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ES8702790A1 - Un metodo para preparar una composicion de anticuerpos monoclonales estable termicamente. - Google Patents

Un metodo para preparar una composicion de anticuerpos monoclonales estable termicamente.

Info

Publication number
ES8702790A1
ES8702790A1 ES545975A ES545975A ES8702790A1 ES 8702790 A1 ES8702790 A1 ES 8702790A1 ES 545975 A ES545975 A ES 545975A ES 545975 A ES545975 A ES 545975A ES 8702790 A1 ES8702790 A1 ES 8702790A1
Authority
ES
Spain
Prior art keywords
monoclonal antibody
antibody stabilization
stabilization
solution containing
monoclonal antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545975A
Other languages
English (en)
Other versions
ES545975A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of ES545975A0 publication Critical patent/ES545975A0/es
Publication of ES8702790A1 publication Critical patent/ES8702790A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

METODO PARA PREPARAR UNA COMPOSICION DE ANTICUERPOS MONOCLONALES ESTABLE TERMICAMENTE. CONSISTE EN INCORPORAR EL ANTICUERPO EN UNA SOLUCION QUE CONTIENE ALREDEDOR DE 0,25 AL 5% EN PESO DE OVALBUMINA HIDROLIZADA, OBTENIENDOSE UNA COMPOSICION DE ANTICUERPOS MONOCLONALES ESTABLES TERMICAMENTE, QUE COMPRENDE 0,5 MMOLES A 0,5 MMOLES DE ANTICUERPO MONOCLONAL POR ML, ALREDEDOR DE 0,25 AL 5% EN PESO DE OVALBUMINA HIDROLIZADA, Y EL RESTO AGUA; SIENDO LA OVALBUMINA UNA PROTEINA SIMPLE, COAGULABLE POR EL CALOR Y SOLUBLE EN AGUA QUE SE OBTIENE DEL HUEVO, LA CUAL ES INCAPAZ DE CONFERIR ESTABILIDAD TERMICAM EN UN PREPARADO DE ANTICUERPO MONOCLONAL, Y SOLO CUANDO LA OVALBUMINA HA SIDO HIDROLIZADA ES CUANDO SE COMUNICA ESTA ESTABILIDAD. TIENE APLICACION EN DIVERSAS TECNICAS DE INVESTIGACION, DIAGNOSTICO Y ANALISIS.
ES545975A 1984-08-09 1985-08-07 Un metodo para preparar una composicion de anticuerpos monoclonales estable termicamente. Expired ES8702790A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/639,156 US4650772A (en) 1984-08-09 1984-08-09 Monoclonal antibody stabilization

Publications (2)

Publication Number Publication Date
ES545975A0 ES545975A0 (es) 1987-01-16
ES8702790A1 true ES8702790A1 (es) 1987-01-16

Family

ID=24562959

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545975A Expired ES8702790A1 (es) 1984-08-09 1985-08-07 Un metodo para preparar una composicion de anticuerpos monoclonales estable termicamente.

Country Status (15)

Country Link
US (1) US4650772A (es)
EP (1) EP0170983B1 (es)
JP (1) JPH0699325B2 (es)
KR (1) KR900002652B1 (es)
AT (1) ATE57021T1 (es)
AU (1) AU592952B2 (es)
CA (1) CA1238284A (es)
DE (1) DE3579868D1 (es)
DK (1) DK333185A (es)
ES (1) ES8702790A1 (es)
GR (1) GR851926B (es)
IE (1) IE58626B1 (es)
IL (1) IL75762A (es)
NZ (1) NZ212694A (es)
ZA (1) ZA855248B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ217844A (en) * 1985-10-11 1989-10-27 Sumitomo Pharma A sustained release pharmaceutical composition containing silicone elastomer and an albumin
ES2053704T3 (es) * 1987-02-20 1994-08-01 Akzo Nv Un metodo de estabilizacion de una composicion acuosa consistente en uno o mas anticuerpos monoclonales.
US5237054A (en) * 1987-02-20 1993-08-17 Akzo Pharma Stabilized aqueous composition containing antibodies
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt
WO1992001808A1 (en) * 1990-07-18 1992-02-06 Dojin Iyaku-Kako Co., Ltd. Reagent for diagnosing mycoplasma pneumoniae
JP2627681B2 (ja) * 1990-07-18 1997-07-09 同仁医薬化工株式会社 マイコプラズマ・ニューモニエ診断用試薬
JPH0565233A (ja) * 1991-03-08 1993-03-19 Mitsui Toatsu Chem Inc モノクローナル抗体含有凍結乾燥製剤
JP2553445B2 (ja) * 1992-12-17 1996-11-13 同仁医薬化工株式会社 抗体の安定化方法
EP0852951A1 (de) 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
MX2007014148A (es) 2005-05-19 2008-01-11 Amgen Inc Composiciones y metodos para incrementar la estabilidad de anticuerpos.
EP2529228A4 (en) * 2010-01-26 2013-09-04 Obschestvo S Ogranichennoi Otvetstvennostyu N Proizv Materia Medika Kholding Fa METHOD FOR DETERMINING THE LEVEL OF AUTOANTIBODIES BY IMMUNOENZYMATIC TESTING

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5816471B2 (ja) * 1977-11-29 1983-03-31 持田製薬株式会社 免疫化学的測定試薬の安定化剤
JPS58144748A (ja) * 1982-02-23 1983-08-29 Eiken Kagaku Kk 免疫学的反応用ラテツクス試薬
US4444880A (en) * 1982-07-27 1984-04-24 Syva Company Periodate removal of ascorbate interference in dipsticks for immunoassays
US4439421A (en) * 1982-08-30 1984-03-27 Baxter Travenol Laboratories, Inc. Stabilized gamma globulin concentrate
US4482483A (en) * 1983-04-06 1984-11-13 Armour Pharmceutical Company Composition of intravenous immune globulin

Also Published As

Publication number Publication date
EP0170983B1 (en) 1990-09-26
AU4536985A (en) 1986-02-13
JPS6176423A (ja) 1986-04-18
ATE57021T1 (de) 1990-10-15
ES545975A0 (es) 1987-01-16
AU592952B2 (en) 1990-02-01
IL75762A (en) 1989-10-31
US4650772A (en) 1987-03-17
KR900002652B1 (ko) 1990-04-21
IL75762A0 (en) 1985-11-29
CA1238284A (en) 1988-06-21
NZ212694A (en) 1988-05-30
IE851964L (en) 1986-02-09
DK333185A (da) 1986-02-10
DE3579868D1 (de) 1990-10-31
JPH0699325B2 (ja) 1994-12-07
IE58626B1 (en) 1993-10-20
DK333185D0 (da) 1985-07-22
KR860001594A (ko) 1986-03-20
GR851926B (es) 1985-12-09
ZA855248B (en) 1986-02-26
EP0170983A3 (en) 1988-01-27
EP0170983A2 (en) 1986-02-12

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