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BR0012751A - Benzofuranos serotonérgicos - Google Patents

Benzofuranos serotonérgicos

Info

Publication number
BR0012751A
BR0012751A BR0012751-5A BR0012751A BR0012751A BR 0012751 A BR0012751 A BR 0012751A BR 0012751 A BR0012751 A BR 0012751A BR 0012751 A BR0012751 A BR 0012751A
Authority
BR
Brazil
Prior art keywords
benzofurans
serotonergic
formula
provides
present
Prior art date
Application number
BR0012751-5A
Other languages
English (en)
Inventor
Karin Briner
Joseph Paul Burkhart
Timothy Paul Burkholder
Brian Eugene Cunningham
Matthew Joseph Fisher
William Harlan Gritton
Cynthia Darshini Jesudason
Shawn Christopher Miller
Jeffrey Thomas Mullaney
Matthew Robert Reinhard
Roger Ryan Rothhaar
Freddie Craig Stevens
Leonard Larry Winneroski Jr
Yanping Xu
Yao-Chang Xu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR0012751A publication Critical patent/BR0012751A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Dental Preparations (AREA)
  • Furan Compounds (AREA)

Abstract

Patente de Invenção: "BENZOFURANOS SEROTONéRGICOS". A presente invenção provê benzo furanos serotonérgicos de Fórmula (I): onde A, R, R^ 1^, R^ 2^, R^ 3^, e R^ 4^ são como descritos no relatório descritivo.
BR0012751-5A 1999-07-29 2000-07-21 Benzofuranos serotonérgicos BR0012751A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14618199P 1999-07-29 1999-07-29
US17260199P 1999-12-20 1999-12-20
PCT/US2000/019544 WO2001009122A2 (en) 1999-07-29 2000-07-21 Serotonergic benzofurans

Publications (1)

Publication Number Publication Date
BR0012751A true BR0012751A (pt) 2002-06-04

Family

ID=26843646

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012751-5A BR0012751A (pt) 1999-07-29 2000-07-21 Benzofuranos serotonérgicos

Country Status (13)

Country Link
EP (1) EP1204659B1 (pt)
JP (1) JP2003506369A (pt)
CN (1) CN1407982A (pt)
AT (1) ATE255105T1 (pt)
AU (1) AU768339B2 (pt)
BR (1) BR0012751A (pt)
CA (1) CA2380608A1 (pt)
DE (1) DE60006825T2 (pt)
DK (1) DK1204659T3 (pt)
ES (1) ES2209951T3 (pt)
MX (1) MXPA02000914A (pt)
PT (1) PT1204659E (pt)
WO (1) WO2001009122A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
DE60139021D1 (de) 2000-11-20 2009-07-30 Biovitrum Ab Publ Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
NZ536664A (en) 2002-06-19 2007-07-27 Biovitrum Ab Piperazinylpyrazine derivative compounds, their use and preparation
JP5173190B2 (ja) 2004-08-25 2013-03-27 武田薬品工業株式会社 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
WO2009063992A1 (ja) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
CN103601669B (zh) * 2013-05-20 2016-08-03 甘肃科瑞生物科技有限公司 一种1-叔丁氧羰基-2-甲基-4-哌啶酮的合成方法
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
KR102037494B1 (ko) 2017-12-11 2019-10-28 씨제이헬스케어 주식회사 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법
JPWO2019131902A1 (ja) 2017-12-27 2020-12-10 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
CN110317129A (zh) * 2019-05-30 2019-10-11 杭州迈世腾药物科技有限公司 2-溴-5-甲氧基苯酚的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006524A1 (de) * 1978-06-22 1980-01-09 Ciba-Geigy Ag Neue Tetrahydropyridin- und Piperidinderivate und deren Säureadditionssalze, Verfahren zu deren Herstellung und solche enthaltende pharmazeutische Zusammensetzungen
DE3586794T2 (de) * 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
EP0398413A1 (en) * 1989-05-16 1990-11-22 Duphar International Research B.V "3,4-dehydropiperidine derivatives having psychotropic activity
JP2883995B2 (ja) * 1990-03-14 1999-04-19 第一製薬株式会社 ピペリジン誘導体及びその製造中間体
US6436964B1 (en) * 1998-06-30 2002-08-20 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
EP1091741A4 (en) * 1998-06-30 2002-12-18 Lilly Co Eli AZEPINE DERIVATIVES PLAYING A ROLE IN SEROTONIN ASSOCIATED SYSTEMS
US6353008B1 (en) * 1998-06-30 2002-03-05 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems

Also Published As

Publication number Publication date
ES2209951T3 (es) 2004-07-01
CN1407982A (zh) 2003-04-02
DE60006825D1 (de) 2004-01-08
WO2001009122A3 (en) 2001-06-28
AU6747400A (en) 2001-02-19
DK1204659T3 (da) 2004-04-05
MXPA02000914A (es) 2002-07-30
WO2001009122A2 (en) 2001-02-08
ATE255105T1 (de) 2003-12-15
JP2003506369A (ja) 2003-02-18
AU768339B2 (en) 2003-12-11
CA2380608A1 (en) 2001-02-08
PT1204659E (pt) 2004-04-30
EP1204659B1 (en) 2003-11-26
EP1204659A2 (en) 2002-05-15
DE60006825T2 (de) 2004-08-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007.