HRP20130228T1 - Antitijela s visokim afinitetom za receptor humanog il 6 - Google Patents
Antitijela s visokim afinitetom za receptor humanog il 6 Download PDFInfo
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- HRP20130228T1 HRP20130228T1 HRP20130228TT HRP20130228T HRP20130228T1 HR P20130228 T1 HRP20130228 T1 HR P20130228T1 HR P20130228T T HRP20130228T T HR P20130228TT HR P20130228 T HRP20130228 T HR P20130228T HR P20130228 T1 HRP20130228 T1 HR P20130228T1
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- Prior art keywords
- antibody
- fragment
- antigen
- binds
- disease
- Prior art date
Links
- 102000010781 Interleukin-6 Receptors Human genes 0.000 title 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- 102000052623 human IL6R Human genes 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 3
- 206010003246 arthritis Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 108040006858 interleukin-6 receptor activity proteins Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Claims (14)
1. Antitijelo ili njegov fragment koji se veže na antigen, koji se specifično veže na receptor humanoginterleukina 6 (hIL-6R) sa konstantom KD od 500 pM ili manje, izmjereno površinskom plazmon rezonancijom, naznačen time, da:
(i) regije CDR teškog lanca uključuju SEQ ID NO 5, 7 i 9 što odgovara regijama CDR1, CDR2 i CDR3 teških lanaca
(ii) regije CDR lakih lanaca CDR uključuju SEQ ID NO 13, 15 i 17 što odgovara regijama CDR1, CDR2 i CDR3 lakih lanaca.
2. Antitijelo, ili njegov fragment koji se veže na antigen prema zahtjevu 1, naznačen time, da sadržava par HCVR / LCVR odsječka SEQ ID NO 3/11.
3. Antitijelo ili njegov fragment koji se veže na antigen prema zahtjevu 1 ili 2, naznačen time, da se specifično veže na receptor hIL-6R s KD od 300 pM ili manje izmjereno rezonancijom površinskih plazmona.
4. Antitijelo ili njegov fragment koji se veže na antigen prema zahtjevu 1, 2 ili 3, naznačen time, da se veže na hIL-6R s afinitetom najmanje 1,5 puta većim u odnosu na afinitet vezivanja prema IL-6R majmuna.
5. Antitijelo ili njegov fragment koji se veže na antigen prema bilo kojem od prethodnih zahtjeva, naznačen time, da je fragment koji se veže na antigen odabran između Fab, F(ab')2 i scFv.
6. Izolirana molekula nukleinske kiseline u skladu s bilo kojim od prethodnih zahtjeva, naznačena time, da kodira antitijelo ili njegov fragment koji se veže na antigen.
7. Ekspresijski vektor, naznačen time, da sadržava molekulu nukleinske kiseline u skladu s patentnim zahtjevom 6.
8. Izolirana stanica domaćina, naznačena time, da sadrži ekspresijski vektor prema zahtjevu 7.
9. Stanica domaćina prema zahtjevu 8, naznačena time, da je stanica domaćina prokariotska ili eukariotska stanice odabrana između E. coli ili CHO stanice.
10. Postupak za proizvodnju anti-IL-6R antitijela ili njegovog fragmenta koji se veže na antigen, naznačen time, da uključuje uzgoj stanica domaćina u skladu sa zahtjevom 8 ili 9 u uvjetima koji omogućavaju proizvodnju antitijela ili njegovog fragmenta i prikupljanje tako proizvedenog protutijela ili njegovog fragmenta.
11. Upotreba antitijela ili njegovog fragmenta koji se veže na antigen prema bilo kojem od patentnih zahtjeva 1 od 5, naznačen time, da se upotrebljava u proizvodnji lijeka čijom uporabom se smanjuje ili inhibira bolest ili poremećaja u čovjeka kojima je IL-6 medijator pri čemu je bolest ili poremećaj kojima je IL-6 medijator artritis, upalna bolest crijeva ili sistemski eritematozni lupus.
12. Antitijelo ili njegov fragment koji se veže na antigen prema bilo kojem od patentnih zahtjeva 1 - 5, naznačen time, da se upotrebljava za ublažavanje ili inhibiciju bolesti ili poremećaja u čovjeka kojima je IL-6 medijator pri čemu su bolest ili poremećaj kojima je IL-6 medijator artritis, upalna bolest crijeva ili sistemski eritematozni lupus.
13. Farmaceutski pripravak, naznačen time, da je to pripravak koji sadrži antitijela ili njegov fragment koji se veže na antigen prema bilo kojem od patentnih zahtjeva 1 - 5 i farmaceutski prihvatljiv nosač ili pomoćnu tvar.
