veže na inhibitor puta ljudskog tkivnog faktora, naznačeno time da protutijelo sadrži: a. ljudski teški lanac koji sadrži: -regiju CDR1 sa sekvencom amino kiseline FTFRSYGMD (što odgovara ostatcima 27 do 35 iz SEQ ID NO: 1 sa supstitucijom S35D); - regiju CDR2 sa sekvencom amino kiseline SIRGSRSSTYYADSVKG (što odgovara ostatcima 50 do 66 iz SEQ ID NO: 1 sa supstitucijom S55R); - regiju CDR3 sa sekvencom amino kiseline LYRYWFDY (što odgovara ostatcima 99 do 106 iz SEQ ID NO: 1 sa supstitucijom K99L); i
2. ljudski laki lanac koji sadrži: - regiju CDR1 sa sekvencom amino kiseline SGDNLRNYYAH (što odgovara ostatcima 23 do 33 iz SEQ ID NO: 2); - regiju CDR2 sa sekvencom amino kiseline FYDVNRPS (što odgovara ostatcima 48 do 55 iz SEQ ID NO: 2 sa supstitucijom Y48F i N51V); - regiju CDR3 sa sekvencom amino kiseline QSWWDGVPV (što odgovara ostatcima 88 do 96 iz SEQ ID NO: 2 sa supstitucijom D91W). 2. Ljudsko monoklonsko IgG protutijelo prema zahtjevu 1, naznačeno time da a. ljudski teški lanac sadrži SEQ ID NO: 7 i b. ljudski laki lanac sadrži SEQ ID NO: 14.
3. Lijek naznačen time da sadrži ljudsko monoklonsko IgG protutijelo prema bilo kojem od zahtjeva 1-2.
HRP20171472TT 2010-03-01 2011-03-01 Optimizirana monoklonska protutijela protiv inhibitora puta tkivnog faktora (tfpi) HRP20171472T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30929010P 2010-03-01 2010-03-01
EP11751244.2A EP2542257B1 (en) 2010-03-01 2011-03-01 Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
PCT/US2011/026766 WO2011109452A1 (en) 2010-03-01 2011-03-01 Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI)

Publications (1)

Publication Number Publication Date
HRP20171472T1 true HRP20171472T1 (hr) 2017-12-01

Family

ID=44542552

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20171472TT HRP20171472T1 (hr) 2010-03-01 2011-03-01 Optimizirana monoklonska protutijela protiv inhibitora puta tkivnog faktora (tfpi)
HRP20192295TT HRP20192295T1 (hr) 2010-03-01 2019-12-20 Optimizirana monoklonska protutijela protiv inhibitora faktora tkivnog puta (tfpi)

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20192295TT HRP20192295T1 (hr) 2010-03-01 2019-12-20 Optimizirana monoklonska protutijela protiv inhibitora faktora tkivnog puta (tfpi)

Country Status (37)

Country Link
US (3) USRE47150E1 (hr)
EP (2) EP2542257B1 (hr)
JP (4) JP6025570B2 (hr)
KR (4) KR101903931B1 (hr)
CN (5) CN107987166A (hr)
AU (1) AU2011223710B2 (hr)
BR (1) BR112012022258A2 (hr)
CA (3) CA2976671C (hr)
CL (2) CL2012002415A1 (hr)
CO (1) CO6620068A2 (hr)
CR (1) CR20120453A (hr)
CU (1) CU23982B1 (hr)
CY (2) CY1119410T1 (hr)
DK (2) DK3345615T3 (hr)
DO (1) DOP2012000239A (hr)
EA (2) EA201892184A1 (hr)
EC (2) ECSP12012134A (hr)
ES (2) ES2642512T3 (hr)
GT (1) GT201200252A (hr)
HK (2) HK1232232A1 (hr)
HR (2) HRP20171472T1 (hr)
HU (2) HUE036655T2 (hr)
IL (3) IL221551B (hr)
LT (2) LT3345615T (hr)
ME (2) ME03578B (hr)
MX (2) MX2012010198A (hr)
MY (1) MY174760A (hr)
NZ (2) NZ602115A (hr)
PE (1) PE20160538A1 (hr)
PH (4) PH12012501742A1 (hr)
PL (2) PL3345615T3 (hr)
PT (2) PT3345615T (hr)
RS (2) RS56409B1 (hr)
SG (3) SG183443A1 (hr)
SI (2) SI3345615T1 (hr)
SM (1) SMT201700454T1 (hr)
WO (1) WO2011109452A1 (hr)

Families Citing this family (16)

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Publication number Priority date Publication date Assignee Title
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
KR101600308B1 (ko) 2008-12-22 2016-03-07 노보 노르디스크 에이/에스 조직 인자 경로 억제자에 대한 항체
SI3345615T1 (sl) 2010-03-01 2020-03-31 Bayer Healthcare Llc Optimizirana monoklonska protitelesa proti zaviralcu poti tkivnega faktorja (TFPI)
US9260518B2 (en) * 2010-06-30 2016-02-16 Novo Nordisk A/S Antibodies that are capable of specifically binding tissue factor pathway inhibitor
BR112013025376A2 (pt) * 2011-04-01 2017-07-25 Bayer Healthcare Llc anticorpos monoclonais contra inibidor da via de fator tecidual (tfpi)
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CA2906128A1 (en) 2013-03-15 2014-09-18 Bayer Healthcare Llc Anti-tfpi antibody variants with differential binding across ph range for improved pharmacokinetics
CN107428838B (zh) 2015-02-25 2021-01-01 财团法人牧岩生命科学研究所 结合tfpi的新型抗体以及包含所述抗体的组合物
JP6664467B2 (ja) 2015-08-19 2020-03-13 ファイザー・インク 組織因子経路インヒビター抗体およびその使用
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
KR20240135884A (ko) * 2018-10-11 2024-09-12 화이자 인코포레이티드 Tfpi 길항제의 투여량 섭생법
KR102692277B1 (ko) * 2019-03-11 2024-08-05 현대자동차주식회사 상용 전기차용 모터 마운트
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体
CN117285632A (zh) * 2022-06-17 2023-12-26 安源医药科技（上海）有限公司 针对tfpi的单克隆抗体及其用途

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