[go: up one dir, main page]

EE05485B1 - Plasmi(i)n(ogeen)i eemaldamine valgulahustest - Google Patents

Plasmi(i)n(ogeen)i eemaldamine valgulahustest

Info

Publication number
EE05485B1
EE05485B1 EEP200300578A EEP200300578A EE05485B1 EE 05485 B1 EE05485 B1 EE 05485B1 EE P200300578 A EEP200300578 A EE P200300578A EE P200300578 A EEP200300578 A EE P200300578A EE 05485 B1 EE05485 B1 EE 05485B1
Authority
EE
Estonia
Prior art keywords
ogen
amino acid
plasmin
plasma
removal
Prior art date
Application number
EEP200300578A
Other languages
English (en)
Estonian (et)
Inventor
Nur Israel
Bar Liliana
Azachi Malkit
Original Assignee
Omrix Biopharmaceuticals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals S.A. filed Critical Omrix Biopharmaceuticals S.A.
Publication of EE200300578A publication Critical patent/EE200300578A/xx
Publication of EE05485B1 publication Critical patent/EE05485B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • C12N9/6435Plasmin (3.4.21.7), i.e. fibrinolysin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21007Plasmin (3.4.21.7), i.e. fibrinolysin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
EEP200300578A 2001-05-21 2002-05-17 Plasmi(i)n(ogeen)i eemaldamine valgulahustest EE05485B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29196801P 2001-05-21 2001-05-21
EP01115157 2001-06-21
PCT/EP2002/005462 WO2002095019A1 (en) 2001-05-21 2002-05-17 Removal of plasmin(ogen) from protein solutions

Publications (2)

Publication Number Publication Date
EE200300578A EE200300578A (et) 2004-02-16
EE05485B1 true EE05485B1 (et) 2011-10-17

Family

ID=26076623

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300578A EE05485B1 (et) 2001-05-21 2002-05-17 Plasmi(i)n(ogeen)i eemaldamine valgulahustest

Country Status (20)