14. Uporaba prema zahtjevu 11 ili antitijelo prema zahtjevu 12, naznačeni time, da je artritis kronični reumatični artritis, a navedena upalna bolest crijeva je Crohnova bolest ili ulcerozni kolitis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81066406P | 2006-06-02 | 2006-06-02 | |
| US84323206P | 2006-09-08 | 2006-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130228T1 true HRP20130228T1 (hr) | 2013-04-30 |
Family
ID=38792460
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120175T HRP20120175T1 (hr) | 2006-06-02 | 2012-02-22 | Antitijela s visokim afinitetom za humani il-6 receptor |
| HRP20130228TT HRP20130228T1 (hr) | 2006-06-02 | 2013-03-15 | Antitijela s visokim afinitetom za receptor humanog il 6 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120175T HRP20120175T1 (hr) | 2006-06-02 | 2012-02-22 | Antitijela s visokim afinitetom za humani il-6 receptor |
Country Status (33)
| Country | Link |
|---|---|
| US (9) | US7582298B2 (hr) |
| EP (2) | EP2374818B1 (hr) |
| JP (3) | JP5307708B2 (hr) |
| KR (1) | KR101464502B1 (hr) |
| CN (2) | CN101454345B (hr) |
| AT (1) | ATE537190T1 (hr) |
| AU (1) | AU2007254831B2 (hr) |
| BR (1) | BRPI0712224B8 (hr) |
| CA (1) | CA2652976C (hr) |
| CR (1) | CR10462A (hr) |
| CY (3) | CY1112456T1 (hr) |
| DK (2) | DK2041177T3 (hr) |
| ES (2) | ES2377579T3 (hr) |
| GT (1) | GT200800272A (hr) |
| HR (2) | HRP20120175T1 (hr) |
| HU (1) | HUS1700050I1 (hr) |
| IL (1) | IL195393A (hr) |
| LT (1) | LTC2041177I2 (hr) |
| LU (1) | LUC00050I2 (hr) |
| ME (1) | ME00519B (hr) |
| MX (1) | MX2008014804A (hr) |
| MY (2) | MY159787A (hr) |
| NL (1) | NL300911I2 (hr) |
| NO (2) | NO340778B1 (hr) |
| NZ (2) | NZ587107A (hr) |
| PL (2) | PL2374818T3 (hr) |
| PT (2) | PT2374818E (hr) |
| RS (2) | RS52643B (hr) |
| RU (1) | RU2433138C2 (hr) |
| SI (2) | SI2041177T1 (hr) |
| SV (1) | SV2008003113A (hr) |
| TN (1) | TNSN08502A1 (hr) |
| WO (1) | WO2007143168A2 (hr) |
Families Citing this family (364)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| ES2368733T3 (es) | 2002-07-18 | 2011-11-21 | Merus B.V. | Producción recombinante de mezclas de anticuerpos. |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| EP1639009B1 (en) | 2003-05-30 | 2013-02-27 | Merus B.V. | Fab library for the preparation of a mixture of antibodies |
| US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
| US8945558B2 (en) | 2005-10-21 | 2015-02-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for treating myocardial infarction comprising administering an IL-6 inhibitor |
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP2025346B1 (en) | 2006-04-07 | 2016-08-10 | Osaka University | Muscle regeneration promoter |
| EP2374818B1 (en) | 2006-06-02 | 2012-12-19 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human IL-6 receptor |
| US8080248B2 (en) | 2006-06-02 | 2011-12-20 | Regeneron Pharmaceuticals, Inc. | Method of treating rheumatoid arthritis with an IL-6R antibody |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| EP2074146B1 (en) * | 2006-11-30 | 2013-08-07 | Medlmmune Limited | Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor |
| RU2448979C2 (ru) | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| AU2008208321B2 (en) | 2007-01-23 | 2013-03-21 | Chugai Seiyaku Kabushiki Kaisha | Chronic rejection inhibitor |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US20090238825A1 (en) * | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
| US7906117B2 (en) | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
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| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| AU2008254578B2 (en) * | 2007-05-21 | 2013-06-06 | Alderbio Holdings Llc | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
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| US9096651B2 (en) | 2007-09-26 | 2015-08-04 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in CDR |
| DK3059246T3 (en) | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modified constant region of an antibody |
| HRP20240722T1 (hr) | 2008-04-11 | 2024-08-30 | Chugai Seiyaku Kabushiki Kaisha | Molekula koja se veže na antigene, koja se može ponavljano vezati na dvje ili više molekula antigena |
| ES2564635T3 (es) | 2008-05-13 | 2016-03-28 | Novimmune Sa | Anticuerpos anti-IL-6/IL-6R y métodos de uso de los mismos |
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| TWI528973B (zh) | 2008-06-05 | 2016-04-11 | Chugai Pharmaceutical Co Ltd | Nerve infiltration inhibitor |
| PT3456190T (pt) | 2008-06-27 | 2022-02-15 | Merus Nv | Animal murino transgénico produtor de anticorpo |
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| WO2010056948A2 (en) * | 2008-11-13 | 2010-05-20 | Femta Pharmaceuticals, Inc. | Humanized anti-il-6 antibodies |
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