EE200300071A - Kinasoliini derivaadid - Google Patents

Kinasoliini derivaadid

Info

Publication number: EE200300071A
Authority: EE; Estonia
Prior art keywords: quinazoline derivatives; quinazoline; derivatives
Prior art date: 2000-08-21

Application number

EEP200300071A

Other languages

English (en)

Inventor

Fran�Ois Andr� Hennequin Laurent

Ple Patrick

Marie Paul Lambert Christine

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-21

Filing date

2001-08-15

Publication date

2004-12-15

2001-08-15 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-12-15 Publication of EE200300071A publication Critical patent/EE200300071A/et

2011-02-15 Publication of EE05387B1 publication Critical patent/EE05387B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200300071A 2000-08-21 2001-08-15 KinasoliiniÁderivaadid,ÁnendeÁvalmistamismeetodÁjaÁkasutamine EE05387B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP00402320		2000-08-21
EP01401006		2001-04-19
PCT/GB2001/003649 WO2002016352A1 (en)	2000-08-21	2001-08-15	Quinazoline derivatives

Publications (2)

Publication Number	Publication Date
EE200300071A true EE200300071A (et)	2004-12-15
EE05387B1 EE05387B1 (et)	2011-02-15

Family

ID=26073540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200300071A EE05387B1 (et)	2000-08-21	2001-08-15	KinasoliiniÁderivaadid,ÁnendeÁvalmistamismeetodÁjaÁkasutamine

Country Status (21)

