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GB721417A - Heterocyclic compounds and methods for obtaining the same - Google Patents

Heterocyclic compounds and methods for obtaining the same

Info

Publication number
GB721417A
GB721417A GB25855/52A GB2585552A GB721417A GB 721417 A GB721417 A GB 721417A GB 25855/52 A GB25855/52 A GB 25855/52A GB 2585552 A GB2585552 A GB 2585552A GB 721417 A GB721417 A GB 721417A
Authority
GB
United Kingdom
Prior art keywords
acid
alkyl
ureide
sulphonamides
chlorides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25855/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Parke Davis and Co LLC
Original Assignee
Parke Davis and Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke Davis and Co LLC filed Critical Parke Davis and Co LLC
Publication of GB721417A publication Critical patent/GB721417A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises amides, ureides, and sulphonamides of 1-phenyl-4-alkyl-piperazines obtainable by converting the corresponding 4-alkyl-amine into the amide, ureide or sulphonamide by means of acids, acid anhydrides, chlorides or esters, or alkyl isocyanates or alkali cyanates, or sulphonyl chlorides. In examples, 4-phenylpiperazines substituted in the 1-position by 3-aminopropyl-, 5-aminoamyl-, and 2-aminopropyl groups are caused to react with ethyl formate, methyl dichloroacetate, methane-sulphonyl chloride, benzoyl chloride, formic acid, acetic anhydride, potassium cyanate, cyclohexylcarboxylic acid, 6-cyclohexylcaproic acid, phenylacetic acid, and benzene sulphonyl chloride, to give the corresponding amides, ureide or sulphonamides. The melting points of some other products including a propionamide are given.
GB25855/52A 1951-10-26 1952-10-15 Heterocyclic compounds and methods for obtaining the same Expired GB721417A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US721417XA 1951-10-26 1951-10-26

Publications (1)

Publication Number Publication Date
GB721417A true GB721417A (en) 1955-01-05

Family

ID=22105847

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25855/52A Expired GB721417A (en) 1951-10-26 1952-10-15 Heterocyclic compounds and methods for obtaining the same

Country Status (1)

Country Link
GB (1) GB721417A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1078130B (en) * 1956-10-22 1960-03-24 Parke Davis & Co Process for the preparation of phenylpiperazines with a dampening effect on the central nervous system
DE1088058B (en) * 1956-08-21 1960-09-01 Davis & Company Process for the preparation of sympatholytically acting N-o-halophenyl-N'-acylamino-alkylpiperazines and their acid salts
DE1089387B (en) * 1956-10-22 1960-09-22 Parke Davis & Co Process for the preparation of antihypertensive 4-phenyl-1-piperazine alkyl carbamates
DE1099542B (en) * 1956-10-22 1961-02-16 Parke Davis & Co Process for the preparation of hypotensive 4-phenyl-1-piperazine alkylcarbamic acid esters
DE1104514B (en) * 1955-06-29 1961-04-13 Parke Davis & Co Process for the preparation of hypotensive 1-mercaptophenyl-4-piperazino alcohols
US3495929A (en) * 1965-12-01 1970-02-17 Geigy Chem Corp Method for improving the fastness to gas fading of dyed material
FR2655988A1 (en) * 1989-12-20 1991-06-21 Adir NOVEL NAPHTH-1-YL PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1104514B (en) * 1955-06-29 1961-04-13 Parke Davis & Co Process for the preparation of hypotensive 1-mercaptophenyl-4-piperazino alcohols
DE1088058B (en) * 1956-08-21 1960-09-01 Davis & Company Process for the preparation of sympatholytically acting N-o-halophenyl-N'-acylamino-alkylpiperazines and their acid salts
DE1078130B (en) * 1956-10-22 1960-03-24 Parke Davis & Co Process for the preparation of phenylpiperazines with a dampening effect on the central nervous system
DE1089387B (en) * 1956-10-22 1960-09-22 Parke Davis & Co Process for the preparation of antihypertensive 4-phenyl-1-piperazine alkyl carbamates
DE1099542B (en) * 1956-10-22 1961-02-16 Parke Davis & Co Process for the preparation of hypotensive 4-phenyl-1-piperazine alkylcarbamic acid esters
US3495929A (en) * 1965-12-01 1970-02-17 Geigy Chem Corp Method for improving the fastness to gas fading of dyed material
FR2655988A1 (en) * 1989-12-20 1991-06-21 Adir NOVEL NAPHTH-1-YL PIPERAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
EP0434561A2 (en) * 1989-12-20 1991-06-26 Adir Et Compagnie 1-Naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0434561A3 (en) * 1989-12-20 1991-09-18 Adir Et Compagnie 1-naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them

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