HK1163081A1 - 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof 6- 3- - Google Patents
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof 6- 3-Info
- Publication number
- HK1163081A1 HK1163081A1 HK12103680A HK12103680A HK1163081A1 HK 1163081 A1 HK1163081 A1 HK 1163081A1 HK 12103680 A HK12103680 A HK 12103680A HK 12103680 A HK12103680 A HK 12103680A HK 1163081 A1 HK1163081 A1 HK 1163081A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation methods
- quinoline derivatives
- pharmaceutical uses
- amino quinazoline
- cyano quinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101958233A CN102020639A (zh) | 2009-09-14 | 2009-09-14 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| PCT/CN2010/001293 WO2011029265A1 (zh) | 2009-09-14 | 2010-08-26 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1163081A1 true HK1163081A1 (en) | 2012-09-07 |
Family
ID=43731939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12103680A HK1163081A1 (en) | 2009-09-14 | 2012-04-16 | 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof 6- 3- |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8901140B2 (da) |
| EP (1) | EP2479174B1 (da) |
| JP (1) | JP5684811B2 (da) |
| KR (1) | KR101738191B1 (da) |
| CN (2) | CN102020639A (da) |
| AU (1) | AU2010292790B2 (da) |
| BR (1) | BR112012005760A2 (da) |
| CA (1) | CA2774099C (da) |
| DK (1) | DK2479174T3 (da) |
| ES (1) | ES2647829T3 (da) |
| HK (1) | HK1163081A1 (da) |
| HR (1) | HRP20171748T1 (da) |
| HU (1) | HUE035873T2 (da) |
| LT (1) | LT2479174T (da) |
| MX (1) | MX2012002875A (da) |
| NO (1) | NO2479174T3 (da) |
| PL (1) | PL2479174T3 (da) |
| PT (1) | PT2479174T (da) |
| RU (1) | RU2536102C2 (da) |
| SI (1) | SI2479174T1 (da) |
| WO (1) | WO2011029265A1 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
| CN102675287A (zh) * | 2011-03-11 | 2012-09-19 | 江苏恒瑞医药股份有限公司 | (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用 |
| CN103717590B (zh) * | 2011-05-17 | 2016-05-11 | 江苏康缘药业股份有限公司 | 喹唑啉-7-醚化合物及使用方法 |
| US9371292B2 (en) | 2011-07-27 | 2016-06-21 | Shanghai Pharmaceuticals Holdings Co., Ltd. | Quinazoline derivative, preparation method therefor, intermediate, composition and application thereof |
| CN103987700B (zh) * | 2012-03-09 | 2016-08-31 | 江苏豪森药业集团有限公司 | 4-喹唑啉胺类衍生物及其用途 |
| CN103539783A (zh) * | 2012-07-12 | 2014-01-29 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法 |
| CN103588755B (zh) * | 2012-08-17 | 2016-06-22 | 正大天晴药业集团股份有限公司 | Neratinib的制备方法 |
| CN103965120B (zh) * | 2013-01-25 | 2016-08-17 | 上海医药集团股份有限公司 | 喹啉及喹唑啉衍生物、制备方法、中间体、组合物及应用 |
| WO2014177038A1 (en) | 2013-04-28 | 2014-11-06 | Sunshine Lake Pharma Co., Ltd. | Aminoquinazoline derivatives and their salts and methods of use thereof |
| KR101847757B1 (ko) * | 2013-12-12 | 2018-05-28 | 톈진 헤메이 파마슈티칼 사이-테크 캄파니 리미티드 | 퀴나졸린 유도체 |
| WO2015154725A1 (zh) * | 2014-04-11 | 2015-10-15 | 四川海思科制药有限公司 | 喹唑啉衍生物及其制备方法和在医药上的应用 |
| DK3378479T3 (da) * | 2016-01-27 | 2020-08-03 | Jiangsu Hengrui Medicine Co | Fremgangsmåde til forberedelse af farmakologisk sammensætning, der omfatter qionolinderivat eller salt deraf |
| CA3011525C (en) | 2016-01-27 | 2023-12-05 | Jiangsu Hengrui Medicine Co., Ltd. | Pharmaceutical composition comprising quinoline derivative or salt thereof |
