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HK1047044B - 釋放抗癌劑的生物降解微球在治療成膠質細胞瘤方面的用途 - Google Patents

釋放抗癌劑的生物降解微球在治療成膠質細胞瘤方面的用途

Info

Publication number
HK1047044B
HK1047044B HK02108661.9A HK02108661A HK1047044B HK 1047044 B HK1047044 B HK 1047044B HK 02108661 A HK02108661 A HK 02108661A HK 1047044 B HK1047044 B HK 1047044B
Authority
HK
Hong Kong
Prior art keywords
glioblasma
treating
release
anticancer agent
biodegradable microspheres
Prior art date
Application number
HK02108661.9A
Other languages
English (en)
Other versions
HK1047044A1 (en
Inventor
N‧費森特
J-P‧比諾特
P‧米耐爾
Original Assignee
埃迪克埃迪法姆藥品實驗室
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 埃迪克埃迪法姆藥品實驗室 filed Critical 埃迪克埃迪法姆藥品實驗室
Publication of HK1047044A1 publication Critical patent/HK1047044A1/xx
Publication of HK1047044B publication Critical patent/HK1047044B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK02108661.9A 1999-05-17 2002-11-29 釋放抗癌劑的生物降解微球在治療成膠質細胞瘤方面的用途 HK1047044B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9906207A FR2793684B1 (fr) 1999-05-17 1999-05-17 Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant
PCT/FR2000/001315 WO2000069413A1 (fr) 1999-05-17 2000-05-17 Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome

Publications (2)

Publication Number Publication Date
HK1047044A1 HK1047044A1 (en) 2003-02-07
HK1047044B true HK1047044B (zh) 2005-12-23

Family

ID=9545636

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108661.9A HK1047044B (zh) 1999-05-17 2002-11-29 釋放抗癌劑的生物降解微球在治療成膠質細胞瘤方面的用途

Country Status (30)

Country Link
US (2) US6803052B2 (zh)
EP (2) EP1228755A1 (zh)
JP (1) JP5230045B2 (zh)
KR (1) KR100649948B1 (zh)
CN (1) CN1210020C (zh)
AR (1) AR024008A1 (zh)
AT (1) ATE228353T1 (zh)
AU (1) AU775320B2 (zh)
BG (1) BG64936B1 (zh)
BR (1) BR0010648A (zh)
CA (1) CA2388656C (zh)
CZ (1) CZ20014137A3 (zh)
DE (1) DE60000842T2 (zh)
DK (1) DK1053746T3 (zh)
EA (1) EA004943B1 (zh)
ES (1) ES2185544T3 (zh)
FR (1) FR2793684B1 (zh)
HK (1) HK1047044B (zh)
HU (1) HUP0201224A3 (zh)
IL (2) IL146467A0 (zh)
MX (1) MXPA01011919A (zh)
NO (1) NO331686B1 (zh)
NZ (1) NZ515515A (zh)
PL (1) PL201614B1 (zh)
PT (1) PT1053746E (zh)
SI (1) SI1053746T1 (zh)
SK (1) SK16342001A3 (zh)
TW (1) TWI229608B (zh)
WO (1) WO2000069413A1 (zh)
ZA (1) ZA200109415B (zh)

