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CO4340654A1 - Procedimientos para producir proteina c - Google Patents

Procedimientos para producir proteina c

Info

Publication number
CO4340654A1
CO4340654A1 CO94056544A CO94056544A CO4340654A1 CO 4340654 A1 CO4340654 A1 CO 4340654A1 CO 94056544 A CO94056544 A CO 94056544A CO 94056544 A CO94056544 A CO 94056544A CO 4340654 A1 CO4340654 A1 CO 4340654A1
Authority
CO
Colombia
Prior art keywords
recombined
protein
recombinant
procedure
procedures
Prior art date
Application number
CO94056544A
Other languages
English (en)
Inventor
Brian William Grinnell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4340654A1 publication Critical patent/CO4340654A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

REIVINDICACION NUMERO PROCEDIMIENTO PARA INCREMENTAR LA PRODUCCION DE PROTEINA C EN UNA CELULA HUESPED MAMIFERA RECOM- BINANTE TRANSFORMADA CON ADENOVIRUS, COMPRENDIEN- DO DICHO PROCEDIMIENTO CULTIVAR DICHA CELULA HUES- PED MAMIFERA RECOMBINANTE TRANSFORMADA CON ADENO- VIRUS A UNA TEMPERATURA DE APROXIMADAMENTE 38 GRA- DOS CENTIGRADOS A APROXIMADAMENTE 39 GRADOS CENTI- GRADOS. REINVINDICACION NUMERO PROCEDIMIENTO PARA INCREMENTAR EL NIVEL DE GAMMA- CARBOXILACION DE UNA MOLECULA DE PROTEINA C PRO- DUCIDA RECOMBINANTEMENTE, COMPRENDIENDO DICHO PROCEDIMIENTO CULTIVAR DICHA MOLECULA DE PROTEINA C PRODUCIDA RECOMBINANTEMENTE EN UNA CELULA HUES- PED AV12 RECOMBINANTE A UNA TEMPERATURA ENTRE APROXIMADAMENTE 38 GRADOS CENTIGRADOS Y APROXIMA- DAMENTE 39 GRADOS CENTIGRADOS."
CO94056544A 1993-12-15 1994-12-14 Procedimientos para producir proteina c CO4340654A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/168,035 US5618714A (en) 1993-12-15 1993-12-15 Methods for producing protein C

Publications (1)

Publication Number Publication Date
CO4340654A1 true CO4340654A1 (es) 1996-07-30

Family

ID=22609820

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94056544A CO4340654A1 (es) 1993-12-15 1994-12-14 Procedimientos para producir proteina c

Country Status (28)