Country	Link
US (1)	US7115615B2 (et)
EP (1)	EP1313727A1 (et)
JP (1)	JP2004506732A (et)
KR (2)	KR100821446B1 (et)
CN (1)	CN100347169C (et)
AR (1)	AR033560A1 (et)
AU (2)	AU2001278609B2 (et)
BR (1)	BR0113358A (et)
CA (1)	CA2419301C (et)
CZ (1)	CZ2003486A3 (et)
EE (1)	EE05387B1 (et)
IL (2)	IL154131A0 (et)
MX (1)	MXPA03001332A (et)
MY (1)	MY129809A (et)
NO (1)	NO326515B1 (et)
NZ (1)	NZ523702A (et)
PL (1)	PL202812B1 (et)
RU (1)	RU2267489C2 (et)
SK (1)	SK2142003A3 (et)
TW (1)	TWI280960B (et)
WO (1)	WO2002016352A1 (et)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA73993C2 (uk)	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
US6849625B2 (en)	2000-10-13	2005-02-01	Astrazeneca Ab	Quinazoline derivatives with anti-tumour activity
WO2002030926A1 (en)	2000-10-13	2002-04-18	Astrazeneca Ab	Quinazoline derivatives
WO2002036587A2 (en)	2000-11-01	2002-05-10	Cor Therapeutics, Inc.	Process for the production of 4-quinazolinylpiperazin-1-carboxylic acid phenylamides
US7141577B2 (en)	2001-04-19	2006-11-28	Astrazeneca Ab	Quinazoline derivatives
US7501516B2 (en)	2001-07-16	2009-03-10	Astrazeneca Ab	Quinoline derivatives and their use as tyrosine kinase inhibitors
GB0128109D0 (en)	2001-11-23	2002-01-16	Astrazeneca Ab	Therapeutic use
WO2003047582A1 (en) *	2001-12-05	2003-06-12	Astrazeneca Ab	Quinoline derivatives as antitumour agents
KR101093345B1 (ko) *	2002-02-01	2011-12-14	아스트라제네카 아베	퀴나졸린 화합물
TW200813014A (en) *	2002-03-28	2008-03-16	Astrazeneca Ab	Quinazoline derivatives
US6924285B2 (en)	2002-03-30	2005-08-02	Boehringer Ingelheim Pharma Gmbh & Co.	Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
DE60327323D1 (de) *	2002-07-09	2009-06-04	Astrazeneca Ab	Chinazoline derivative und ihre anwendung in der krebsbehandlung
GB0215823D0 (en)	2002-07-09	2002-08-14	Astrazeneca Ab	Quinazoline derivatives
US7576074B2 (en)	2002-07-15	2009-08-18	Rice Kenneth D	Receptor-type kinase modulators and methods of use
GB0225579D0 (en) *	2002-11-02	2002-12-11	Astrazeneca Ab	Chemical compounds
CN100354278C (zh) *	2002-11-04	2007-12-12	阿斯利康(瑞典)有限公司	作为src酪氨酸激酶抑制剂的喹唑啉衍生物
JP4593464B2 (ja) *	2002-11-04	2010-12-08	アストラゼネカアクチボラグ	Ｓｒｃチロシンキナーゼ阻害剤としてのキナゾリン誘導体
MXPA06002608A (es)	2002-12-20	2007-01-23	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
US7109337B2 (en)	2002-12-20	2006-09-19	Pfizer Inc	Pyrimidine derivatives for the treatment of abnormal cell growth
GB0307333D0 (en) *	2003-03-29	2003-05-07	Astrazeneca Ab	Therapeutic agent
GB0310401D0 (en) *	2003-05-07	2003-06-11	Astrazeneca Ab	Therapeutic agent
GB0317665D0 (en)	2003-07-29	2003-09-03	Astrazeneca Ab	Qinazoline derivatives
DE602004013806D1 (en)	2003-09-16	2008-06-26	Astrazeneca Ab	Chinazolinderivate als tyrosinkinaseinhibitoren
PL2392565T3 (pl)	2003-09-26	2014-08-29	Exelixis Inc	Modulatory c-Met i sposoby stosowania
DE602005010824D1 (de)	2004-02-03	2008-12-18	Astrazeneca Ab	Chinazolinderivate
JP2007537238A (ja)	2004-05-14	2007-12-20	ファイザー・プロダクツ・インク	異常細胞増殖の治療のためのピリミジン誘導体
MXPA06011658A (es)	2004-05-14	2006-12-14	Pfizer Prod Inc	Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
CA2566332A1 (en)	2004-05-14	2005-11-24	Pfizer Products Inc.	Pyrimidine derivatives for the treatment of abnormal cell growth
PE20060582A1 (es) *	2004-10-13	2006-08-17	Wyeth Corp	Analogos de anilino-pirimidina
GB0427697D0 (en) *	2004-12-17	2005-01-19	Astrazeneca Ab	Chemical process
JP5338072B2 (ja) *	2005-08-17	2013-11-13	宇部興産株式会社	４−ハロカテコール化合物の製法
CN101490060B (zh) *	2006-07-13	2012-04-11	詹森药业有限公司	Mtki喹唑啉衍生物
EP1921070A1 (de)	2006-11-10	2008-05-14	Boehringer Ingelheim Pharma GmbH & Co. KG	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
EP2425840B1 (en)	2006-12-15	2015-04-08	Abraxis BioScience, Inc.	Triazine derivatives and their therapeutical applications
WO2008095847A1 (de)	2007-02-06	2008-08-14	Boehringer Ingelheim International Gmbh	Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
TWI377944B (en) *	2007-06-05	2012-12-01	Hanmi Holdings Co Ltd	Novel amide derivative for inhibiting the growth of cancer cells
AU2009211523B2 (en)	2008-02-07	2014-03-13	Boehringer Ingelheim International Gmbh	Spirocyclic heterocycles, medicaments containing said compounds, use thereof and method for their production
EP2303276B1 (en)	2008-05-13	2013-11-13	AstraZeneca AB	Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
JP5539351B2 (ja)	2008-08-08	2014-07-02	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	シクロヘキシルオキシ置換ヘテロ環、これらの化合物を含有する医薬、およびそれらを生成するための方法
US20100069340A1 (en) *	2008-09-11	2010-03-18	Wyeth	Pharmaceutical compositions of an src kinase inhibitor and an aromatase inhibitor
MX2011003372A (es) *	2008-09-29	2011-06-09	Sirtris Pharmaceuticals Inc	Analogos de cromenona como modulares de sirtuina.
TWI447108B (zh)	2009-01-16	2014-08-01	Exelixis Inc	Ｎ－（４－｛〔６，７雙（甲氧基）喹啉－４－基〕氧基｝苯基）－ｎ’－（４－氟苯基）環丙烷－１，１－二甲醯胺之蘋果酸鹽及其結晶型
JP2012529517A (ja)	2009-06-09	2012-11-22	アブラクシスバイオサイエンスリミテッドライアビリティーカンパニー	ベンジル置換トリアジン誘導体類及びそれらの治療応用
CA2765030C (en)	2009-06-09	2015-10-27	California Capital Equity, Llc	Triazine derivatives and their therapeutical applications
UA108618C2 (uk)	2009-08-07	2015-05-25		Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CN102617463A (zh) *	2012-02-28	2012-08-01	苏州卡耐博生物技术有限公司	喹啉衍生物和喹唑啉衍生物及它们的制备方法
WO2016016894A1 (en)	2014-07-30	2016-02-04	Yeda Research And Development Co. Ltd.	Media for culturing pluripotent stem cells
KR102798145B1 (ko)	2018-04-18	2025-04-22	콘스텔레이션 파마슈티칼스, 인크.	메틸 변형 효소 조절제, 이의 조성물 및 용도
EP3797108B1 (en)	2018-05-21	2022-07-20	Constellation Pharmaceuticals, Inc.	Modulators of methyl modifying enzymes, compositions and uses thereof
WO2020152686A1 (en)	2019-01-23	2020-07-30	Yeda Research And Development Co. Ltd.	Culture media for pluripotent stem cells
CN116120273B (zh) *	2023-02-15	2025-05-13	爱斯特（成都）生物制药股份有限公司	一种制备5-溴苯并[d][1,3]二氧-4-胺的方法
WO2025009910A1 (ko) *	2023-07-04	2025-01-09	부산대학교 산학협력단	퀴나졸린 유도체 화합물 및 이의 용도

