FI945877L - Förfarande för att producera protein C - Google Patents

Förfarande för att producera protein C Download PDF

Info

Publication number: FI945877L
Authority: FI; Finland
Prior art keywords: producing protein; protein; producing
Prior art date: 1993-12-15

Application number

FI945877A

Other languages

English (en)

Finnish (fi)

Other versions

FI106385B (sv

FI945877A0 (sv

Inventor

Brian William Grinnell

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-15

Filing date

1994-12-14

Publication date

1995-06-16

1994-12-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1994-12-14 Publication of FI945877A0 publication Critical patent/FI945877A0/sv

1995-06-16 Publication of FI945877L publication Critical patent/FI945877L/sv

2001-01-31 Application granted granted Critical

2001-01-31 Publication of FI106385B publication Critical patent/FI106385B/sv

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2523/00—Culture process characterised by temperature

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Hematology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

FI945877A 1993-12-15 1994-12-14 Förfaranden för att producera protein C FI106385B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/168,035 US5618714A (en)	1993-12-15	1993-12-15	Methods for producing protein C
US16803593		1993-12-15

Publications (3)

Publication Number	Publication Date
FI945877A0 FI945877A0 (sv)	1994-12-14
FI945877L true FI945877L (sv)	1995-06-16
FI106385B FI106385B (sv)	2001-01-31

Family

ID=22609820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI945877A FI106385B (sv)	1993-12-15	1994-12-14	Förfaranden för att producera protein C

Country Status (28)

Country	Link
US (1)	US5618714A (sv)
EP (1)	EP0658626B1 (sv)
JP (1)	JP3662614B2 (sv)
KR (1)	KR950018454A (sv)
CN (1)	CN1107887A (sv)
AT (1)	ATE196165T1 (sv)
AU (1)	AU687914B2 (sv)
BR (1)	BR9404991A (sv)
CA (1)	CA2138101A1 (sv)
CO (1)	CO4340654A1 (sv)
CZ (2)	CZ315794A3 (sv)
DE (1)	DE69425809T2 (sv)
DK (1)	DK0658626T3 (sv)
ES (1)	ES2149244T3 (sv)
FI (1)	FI106385B (sv)
GR (1)	GR3034909T3 (sv)
HU (1)	HU219508B (sv)
IL (1)	IL111983A0 (sv)
NO (1)	NO944846L (sv)
NZ (1)	NZ270140A (sv)
PE (1)	PE42695A1 (sv)
PL (1)	PL176381B1 (sv)
PT (1)	PT658626E (sv)
RU (1)	RU2110574C1 (sv)
SI (1)	SI0658626T1 (sv)
UA (1)	UA26870C2 (sv)
YU (1)	YU73494A (sv)
ZA (1)	ZA949981B (sv)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19724543A1 (de) *	1997-06-11	1998-12-17	Philips Patentverwaltung	Wechsler-Gerät für Informationsplatten
ATE400030T1 (de)	2001-02-19	2008-07-15	Merck Patent Gmbh	Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität
ATE386824T1 (de) *	2002-03-29	2008-03-15	Merck & Co Inc	Verfahren zur virusproduktion
US20070142272A1 (en) *	2003-01-24	2007-06-21	Zlokovic Berislav V	Neuroprotective activity of activated protein c independent of its anticoagulant activity
US20080305100A1 (en) *	2004-07-23	2008-12-11	Zlokovic Berislav V	Activated Protein C Inhibits Undesirable Effects of Plasminogen Activator in the Brain
WO2006136033A1 (en) *	2005-06-23	2006-12-28	The University Of British Columbia	Coagulation factor iii polymorphisms associated with prediction of subject outcome and response to therapy
CA2654761A1 (en) *	2006-06-09	2007-12-13	The University Of British Columbia	Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
WO2009089620A1 (en) *	2008-01-15	2009-07-23	The Universityof British Columbia	Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
WO2012068519A2 (en)	2010-11-19	2012-05-24	Sirius Genomics Inc.	Markers associated with response to activated protein c administration, and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4775624A (en) *	1985-02-08	1988-10-04	Eli Lilly And Company	Vectors and compounds for expression of human protein C
US4959318A (en) *	1985-06-27	1990-09-25	Zymogenetics, Inc.	Expression of protein C
US4968626A (en) *	1985-08-15	1990-11-06	Board Of Reagents Of The University Of Washington	DNA sequence coding for protein C
EP0245949B1 (en) *	1986-04-09	1997-10-29	Eli Lilly And Company	A method of using eukaryotic expression vectors comprising the bk virus enhancer
JPH01502080A (ja) *	1986-11-17	1989-07-27	ニュー・イングランド・メディカル・センター	組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
US4992373A (en) *	1987-12-04	1991-02-12	Eli Lilly And Company	Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) *	1987-12-28	1990-08-29	Lilly Co Eli	Vectors and compounds for expression of zymogen forms of human protein c
JPH0246296A (ja) *	1988-08-09	1990-02-15	Hoechst Japan Ltd	雑種プロテインｃ及びその製造方法
US4981952A (en) *	1988-10-04	1991-01-01	Eli Lilly And Company	Method for the purification of vitamin K-dependent proteins
CA1332049C (en) *	1988-10-07	1994-09-20	Eli Lilly And Company	Eukaryotic expression
JP3045307B2 (ja) *	1989-08-11	2000-05-29	ザイモジェネティクス，インコーポレイティド	活性化プロテインｃを生成するための細胞培養法
IL97312A (en) *	1990-02-23	1999-01-26	Lilly Co Eli	A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient
EP0530365A1 (en) *	1991-01-29	1993-03-10	Teijin Limited	Human protein c expression vector