Country Link
US (1) US5618714A (es)
EP (1) EP0658626B1 (es)
JP (1) JP3662614B2 (es)
KR (1) KR950018454A (es)
CN (1) CN1107887A (es)
AT (1) ATE196165T1 (es)
AU (1) AU687914B2 (es)
BR (1) BR9404991A (es)
CA (1) CA2138101A1 (es)
CO (1) CO4340654A1 (es)
CZ (2) CZ315794A3 (es)
DE (1) DE69425809T2 (es)
DK (1) DK0658626T3 (es)
ES (1) ES2149244T3 (es)
FI (1) FI106385B (es)
GR (1) GR3034909T3 (es)
HU (1) HU219508B (es)
IL (1) IL111983A0 (es)
NO (1) NO944846L (es)
NZ (1) NZ270140A (es)
PE (1) PE42695A1 (es)
PL (1) PL176381B1 (es)
PT (1) PT658626E (es)
RU (1) RU2110574C1 (es)
SI (1) SI0658626T1 (es)
UA (1) UA26870C2 (es)
YU (1) YU73494A (es)
ZA (1) ZA949981B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19724543A1 (de) * 1997-06-11 1998-12-17 Philips Patentverwaltung Wechsler-Gerät für Informationsplatten
ATE400030T1 (de) 2001-02-19 2008-07-15 Merck Patent Gmbh Methode zur identifizierung von t-zellepitopen und deren anwendung zur herstellung von molekülen mit reduzierter immunogenität
ATE386824T1 (de) * 2002-03-29 2008-03-15 Merck & Co Inc Verfahren zur virusproduktion
US20070142272A1 (en) * 2003-01-24 2007-06-21 Zlokovic Berislav V Neuroprotective activity of activated protein c independent of its anticoagulant activity
US20080305100A1 (en) * 2004-07-23 2008-12-11 Zlokovic Berislav V Activated Protein C Inhibits Undesirable Effects of Plasminogen Activator in the Brain
WO2006136033A1 (en) * 2005-06-23 2006-12-28 The University Of British Columbia Coagulation factor iii polymorphisms associated with prediction of subject outcome and response to therapy
CA2654761A1 (en) * 2006-06-09 2007-12-13 The University Of British Columbia Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
WO2009089620A1 (en) * 2008-01-15 2009-07-23 The Universityof British Columbia Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
US4968626A (en) * 1985-08-15 1990-11-06 Board Of Reagents Of The University Of Washington DNA sequence coding for protein C
EP0245949B1 (en) * 1986-04-09 1997-10-29 Eli Lilly And Company A method of using eukaryotic expression vectors comprising the bk virus enhancer
JPH01502080A (ja) * 1986-11-17 1989-07-27 ニュー・イングランド・メディカル・センター 組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c
JPH0246296A (ja) * 1988-08-09 1990-02-15 Hoechst Japan Ltd 雑種プロテインｃ及びその製造方法
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
CA1332049C (en) * 1988-10-07 1994-09-20 Eli Lilly And Company Eukaryotic expression
JP3045307B2 (ja) * 1989-08-11 2000-05-29 ザイモジェネティクス，インコーポレイティド 活性化プロテインｃを生成するための細胞培養法
IL97312A (en) * 1990-02-23 1999-01-26 Lilly Co Eli A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient
EP0530365A1 (en) * 1991-01-29 1993-03-10 Teijin Limited Human protein c expression vector

Also Published As

Publication number Publication date
NO944846D0 (no) 1994-12-14
BR9404991A (pt) 1995-08-08
IL111983A0 (en) 1995-03-15
FI945877L (fi) 1995-06-16
ES2149244T3 (es) 2000-11-01
SI0658626T1 (en) 2001-02-28
CZ290724B6 (cs) 2002-10-16
EP0658626A1 (en) 1995-06-21
DE69425809D1 (de) 2000-10-12
AU8045294A (en) 1995-06-22
PL176381B1 (pl) 1999-05-31
EP0658626B1 (en) 2000-09-06
FI106385B (fi) 2001-01-31
HU9403600D0 (en) 1995-02-28
ZA949981B (en) 1996-06-14
YU73494A (sh) 1997-03-07
KR950018454A (ko) 1995-07-22
RU2110574C1 (ru) 1998-05-10
HU219508B (hu) 2001-04-28
RU94043769A (ru) 1997-03-27
FI945877A0 (fi) 1994-12-14
US5618714A (en) 1997-04-08
CZ315794A3 (en) 1995-10-18
HUT69979A (en) 1995-09-28
NZ270140A (en) 1996-05-28
DK0658626T3 (da) 2000-10-16
JP3662614B2 (ja) 2005-06-22
CN1107887A (zh) 1995-09-06
GR3034909T3 (en) 2001-02-28
UA26870C2 (uk) 1999-12-29
PE42695A1 (es) 1995-12-12
NO944846L (no) 1995-06-16
DE69425809T2 (de) 2001-02-01
AU687914B2 (en) 1998-03-05
JPH07222589A (ja) 1995-08-22
PL306291A1 (en) 1995-06-26
ATE196165T1 (de) 2000-09-15
PT658626E (pt) 2001-01-31
CA2138101A1 (en) 1995-06-16

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