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5411963A (en)	1988-01-29	1995-05-02	Dowelanco	Quinazoline derivatives
IL89029A (en)	1988-01-29	1993-01-31	Lilly Co Eli	Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
US5721237A (en)	1991-05-10	1998-02-24	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
ES2108120T3 (es)	1991-05-10	1997-12-16	Rhone Poulenc Rorer Int	Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.
US5710158A (en)	1991-05-10	1998-01-20	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
NZ243082A (en)	1991-06-28	1995-02-24	Ici Plc	4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
RU2043352C1 (ru) *	1991-07-01	1995-09-10	Пермский фармацевтический институт	2-пропил-3- (5-нитрофурфулиден)амино- 4(3н)-хиназолинон, проявляющий противостафилококковую и анальгетическую активность
PT100905A (pt)	1991-09-30	1994-02-28	Eisai Co Ltd	Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
GB9300059D0 (en)	1992-01-20	1993-03-03	Zeneca Ltd	Quinazoline derivatives
GB9323290D0 (en)	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
RU2118322C1 (ru) *	1993-07-05	1998-08-27	Дюфар Интернэшнл Рисерч Б.В.	2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
EP0746554A1 (en)	1994-02-23	1996-12-11	Pfizer Inc.	4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents
AU2096895A (en) *	1994-03-07	1995-09-25	Sugen, Incorporated	Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9510757D0 (en)	1994-09-19	1995-07-19	Wellcome Found	Therapeuticaly active compounds
GB9419318D0 (en) *	1994-09-24	1994-11-09	Pfizer Ltd	Therapeutic agents
TW321649B (et)	1994-11-12	1997-12-01	Zeneca Ltd
GB2295387A (en)	1994-11-23	1996-05-29	Glaxo Inc	Quinazoline antagonists of alpha 1c adrenergic receptors
GB9424233D0 (en)	1994-11-30	1995-01-18	Zeneca Ltd	Quinazoline derivatives
JP3088018B2 (ja)	1995-03-30	2000-09-18	ファイザー・インコーポレーテッド	キナゾリン誘導体
US6046206A (en) *	1995-06-07	2000-04-04	Cell Pathways, Inc.	Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
GB9514265D0 (en)	1995-07-13	1995-09-13	Wellcome Found	Hetrocyclic compounds
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
US5760041A (en)	1996-02-05	1998-06-02	American Cyanamid Company	4-aminoquinazoline EGFR Inhibitors
HUP9901155A3 (en)	1996-02-13	2003-04-28	Astrazeneca Ab	Quinazoline derivatives as vegf inhibitors
GB9603095D0 (en)	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline derivatives
GB9603097D0 (en)	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline compounds
GB9607729D0 (en)	1996-04-13	1996-06-19	Zeneca Ltd	Quinazoline derivatives
ES2186908T3 (es)	1996-07-13	2003-05-16	Glaxo Group Ltd	Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas.
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
AUPO257096A0 (en) *	1996-09-25	1996-10-17	Bhp Steel (Jla) Pty Limited	Production of striped coatings on strip
EP0837063A1 (en)	1996-10-17	1998-04-22	Pfizer Inc.	4-Aminoquinazoline derivatives
AR012634A1 (es)	1997-05-02	2000-11-08	Sugen Inc	Compuesto basado en quinazolina, composicion famaceutica que lo comprende, metodo para sintetizarlo, su uso, metodos de modulacion de la funcion deserina/treonina proteinaquinasa con dicho compuesto y metodo in vitro para identificar compuestos que modulan dicha funcion
TW436485B (en)	1997-08-01	2001-05-28	American Cyanamid Co	Substituted quinazoline derivatives
KR20010052450A (ko)	1998-05-28	2001-06-25	파커 휴우즈 인스티튜트	뇌종양 치료를 위한 퀴나졸린
JP2004504259A (ja)	1998-06-30	2004-02-12	パーカー　ヒューズ　インスティテュート	Ｊａｋ−３インヒビターを用いたｃ−ｊｕｎ発現の阻害方法
KR20010089171A (ko)	1998-08-21	2001-09-29	추후제출	퀴나졸린 유도체
US7262201B1 (en)	1998-10-08	2007-08-28	Astrazeneca Ab	Quinazoline derivatives
IL132366A0 (en) *	1998-10-15	2001-03-19	Cell Pathways Inc	Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds
NZ530832A (en) *	1999-02-10	2005-05-27	Astrazeneca Ab	Quinazoline derivatives as angiogenesis inhibitors
HRP20010617A2 (en)	1999-02-27	2002-10-31	Boehringer Ingelheim Pharma	4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases
US6080747A (en)	1999-03-05	2000-06-27	Hughes Institute	JAK-3 inhibitors for treating allergic disorders
DE19911509A1 (de)	1999-03-15	2000-09-21	Boehringer Ingelheim Pharma	Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
GB9922173D0 (en)	1999-09-21	1999-11-17	Zeneca Ltd	Chemical compounds
EE200200149A (et)	1999-09-21	2003-04-15	Astrazeneca Ab	Kinasoliinühendid ja neid sisaldavad ravimkoostised
CZ20021009A3 (cs)	1999-09-21	2002-06-12	Astrazeneca Ab	Deriváty chinazolinu, způsob jejich přípravy a jejich pouľití jako léčiv
CA2403365A1 (en)	2000-04-07	2001-10-18	Astrazeneca Ab	Quinazoline compounds
UA73993C2 (uk)	2000-06-06	2005-10-17	Астразенека Аб	Хіназолінові похідні для лікування пухлин та фармацевтична композиція
WO2002030926A1 (en)	2000-10-13	2002-04-18	Astrazeneca Ab	Quinazoline derivatives
US6849625B2 (en)	2000-10-13	2005-02-01	Astrazeneca Ab	Quinazoline derivatives with anti-tumour activity
WO2002034744A1 (en)	2000-10-25	2002-05-02	Astrazeneca Ab	Quinazoline derivatives
US7141577B2 (en)	2001-04-19	2006-11-28	Astrazeneca Ab	Quinazoline derivatives
US7501516B2 (en)	2001-07-16	2009-03-10	Astrazeneca Ab	Quinoline derivatives and their use as tyrosine kinase inhibitors

