HRP20080537T3 - Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these - Google Patents

Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these

Info

Publication number: HRP20080537T3
Authority: HR; Croatia
Prior art keywords: compound; formula; give; straight; group
Prior art date: 2004-02-13

Application number

HR20080537T

Other languages

English (en)

Croatian (hr)

Inventor

Souvie Jean-Claude

Gonzalez Blanco Isaac

Thominot Gilles

Chapuis Geneviève

Horvath St�phane

Damien G�rard

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-13

Filing date

2008-11-25

Publication date

2008-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34685019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20080537(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-11-25 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2008-12-31 Publication of HRP20080537T3 publication Critical patent/HRP20080537T3/xx

Classifications

- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F03—MACHINES OR ENGINES FOR LIQUIDS; WIND, SPRING, OR WEIGHT MOTORS; PRODUCING MECHANICAL POWER OR A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
- F03D—WIND MOTORS
- F03D9/00—Adaptations of wind motors for special use; Combinations of wind motors with apparatus driven thereby; Wind motors specially adapted for installation in particular locations
- F03D9/008—Adaptations of wind motors for special use; Combinations of wind motors with apparatus driven thereby; Wind motors specially adapted for installation in particular locations the wind motor being combined with water energy converters, e.g. a water turbine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F03—MACHINES OR ENGINES FOR LIQUIDS; WIND, SPRING, OR WEIGHT MOTORS; PRODUCING MECHANICAL POWER OR A REACTIVE PROPULSIVE THRUST, NOT OTHERWISE PROVIDED FOR
- F03B—MACHINES OR ENGINES FOR LIQUIDS
- F03B13/00—Adaptations of machines or engines for special use; Combinations of machines or engines with driving or driven apparatus; Power stations or aggregates
- F03B13/12—Adaptations of machines or engines for special use; Combinations of machines or engines with driving or driven apparatus; Power stations or aggregates characterised by using wave or tide energy
- F03B13/26—Adaptations of machines or engines for special use; Combinations of machines or engines with driving or driven apparatus; Power stations or aggregates characterised by using wave or tide energy using tide energy
- F03B13/264—Adaptations of machines or engines for special use; Combinations of machines or engines with driving or driven apparatus; Power stations or aggregates characterised by using wave or tide energy using tide energy using the horizontal flow of water resulting from tide movement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05B—INDEXING SCHEME RELATING TO WIND, SPRING, WEIGHT, INERTIA OR LIKE MOTORS, TO MACHINES OR ENGINES FOR LIQUIDS COVERED BY SUBCLASSES F03B, F03D AND F03G
- F05B2220/00—Application
- F05B2220/30—Application in turbines
- F05B2220/32—Application in turbines in water turbines
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
- F05B—INDEXING SCHEME RELATING TO WIND, SPRING, WEIGHT, INERTIA OR LIKE MOTORS, TO MACHINES OR ENGINES FOR LIQUIDS COVERED BY SUBCLASSES F03B, F03D AND F03G
- F05B2220/00—Application
- F05B2220/70—Application in combination with
- F05B2220/706—Application in combination with an electrical generator
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/20—Hydro energy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/30—Energy from the sea, e.g. using wave energy or salinity gradient
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/70—Wind energy
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E10/00—Energy generation through renewable energy sources
- Y02E10/70—Wind energy
- Y02E10/72—Wind turbines with rotation axis in wind direction

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Virology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Obesity (AREA)
Cardiology (AREA)
Mechanical Engineering (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Combustion & Propulsion (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
General Engineering & Computer Science (AREA)
Anesthesiology (AREA)
Molecular Biology (AREA)
Sustainable Development (AREA)
Power Engineering (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
Psychology (AREA)

HR20080537T 2004-02-13 2008-11-25 Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these HRP20080537T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0401439A FR2866335B1 (fr)	2004-02-13	2004-02-13	Nouveau procede de synthese de l'agomelatine

Publications (1)

