[go: up one dir, main page]

ES2780357T3 - Derivados de retinal para usar en la mejora de la función visual - Google Patents

Derivados de retinal para usar en la mejora de la función visual Download PDF

Info

Publication number
ES2780357T3
ES2780357T3 ES13760943T ES13760943T ES2780357T3 ES 2780357 T3 ES2780357 T3 ES 2780357T3 ES 13760943 T ES13760943 T ES 13760943T ES 13760943 T ES13760943 T ES 13760943T ES 2780357 T3 ES2780357 T3 ES 2780357T3
Authority
ES
Spain
Prior art keywords
days
subject
retinal
subjects
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13760943T
Other languages
English (en)
Spanish (es)
Inventor
Suzanne Cadden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Retinagenix Therapeutics Inc
Original Assignee
Retinagenix Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Retinagenix Therapeutics Inc filed Critical Retinagenix Therapeutics Inc
Application granted granted Critical
Publication of ES2780357T3 publication Critical patent/ES2780357T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES13760943T 2012-03-01 2013-03-01 Derivados de retinal para usar en la mejora de la función visual Active ES2780357T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261605729P 2012-03-01 2012-03-01
US201261642212P 2012-05-03 2012-05-03
US201261644360P 2012-05-08 2012-05-08
PCT/CA2013/050155 WO2013134867A1 (fr) 2012-03-01 2013-03-01 Schémas et procédé thérapeutiques utilisés pour améliorer la fonction visuelle dans les troubles de la vue associés à une carence en rétinoïdes endogènes

Publications (1)

Publication Number Publication Date
ES2780357T3 true ES2780357T3 (es) 2020-08-25

Family

ID=49160185

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13760943T Active ES2780357T3 (es) 2012-03-01 2013-03-01 Derivados de retinal para usar en la mejora de la función visual

Country Status (17)

Country Link
US (2) US20160296478A1 (fr)
EP (1) EP2819667B8 (fr)
JP (3) JP6576636B2 (fr)
KR (1) KR102133608B1 (fr)
CN (2) CN109248163A (fr)
AU (3) AU2013232697B2 (fr)
BR (1) BR112014021602A2 (fr)
CA (1) CA2865935C (fr)
DK (1) DK2819667T3 (fr)
ES (1) ES2780357T3 (fr)
HK (1) HK1205469A1 (fr)
IL (1) IL234306B (fr)
MX (1) MX370928B (fr)
NZ (1) NZ629267A (fr)
PT (1) PT2819667T (fr)
RU (1) RU2635536C2 (fr)
WO (1) WO2013134867A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ603331A (en) 2010-04-19 2015-02-27 Quadra Logic Tech Inc Therapeutic regimens and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
KR102133608B1 (ko) 2012-03-01 2020-07-13 레티나제닉스, 엘엘씨 내인성 레티노이드 결핍증과 관련된 시각 장애에서 시각 기능의 개선을 위한 치료 요법 및 방법
WO2015164419A1 (fr) * 2014-04-22 2015-10-29 Acucela Inc. Evaluation pupillométrique de pharmacodynamies rétiniennes et réactions correspondantes
US12029715B2 (en) * 2015-05-08 2024-07-09 University Of Debrecen Precursor compounds for providing retinoids of the vitamin A5 pathway and uses thereof
EP3294711B1 (fr) * 2015-05-08 2020-01-08 University of Debrecen Synthèse stéréosélective d'acide 9-cis-13,14-dihydrorétinoïque et de ses esters d'éthyle
CN116268424A (zh) 2016-11-17 2023-06-23 德布勒森大学 提供维生素a5途径的维甲类的前体化合物及其用途
RU186184U1 (ru) * 2018-06-06 2019-01-11 Федеральное государственное бюджетное учреждение "33 Центральный научно-исследовательский испытательный институт" Министерства обороны Российской Федерации Устройство для оценки углов обзора и поля зрения испытателей в противогазе
CN116056691A (zh) * 2020-06-09 2023-05-02 典晶生物医药科技(苏州)有限公司 使用每日低剂量的类视黄醇化合物治疗视觉障碍的方法
WO2024110625A1 (fr) 2022-11-24 2024-05-30 Universität Bern Agents thérapeutiques à base de cralbp dirigés contre des troubles rétiniens