2001
- 2001-08-15 EP EP01956688A patent/EP1313727A1/en not_active Withdrawn
- 2001-08-15 SK SK214-2003A patent/SK2142003A3/sk not_active Application Discontinuation
- 2001-08-15 CZ CZ2003486A patent/CZ2003486A3/cs unknown
- 2001-08-15 CN CNB018177409A patent/CN100347169C/zh not_active Expired - Fee Related
- 2001-08-15 BR BR0113358-6A patent/BR0113358A/pt not_active Application Discontinuation
- 2001-08-15 WO PCT/GB2001/003649 patent/WO2002016352A1/en active IP Right Grant
- 2001-08-15 MX MXPA03001332A patent/MXPA03001332A/es active IP Right Grant
- 2001-08-15 KR KR1020037002441A patent/KR100821446B1/ko not_active Expired - Fee Related
- 2001-08-15 NZ NZ523702A patent/NZ523702A/en unknown
- 2001-08-15 IL IL15413101A patent/IL154131A0/xx unknown
- 2001-08-15 RU RU2003107683/04A patent/RU2267489C2/ru not_active IP Right Cessation
- 2001-08-15 AU AU2001278609A patent/AU2001278609B2/en not_active Ceased
- 2001-08-15 KR KR1020087005460A patent/KR20080027400A/ko not_active Withdrawn
- 2001-08-15 CA CA002419301A patent/CA2419301C/en not_active Expired - Fee Related
- 2001-08-15 US US10/344,678 patent/US7115615B2/en not_active Expired - Fee Related
- 2001-08-15 JP JP2002521453A patent/JP2004506732A/ja not_active Ceased
- 2001-08-15 EE EEP200300071A patent/EE05387B1/et not_active IP Right Cessation
- 2001-08-15 AU AU7860901A patent/AU7860901A/xx active Pending
- 2001-08-15 PL PL360591A patent/PL202812B1/pl not_active IP Right Cessation
- 2001-08-20 MY MYPI20013907A patent/MY129809A/en unknown
- 2001-08-21 AR ARP010103972A patent/AR033560A1/es not_active Application Discontinuation
- 2001-09-14 TW TW90122895A patent/TWI280960B/zh not_active IP Right Cessation
2003
- 2003-01-26 IL IL154131A patent/IL154131A/en not_active IP Right Cessation
- 2003-02-20 NO NO20030795A patent/NO326515B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20030795L (no)	2003-04-04
CN100347169C (zh)	2007-11-07
US7115615B2 (en)	2006-10-03
WO2002016352A1 (en)	2002-02-28
CN1471527A (zh)	2004-01-28
AR033560A1 (es)	2003-12-26
CA2419301A1 (en)	2002-02-28
AU2001278609B2 (en)	2005-04-14
PL202812B1 (pl)	2009-07-31
NO20030795D0 (no)	2003-02-20
TWI280960B (en)	2007-05-11
KR20080027400A (ko)	2008-03-26
CZ2003486A3 (cs)	2003-05-14
RU2267489C2 (ru)	2006-01-10
MY129809A (en)	2007-05-31
PL360591A1 (en)	2004-09-06
CA2419301C (en)	2009-12-08
NZ523702A (en)	2004-08-27
IL154131A0 (en)	2003-07-31
IL154131A (en)	2010-04-15
MXPA03001332A (es)	2004-07-08
JP2004506732A (ja)	2004-03-04
BR0113358A (pt)	2003-07-01
NO326515B1 (no)	2008-12-22
KR20030022416A (ko)	2003-03-15
SK2142003A3 (en)	2003-07-01
US20040034046A1 (en)	2004-02-19
EE05387B1 (et)	2011-02-15
KR100821446B1 (ko)	2008-04-10
EP1313727A1 (en)	2003-05-28
AU7860901A (en)	2002-03-04