Publication Number	Publication Date
HRP20080537T3 true HRP20080537T3 (en)	2008-12-31

Family

ID=34685019

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080537T HRP20080537T3 (en)	2004-02-13	2008-11-25	Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these

Country Status (40)

Country	Link
US (2)	US7250531B2 (pt)
EP (1)	EP1564202B1 (pt)
JP (1)	JP4316517B2 (pt)
KR (1)	KR100692776B1 (pt)
CN (2)	CN1321106C (pt)
AP (1)	AP1839A (pt)
AR (1)	AR047741A1 (pt)
AT (1)	ATE407921T1 (pt)
AU (2)	AU2005200616B8 (pt)
BR (2)	BR122018068717B8 (pt)
CA (1)	CA2495967C (pt)
CR (1)	CR7680A (pt)
CU (1)	CU23515A3 (pt)
CY (1)	CY1108445T1 (pt)
DE (1)	DE602005009585D1 (pt)
DK (1)	DK1564202T3 (pt)
EA (1)	EA008473B1 (pt)
EC (1)	ECSP055601A (pt)
ES (1)	ES2314588T3 (pt)
FR (1)	FR2866335B1 (pt)
GE (1)	GEP20074133B (pt)
HR (1)	HRP20080537T3 (pt)
IL (1)	IL166815A (pt)
MA (1)	MA27518A1 (pt)
ME (1)	ME01364B (pt)
MX (1)	MXPA05001637A (pt)
MY (1)	MY138452A (pt)
NO (1)	NO333500B1 (pt)
NZ (1)	NZ538191A (pt)
PL (1)	PL1564202T3 (pt)
PT (1)	PT1564202E (pt)
RS (1)	RS50662B (pt)
SA (1)	SA05260001B1 (pt)
SG (1)	SG114703A1 (pt)
SI (1)	SI1564202T1 (pt)
TW (1)	TW200716511A (pt)
UA (1)	UA78825C2 (pt)
UY (1)	UY28747A1 (pt)
WO (1)	WO2005077887A1 (pt)
ZA (1)	ZA200501257B (pt)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7498466B2 (en) *	2004-02-13	2009-03-03	Les Laboratoires Servier	Process for the synthesis and crystalline form of agomelatine
FR2866334B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
US7498465B2 (en) *	2004-02-13	2009-03-03	Les Laboratoires Servier	Process for the synthesis and crystalline form of agomelatine
FR2889522B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
US7635721B2 (en)	2005-08-03	2009-12-22	Les Laboratoires Servier	Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it
US7645905B2 (en)	2005-08-03	2010-01-12	Les Laboratoires Servier	Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it
US7358395B2 (en)	2005-08-03	2008-04-15	Les Laboratories Servier	Crystalline form V of agomelatine, a process for its preparation and pharmaceutical compositions containing it
FR2889523B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2889521B1 (fr) *	2005-08-03	2007-12-28	Servier Lab	Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2890562B1 (fr) *	2005-09-09	2012-10-12	Servier Lab	Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime
FR2894475B1 (fr) *	2005-12-14	2008-05-16	Servier Lab	Composition pharmaceutique orodispersible pour administra- -tion oromucosale ou sublinguale d'agomelatine
FR2899472B1 (fr) *	2006-04-07	2008-09-12	Servier Lab	Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee
CN101161638B (zh) *	2006-10-13	2010-09-29	北京德众万全药物技术开发有限公司	一种新的阿戈美拉汀重要中间体的制备方法
FR2908994B1 (fr) *	2006-11-24	2009-04-03	Servier Lab	Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement de la leucomalacie periventriculaire
FR2908995B1 (fr) *	2006-11-24	2009-02-06	Servier Lab	Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du syndrome de smith magenis
