DE60139021D1 - Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors - Google Patents
Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptorsInfo
- Publication number
- DE60139021D1 DE60139021D1 DE60139021T DE60139021T DE60139021D1 DE 60139021 D1 DE60139021 D1 DE 60139021D1 DE 60139021 T DE60139021 T DE 60139021T DE 60139021 T DE60139021 T DE 60139021T DE 60139021 D1 DE60139021 D1 DE 60139021D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- serotonin
- receptor
- piperazinylpyrazin
- antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004244A SE0004244D0 (sv) | 2000-11-20 | 2000-11-20 | Novel compounds and their use |
| US25370200P | 2000-11-28 | 2000-11-28 | |
| PCT/SE2001/002570 WO2002040457A1 (en) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60139021D1 true DE60139021D1 (de) | 2009-07-30 |
Family
ID=26655310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60139021T Expired - Lifetime DE60139021D1 (de) | 2000-11-20 | 2001-11-20 | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1337518B1 (de) |
| JP (1) | JP4204315B2 (de) |
| KR (1) | KR100831909B1 (de) |
| CN (1) | CN1227237C (de) |
| AT (1) | ATE433962T1 (de) |
| AU (1) | AU1529402A (de) |
| BR (1) | BR0115436A (de) |
| CA (2) | CA2428905A1 (de) |
| DE (1) | DE60139021D1 (de) |
| DK (1) | DK1337518T3 (de) |
| EA (1) | EA005975B1 (de) |
| ES (1) | ES2328671T3 (de) |
| HK (1) | HK1066810A1 (de) |
| IL (2) | IL155875A0 (de) |
| MX (1) | MXPA03004391A (de) |
| NO (1) | NO325321B1 (de) |
| NZ (1) | NZ525699A (de) |
| PL (1) | PL360982A1 (de) |
| WO (1) | WO2002040457A1 (de) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825198B2 (en) | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| NZ536664A (en) * | 2002-06-19 | 2007-07-27 | Biovitrum Ab | Piperazinylpyrazine derivative compounds, their use and preparation |
| DK1529043T3 (da) * | 2002-06-19 | 2006-12-04 | Biovitrum Ab | Fremgangsmåde til fremstilling af 2-methylpiperazin-derivater |
| US7226925B2 (en) | 2002-06-19 | 2007-06-05 | Biovitrum Ab | Compounds, their use and preparation |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CL2004000826A1 (es) * | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
| US7547693B2 (en) | 2003-09-22 | 2009-06-16 | Banyu Pharmaceutical Co. Ltd. | Piperidine derivative |
| EP2305352A1 (de) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-Reduktaseinhibitoren zur Behandlung von Stoffwechsel- und anthropometrischen Störungen |
| CA2577060A1 (en) | 2004-08-13 | 2006-02-23 | Amgen Inc. | Substituted benzofused heterocycles |
| EP1792629A4 (de) | 2004-08-25 | 2010-08-25 | Takeda Pharmaceutical | Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür |
| ATE427759T1 (de) | 2004-11-01 | 2009-04-15 | Amylin Pharmaceuticals Inc | Behandlung von fettsucht und verbundenen erkrankungen |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| JP5154927B2 (ja) | 2005-05-30 | 2013-02-27 | Ｍｓｄ株式会社 | 新規ピペリジン誘導体 |
| AU2006277253A1 (en) | 2005-08-10 | 2007-02-15 | Msd K.K. | Pyridone compound |
| EP1922336B1 (de) | 2005-08-11 | 2012-11-21 | Amylin Pharmaceuticals, LLC | Hybridpolypeptide mit auswählbaren eigenschaften |
| EP2330125A3 (de) | 2005-08-11 | 2012-12-12 | Amylin Pharmaceuticals, Inc. | Hybridpolypeptide mit auswählbaren Eigenschaften |
| WO2007024004A1 (ja) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | フェニルピリドン誘導体 |
| US20090264426A1 (en) | 2005-09-07 | 2009-10-22 | Shunji Sakuraba | Bicyclic aromatic substituted pyridone derivative |
| AU2006297443B2 (en) | 2005-09-29 | 2010-08-12 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| KR20080059233A (ko) | 2005-10-21 | 2008-06-26 | 노파르티스 아게 | 레닌 억제제, 및 항이상지질혈증제 및/또는 항비만제의조합물 |
| WO2007049798A1 (ja) | 2005-10-27 | 2007-05-03 | Banyu Pharmaceutical Co., Ltd. | 新規ベンゾオキサチイン誘導体 |
