DE60226896D1 - Herstellung von f(ab')2 fragmenten in saügetierzelle - Google Patents
Herstellung von f(ab')2 fragmenten in saügetierzelleInfo
- Publication number
- DE60226896D1 DE60226896D1 DE60226896T DE60226896T DE60226896D1 DE 60226896 D1 DE60226896 D1 DE 60226896D1 DE 60226896 T DE60226896 T DE 60226896T DE 60226896 T DE60226896 T DE 60226896T DE 60226896 D1 DE60226896 D1 DE 60226896D1
- Authority
- DE
- Germany
- Prior art keywords
- fragments
- preparation
- tissue cell
- antibody fragments
- bivalent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL0100917 | 2001-12-17 | ||
PCT/NL2002/000841 WO2003051927A2 (en) | 2001-12-17 | 2002-12-17 | Production of f(ab')2 fragments in mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60226896D1 true DE60226896D1 (de) | 2008-07-10 |
Family
ID=19760784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60226896T Expired - Lifetime DE60226896D1 (de) | 2001-12-17 | 2002-12-17 | Herstellung von f(ab')2 fragmenten in saügetierzelle |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050048038A1 (de) |
EP (1) | EP1456238B1 (de) |
AT (1) | ATE397019T1 (de) |
AU (1) | AU2002353662B2 (de) |
CA (1) | CA2470579C (de) |
DE (1) | DE60226896D1 (de) |
DK (1) | DK1456238T3 (de) |
ES (1) | ES2307807T3 (de) |
NZ (1) | NZ533332A (de) |
SI (1) | SI1456238T1 (de) |
WO (1) | WO2003051927A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
DE60224843T2 (de) | 2001-12-07 | 2009-01-08 | Crucell Holland B.V. | Herstellung von viren, virusisolaten, und impfstoffen |
US20050048038A1 (en) | 2001-12-17 | 2005-03-03 | Jones David Halford Ashton | Efficient production of f(ab')2 fragments in mammalian cells |
KR101183770B1 (ko) | 2003-05-09 | 2012-09-17 | 크루셀 홀란드 비.브이. | E1-불멸화된 세포의 배양물 및 이로부터 생성 수율을 증가시키기 위한 동일물의 배양 방법 |
MA49426B1 (fr) | 2017-10-02 | 2022-09-30 | Laboratorios Silanes S A De C V | Processus à haut rendement pour la production d’antivenins à partir de fragments d’anticorps f(ab') 2 |
WO2023205656A2 (en) * | 2022-04-18 | 2023-10-26 | John Paul Ii Medical Research Institute | Immortalized cells for production of bioproducts, methods of producing bioproducts with an immortalized cell, and methods of making immortalized cells for production of bioproducts |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4624846A (en) * | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
EP0173552B1 (de) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Rekombinante DNA-Verbindungen und Expression von Polypeptiden wie tPA |
US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US7018809B1 (en) * | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
KR100449181B1 (ko) | 1995-06-15 | 2005-01-24 | 크루셀 홀란드 비.브이. | 유전자요법에사용할수있는사람의재조합아데노바이러스패키징시스템 |
PT1161548E (pt) * | 1999-04-15 | 2005-06-30 | Crucell Holland Bv | Producao de proteinas recombinantes numa celula humana utilizando sequencias codificando a proteina e1 de adenovirus |
EP1103610A1 (de) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Impfstoffherstellung von immortalisierten Säugetierzellinien |
EP1130099A1 (de) * | 2000-02-25 | 2001-09-05 | Crucell Holland B.V. | Aktiviertes Vitronektin als Angiogenesemarker nachgewiesen durch Phagen-Antikörper |
US20050048038A1 (en) | 2001-12-17 | 2005-03-03 | Jones David Halford Ashton | Efficient production of f(ab')2 fragments in mammalian cells |
-
2002
- 2002-12-17 US US10/499,298 patent/US20050048038A1/en not_active Abandoned
- 2002-12-17 EP EP02789019A patent/EP1456238B1/de not_active Expired - Lifetime
- 2002-12-17 DE DE60226896T patent/DE60226896D1/de not_active Expired - Lifetime
- 2002-12-17 AU AU2002353662A patent/AU2002353662B2/en not_active Ceased
- 2002-12-17 NZ NZ533332A patent/NZ533332A/en not_active IP Right Cessation
- 2002-12-17 AT AT02789019T patent/ATE397019T1/de active
- 2002-12-17 CA CA2470579A patent/CA2470579C/en not_active Expired - Lifetime
- 2002-12-17 SI SI200230701T patent/SI1456238T1/sl unknown
- 2002-12-17 WO PCT/NL2002/000841 patent/WO2003051927A2/en not_active Application Discontinuation
- 2002-12-17 DK DK02789019T patent/DK1456238T3/da active
- 2002-12-17 ES ES02789019T patent/ES2307807T3/es not_active Expired - Lifetime
-
2008
- 2008-02-14 US US12/070,145 patent/US7537916B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1456238B1 (de) | 2008-05-28 |
WO2003051927A3 (en) | 2003-11-20 |
CA2470579C (en) | 2012-03-06 |
DK1456238T3 (da) | 2008-08-18 |
EP1456238A2 (de) | 2004-09-15 |
CA2470579A1 (en) | 2003-06-26 |
SI1456238T1 (sl) | 2008-08-31 |
US20080166767A1 (en) | 2008-07-10 |
US20050048038A1 (en) | 2005-03-03 |
US7537916B2 (en) | 2009-05-26 |
WO2003051927A2 (en) | 2003-06-26 |
ES2307807T3 (es) | 2008-12-01 |
AU2002353662A1 (en) | 2003-06-30 |
ATE397019T1 (de) | 2008-06-15 |
NZ533332A (en) | 2005-07-29 |
AU2002353662B2 (en) | 2009-04-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |