DK1456238T3 - Produktion af F(ab')2-fragmenter i pattedyrceller - Google Patents
Produktion af F(ab')2-fragmenter i pattedyrcellerInfo
- Publication number
- DK1456238T3 DK1456238T3 DK02789019T DK02789019T DK1456238T3 DK 1456238 T3 DK1456238 T3 DK 1456238T3 DK 02789019 T DK02789019 T DK 02789019T DK 02789019 T DK02789019 T DK 02789019T DK 1456238 T3 DK1456238 T3 DK 1456238T3
- Authority
- DK
- Denmark
- Prior art keywords
- fragments
- production
- mammalian cells
- antibody fragments
- bivalent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL0100917 | 2001-12-17 | ||
PCT/NL2002/000841 WO2003051927A2 (en) | 2001-12-17 | 2002-12-17 | Production of f(ab')2 fragments in mammalian cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1456238T3 true DK1456238T3 (da) | 2008-08-18 |
Family
ID=19760784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02789019T DK1456238T3 (da) | 2001-12-17 | 2002-12-17 | Produktion af F(ab')2-fragmenter i pattedyrceller |
Country Status (11)
Country | Link |
---|---|
US (2) | US20050048038A1 (da) |
EP (1) | EP1456238B1 (da) |
AT (1) | ATE397019T1 (da) |
AU (1) | AU2002353662B2 (da) |
CA (1) | CA2470579C (da) |
DE (1) | DE60226896D1 (da) |
DK (1) | DK1456238T3 (da) |
ES (1) | ES2307807T3 (da) |
NZ (1) | NZ533332A (da) |
SI (1) | SI1456238T1 (da) |
WO (1) | WO2003051927A2 (da) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7604960B2 (en) | 1999-04-15 | 2009-10-20 | Crucell Holland B.V. | Transient protein expression methods |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
US8236561B2 (en) | 1999-04-15 | 2012-08-07 | Crucell Holland B.V. | Efficient production of IgA in recombinant mammalian cells |
US6855544B1 (en) | 1999-04-15 | 2005-02-15 | Crucell Holland B.V. | Recombinant protein production in a human cell |
US7521220B2 (en) | 1999-11-26 | 2009-04-21 | Crucell Holland B.V. | Production of vaccines |
US7527961B2 (en) | 1999-11-26 | 2009-05-05 | Crucell Holland B.V. | Production of vaccines |
US7192759B1 (en) | 1999-11-26 | 2007-03-20 | Crucell Holland B.V. | Production of vaccines |
DE60224843T2 (de) | 2001-12-07 | 2009-01-08 | Crucell Holland B.V. | Herstellung von viren, virusisolaten, und impfstoffen |
US20050048038A1 (en) | 2001-12-17 | 2005-03-03 | Jones David Halford Ashton | Efficient production of f(ab')2 fragments in mammalian cells |
KR101183770B1 (ko) | 2003-05-09 | 2012-09-17 | 크루셀 홀란드 비.브이. | E1-불멸화된 세포의 배양물 및 이로부터 생성 수율을 증가시키기 위한 동일물의 배양 방법 |
MA49426B1 (fr) | 2017-10-02 | 2022-09-30 | Laboratorios Silanes S A De C V | Processus à haut rendement pour la production d’antivenins à partir de fragments d’anticorps f(ab') 2 |
WO2023205656A2 (en) * | 2022-04-18 | 2023-10-26 | John Paul Ii Medical Research Institute | Immortalized cells for production of bioproducts, methods of producing bioproducts with an immortalized cell, and methods of making immortalized cells for production of bioproducts |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4624846A (en) * | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
EP0173552B1 (en) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
US5168062A (en) * | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
DE3920358A1 (de) * | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US7018809B1 (en) * | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
KR100449181B1 (ko) | 1995-06-15 | 2005-01-24 | 크루셀 홀란드 비.브이. | 유전자요법에사용할수있는사람의재조합아데노바이러스패키징시스템 |
PT1161548E (pt) * | 1999-04-15 | 2005-06-30 | Crucell Holland Bv | Producao de proteinas recombinantes numa celula humana utilizando sequencias codificando a proteina e1 de adenovirus |
EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
EP1130099A1 (en) * | 2000-02-25 | 2001-09-05 | Crucell Holland B.V. | Activated vitronectin as a marker of angiogenesis detected with phage antibodies |
US20050048038A1 (en) | 2001-12-17 | 2005-03-03 | Jones David Halford Ashton | Efficient production of f(ab')2 fragments in mammalian cells |