| WO2017129094A1 (zh) * | 2016-01-28 | 2017-08-03 | 江苏恒瑞医药股份有限公司 | 一种egfr/her2受体酪氨酸激酶抑制剂在制备治疗her2突变癌症药物中的用途 |
| CN105777604A (zh) * | 2016-04-14 | 2016-07-20 | 上海凯宝药业股份有限公司 | 一种n-甲基-反式-4-羟基-l-脯氨酸晶体化合物及其制备方法 |
| PT3447051T (pt) | 2016-04-28 | 2022-01-06 | Jiangsu Hengrui Medicine Co | Método para preparar um inibidor de tirosina quinase e um derivado do mesmo |
| CN106008471B (zh) * | 2016-05-25 | 2019-09-03 | 江苏医诺万细胞诊疗有限公司 | 一种喹唑啉类化合物的合成方法 |
| CN108289885B (zh) * | 2016-09-23 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 酪氨酸激酶抑制剂在制备治疗癌症药物中的用途 |
| KR102355955B1 (ko) | 2016-09-23 | 2022-01-25 | 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 | 퀴나졸린 유도체의 염, 이의 제조 방법 및 응용 |
| CN106565692A (zh) * | 2016-11-03 | 2017-04-19 | 常茂生物化学工程股份有限公司 | 一种阿法替尼合成工艺的改进方法 |
| EP3572082A4 (en) * | 2017-01-22 | 2021-01-06 | Jiangsu Hengrui Medicine Co., Ltd. | USE OF EGFR / HER2 INHIBITOR IN COMBINATION WITH PYRIMIDINE-LIKE ANTIMETABOLIC DRUG |
| CN109963846A (zh) * | 2017-08-07 | 2019-07-02 | 江苏恒瑞医药股份有限公司 | 一种酪氨酸激酶抑制剂的二马来酸盐的晶型及其制备方法 |
| WO2019042409A1 (zh) | 2017-09-01 | 2019-03-07 | 上海医药集团股份有限公司 | 一种含氮杂环化合物、制备方法、中间体、组合物和应用 |
| TWI691495B (zh) * | 2017-10-18 | 2020-04-21 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種酪胺酸激酶抑制劑及其中間體的製備方法 |
| TWI700086B (zh) * | 2017-10-24 | 2020-08-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 一種含有喹啉衍生物的藥物組合物 |
| CN110913894B (zh) * | 2017-10-26 | 2023-03-10 | 江苏恒瑞医药股份有限公司 | 抗csf-1r抗体、其抗原结合片段及其医药用途 |
| CN108314639B (zh) * | 2018-05-09 | 2019-04-30 | 山东铂源药业有限公司 | 化合物（e）-3-（1-甲基吡咯烷-2-基）-丙烯酸盐酸盐及合成方法 |
| US10857146B2 (en) * | 2018-08-21 | 2020-12-08 | Jiangsu Hengrui Medicine Co., Ltd. | Method for preventing or treating tumor diseases with a combination of tyrosine kinase inhibitor and CDK4/6 inhibitor |
| CN110960529A (zh) * | 2018-09-30 | 2020-04-07 | 江苏恒瑞医药股份有限公司 | 一种降低了毒性杂质含量的酪氨酸激酶抑制剂的原料药 |
| JP2022508864A (ja) | 2018-10-22 | 2022-01-19 | 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 | チロシンキナーゼ阻害剤のマレイン酸塩の結晶形及びその調製方法 |
| CN113195000A (zh) | 2018-12-21 | 2021-07-30 | 第一三共株式会社 | 抗体-药物缀合物和激酶抑制剂的组合 |
| CN112279838B (zh) * | 2020-10-29 | 2021-07-13 | 苏州富士莱医药股份有限公司 | 一种吡咯替尼的制备方法 |
| CN112694439B (zh) * | 2020-12-31 | 2022-08-30 | 河南省医药科学研究院 | 苯基丙烯酰胺基喹啉类衍生物及其制备方法和用途 |
| CN112759583B (zh) * | 2020-12-31 | 2022-10-11 | 河南省医药科学研究院 | 包含呋喃基的喹啉类衍生物及其制备方法和用途 |
| CN112625025B (zh) * | 2020-12-31 | 2022-03-29 | 河南省医药科学研究院 | 吡啶基取代的喹啉类衍生物及其制备方法和用途 |
| KR20230156767A (ko) | 2021-03-19 | 2023-11-14 | 베이징 사이텍-엠큐 파마슈티컬즈 리미티드 | 퀴나졸린계 화합물, 조성물 및 퀴나졸린계 화합물의 적용 |
| CN118201613A (zh) * | 2021-10-14 | 2024-06-14 | 江苏恒瑞医药股份有限公司 | 抗her2抗体药物偶联物和酪氨酸激酶抑制剂联合在制备治疗肿瘤的药物中的用途 |
| WO2024187321A1 (zh) * | 2023-03-10 | 2024-09-19 | 甫康（上海）健康科技有限责任公司 | 含有egfr抑制剂的药物组合物及其制备方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| UA72749C2 (en) | 1998-09-29 | 2005-04-15 | White Holdings Corp | Substituted 3-cyanoquinolines, a method for the preparation thereof (variants), pharmaceutical composition based thereon, a method for the treatment, inhibiting the growth or elimination of neoplasms and a method for the treatment, inhibiting progressing or elimination of polycystic kidney disease using them |