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196078A (en) 1962-01-30 1965-07-20 Ortho Pharma Corp Process for combating retinits pigmentosa
US3517067A (en) 1964-02-11 1970-06-23 Eastman Kodak Co Syntheses of quaternary phosphonium salts
DE2300107C2 (de) 1973-01-03 1982-03-11 Basf Ag, 6700 Ludwigshafen Vitamin A-Säureanilid-4-carbonsäureäthylester, Verfahren zu seiner Herstellung und diesen enthaltende Zubereitungen
CH590222A5 (fr) 1973-08-21 1977-07-29 Hoffmann La Roche
US4022913A (en) 1973-09-13 1977-05-10 Hoffmann-La Roche Inc. High potency vitamin A compositions
DE2456959A1 (de) 1974-12-03 1976-06-16 Basf Ag 4-(e)- und 4-(z)-7-methyl-9-(2,6,6trimethyl-1-cyclohexen-1-yl)-nona-2,4,6,8tetraencarbonsaeure, ihre derivate und diese enthaltende zubereitungen
CA1198859A (fr) 1982-04-21 1986-01-07 Chester L. O'neal Brosse a dent jetable avec etui
US4532133A (en) 1983-05-24 1985-07-30 Basf Wyandotte Corporation Low temperature stable, emulsifiable vitamin A concentrates
CA1282326C (fr) 1984-12-14 1991-04-02 Paul J. Jarosz Compose pharmaceutique contenant de la vitamine a 13-cis acide comme ingredient actif
JPS61275266A (ja) 1985-05-28 1986-12-05 Taisho Pharmaceut Co Ltd レチノイド誘導体
CZ282548B6 (cs) 1992-01-22 1997-08-13 F. Hoffmann-La Roche Ag Farmaceutický přípravek
US5310764A (en) 1992-05-08 1994-05-10 Steven Baranowitz Treatment of age related macular degeneration with beta-carotene
JPH06340525A (ja) 1993-06-02 1994-12-13 Lion Corp 安定な低眼刺激性ビタミンa類可溶化点眼剤
CA2185699A1 (fr) 1994-04-04 1995-10-12 William R. Freeman Emploi de nucleosides de phosphonylemethoxyalkyle pour traiter la pression intra-oculaire elevee
RU2106843C1 (ru) 1994-06-29 1998-03-20 Красноярская государственная медицинская академия Способ лечения близорукости
JPH08198746A (ja) 1995-01-18 1996-08-06 Lion Corp 可溶化点眼剤
US5837728A (en) 1995-01-27 1998-11-17 Molecular Design International 9-cis retinoic acid esters and amides and uses thereof
US5489611A (en) 1995-02-10 1996-02-06 Warner-Lambert Company Method for lowering plasma levels of lipoprotein (a)
US5620970A (en) 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
EP0839029A1 (fr) 1995-07-20 1998-05-06 PHARMACIA & UPJOHN COMPANY Solution claire et stable d'anti-inflammatoires non steroidiens a integrer dans des gelules de gelatine
US5716627A (en) 1996-04-25 1998-02-10 Elizabeth Arden Co., Division Of Conopco, Inc. Skin care compositions containing fatty acid amides, azoles, and retinol or retinyl ester
EP0908179A1 (fr) 1997-08-23 1999-04-14 Werner Bollag Traitement de troubles immunitaires induits par les cellules
ZA989513B (en) 1997-10-21 1999-04-21 Alcon Lab Inc Compositions containing histamine H2 agonists and methods of use in treating dry eye
US6391924B1 (en) 1997-12-10 2002-05-21 Hampar Karageozian Taurine derivatives useable in the treatment of ophthalmic disorders
US6552009B2 (en) 1998-07-16 2003-04-22 Gentrix Llc Compositions and methods of treating abnormal cell proliferation
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6372463B1 (en) 1999-05-06 2002-04-16 The President & Fellows Of Harvard College Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof
US6300328B1 (en) 1999-08-06 2001-10-09 Alcon Universal Ltd. Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
US20020028849A1 (en) 2000-04-18 2002-03-07 Godkin James D. Use of retinol in assisted-reproduction protocols
US6696069B2 (en) 2000-06-30 2004-02-24 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin care cosmetic compositions containing phosphates and/or sulfates of branched alcohols and/or ethoxylates thereof
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
WO2002055540A1 (fr) 2001-01-11 2002-07-18 Chebigen Inc. Nouveaux derives de retinol, procede de preparation et d'utilisation de ceux-ci
WO2002082904A2 (fr) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Traitement soignant ou retardant l'installation de la cecite
ITMI20012366A1 (it) 2001-11-09 2003-05-09 Farmatron Ltd Sistemi terapeutici stabilizzati a rilascio immediato e/o modificato per la somministrazione orale di principi attivi e/o eccipienti e/o ali
MXPA04005204A (es) 2001-11-30 2005-11-04 Quadra Logic Tech Inc Derivados de hidrazonipirazol y su uso como terpapeuticos.
JP2005524626A (ja) 2002-01-18 2005-08-18 タットン テクノロジーズ エルエルシー. 眼疾患を治療するための方法
US20030215413A1 (en) 2002-03-22 2003-11-20 L'oreal Compositions containing stabilized retinoid
US20040097587A1 (en) 2002-03-27 2004-05-20 Arbiser Jack L Compositions and methods of treatment of ulcerating diseases, burns, and related conditions
WO2003082081A2 (fr) 2002-03-29 2003-10-09 Maxim Pharmaceuticals, Inc. Utilisation de la production de rom et d'inhibiteurs de liberation pour traiter et prevenir des dommages intraoculaires
JP3854524B2 (ja) 2002-04-01 2006-12-06 ピアス株式会社 油溶性成分安定化組成物及びその組成物を配合した化粧料、並びに油溶性成分の安定化方法
EP1367493A1 (fr) 2002-05-30 2003-12-03 STMicroelectronics Limited Tampon de préextraction
EP1527774A1 (fr) 2003-11-03 2005-05-04 Basilea Pharmaceutica AG Formulations nouvelle pour retinoides contenant capsules de gélatine molle
JP2006520393A (ja) 2003-03-14 2006-09-07 ユニバーシティ オブ ワシントン レチノイド補充物およびオプシンアゴニスト、ならびにそれらの使用法
EP1510133A1 (fr) 2003-09-01 2005-03-02 Belovo S.A., Egg Science & Technology Composition d'huile équilibrée
ES2563733T3 (es) 2003-09-04 2016-03-16 The Uab Research Foundation Procedimiento y aparato para la detección del deterioro en la adaptación a la oscuridad
US7706863B2 (en) 2004-01-21 2010-04-27 University Of Washington Methods for assessing a physiological state of a mammalian retina
US20080176952A1 (en) 2004-02-17 2008-07-24 Rando Robert R Management of Ophthalmologic Disorders, Including Macular Degeneration
JP2007526943A (ja) 2004-03-04 2007-09-20 エイチティーエル ハイ − テック リピッズ リミテッド 構造化されたトリグリセリド類およびそれを含むエマルション類
JP2007529434A (ja) 2004-03-17 2007-10-25 ラース マイケル ラーセン, 視覚サイクルの阻害による網膜症の予防
CA2931917A1 (fr) * 2004-06-18 2006-01-05 University Of Washington Derive de la retine et leurs procedes d'utilisation dans le traitement des troubles visuels
WO2006007314A1 (fr) 2004-06-23 2006-01-19 Sirion Therapeutics, Inc. Methodes et compositions pour traitement de manifestations ophtalmiques au moyen de derives de retinyl
US20060240098A1 (en) 2004-07-14 2006-10-26 Aphios Corporation Formulations for hyperforin-enriched hypericum fractions
AU2005287343A1 (en) 2004-08-18 2006-03-30 Sirion Therapeutics, Inc. Combination compositions comprising 13-cis-retinyl derivatives and uses thereof to treat opthalmic disorders
WO2006039551A2 (fr) * 2004-09-30 2006-04-13 The Regents Of The University Of California Administration locale de retinoides pour traiter les deficiences de l'adaptation a l'obscurite
US20060177392A1 (en) 2005-02-10 2006-08-10 William Walden Oil-based composition for acne
PT1903866E (pt) 2005-11-07 2016-06-09 Murty Pharmaceuticals Inc Distribuição melhorada de tetra-hidrocanabinol
US8202541B2 (en) 2006-02-07 2012-06-19 U.S. Nutraceuticals, LLC Dietary supplement composition for blood lipid health
AU2007277032A1 (en) 2006-07-27 2008-01-31 University Of Florida Research Foundation, Inc. Opsin stabilizing compounds and methods of use
EP3181132A1 (fr) 2007-01-15 2017-06-21 Chongxi Yu Promédicaments positivement chargés solubles dans l'eau de rétinoïdes et de composés semblables à des rétinoïdes ayant des vitesses de pénétration dans la peau très élevées
WO2009035673A1 (fr) 2007-09-12 2009-03-19 Trustees Of Columbia University In The City Of Newyork Compositions et procédés de traitement de la dégénérescence maculaire
WO2009102418A1 (fr) 2008-02-11 2009-08-20 University Of Washington Procédés pour le traitement et la prévention d'un dysfonctionnement rétinien lié à l'âge
JP5663025B2 (ja) 2009-09-15 2015-02-04 キューエルティー インコーポレイテッド 9−cis−レチニルエステルを脂質ビヒクル中に含む医薬製剤
FR2955459B1 (fr) 2010-01-28 2013-11-22 Polaris Composition huileuse riche en monoglycerides de dha
NZ603331A (en) 2010-04-19 2015-02-27 Quadra Logic Tech Inc Therapeutic regimens and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
KR102133608B1 (ko) 2012-03-01 2020-07-13 레티나제닉스, 엘엘씨 내인성 레티노이드 결핍증과 관련된 시각 장애에서 시각 기능의 개선을 위한 치료 요법 및 방법
US20150038582A1 (en) 2012-03-01 2015-02-05 Qlt Inc. Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency

Also Published As

Publication number Publication date
AU2018200415B2 (en) 2019-09-26
JP2017197588A (ja) 2017-11-02
RU2014139666A (ru) 2016-04-20
CA2865935C (fr) 2021-12-14
RU2635536C2 (ru) 2017-11-13
EP2819667B1 (fr) 2019-12-25
JP2015508783A (ja) 2015-03-23
PT2819667T (pt) 2020-03-31
DK2819667T3 (da) 2020-03-30
US20190054039A1 (en) 2019-02-21
CA2865935A1 (fr) 2013-09-19
EP2819667A4 (fr) 2015-08-05
MX370928B (es) 2020-01-08
AU2019283995B2 (en) 2021-11-11
CN104470511A (zh) 2015-03-25
JP6576636B2 (ja) 2019-09-18
EP2819667A1 (fr) 2015-01-07
AU2019283995A1 (en) 2020-01-23
AU2013232697A1 (en) 2014-09-18
BR112014021602A2 (pt) 2021-06-08
JP2020073597A (ja) 2020-05-14
KR20150000881A (ko) 2015-01-05
WO2013134867A1 (fr) 2013-09-19
AU2013232697B2 (en) 2017-10-19
EP2819667B8 (fr) 2020-03-04
IL234306B (en) 2022-02-01
CN109248163A (zh) 2019-01-22
KR102133608B1 (ko) 2020-07-13
HK1205469A1 (en) 2015-12-18
MX2014010457A (es) 2015-04-08
US20160296478A1 (en) 2016-10-13
NZ629267A (en) 2016-11-25
AU2018200415A1 (en) 2018-02-08
US10828267B2 (en) 2020-11-10

Similar Documents

Publication Publication Date Title
ES2780357T3 (es) Derivados de retinal para usar en la mejora de la función visual
US20190029986A1 (en) Therapeutic regimen and methods for treating or ameliorating visual disorders associated with an endogenous retinoid deficiency
US20150038582A1 (en) Therapeutic regimens and methods for improving visual function in visual disorders associated with an endogenous retinoid deficiency