CA2685924A1 (en) *	2007-05-01	2008-11-13	Concert Pharmaceuticals Inc.	Naphthyl(ethyl)acetamides
US20080280991A1 (en) *	2007-05-08	2008-11-13	Auspex Pharmaceuticals, Inc.	Substituted naphthalenes
JP2009013074A (ja) *	2007-06-30	2009-01-22	Lab Servier	全般性不安障害の処置を目的とする医薬を得るためのアゴメラチンの使用
FR2919606B1 (fr)	2007-08-03	2010-09-17	Servier Lab	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine.
FR2923482B1 (fr) *	2007-11-09	2010-01-29	Servier Lab	Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
CN101638376B (zh)	2008-07-29	2011-04-27	江苏恩华药业股份有限公司	阿戈美拉汀的制备方法及其中间体
FR2934859B1 (fr) *	2008-08-05	2010-08-13	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR2934855B1 (fr) *	2008-08-05	2010-08-13	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR2934857B1 (fr) *	2008-08-05	2010-08-27	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR2934856B1 (fr) *	2008-08-05	2010-08-13	Servier Lab	Nouveau procede d'obtention de la forme cristalline v de l'agomelatine
CN101481321B (zh) *	2009-02-27	2012-04-18	上海医药工业研究院	阿戈美拉汀卤化氢复合物及其制备方法
CN101585779B (zh) *	2009-03-10	2014-04-02	上海医药工业研究院	阿戈美拉汀的晶型vi及其制备方法和应用
WO2011006387A1 (zh) *	2009-07-11	2011-01-20	浙江华海药业股份有限公司	阿戈美拉汀的制备方法、阿戈美拉汀晶形及其制备方法
CN102001959B (zh) *	2009-09-01	2014-07-02	北京本草天源药物研究院	一种药物晶体及其制备方法和用途
CN102050756A (zh) *	2009-11-09	2011-05-11	北京利乐生制药科技有限公司	阿戈美拉汀新晶型及其制备方法
EP2319827A1 (en)	2009-11-09	2011-05-11	Ratiopharm GmbH	Process for the production of polymorph form I of agomelatine
CN101704763B (zh) *	2009-11-25	2012-03-28	天津泰普药品科技发展有限公司	阿戈美拉汀i型晶体的制备方法
CN101709036B (zh) *	2009-12-17	2012-07-04	天津药物研究院	阿戈美拉汀中间体2-(7-甲氧基-1-萘基)乙胺的制备
TW201139370A (en)	2009-12-23	2011-11-16	Lundbeck & Co As H	Processes for the manufacture of a pharmaceutically active agent
CN101781226B (zh) *	2009-12-23	2012-03-28	天津泰普药品科技发展有限公司	阿戈美拉汀及其药物组合物
CN102146046B (zh) *	2010-02-05	2013-07-03	天津市汉康医药生物技术有限公司	一种n-[2-(7-甲氧基-1-萘基)乙基]乙酰胺新的制备方法
FR2956031B1 (fr) *	2010-02-11	2012-03-02	Servier Lab	Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble obsessionnel compulsif (toc)
CN101792400B (zh) *	2010-03-16	2013-01-30	华东师范大学	一种阿戈美拉汀的合成方法
EP2558440B1 (en)	2010-04-15	2016-11-16	ratiopharm GmbH	Process for the production of polymorph form i of agomelatine
CN101870662B (zh) *	2010-05-21	2013-03-20	中山大学	结晶型阿戈美拉汀溶剂化物及其制备方法
CN102276492B (zh) *	2010-06-08	2013-04-10	上海医药工业研究院	阿戈美拉汀中间体及其制备方法
EP2580183B1 (en)	2010-06-10	2014-07-23	Gador S.A.	New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
CN102229541A (zh) *	2010-09-17	2011-11-02	福建广生堂药业有限公司	阿戈美拉汀n-[2-(7-甲氧基萘-1-基)乙基]乙酰胺的制备方法
CN102452951B (zh) *	2010-10-25	2014-02-19	天津泰普药品科技发展有限公司	阿戈美拉汀及其药物组合物
CN102030673B (zh) *	2010-11-24	2014-04-23	威海迪素制药有限公司	一种阿戈美拉汀新晶型及制备方法
CN102531956B (zh) *	2010-12-21	2014-07-09	浙江九洲药业股份有限公司	用于制备阿戈美拉汀的中间体及相关制备方法
EP2705023A4 (en) *	2011-01-04	2014-11-19	Symed Labs Ltd	PROCESSES FOR THE PREPARATION OF N- [2- (7-METHOXY-1-NAPHTHYLLELYHYL) ACETAMIDE
FR2970001B1 (fr)	2011-01-05	2013-01-04	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR2970000B1 (fr) *	2011-01-05	2013-01-04	Servier Lab	Nouveau procede de synthese de l'agomelatine