| AU6383101A (en) * | 2000-04-08 | 2001-10-23 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocylces, medicaments containing said compounds, the use thereof and method for producing them |
| US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| US20040044014A1 (en) * | 2002-04-19 | 2004-03-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof |
| DE10217689A1 (de) * | 2002-04-19 | 2003-11-13 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| DE10307165A1 (de) * | 2003-02-20 | 2004-09-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, ihre Verwendung und Verfahren zu ihrer Herstellung |
| US7399865B2 (en) | 2003-09-15 | 2008-07-15 | Wyeth | Protein tyrosine kinase enzyme inhibitors |
| KR100832594B1 (ko) | 2005-11-08 | 2008-05-27 | 한미약품 주식회사 | 다중저해제로서의 퀴나졸린 유도체 및 이의 제조방법 |
| CN101824029A (zh) * | 2009-03-05 | 2010-09-08 | 厦门艾德生物医药科技有限公司 | 酪氨酸激酶不可逆抑制剂、其药物组合物及其用途 |
| CN102020639A (zh) | 2009-09-14 | 2011-04-20 | 上海恒瑞医药有限公司 | 6-氨基喹唑啉或3-氰基喹啉类衍生物、其制备方法及其在医药上的应用 |
-
2009
- 2009-09-14 CN CN2009101958233A patent/CN102020639A/zh active Pending
-
2010
- 2010-08-26 US US13/395,892 patent/US8901140B2/en active Active
- 2010-08-26 DK DK10814867.7T patent/DK2479174T3/da active
- 2010-08-26 WO PCT/CN2010/001293 patent/WO2011029265A1/zh active Application Filing
- 2010-08-26 CA CA2774099A patent/CA2774099C/en active Active
- 2010-08-26 HU HUE10814867A patent/HUE035873T2/en unknown
- 2010-08-26 JP JP2012528211A patent/JP5684811B2/ja active Active
- 2010-08-26 PT PT108148677T patent/PT2479174T/pt unknown
- 2010-08-26 KR KR1020127009554A patent/KR101738191B1/ko active Active
- 2010-08-26 SI SI201031574T patent/SI2479174T1/sl unknown
- 2010-08-26 PL PL10814867T patent/PL2479174T3/pl unknown
- 2010-08-26 BR BR112012005760A patent/BR112012005760A2/pt not_active Application Discontinuation
- 2010-08-26 NO NO10814867A patent/NO2479174T3/no unknown
- 2010-08-26 LT LTEP10814867.7T patent/LT2479174T/lt unknown
- 2010-08-26 CN CN201080030048.7A patent/CN102471312B/zh active Active
- 2010-08-26 ES ES10814867.7T patent/ES2647829T3/es active Active
- 2010-08-26 AU AU2010292790A patent/AU2010292790B2/en active Active
- 2010-08-26 MX MX2012002875A patent/MX2012002875A/es active IP Right Grant
- 2010-08-26 RU RU2012110882/04A patent/RU2536102C2/ru active
- 2010-08-26 EP EP10814867.7A patent/EP2479174B1/en active Active
-
2012
- 2012-04-16 HK HK12103680A patent/HK1163081A1/xx unknown
-
2014
- 2014-12-01 US US14/556,792 patent/US9358227B2/en active Active
-
2017
- 2017-11-14 HR HRP20171748TT patent/HRP20171748T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2479174B1 (en) | 2017-10-18 |
| ES2647829T3 (es) | 2017-12-26 |
| SI2479174T1 (sl) | 2017-12-29 |
| US20150126550A1 (en) | 2015-05-07 |
| AU2010292790B2 (en) | 2015-03-26 |
| CA2774099A1 (en) | 2011-03-17 |
| DK2479174T3 (da) | 2017-11-27 |
| PL2479174T3 (pl) | 2018-02-28 |
| LT2479174T (lt) | 2017-11-27 |
| US8901140B2 (en) | 2014-12-02 |
| BR112012005760A2 (pt) | 2016-02-16 |
| US9358227B2 (en) | 2016-06-07 |
| CN102471312A (zh) | 2012-05-23 |
| JP5684811B2 (ja) | 2015-03-18 |
| MX2012002875A (es) | 2012-04-20 |
| EP2479174A4 (en) | 2013-04-17 |