1993
- 1993-12-15 US US08/168,035 patent/US5618714A/en not_active Expired - Lifetime
1994
- 1994-12-14 PT PT94309314T patent/PT658626E/pt unknown
- 1994-12-14 UA UA94129175A patent/UA26870C2/uk unknown
- 1994-12-14 CZ CZ943157A patent/CZ315794A3/cs unknown
- 1994-12-14 NO NO944846A patent/NO944846L/no not_active Application Discontinuation
- 1994-12-14 RU RU94043769A patent/RU2110574C1/ru active
- 1994-12-14 NZ NZ270140A patent/NZ270140A/en unknown
- 1994-12-14 FI FI945877A patent/FI106385B/sv active
- 1994-12-14 KR KR1019940034085A patent/KR950018454A/ko not_active Ceased
- 1994-12-14 YU YU73494A patent/YU73494A/sh unknown
- 1994-12-14 SI SI9430347T patent/SI0658626T1/xx unknown
- 1994-12-14 ES ES94309314T patent/ES2149244T3/es not_active Expired - Lifetime
- 1994-12-14 AU AU80452/94A patent/AU687914B2/en not_active Ceased
- 1994-12-14 HU HU9403600A patent/HU219508B/hu not_active IP Right Cessation
- 1994-12-14 IL IL11198394A patent/IL111983A0/xx unknown
- 1994-12-14 EP EP94309314A patent/EP0658626B1/en not_active Expired - Lifetime
- 1994-12-14 CO CO94056544A patent/CO4340654A1/es unknown
- 1994-12-14 DK DK94309314T patent/DK0658626T3/da active
- 1994-12-14 DE DE69425809T patent/DE69425809T2/de not_active Expired - Lifetime
- 1994-12-14 PE PE1994257065A patent/PE42695A1/es not_active Application Discontinuation
- 1994-12-14 BR BR9404991A patent/BR9404991A/pt not_active Application Discontinuation
- 1994-12-14 AT AT94309314T patent/ATE196165T1/de not_active IP Right Cessation
- 1994-12-14 CA CA002138101A patent/CA2138101A1/en not_active Abandoned
- 1994-12-14 ZA ZA949981A patent/ZA949981B/xx unknown
- 1994-12-15 CN CN94119106A patent/CN1107887A/zh active Pending
- 1994-12-15 JP JP31160994A patent/JP3662614B2/ja not_active Expired - Fee Related
- 1994-12-15 PL PL94306291A patent/PL176381B1/pl unknown
2000
- 2000-11-24 GR GR20000402615T patent/GR3034909T3/el not_active IP Right Cessation
2001
- 2001-06-22 CZ CZ20012322A patent/CZ290724B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO944846D0 (no)	1994-12-14
BR9404991A (pt)	1995-08-08
IL111983A0 (en)	1995-03-15
ES2149244T3 (es)	2000-11-01
SI0658626T1 (en)	2001-02-28
CZ290724B6 (cs)	2002-10-16
EP0658626A1 (en)	1995-06-21
DE69425809D1 (de)	2000-10-12
AU8045294A (en)	1995-06-22
PL176381B1 (pl)	1999-05-31
EP0658626B1 (en)	2000-09-06
FI106385B (sv)	2001-01-31
HU9403600D0 (en)	1995-02-28
ZA949981B (en)	1996-06-14
YU73494A (sh)	1997-03-07
KR950018454A (ko)	1995-07-22
RU2110574C1 (ru)	1998-05-10
HU219508B (hu)	2001-04-28
RU94043769A (ru)	1997-03-27
FI945877A0 (sv)	1994-12-14
US5618714A (en)	1997-04-08
CZ315794A3 (en)	1995-10-18
HUT69979A (en)	1995-09-28
NZ270140A (en)	1996-05-28
DK0658626T3 (da)	2000-10-16
JP3662614B2 (ja)	2005-06-22
CN1107887A (zh)	1995-09-06
GR3034909T3 (en)	2001-02-28
UA26870C2 (uk)	1999-12-29
PE42695A1 (es)	1995-12-12
NO944846L (no)	1995-06-16
DE69425809T2 (de)	2001-02-01
AU687914B2 (en)	1998-03-05
JPH07222589A (ja)	1995-08-22
CO4340654A1 (es)	1996-07-30
PL306291A1 (en)	1995-06-26
ATE196165T1 (de)	2000-09-15
PT658626E (pt)	2001-01-31
CA2138101A1 (en)	1995-06-16