CZ303787B6 (cs)	2011-01-21	2013-05-02	Zentiva, K.S.	Metastabilní krystalové formy agomelatinu a jejich farmaceutické kompozice
CN102690209A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的混晶(形式-ⅷ)、其制备方法、应用和包含其的药物组合物
CN102690210A (zh) *	2011-03-23	2012-09-26	上海医药工业研究院	阿戈美拉汀的新晶型ⅶ、其制备方法、应用和包含其的药物组合物
WO2012127483A1 (en) *	2011-03-24	2012-09-27	Symed Labs Limited	Processes for the preparation of intermediates of n-[2-(7-methoxy-1-naphthyl) ethyl] acetamide
WO2012130837A1 (en)	2011-03-28	2012-10-04	Ratiopharm Gmbh	Solid agomelatine in non-crystalline form
FR2976284B1 (fr) *	2011-06-09	2013-05-24	Servier Lab	Nouveaux co-cristaux d'agomelatine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PH12012000132A1 (en) *	2011-06-09	2014-10-20	Servier Lab	New co-crystals of agomelatine, a process for their preparation and pharmaceutical compositions containing them
ITMI20111078A1 (it)	2011-06-15	2012-12-16	Laboratorio Chimico Int Spa	Procedimento per la preparazione di forme cristalline dell?agomelatina e nuovo polimorfo
WO2013018100A1 (en) *	2011-08-01	2013-02-07	Symed Labs Limited	A process for the preparation of n-[2-(7-methoxy-1-naphthyl) ethyl] acetamide crystalline form i
WO2013017903A1 (en)	2011-08-03	2013-02-07	Laboratorio Chimico Internazionale S.P.A.	Process for the preparation of crystalline form i of agomelatine
FR2978916B1 (fr)	2011-08-10	2013-07-26	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
EP2562151A1 (en) *	2011-08-25	2013-02-27	Dr. Reddy's Laboratories Ltd.	Processes for the preparation of agomelatine and its intermediates
CN102367228A (zh) *	2011-10-24	2012-03-07	南京工业大学	一种合成阿戈美拉汀的方法
WO2013082302A1 (en)	2011-11-30	2013-06-06	Ratiopharm Gmbh	Agomelatine-urea complex and crystalline forms thereof
CZ2012108A3 (en)	2012-02-15	2013-02-27	Zentiva Ks	A method for the manufacture of a polymorphously stable pharmaceutical composition containing agomelatine
CN103319370B (zh) *	2012-03-21	2016-08-03	黑龙江福和华星制药集团股份有限公司	一种(7-甲氧基-1-萘基)乙腈的制备方法
KR20150020191A (ko)	2012-05-14	2015-02-25	상하이 라이트핸드 팜테크 주식회사	아고멜라틴 산기 복합체와 그의 제조방법 및 용도
CA2877410A1 (en)	2012-07-16	2014-01-23	Ratiopharm Gmbh	Complex of agomelatine and cyclodextrin
ITMI20121444A1 (it)	2012-08-27	2014-02-28	Procos Spa	Processo per la produzione di agomelatine
CN102838504A (zh) *	2012-09-12	2012-12-26	福建广生堂药业股份有限公司	一种阿戈美拉汀的新晶型l及其制备方法
CN102875408B (zh) *	2012-10-09	2014-07-16	江西同和药业有限责任公司	一种阿戈美拉汀的制备方法
WO2014056421A1 (zh) *	2012-10-09	2014-04-17	江西同和药业有限责任公司	1-氰基-1-（7-甲氧基-1-萘基）甲醇酯类化合物及其制备方法和应用
EP2909166A4 (en) *	2012-10-22	2016-10-26	Symed Labs Ltd	PROCESS FOR THE PREPARATION OF AGOMALATIN USING NEW INTERMEDIATES
WO2014072998A1 (en)	2012-11-07	2014-05-15	Cadila Healthcare Limited	An improved process for preparation of agomelatine
CN102942501B (zh) *	2012-12-10	2015-08-19	天津泰普药品科技发展有限公司	一种氢化制备阿戈美拉汀的生产方法
EP2743255B1 (en)	2012-12-17	2016-06-22	Dr. Reddy's Laboratories Ltd.	Cocrystal of agomelatine with phosphoric acid
WO2014096373A1 (en)	2012-12-21	2014-06-26	Laboratorios Lesvi, S. L.	Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof
FR3001894A1 (fr)	2013-02-08	2014-08-15	Servier Lab	Composition pharmaceutique solide pour administration buccale d'agomelatine
CN104130154A (zh) *	2013-05-03	2014-11-05	郭炳华	一种制备高纯度阿戈美拉汀的方法
PL2810656T3 (pl)	2013-06-06	2018-01-31	Zentiva Ks	Preparaty agomelatyny zawierające agomelatynę w postaci kokryształów
EP2810647A1 (en)	2013-06-06	2014-12-10	Zentiva, a.s.	Pharmaceutical formulations comprising agomelatine in the form of agomelatine co-crystal with an organic acid
ES2863977T3 (es) *	2013-07-04	2021-10-13	Pharmathen Sa	Un nuevo procedimiento para la preparación de derivados de tetralina y naftaleno
CZ2013621A3 (cs)	2013-08-13	2015-02-25	Zentiva, K.S.	Termodynamicky stabilní tuhý roztok agomelatinu pro použití ve farmaceutické formulaci
FR3014434B1 (fr)	2013-12-05	2015-12-25	Servier Lab	Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine
FR3014437B1 (fr) *	2013-12-05	2016-12-23	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR3014433B1 (fr)	2013-12-05	2015-12-25	Servier Lab	Nouveau procede de synthese du 7-methoxy-naphtalene-1-carbaldehyde et application a la synthese de l'agomelatine
WO2015124496A1 (en)	2014-02-19	2015-08-27	Synthon B.V.	Pharmaceutical composition comprising amorphous agomelatine
PL3075724T3 (pl)	2015-03-31	2023-12-27	F.I.S.- Fabbrica Italiana Sintetici S.P.A.	Stała postać agomelatyny
WO2017005954A1 (es) *	2015-07-03	2017-01-12	Universidad De Granada	Análogos de la melatonina para el tratamiento del cáncer
CN105601537B (zh) *	2016-01-25	2018-11-06	江西同和药业股份有限公司	一种2-(7-甲氧基-1-萘基)乙腈的制备方法
CN105669494A (zh) *	2016-03-11	2016-06-15	上海韬鸿化工科技有限公司	一种2-(7-甲氧基-1-萘基)乙氰的制备方法
FR3056211B1 (fr)	2016-09-19	2018-09-07	Servier Lab	Nouveau procede de synthese de l'agomelatine
CN106928082A (zh) *	2016-12-27	2017-07-07	湖南天济草堂制药股份有限公司	一种新的阿戈美拉汀合成及纯化方法
CN107382773A (zh) *	2017-06-19	2017-11-24	太仓弘杉环保科技有限公司	一种合成7‑甲氧基萘乙腈的方法
CN107162933A (zh) *	2017-06-19	2017-09-15	太仓大唐化纤厂	一种合成阿戈美拉汀重要中间体7‑甲氧基萘乙腈的方法
EP3466923A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Process for the preparation of agomelatine in crystalline form
EP3466413A1 (en)	2017-10-09	2019-04-10	KRKA, d.d., Novo mesto	Pharmaceutical composition containing agomelatine and process for the preparation thereof
CN117304053A (zh) *	2022-06-22	2023-12-29	北京海美源医药科技有限公司	一种阿戈美拉汀和/或其中间体的纯化方法和其应用
EP4342879A1 (en)	2022-09-21	2024-03-27	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Very efficient process for the preparation of agomelatine
CN117776934A (zh) *	2023-12-22	2024-03-29	江苏威奇达药业有限公司	一种阿戈美拉汀中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4327022A (en) *	1973-08-16	1982-04-27	Sterling Drug Inc.	Heterocyclic alkyl naphthols
US3931188A (en) *	1974-05-06	1976-01-06	Bristol-Myers Company	3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) *	1975-05-30	1976-11-16	Schering Corporation	2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2737725B1 (fr) *	1995-08-08	1997-10-31	Valentonine	Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament
US20050164987A1 (en) *	2003-12-24	2005-07-28	Barberich Timothy J.	Melatonin combination therapy for improving sleep quality

2004
- 2004-02-13 FR FR0401439A patent/FR2866335B1/fr not_active Expired - Fee Related
2005
- 2005-02-03 CA CA002495967A patent/CA2495967C/fr not_active Expired - Lifetime
- 2005-02-07 AP AP2005003221A patent/AP1839A/xx active
- 2005-02-07 US US11/052,630 patent/US7250531B2/en not_active Expired - Lifetime
- 2005-02-07 MY MYPI20050476A patent/MY138452A/en unknown
- 2005-02-07 SG SG200500677A patent/SG114703A1/en unknown
- 2005-02-10 MX MXPA05001637A patent/MXPA05001637A/es active IP Right Grant
- 2005-02-10 CR CR7680A patent/CR7680A/es unknown
- 2005-02-10 IL IL166815A patent/IL166815A/en active IP Right Grant
- 2005-02-11 AU AU2005200616A patent/AU2005200616B8/en active Active
- 2005-02-11 AT AT05290308T patent/ATE407921T1/de active
- 2005-02-11 PT PT05290308T patent/PT1564202E/pt unknown
- 2005-02-11 ZA ZA2005/01257A patent/ZA200501257B/en unknown
- 2005-02-11 NO NO20050741A patent/NO333500B1/no unknown
- 2005-02-11 ES ES05290308T patent/ES2314588T3/es not_active Expired - Lifetime
- 2005-02-11 RS RSP-2008/0552A patent/RS50662B/sr unknown
- 2005-02-11 MA MA28101A patent/MA27518A1/fr unknown
- 2005-02-11 SI SI200530417T patent/SI1564202T1/sl unknown
- 2005-02-11 DE DE602005009585T patent/DE602005009585D1/de not_active Expired - Lifetime
- 2005-02-11 NZ NZ538191A patent/NZ538191A/en not_active IP Right Cessation
- 2005-02-11 ME MEP-2008-552A patent/ME01364B/me unknown
- 2005-02-11 GE GEAP8625A patent/GEP20074133B/en unknown
- 2005-02-11 UA UAA200501277A patent/UA78825C2/uk unknown
- 2005-02-11 UY UY28747A patent/UY28747A1/es not_active IP Right Cessation
- 2005-02-11 AR ARP050100502A patent/AR047741A1/es active IP Right Grant
- 2005-02-11 WO PCT/FR2005/000327 patent/WO2005077887A1/fr active Application Filing
- 2005-02-11 DK DK05290308T patent/DK1564202T3/da active
- 2005-02-11 EP EP05290308A patent/EP1564202B1/fr not_active Expired - Lifetime
- 2005-02-11 PL PL05290308T patent/PL1564202T3/pl unknown
- 2005-02-12 KR KR1020050011747A patent/KR100692776B1/ko not_active Expired - Lifetime
- 2005-02-12 SA SA05260001A patent/SA05260001B1/ar unknown
- 2005-02-14 EC EC2005005601A patent/ECSP055601A/es unknown
- 2005-02-14 CU CU20050032A patent/CU23515A3/es active IP Right Grant
- 2005-02-14 BR BR122018068717A patent/BR122018068717B8/pt active IP Right Grant
- 2005-02-14 BR BRPI0500393A patent/BRPI0500393B8/pt active IP Right Grant
- 2005-02-14 JP JP2005035758A patent/JP4316517B2/ja not_active Expired - Lifetime
- 2005-02-14 EA EA200500203A patent/EA008473B1/ru unknown
- 2005-02-16 CN CNB2005100716116A patent/CN1321106C/zh not_active Expired - Lifetime
- 2005-02-16 CN CN200710096437XA patent/CN101041629B/zh not_active Expired - Lifetime
2006
- 2006-06-06 TW TW095120045A patent/TW200716511A/zh unknown
2007
- 2007-04-06 US US11/784,484 patent/US7544839B2/en not_active Expired - Lifetime
2008
- 2008-10-23 CY CY20081101191T patent/CY1108445T1/el unknown
- 2008-11-25 HR HR20080537T patent/HRP20080537T3/xx unknown
2010
- 2010-08-04 AU AU2010207746A patent/AU2010207746B2/en not_active Expired