| CA2774099C (en) | 2017-07-04 |
| CN102471312B (zh) | 2014-06-18 |
| PT2479174T (pt) | 2017-11-20 |
| RU2012110882A (ru) | 2013-11-10 |
| HRP20171748T1 (hr) | 2017-12-29 |
| KR20120081142A (ko) | 2012-07-18 |
| AU2010292790A1 (en) | 2012-05-10 |
| US20120165352A1 (en) | 2012-06-28 |
| RU2536102C2 (ru) | 2014-12-20 |
| KR101738191B1 (ko) | 2017-05-19 |
| NO2479174T3 (da) | 2018-03-17 |
| HUE035873T2 (en) | 2018-05-28 |
| WO2011029265A1 (zh) | 2011-03-17 |
| JP2013504521A (ja) | 2013-02-07 |
| CN102020639A (zh) | 2011-04-20 |
| EP2479174A1 (en) | 2012-07-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1163081A1 (en) | 6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof 6- 3- | |
| IL216830A0 (en) | Isoquinoline, quinoline and quinazoline derivatives, compositions comprising the same and uses thereof | |
| IL220492A0 (en) | Substituted isoquinolinones and quinazolinones | |
| ZA201005202B (en) | Azabicyclic carboxamide derivatives,preparation thereof and theapeutic use thereof | |
| IL218490A0 (en) | Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof | |
| PL2612677T3 (pl) | Preparat zawierający insulinę, nikotynamid i argininę | |
| IL206360A0 (en) | Quinoline derivatives and their use as fungicides | |
| HK1161878A1 (en) | Dihydropteridinone derivatives, preparation process and pharmaceutical use thereof | |
| PT2655375E (pt) | Derivados de pirimidinona, sua preparação e sua utilização farmacêutica | |
| EP2570410A4 (en) | 1 - [(4-HYDROXYPRIDIN-4-YL-) METHYL-] PYRIDINE-2 (1H) -ONE DERIVATIVES, METHOD OF MANUFACTURING THEREOF AND USES THEREOF | |
| IL215285A0 (en) | Nicotinamide derivatives, preparation thereof, and therapeutic use thereof as anticancer drugs | |
| IL222080B (en) | 6-alkyl-thieno[2,3-c]quinolin-4(5h)-one derivatives | |
| EP2184277A4 (en) | ARYLPYRIMIDINE DERIVATIVES, METHODS OF PREPARATION AND PHARMACEUTICAL USES OF THE DERIVATIVES | |
| ZA201107363B (en) | Quinazolinedione derivatives,preparation thereof and various therapeutic uses thereof | |
| EP2269994A4 (en) | POLYMORPHES OF 4-ANILINOCHINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USES | |
| EP2292234A4 (en) | COMPOSITION CONTAINING QUINAZOLINE DERIVATIVES, PROCESS FOR PREPARING SAME AND APPLICATIONS THEREOF. | |
| IL214408A0 (en) | Derivatives of 6-(6-substituted-triazolopyidazine-sulfanyl) 5-fluoro-benzothiazoles and 5-fluoro-benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors | |
| IL210458A0 (en) | Antineoplastic derivatives of 4 - oxo - 1, 4 - dihydro - quinoline, preparation thereof, and therapeutic use thereof | |
| IL219872A (en) | Quinazoline derivatives, their uses, their preparation, and their medications | |
| PT2220047E (pt) | Derivados de quinolina, composições farmacêuticas que os contêm e sua utilização | |
| HK1158643A1 (en) | 6-substituted isoquinolines and isoquinolinones 6- | |
| IL214544A0 (en) | Substituted 3-benzofuranyl-indol-2-one-3-acetamidopiperazine derivatives, preparation thereof, and therapeutic use thereof | |
| IL219495A0 (en) | 9-aminoacridine derivatives, their preparation and uses | |
| HK1145492A1 (en) | Quinoline derivatives, pharmaceutical compositions comprising them, and use thereof |