| EP1953165B1 (de) | 2005-11-10 | 2012-02-01 | Msd K.K. | Aza-substituierte spiroderivate |
| EP2742936A1 (de) | 2006-05-16 | 2014-06-18 | Takeda Pharmaceutical Company Limited | Kondensierte heterocyclische Verbindung und ihre Verwendung |
| WO2008039327A2 (en) | 2006-09-22 | 2008-04-03 | Merck & Co., Inc. | Method of treatment using fatty acid synthesis inhibitors |
| CA2664358A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diarylketimine derivative |
| NZ578891A (en) | 2007-01-16 | 2012-03-30 | Ipintl Llc | Novel composition for treating metabolic syndrome |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| CA3089569C (en) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
| WO2009110510A1 (ja) | 2008-03-06 | 2009-09-11 | 萬有製薬株式会社 | アルキルアミノピリジン誘導体 |
| CA2717384A1 (en) | 2008-03-28 | 2009-10-01 | Banyu Pharmaceutical Co., Ltd. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
| CA2666036C (en) | 2008-05-16 | 2017-09-12 | Chien-Hung Chen | Novel compositions and methods for treating hyperproliferative diseases |
| US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| AU2009277736A1 (en) | 2008-07-30 | 2010-02-04 | Banyu Pharmaceutical Co., Ltd. | (5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative |
| EP2348857B1 (de) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| KR101320245B1 (ko) | 2008-10-30 | 2013-10-30 | 머크 샤프 앤드 돔 코포레이션 | 이소니코틴아미드 오렉신 수용체 길항제 |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| WO2010075068A1 (en) | 2008-12-16 | 2010-07-01 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| JP5579262B2 (ja) | 2009-06-15 | 2014-08-27 | 武田薬品工業株式会社 | ピラジノオキサゼピン誘導体 |
| EP2510949A4 (de) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | Therapeutikum für fibromyalgie |
| WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN103476258B (zh) | 2011-02-25 | 2017-04-26 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
| EP3366698A1 (de) | 2011-03-01 | 2018-08-29 | Synergy Pharmaceuticals Inc. | Guanylat-cyclase-c-agonisten |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| BR112015002080A2 (pt) | 2012-08-02 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, uso de um composto, e, método de tratamento ou de prevenção de um transtorno, de uma condição ou de uma doença |
| AU2013363215B2 (en) * | 2012-12-17 | 2018-03-01 | Parion Sciences, Inc. | 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds |
| ES2619954T3 (es) | 2012-12-17 | 2017-06-27 | Parion Sciences, Inc. | Derivados de cloropiracinocarboxamida útiles para el tratamiento de enfermedades favorecidas por una hidratación mucosa insuficiente |
| US9650375B2 (en) | 2013-03-14 | 2017-05-16 | Merck Sharp & Dohme Corp. | Indole derivatives useful as anti-diabetic agents |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| ES2981866T3 (es) | 2013-06-05 | 2024-10-10 | Bausch Health Ireland Ltd | Agonistas ultrapuros de guanilato ciclasa C, método de elaboración y uso de los mismos |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| RU2746405C2 (ru) | 2014-08-29 | 2021-04-13 | Тес Фарма С.Р.Л. | ИНГИБИТОРЫ α-АМИНО-β-КАРБОКСИМУКОНАТ-ε-СЕМИАЛЬДЕГИД-ДЕКАРБОКСИЛАЗЫ |
| TW201729814A (zh) * | 2015-12-24 | 2017-09-01 | 武田藥品工業股份有限公司 | 固形製劑 |
| KR20190065312A (ko) | 2016-10-14 | 2019-06-11 | 테스 파마 에스.알.엘. | 알파-아미노-베타-카복시뮤콘산 세미알데하이드 데카복실라제의 저해제 |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| WO2020104456A1 (en) | 2018-11-20 | 2020-05-28 | Tes Pharma S.R.L | INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE |
| WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
| US20230018413A1 (en) | 2019-08-08 | 2023-01-19 | Merck Sharp & Dohme Corp. | Heteroaryl pyrrolidine and piperidine orexin receptor agonists |