Also Published As

Publication number	Publication date
WO2005077887A1 (fr)	2005-08-25
EP1564202A1 (fr)	2005-08-17
EA200500203A1 (ru)	2005-08-25
NO20050741D0 (no)	2005-02-11
DE602005009585D1 (de)	2008-10-23
CR7680A (es)	2008-09-23
AR047741A1 (es)	2006-02-15
US20070197829A1 (en)	2007-08-23
CN1321106C (zh)	2007-06-13
PL1564202T3 (pl)	2009-02-27
EP1564202B1 (fr)	2008-09-10
US20050182276A1 (en)	2005-08-18
PT1564202E (pt)	2008-10-22
DK1564202T3 (da)	2008-12-15
BRPI0500393B8 (pt)	2021-05-25
JP4316517B2 (ja)	2009-08-19
CU23515A3 (es)	2010-05-19
AP1839A (en)	2008-04-10
ATE407921T1 (de)	2008-09-15
MY138452A (en)	2009-06-30
UA78825C2 (en)	2007-04-25
EA008473B1 (ru)	2007-06-29
JP2005247844A (ja)	2005-09-15
ME01364B (me)	2010-06-30
NO20050741L (no)	2005-08-15
GEP20074133B (en)	2007-06-25
CA2495967A1 (fr)	2005-08-13
HK1078563A1 (en)	2006-03-17
RS50662B (sr)	2010-06-30
ZA200501257B (en)	2005-11-30
AP2005003221A0 (en)	2005-03-31
CN101041629B (zh)	2010-10-13
CN101041629A (zh)	2007-09-26
MA27518A1 (fr)	2005-09-01
AU2010207746B2 (en)	2012-01-19
FR2866335A1 (fr)	2005-08-19
IL166815A (en)	2010-04-29
US7250531B2 (en)	2007-07-31
BRPI0500393A (pt)	2005-09-27
CY1108445T1 (el)	2014-04-09
KR100692776B1 (ko)	2007-03-12
TW200716511A (en)	2007-05-01
AU2005200616B2 (en)	2010-08-19
US7544839B2 (en)	2009-06-09
ES2314588T3 (es)	2009-03-16
SA05260001B1 (ar)	2009-11-11
UY28747A1 (es)	2005-10-31
KR20060042943A (ko)	2006-05-15
SG114703A1 (en)	2005-09-28
IL166815A0 (en)	2006-01-15
MXPA05001637A (es)	2005-08-19
CN1680284A (zh)	2005-10-12
FR2866335B1 (fr)	2006-05-26
NZ538191A (en)	2005-12-23
ECSP055601A (es)	2005-11-22
AU2005200616B8 (en)	2010-09-02
AU2010207746A1 (en)	2010-08-26
BR122018068717B8 (pt)	2021-07-27
BRPI0500393B1 (pt)	2020-12-22
SI1564202T1 (sl)	2008-12-31
BR122018068717B1 (pt)	2019-11-05
AU2005200616A1 (en)	2005-09-01
NO333500B1 (no)	2013-06-24
CA2495967C (fr)	2008-01-22
HK1107081A1 (zh)	2008-03-28