-
2002
- 2002-12-17 US US10/499,298 patent/US20050048038A1/en not_active Abandoned
- 2002-12-17 EP EP02789019A patent/EP1456238B1/en not_active Expired - Lifetime
- 2002-12-17 DE DE60226896T patent/DE60226896D1/de not_active Expired - Lifetime
- 2002-12-17 AU AU2002353662A patent/AU2002353662B2/en not_active Ceased
- 2002-12-17 NZ NZ533332A patent/NZ533332A/en not_active IP Right Cessation
- 2002-12-17 AT AT02789019T patent/ATE397019T1/de active
- 2002-12-17 CA CA2470579A patent/CA2470579C/en not_active Expired - Lifetime
- 2002-12-17 SI SI200230701T patent/SI1456238T1/sl unknown
- 2002-12-17 WO PCT/NL2002/000841 patent/WO2003051927A2/en not_active Application Discontinuation
- 2002-12-17 DK DK02789019T patent/DK1456238T3/da active
- 2002-12-17 ES ES02789019T patent/ES2307807T3/es not_active Expired - Lifetime
-
2008
- 2008-02-14 US US12/070,145 patent/US7537916B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1456238B1 (en) | 2008-05-28 |
WO2003051927A3 (en) | 2003-11-20 |
CA2470579C (en) | 2012-03-06 |
EP1456238A2 (en) | 2004-09-15 |
CA2470579A1 (en) | 2003-06-26 |
SI1456238T1 (sl) | 2008-08-31 |
US20080166767A1 (en) | 2008-07-10 |
DE60226896D1 (de) | 2008-07-10 |
US20050048038A1 (en) | 2005-03-03 |
US7537916B2 (en) | 2009-05-26 |
WO2003051927A2 (en) | 2003-06-26 |
ES2307807T3 (es) | 2008-12-01 |
AU2002353662A1 (en) | 2003-06-30 |
ATE397019T1 (de) | 2008-06-15 |
NZ533332A (en) | 2005-07-29 |
AU2002353662B2 (en) | 2009-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1379671T3 (da) | Fremgangsmåder til dyrkning af circovirus | |
DK1456238T3 (da) | Produktion af F(ab')2-fragmenter i pattedyrceller | |
DE60238308D1 (de) | Schnellproduktion monoklonaler antikörper | |
TR200001946T2 (tr) | Aşı | |
DK1650307T3 (da) | Fremgangsmåde til fremstilling af rekombinante proteiner ved anvendelse af apoptoseinhibitorer | |
AU2002364935A1 (en) | Enhancement of immune responses by 4-1bb-binding agents | |
DE60236016D1 (de) | Zelluläre zusammensetzungen und verfahren zur deren bereitung und verwendung | |
TR200003513T2 (tr) | Pirolo[2,3d]Pirimidin kompozisyonları ve kullanımları | |
ATA165999A (de) | Medium zur protein- und serumfreien kultivierung von zellen | |
DE60037450D1 (de) | Funf-helix protein | |
BR0015224A (pt) | Anticorpo anti-antìgeno de célula estaminal prostática (psca) isolado, anticorpo monoclonal anti-psca, ácido nucleico isolado, vetor de expressão, célula, célula hospedeira, método de produção de anticorpo, composição método in vitro para matar uma célula cancerosa que expresse psca, uso de uma anticorpo monoclonal anti-psca e artigo industrializado | |
NZ592159A (en) | Means and methods for influencing the stability of antibody producing cells | |
NO20061470L (no) | Fremgangsmate for fremstilling av gamma-karboksylerte proteiner | |
SI1644484T1 (sl) | Avtologne samo-toleranco inducirajoče celice monocitnega izvora in njihova uporaba v farmacevtskihpripravah | |
DE60332966D1 (de) | Kollektoren in zwei hemispheren | |
PT1451302E (pt) | Folhas reconstituídas in vitro de epitélio corneal humano e método de produção das mesmas | |
DK1321477T3 (da) | Fremgangsmåde til frembringelsen af genetisk modificerede vertebrate precursor-lymfocytter og anvendelse deraf til fremstillingen af heterologe bindende proteiner | |
PT1200561E (pt) | Clone celular recombinante estavel, sua producao e utilizacao | |
HK1063334A1 (en) | Compositions and methods useful for hcv infection | |
PL367306A1 (pl) | Szczepionki na bazie autologicznych komórek T i sposoby ich otrzymywania | |
MX2023011316A (es) | Construcciones de anticuerpos modificados con cisteina, conjugados y metodos de uso. | |
GB2351296A (en) | Keratinocyte stem cells | |
SE0002835D0 (sv) | Method and kit for production of monoclonal antibodies | |
TR200100013T2 (tr) | N-tert-butilhidroksilaminin yeni tuzları. | |
GB2379446A (en) | Cells,culture methods and their uses |