| CN112341397B (zh) * | 2019-08-09 | 2023-05-23 | 成都苑东生物制药股份有限公司 | 吡嗪类衍生物或盐、异构体、其制备方法及用途 |
| WO2022040070A1 (en) | 2020-08-18 | 2022-02-24 | Merck Sharp & Dohme Corp. | Bicycloheptane pyrrolidine orexin receptor agonists |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3253989A (en) | 1963-02-11 | 1966-05-31 | American Cyanamid Co | Process for producing anorexia |
| US4081542A (en) | 1975-04-21 | 1978-03-28 | Merck & Co., Inc. | Piperazinylpyrazines |
| EP0572863A1 (de) | 1992-06-05 | 1993-12-08 | F. Hoffmann-La Roche Ag | ZNS Pyrazinoindole |
| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (de) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| FR2722788B1 (fr) | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| GB9420999D0 (en) | 1994-10-18 | 1994-12-07 | Smithkline Beecham Plc | Novel compounds |
| US5688795A (en) | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
| FR2740134B1 (fr) | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| JP3560986B2 (ja) | 1997-01-13 | 2004-09-02 | 山之内製薬株式会社 | ５―ｈｔ２ｃ受容体作用薬及びアミノアルキルインダゾール誘導体 |
| ATE250573T1 (de) | 1997-02-25 | 2003-10-15 | Akzo Nobel Nv | Azetidin- und pyrrolidinderivate |
| AU727654B2 (en) | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| DE19881578D2 (de) | 1997-08-29 | 2000-07-13 | Luk Fahrzeug Hydraulik | Taumelscheibenkompressor |
| JPH11279159A (ja) * | 1998-03-24 | 1999-10-12 | Nippon Soda Co Ltd | 光学活性なピペラジンカルボン酸エステルの製造方法 |
| AU4037699A (en) | 1998-05-08 | 1999-11-29 | Akzo Nobel N.V. | Novel aryl-hydro naphthalenal kanamines |
| GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9819032D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| GB9819020D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds III |
| GB9820767D0 (en) | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
| JP2002532504A (ja) | 1998-12-17 | 2002-10-02 | アメリカン・ホーム・プロダクツ・コーポレイション | ５−ｈｔ２ｃ作動薬である２，３，４，４ａ−テトラヒドロ−１ｈ−ピラジノ（１，２−ａ）キノキサリン−５（６ｈ）−オン誘導体 |
| WO2000044737A1 (en) | 1999-01-27 | 2000-08-03 | Eli Lilly And Company | Aminoalkylbenzofurans as serotonin (5-ht(2c)) agonists |
| GB9902047D0 (en) | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| IL146582A0 (en) | 1999-05-21 | 2002-07-25 | Biovitrum Ab | Novel compounds, their use and preparation |
| WO2000077010A2 (en) | 1999-06-15 | 2000-12-21 | Du Pont Pharmaceuticals Company | Substituted heterocycle fused gamma-carbolines |
| MXPA02000973A (es) | 1999-07-29 | 2002-07-30 | Lilly Co Eli | Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina. |
| EP1204658B1 (de) | 1999-07-29 | 2003-05-07 | Eli Lilly And Company | Benzofurylpiperazine als serotonin-agonisten |
| WO2001009126A1 (en) | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | Serotonergic benzothiophenes |
| BR0012751A (pt) | 1999-07-29 | 2002-06-04 | Lilly Co Eli | Benzofuranos serotonérgicos |
| GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
-
2001
- 2001-11-20 DK DK01983901T patent/DK1337518T3/da active
- 2001-11-20 PL PL36098201A patent/PL360982A1/xx unknown
- 2001-11-20 NZ NZ525699A patent/NZ525699A/en unknown
- 2001-11-20 MX MXPA03004391A patent/MXPA03004391A/es active IP Right Grant
- 2001-11-20 CA CA002428905A patent/CA2428905A1/en active Pending
- 2001-11-20 BR BR0115436-2A patent/BR0115436A/pt not_active IP Right Cessation
- 2001-11-20 IL IL15587501A patent/IL155875A0/xx active IP Right Grant
- 2001-11-20 EA EA200300595A patent/EA005975B1/ru not_active IP Right Cessation
- 2001-11-20 AT AT01983901T patent/ATE433962T1/de not_active IP Right Cessation
- 2001-11-20 AU AU1529402A patent/AU1529402A/xx not_active Withdrawn
- 2001-11-20 WO PCT/SE2001/002570 patent/WO2002040457A1/en active IP Right Grant
- 2001-11-20 CN CNB018192416A patent/CN1227237C/zh not_active Expired - Fee Related
- 2001-11-20 EP EP01983901A patent/EP1337518B1/de not_active Expired - Lifetime