Publication	Publication Date	Title
FI951596L (sv)	1995-04-04	Förfarande för erhållande av 10-desacetylbakkatin III
FI962069L (sv)	1996-05-15	Förfarande för framställning av karpolaktam
FI956135A0 (sv)	1995-12-20	Separeringsförfarande
FI961071L (sv)	1996-05-07	Förfarande för framställning av zeolit
FI961430L (sv)	1996-03-29	Process I
FI973402L (sv)	1997-10-17	Nya proteiner och förfaranden för producering av proteinerna
FI944480L (sv)	1995-03-30	Förfarande för framställning av polyolefiner
DE69414001D1 (de)	1998-11-19	Bestimmungsmethode
FI954423L (sv)	1995-09-19	Förfarande för rening av taxoider
FI961431L (sv)	1996-03-29	Process II
KR970001365A (ko)	1997-01-24	알킬하이드로겐클로로실란의 제조방법
DE69400308D1 (de)	1996-08-22	Verbrennungsverfahren
FI960158L (sv)	1996-01-12	Limningsförfarande
NO974169D0 (no)	1997-09-09	Fremgangsmåte for tetra-azacykloalkan-fremstilling
FI955800L (sv)	1995-12-01	Metod att framställa aminoalkylguanidiner
FI19992038L (sv)	1999-09-23	Förfarande för framställning av azepinoner
FI931850L (sv)	1994-10-24	Foerfarande foer framstaellning av en mellanprodukt
FI942102L (sv)	1994-11-07	Förfarande för framställning av aluminoxaner
FI964001L (sv)	1996-10-04	Förfarande för framställning av 7-trialkylsilylbackatin III
FI945877L (sv)	1995-06-16	Förfarande för att producera protein C
IT1270841B (it)	1997-05-13	Metodo per produrre formilimidazoli
DK96392D0 (da)	1992-07-27	Modifikationsmetode
DK0736605T3 (da)	2003-04-22	Fremgangsmåde til fremstilling af proteiner
FI954786L (sv)	1995-10-06	Förfarande för framställning av aminometanfosfonsyra
EE9400450A (et)	1996-06-17	Meetod detailide töötlemiseks