Publication	Publication Date	Title
EE200300071A (et)	2004-12-15	Kinasoliini derivaadid
DK1292604T3 (da)	2009-06-15	2-Aminocarbonyl-9H-purinderivater
DE60130463D1 (de)	2007-10-25	Pyrimidin-derivate
ATE288437T1 (de)	2005-02-15	Tetrahydro-heterocycloazepinyl-pyrimidin-deriva e
DK1280809T3 (da)	2005-11-07	Antitumorecteinascidinderivater
ATE298332T1 (de)	2005-07-15	Decahydro-isochinolinderivate
NO20030276D0 (no)	2003-01-20	Fremgangsmåte
DE50114491D1 (de)	2008-12-24	Substituierte C-Cyclohexylmethylamin-Derivative
AR028602A1 (es)	2003-05-14	Derivados de pirrol
AR028282A1 (es)	2003-04-30	Derivados de aminofenil pirimidona
DK1322593T3 (da)	2004-10-11	O-substituerede-6-methyl-tramadol-derivater
ATE282021T1 (de)	2004-11-15	Substituierte aminomethyl-phenyl- cyclohexanderivate
PT1351959E (pt)	2005-09-30	Novos derivados de pleuromutilina
ATE280752T1 (de)	2004-11-15	Aminomethyl-phenyl-cyclohexanonderivate
DK1330442T3 (da)	2011-04-11	Phthalazinon-derivativer
DK1322590T3 (da)	2007-09-03	Substituerede 5-amino-1-penten-3-ol-derivater
ATE374776T1 (de)	2007-10-15	Pyrrolotriazolopyrimidinonderivate
NO20024393D0 (no)	2002-09-13	2-fenylpyran-4-on-derivater
DK1246793T3 (da)	2005-02-21	Substituerede aminomethyl-phenyl-cyclohexanderivater

Legal Events

Date	Code	Title	Description
2012-04-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20110815