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MX2022000896A - Receptores de antigenos quimericos con especificidad por mage-a4 y usos de los mismos. - Google Patents

Receptores de antigenos quimericos con especificidad por mage-a4 y usos de los mismos.

Info

Publication number
MX2022000896A
MX2022000896A MX2022000896A MX2022000896A MX2022000896A MX 2022000896 A MX2022000896 A MX 2022000896A MX 2022000896 A MX2022000896 A MX 2022000896A MX 2022000896 A MX2022000896 A MX 2022000896A MX 2022000896 A MX2022000896 A MX 2022000896A
Authority
MX
Mexico
Prior art keywords
mage
chimeric antigen
antigen receptors
present disclosure
engineered cells
Prior art date
Application number
MX2022000896A
Other languages
English (en)
Inventor
Frank Delfino
David Dilillo
Kevin Bray
Thomas Craig Meagher
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2022000896A publication Critical patent/MX2022000896A/es

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K2319/00—Fusion polypeptide
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Abstract

El MAGE-A4, o antígeno A4 asociado al melanoma, es un antígeno de cáncer-testículos (CTA) en el cromosoma X. La presente descripción proporciona receptores de antígenos quiméricos específicos para MAGE-A4 y células que expresan dichos receptores de antígenos quiméricos. En determinadas modalidades, las células modificadas por ingeniería genética que expresan los receptores de antígenos quiméricos de la presente descripción son capaces de inhibir el crecimiento de tumores que expresan MAGE-A4. Las células modificadas por ingeniería genética de la presente descripción son útiles para el tratamiento de enfermedades y trastornos en los que se desea y/o es terapéuticamente beneficiosa una respuesta inmunitaria dirigida a MAGE-A4 inducida o regulada positivamente. Por ejemplo, las células modificadas por ingeniería genética que expresan los receptores de antígenos quiméricos específicos para MAGE-A4 de la presente descripción son útiles para el tratamiento de varios tipos de cáncer.
MX2022000896A 2019-07-24 2020-07-24 Receptores de antigenos quimericos con especificidad por mage-a4 y usos de los mismos. MX2022000896A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962878125P 2019-07-24 2019-07-24
US202063020177P 2020-05-05 2020-05-05
US202063021407P 2020-05-07 2020-05-07
PCT/US2020/043567 WO2021016585A1 (en) 2019-07-24 2020-07-24 Chimeric antigen receptors with mage-a4 specificity and uses thereof

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MX2022000896A true MX2022000896A (es) 2022-02-14

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US (1) US20220281994A1 (es)
EP (1) EP4004049A1 (es)
JP (1) JP2022542559A (es)
KR (1) KR20220038397A (es)
CN (1) CN114174345B (es)
AU (1) AU2020316516A1 (es)
BR (1) BR112022001194A2 (es)
CA (1) CA3147903A1 (es)
CL (1) CL2022000130A1 (es)
CO (1) CO2022000451A2 (es)
IL (1) IL289820A (es)
MX (1) MX2022000896A (es)
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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11826386B2 (en) * 2020-05-05 2023-11-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for treating cancer
AU2022233285A1 (en) * 2021-03-09 2023-10-19 Cdr-Life Ag Mage-a4 peptide-mhc antigen binding proteins
AU2022271212A1 (en) * 2021-05-04 2023-11-30 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors with mage-a4 specificity and uses thereof
CA3225252A1 (en) * 2021-07-14 2023-01-19 Jordan JARJOUR Engineered t cell receptors fused to binding domains from antibodies
WO2024056758A1 (en) * 2022-09-14 2024-03-21 Cdr-Life Ag Mage-a4 peptide dual t cell engagers

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