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ES2190275T3 - Nuevos intermediarios y procedimiento para la preparacion de agentes antibioticos macrolidos a partir de dichos intermediarios. - Google Patents

Nuevos intermediarios y procedimiento para la preparacion de agentes antibioticos macrolidos a partir de dichos intermediarios.

Info

Publication number
ES2190275T3
ES2190275T3 ES99958490T ES99958490T ES2190275T3 ES 2190275 T3 ES2190275 T3 ES 2190275T3 ES 99958490 T ES99958490 T ES 99958490T ES 99958490 T ES99958490 T ES 99958490T ES 2190275 T3 ES2190275 T3 ES 2190275T3
Authority
ES
Spain
Prior art keywords
intermediaries
procedure
preparation
new
antibiotic agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99958490T
Other languages
English (en)
Inventor
Tae Suk Lee
Chang Hyun Yoo
Kyoung Soo Kim
Hyun Suk An
Jung Young Kim
Wan Joo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemtech Research Inc
Hansol Chemience Co Ltd
Original Assignee
Chemtech Research Inc
Hansol Chemience Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemtech Research Inc, Hansol Chemience Co Ltd filed Critical Chemtech Research Inc
Application granted granted Critical
Publication of ES2190275T3 publication Critical patent/ES2190275T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Intermediario de eritromicina A 9-O-benzoditido oxima útil para la síntesis de claritromicina preparada por reacción de eritromicina A 9-Oxima o el clorhidrato de la misma con tetrafluoroborato de 5 1, 3-benzoditiol-2-ylium (BDTF) representado por la fórmula (III); **(Fórmula)** en la que, Y1 e Y2 son átomos de hidrógeno o grupos trimetilsililo.
ES99958490T 1998-11-24 1999-11-24 Nuevos intermediarios y procedimiento para la preparacion de agentes antibioticos macrolidos a partir de dichos intermediarios. Expired - Lifetime ES2190275T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19980050425 1998-11-24
KR1019990050802A KR100317907B1 (ko) 1998-11-24 1999-11-16 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법

Publications (1)

Publication Number Publication Date
ES2190275T3 true ES2190275T3 (es) 2003-07-16

Family

ID=26634358

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99958490T Expired - Lifetime ES2190275T3 (es) 1998-11-24 1999-11-24 Nuevos intermediarios y procedimiento para la preparacion de agentes antibioticos macrolidos a partir de dichos intermediarios.

Country Status (21)

Country Link
US (1) US6600025B1 (es)
EP (1) EP1133511B1 (es)
JP (1) JP3848837B2 (es)
KR (1) KR100317907B1 (es)
CN (1) CN1354753A (es)
AT (1) ATE234321T1 (es)
AU (1) AU751874B2 (es)
BR (1) BR9915646A (es)
CA (1) CA2352162A1 (es)
CZ (1) CZ20011803A3 (es)
DE (1) DE69905935T2 (es)
DK (1) DK1133511T3 (es)
ES (1) ES2190275T3 (es)
HU (1) HUP0104600A3 (es)
IL (1) IL143331A0 (es)
MX (1) MXPA01005248A (es)
PL (1) PL348607A1 (es)
PT (1) PT1133511E (es)
RU (1) RU2208615C2 (es)
TR (1) TR200101474T2 (es)
WO (1) WO2000031099A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2664331B1 (en) 2003-03-10 2015-09-16 Merck Sharp & Dohme Corp. Novel Antibacterial Agents
ES2221807B1 (es) * 2003-06-24 2005-12-16 Ercros Industrial, S.A. Un procedimiento para la obtencion de claritromicina.
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
EP1904041A2 (en) * 2005-07-07 2008-04-02 Elan Pharma International Limited Nanoparticulate clarithromycin formulations
US20090054634A1 (en) * 2007-08-09 2009-02-26 Vinod Kumar Kansal Process for the preparation of clarithromycin
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
JP5914335B2 (ja) 2009-09-10 2016-05-11 センプラ ファーマシューティカルズ，インコーポレイテッド マラリア、結核、及びｍａｃ病の治療方法
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
KR20180110181A (ko) 2010-09-10 2018-10-08 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
RU2015138796A (ru) 2013-03-14 2017-04-19 Семпра Фармасьютикалс, Инк. Способы и составы для лечения респираторных заболеваний
KR20160020403A (ko) 2013-03-15 2016-02-23 셈프라 파마슈티컬스, 인크. 매크로라이드 항세균제들을 제조하기 위한 수렴 프로세스들

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5872229A (en) * 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) * 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5864023A (en) * 1997-02-13 1999-01-26 Abbott Laboratories 3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) * 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
WO1999028333A1 (en) * 1997-12-01 1999-06-10 Abbott Laboratories Chemical synthesis of 6-o-alkyl erythromycin c
WO1999032500A2 (en) * 1997-12-22 1999-07-01 Biochemie S.A. Intermediates in macrolide production
AU2658899A (en) * 1998-02-04 1999-08-23 Teva Pharmaceutical Industries Ltd. Process for making clarithromycin

Also Published As

Publication number Publication date
US6600025B1 (en) 2003-07-29
HUP0104600A3 (en) 2003-12-29
PT1133511E (pt) 2003-06-30
PL348607A1 (en) 2002-06-03
EP1133511A1 (en) 2001-09-19
HUP0104600A2 (hu) 2002-03-28
ATE234321T1 (de) 2003-03-15
TR200101474T2 (tr) 2001-12-21
AU1584700A (en) 2000-06-13
CA2352162A1 (en) 2000-06-02
EP1133511B1 (en) 2003-03-12
CN1354753A (zh) 2002-06-19
KR100317907B1 (ko) 2001-12-24
IL143331A0 (en) 2002-04-21
DE69905935T2 (de) 2003-09-04
CZ20011803A3 (cs) 2001-10-17
RU2208615C2 (ru) 2003-07-20
DK1133511T3 (da) 2003-07-14
JP3848837B2 (ja) 2006-11-22
MXPA01005248A (es) 2003-08-19
DE69905935D1 (de) 2003-04-17
WO2000031099A1 (en) 2000-06-02
BR9915646A (pt) 2001-08-07
AU751874B2 (en) 2002-08-29
JP2002530423A (ja) 2002-09-17
KR20000057013A (ko) 2000-09-15

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