- 2001-11-20 KR KR1020037006822A patent/KR100831909B1/ko not_active IP Right Cessation
- 2001-11-20 JP JP2002542785A patent/JP4204315B2/ja not_active Expired - Fee Related
- 2001-11-20 CA CA2449899A patent/CA2449899C/en not_active Expired - Fee Related
- 2001-11-20 ES ES01983901T patent/ES2328671T3/es not_active Expired - Lifetime
- 2001-11-20 DE DE60139021T patent/DE60139021D1/de not_active Expired - Lifetime
-
2003
- 2003-05-12 IL IL155875A patent/IL155875A/en not_active IP Right Cessation
- 2003-05-19 NO NO20032253A patent/NO325321B1/no not_active IP Right Cessation
-
2004
- 2004-12-14 HK HK04109907A patent/HK1066810A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL360982A1 (en) | 2004-09-20 |
| CA2449899A1 (en) | 2002-05-23 |
| EP1337518B1 (de) | 2009-06-17 |
| MXPA03004391A (es) | 2004-05-31 |
| ATE433962T1 (de) | 2009-07-15 |
| NO325321B1 (no) | 2008-03-31 |
| CA2428905A1 (en) | 2002-05-23 |
| EA200300595A1 (ru) | 2003-10-30 |
| NZ525699A (en) | 2005-03-24 |
| CN1520404A (zh) | 2004-08-11 |
| IL155875A0 (en) | 2003-12-23 |
| HK1066810A1 (en) | 2005-04-01 |
| WO2002040457A1 (en) | 2002-05-23 |
| KR100831909B1 (ko) | 2008-05-26 |
| KR20030060946A (ko) | 2003-07-16 |
| NO20032253L (no) | 2003-07-18 |
| CN1227237C (zh) | 2005-11-16 |
| NO20032253D0 (no) | 2003-05-19 |
| EA005975B1 (ru) | 2005-08-25 |
| BR0115436A (pt) | 2004-01-06 |
| JP2004531465A (ja) | 2004-10-14 |
| JP4204315B2 (ja) | 2009-01-07 |
| DK1337518T3 (da) | 2009-10-19 |
| EP1337518A1 (de) | 2003-08-27 |
| IL155875A (en) | 2007-06-17 |
| AU1529402A (en) | 2002-05-27 |
| ES2328671T3 (es) | 2009-11-17 |
| CA2449899C (en) | 2010-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE433962T1 (de) | Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors | |
| MXPA05010652A (es) | Pirazoles sustituidos. | |
| DE602006007556D1 (de) | Heteroarylsulfonylstilbene als 5-ht2a-antagonisten | |
| EA200301073A1 (ru) | N-(2-арилэтил)бензиламины в качестве антагонистов 5-ht-рецептора | |
| ATE354568T1 (de) | Nicht-imidazol aryloxypiperidine als h3 rezeptor liganden | |
| IL155702A0 (en) | Piperazinylpyrazine compounds as agonist or antagonist of serotonin 5-ht2 receptor | |
| MXPA02000973A (es) | Benzofurilpiperazinas y benzofurilhomopiperazinas: agonistas de serotonina. | |
| DE60142921D1 (de) | Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren | |
| DE60236600D1 (de) | Substituierte 1h-dihydropyrazole, ihre herstellung und verwendung | |
| ATE374190T1 (de) | Tetrahydrochinazolinderivate als cfr-antagonisten | |
| EA200300593A1 (ru) | Соединения пиперазинилпиразинов в качестве агонистов или антагонистов серотонин 5-ht2 рецептора | |
| ATE293448T1 (de) | Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten | |
| ATE438398T1 (de) | Pyrrolo-dihydroisochinolin-derivate als pde10- inhibitoren | |
| SE9901077D0 (sv) | Novel use | |
| ATE383345T1 (de) | Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten. | |
| AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
| MXPA05010651A (es) | Compuestos de pirazol. | |
| MXPA05010650A (es) | Pirazoles sustituidos. | |
| EA200200727A1 (ru) | Новые производные индола | |
| DE60319989D1 (de) | Diazabicylononan - und decanderivate und ihre verwendung als opioid-rezeptorligande | |
| YU39603A (sh) | Jedinjenja piperazinilpirazina kao antagonisti serotonin 5-ht2 receptora | |
| ATE398617T1 (de) | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase | |
| ATE374751T1 (de) | 3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern | |
| DE60311000D1 (de) | Indolderivate und deren verwendung als 5-ht liganden | |
| TR200401422T4 (tr) | Yeni trioksepan bileşikleri |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PROXIMAGEN LTD., LONDON, GB |