Publication	Publication Date	Title
HRP20080537T3 (en)	2008-12-31	Novel process for synthesizing and a novel crystal form of agomelatin as well as pharmaceutical preparations containing these
AU632992B2 (en)	1993-01-21	Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
Dabiri et al.	2009	Ammonium salt catalyzed multicomponent transformation: simple route to functionalized spirochromenes and spiroacridines
HRP20100103T1 (hr)	2010-04-30	Novi postupak za sintetiziranje (7-metoksi-1-naftil)acetonitrila i njegova primjena u sintezi agomelatina
Gu et al.	2020	Detection of endogenous hydrogen peroxide in living cells with para-nitrophenyl oxoacetyl rhodamine as turn-on mitochondria-targeted fluorescent probe
HRP20080134T3 (en)	2008-05-31	New process for synthesizing (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile and its application in the synthesis of agomelatine
Sharma et al.	2001	Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties
CN104529786B (zh)	2019-10-11	3,4,5-三氟-2’-硝基联苯的合成方法
US20180072944A1 (en)	2018-03-15	Stannous Fluorescent Probe
Kongkathip et al.	2013	Synthesis of novel naphthoquinone aliphatic amides and esters and their anticancer evaluation
CA2940634A1 (en)	2015-09-24	Stannous fluorescent probe
Liew et al.	2013	Synthesis and in vitro and in vivo evaluation of antimalarial polyamines
Thota et al.	2008	Citral derived amides as potent bacterial NorA efflux pump inhibitors
EP2955174A1 (en)	2015-12-16	Derivative of homoserine lactone, and preparation method and use thereof
Hadjipavlou-Litina et al.	2010	Syntheses and evaluation of the antioxidant activity of acitretin analogs with amide bond (s) in the polyene spacer
HU228841B1 (hu)	2013-06-28	Eljárás 5-(1-piperazinil)-benzofurán-2-karboxamid elõállítására átmeneti fémkatalizált aminálással
Böck et al.	2020	N‐Substituted Nipecotic Acids as (S)‐SNAP‐5114 Analogues with Modified Lipophilic Domains
Falch et al.	1991	GABA uptake inhibitors. Syntheses and structure—activity studies on GABA analogues containing diarylbutenyl and diarylmethoxyalkyl N-substituents
Trump et al.	2007	Co-crystal structure guided array synthesis of PPARγ inverse agonists
EP2257523B1 (fr)	2011-08-10	Préparation de composés hydroquinone amide à propriétés antioxydantes
CN108586425B (zh)	2019-11-29	一种烷氧基联苯α,β-不饱和酰胺类化合物、其制备方法及医药用途
CN106279014A (zh)	2017-01-04	一种合成苯甘氨酸类衍生物及方法
CN109232316B (zh)	2021-03-26	一类α-三级腈结构β-二羰基化合物的合成方法
CN106866480A (zh)	2017-06-20	多环芳硒醚类衍生物及其制备方法
Yalcin et al.	2019	The synthesis of blue emitting 3-Amino-1-hetarylfluorenes and their unprecedented alkylated derivatives