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HK1254323A1 - 作為irak4調節劑的雙環稠合雜芳基或芳基化合物 - Google Patents

作為irak4調節劑的雙環稠合雜芳基或芳基化合物

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Publication number
HK1254323A1
HK1254323A1 HK18113292.8A HK18113292A HK1254323A1 HK 1254323 A1 HK1254323 A1 HK 1254323A1 HK 18113292 A HK18113292 A HK 18113292A HK 1254323 A1 HK1254323 A1 HK 1254323A1
Authority
HK
Hong Kong
Prior art keywords
bicyclic
fused heteroaryl
aryl compounds
irak4
modulators
Prior art date
Application number
HK18113292.8A
Other languages
English (en)
Inventor
K‧L‧李
C‧P‧阿萊
C‧M‧德恩哈特
L‧K‧加夫林
S‧韓
D‧赫普沃斯
A‧李
F‧E‧洛夫林
J‧P‧馬蒂亞斯
D‧R‧歐文
N‧帕帕約安努
E‧薩亞
J‧W‧施特羅巴赫
J‧D‧齊佩克
S‧W‧賴特
C‧W‧查普夫
Original Assignee
輝瑞公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 輝瑞公司 filed Critical 輝瑞公司
Publication of HK1254323A1 publication Critical patent/HK1254323A1/zh

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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