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EP2345449B1 (de) 1999-08-05 2019-05-01 ResMed R&D Germany GmbH Atemgasschlauch, Anschlussvorrichtung hierfür und Anschlussstrukturbauteil
AUPR098300A0 (en) 2000-10-25 2000-11-16 Sirtex Medical Limited Polymer based radionuclide containing microspheres
JP2002154963A (ja) * 2000-11-14 2002-05-28 Yakult Honsha Co Ltd 徐放性抗腫瘍剤
US20020081339A1 (en) * 2000-12-22 2002-06-27 Philippe Menei Treatment of inoperable tumors by stereotactic injection of microspheres
KR20040007596A (ko) * 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
ES2427930T3 (es) * 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
EP1411861B1 (en) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
UA77999C2 (en) * 2001-12-10 2007-02-15 Thymosin-alpha 1 for treatment of malignant glioblastoma
EP2075256A2 (en) 2002-01-14 2009-07-01 William Herman Multispecific binding molecules
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
CA3081288C (en) 2003-06-20 2022-10-18 ResMed Pty Ltd Breathable gas apparatus with humidifier
US20070026005A1 (en) * 2003-09-09 2007-02-01 Sung Young C Vaccine composition comprising il-12 adjuvant encapsulated in controlled-release microsphere
CN1909920A (zh) * 2004-03-18 2007-02-07 圣卢加医院 缓释剂的传送方法
US7833187B2 (en) * 2004-04-16 2010-11-16 Nuvue Therapeutics, Inc. Systems and methods for improving image-guided tissue ablation
US8088413B2 (en) * 2004-04-16 2012-01-03 Nuvue Therapeutics, Inc. Methods for improved cryo-chemotherapy tissue ablation
EP1796644B1 (en) 2004-09-07 2011-04-13 Biocompatibles UK Limited Drug delivery from embolic agents
US8702580B2 (en) * 2004-10-06 2014-04-22 Brainlab Ag Method and device for assisting in a tissue treatment
CN100386115C (zh) * 2004-10-14 2008-05-07 孔庆忠 一种抗癌药物组合物
CN1299685C (zh) * 2005-01-26 2007-02-14 上海大学 氟尿嘧啶载药微球及其制备方法
CN100340297C (zh) * 2005-02-03 2007-10-03 山东蓝金生物工程有限公司 抗癌体内植入剂
CN1923282B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含激素类药物的抗癌缓释注射剂
CN1923281B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含植物生物碱的抗癌缓释注射剂
CN100464785C (zh) * 2005-08-30 2009-03-04 孔庆忠 一种抗癌药物缓释注射剂及其应用
CN1923173B (zh) * 2006-02-24 2010-05-19 济南康泉医药科技有限公司 一种同载抗癌抗生素及其增效剂的抗癌药物缓释剂
US20090036380A1 (en) * 2006-03-14 2009-02-05 Yeda Research And Development Co., Ltd. Composition And Method For Brain Tumor Therapy
CN100464736C (zh) * 2006-03-17 2009-03-04 山东蓝金生物工程有限公司 同载抗代谢药物及其增效剂的抗癌缓释注射剂
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
DK2790668T3 (da) 2011-12-13 2020-11-23 Engeneic Molecular Delivery Pty Ltd Bakterielt afledte, intakte miniceller til levering af terapeutiske midler til hjernetumorer
US10342769B2 (en) 2014-11-14 2019-07-09 Navinta Iii Inc Carmustine pharmaceutical composition
WO2017083717A1 (en) * 2015-11-11 2017-05-18 Qrono, Inc. Sustained release pharmaceutical compositions and methods of use
CN118903386A (zh) 2017-08-24 2024-11-08 诺和诺德股份有限公司 Glp-1组合物及其用途
KR20220143811A (ko) 2019-12-05 2022-10-25 웨스트 버지니아 유니버시티 단백질 로딩된 plga 나노구체
BR112022013746A2 (pt) 2020-02-18 2022-10-11 Novo Nordisk As Formulação aquosa de cagrilintida, formulação aquosa de semaglutida, dispositivo médico, e, combinação de dose fixa

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
US5626862A (en) * 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
EP0938333B1 (en) * 1996-10-16 2004-02-04 Regeneron Pharmaceuticals, Inc. Method of enhancing the delivery of growth factors
TW519543B (en) * 1997-03-31 2003-02-01 Toray Industries Quinolinomorphinan derivative and pharmaceutical composition for curing-preventing cerebral disorder
KR20010031103A (ko) * 1997-10-14 2001-04-16 버틀러 그레고리 비. 네우레굴린을 사용하는 치료요법적 방법

Also Published As

Publication number Publication date
HUP0201224A2 (hu) 2002-11-28
BR0010648A (pt) 2002-02-19
DE60000842T2 (de) 2003-08-28
SI1053746T1 (en) 2003-04-30
NZ515515A (en) 2004-02-27
PT1053746E (pt) 2003-04-30
NO331686B1 (no) 2012-02-20
CA2388656C (fr) 2011-04-26
CA2388656A1 (fr) 2000-11-23
TWI229608B (en) 2005-03-21
CZ20014137A3 (cs) 2002-06-12
ATE228353T1 (de) 2002-12-15
BG106106A (en) 2002-05-31
PL352372A1 (en) 2003-08-25
US7041241B2 (en) 2006-05-09
HUP0201224A3 (en) 2004-05-28
AR024008A1 (es) 2002-09-04
FR2793684B1 (fr) 2001-08-10
US6803052B2 (en) 2004-10-12
AU775320B2 (en) 2004-07-29
MXPA01011919A (es) 2002-05-06
FR2793684A1 (fr) 2000-11-24
KR20020000178A (ko) 2002-01-04
JP2002544219A (ja) 2002-12-24
AU4764100A (en) 2000-12-05
EA200101206A1 (ru) 2002-04-25
DE60000842D1 (de) 2003-01-09
ZA200109415B (en) 2003-01-29
CN1210020C (zh) 2005-07-13
BG64936B1 (bg) 2006-10-31
EA004943B1 (ru) 2004-10-28
US20030175356A1 (en) 2003-09-18
DK1053746T3 (da) 2003-03-31
NO20015501D0 (no) 2001-11-09
IL146467A0 (en) 2002-07-25
SK16342001A3 (sk) 2002-08-06
HK1047044A1 (en) 2003-02-07
EP1053746B1 (fr) 2002-11-27
WO2000069413A1 (fr) 2000-11-23
KR100649948B1 (ko) 2006-11-24
IL146467A (en) 2006-06-11
EP1228755A1 (fr) 2002-08-07
US20020051749A1 (en) 2002-05-02
NO20015501L (no) 2002-01-09
EP1053746A1 (fr) 2000-11-22
CN1356892A (zh) 2002-07-03
PL201614B1 (pl) 2009-04-30
ES2185544T3 (es) 2003-05-01
JP5230045B2 (ja) 2013-07-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150517