Country Link
US (4) US20040197891A1 (xx)
EP (1) EP1390485B1 (xx)
JP (1) JP4385097B2 (xx)
KR (1) KR100871454B1 (xx)
AT (1) ATE342353T1 (xx)
AU (1) AU2002314081B2 (xx)
CA (1) CA2447789C (xx)
CZ (1) CZ20033097A3 (xx)
DE (1) DE60215338T2 (xx)
EE (1) EE05485B1 (xx)
ES (1) ES2274044T3 (xx)
HK (1) HK1060902A1 (xx)
HU (1) HU228899B1 (xx)
IL (2) IL158754A0 (xx)
MX (1) MXPA03010616A (xx)
PL (1) PL205685B1 (xx)
RU (2) RU2458067C2 (xx)
SK (1) SK288005B6 (xx)
WO (1) WO2002095019A1 (xx)
ZA (1) ZA200309030B (xx)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL205685B1 (pl) 2001-05-21 2010-05-31 Omrix Biopharm Sa Sposób in vitro usuwania lub wyodrębniania plazminogenu lub plazminy w obecności fibrynogenu, stałe podłoże powinowactwa do oczyszczania mieszaniny zawierającej fibrynogen i plazminę i/lub plazminogen oraz krioprecypitat
SE526038C2 (sv) * 2002-07-08 2005-06-21 Gambro Lundia Ab Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav
CA2514474C (en) 2003-01-30 2014-05-06 Avner Yayon Freeze-dried fibrin matrices and methods for preparation thereof
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
DE102004009400A1 (de) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen Reinigung
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
EP2052746B1 (en) 2004-10-20 2014-11-26 Ethicon, Inc. Absorbable hemostat
US9358318B2 (en) 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
JP2007068497A (ja) * 2005-09-09 2007-03-22 Nihon Pharmaceutical Co Ltd プラスミンの精製法
US8921109B2 (en) 2005-09-19 2014-12-30 Histogenics Corporation Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
US20070134231A1 (en) * 2005-12-13 2007-06-14 Jani Dharmendra M Method for prolonging activity of autodegradable enzymes and compositions thereof
BRPI0718145B8 (pt) 2006-11-02 2021-05-25 Omrix Biopharmaceuticals Ltd método de micronização
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8409499B2 (en) 2007-06-07 2013-04-02 Ethicon, Inc. Method for establishing a sterilizing dose for radiation sensitive products
US7704453B2 (en) 2007-06-07 2010-04-27 Ethicon, Inc. Method for establishing a sterilizing dose for radiation sensitive products
EP2011524A1 (en) * 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrin glue with a visualization agent
EP2034010A1 (en) 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Compositions suitable for repair and/or treatment of injured spinal tissue
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
EP2331158B1 (en) 2008-09-22 2013-09-11 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
EP2398394B1 (en) * 2009-02-20 2021-08-04 Omrix Biopharmaceuticals Ltd. Device for administering an at least two-component substance
CN102791299B (zh) 2010-01-28 2014-10-22 奥姆里克斯生物药品有限公司 具有改善的密封特性的纤维蛋白基质及其制备和用途
WO2011146179A2 (en) * 2010-05-18 2011-11-24 Abbott Laboratories Apparatus and process of purification of proteins
IL207586A0 (en) * 2010-08-12 2010-12-30 Omrix Biopharmaceuticals Ltd A fibrin based therapeutic preparation and use thereof
JP5836577B2 (ja) * 2010-09-14 2015-12-24 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体の製造方法、その精製方法、除去方法
WO2012036140A1 (ja) * 2010-09-14 2012-03-22 株式会社カネカ クリングル配列を有する蛋白質またはペプチドを精製または除去するアフィニティ担体、及びそれを用いた精製方法、除去方法
CN106046147B (zh) * 2010-09-20 2019-11-19 欧克塔医药公司 纤维蛋白原生产方法
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
IL213375A0 (en) 2011-06-05 2011-07-31 Omrix Biopharmaceuticals Device for spraying fluids in proximity to a surface
EP2723354B3 (en) 2011-06-27 2021-03-24 Emory University Compositions, uses, and preparation of platelet lysates
IL213864A0 (en) 2011-06-30 2011-08-31 Omrix Biopharmaceuticals Ltd Method for removing a lytic enzyme from a heterogeneous mixture
RU2605710C2 (ru) 2011-12-29 2016-12-27 Омрикс Биофармасьютикалс Лтд. Способ и устройство для быстрого растворения твердой белковой композиции
US10130346B2 (en) 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
US20140154233A1 (en) * 2012-12-05 2014-06-05 Csl Limited Method of purifying therapeutic proteins
CN104994886B (zh) 2012-12-20 2017-10-03 奥姆里克斯生物药品有限公司 病毒灭活的生物混合物
CA2896760A1 (en) 2012-12-30 2014-07-03 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a portion of a bodily organ
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen preparation
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
IL235751A0 (en) 2014-11-18 2015-02-26 Omrix Biopharmaceuticals Ltd An addition to the spray dryer
WO2016079727A1 (en) 2014-11-18 2016-05-26 Omrix Biopharmaceuticals Ltd. Spray-drying apparatus and method of use
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
WO2016132357A1 (en) 2015-02-16 2016-08-25 Nayacure Therapeutics Ltd. Modified blood clots
CA2976875A1 (en) 2015-02-25 2016-09-01 Omrix Biopharmaceuticals Ltd. Method for purifying and quantifying thrombin and its degradation polypeptides
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them
US10159720B2 (en) 2015-12-08 2018-12-25 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, preparation and uses thereof
EP3373986A1 (en) 2015-11-11 2018-09-19 Ethicon, Inc. Sealant formulation and uses thereof
IL242924A0 (en) 2015-12-03 2016-04-21 Omrix Biopharmaceuticals Ltd Syringe system for storing and mixing two ingredients
IL265102B2 (en) * 2016-09-01 2023-11-01 Plas Free Ltd Human Blood-Derived Products Having Decreased Fibrinolytic Activity And Uses Thereof In Hemostatic Disorders
IT201600091964A1 (it) 2016-09-13 2018-03-13 Kedrion Spa Processo per la purificazione del plasminogeno a partire da plasma umano.
IL247821A0 (en) * 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Adhesive preparations and their use
JP7269184B2 (ja) * 2017-03-09 2023-05-08 プリビファーマ・コンサルティング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 血液画分からのGlu-プラスミノーゲンの製造および使用
IL256405A (en) 2017-12-19 2018-01-31 Omrix Biopharmaceuticals Ltd Wound bandage and method for its production
ES2983341T3 (es) * 2018-02-28 2024-10-22 Plas Free Ltd Dispositivo extracorpóreo y matriz para la eliminación de proteínas fibrinolíticas de fluidos biológicos, métodos y usos de los mismos
WO2020121290A1 (en) 2018-12-12 2020-06-18 Omrix Biopharmaceuticals Ltd. High concentrated protein compositions for preventing tissue adhesion
IL263679A (en) 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and compositions for preventing tissue adhesion
CN111760556B (zh) * 2020-07-09 2023-06-30 江苏尤里卡生物科技有限公司 一种尿激酶吸附剂及其制备方法和应用
WO2022099223A2 (en) 2020-11-09 2022-05-12 Takeda Pharmaceutical Company Limited Purification of fviii from plasma using silicon oxide adsorption
CN117460823A (zh) 2021-06-08 2024-01-26 先觉药业咨询公司 从血浆级分中分离纤溶酶原的方法
CN113533594A (zh) * 2021-06-30 2021-10-22 长沙都正生物科技股份有限公司 用于测定氨甲环酸含量的方法及试剂盒
US20230085152A1 (en) 2021-09-16 2023-03-16 Ethicon, Inc. Kit for Composition for Tissue Tract Sealing
US20250073313A1 (en) 2021-12-21 2025-03-06 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
SU979508A1 (ru) * 1980-07-23 1982-12-07 Ордена Трудового Красного Знамени Институт Биохимии Им.А.В.Палладина Способ получени иммобилизованного плазминогена
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4639543A (en) 1985-02-04 1987-01-27 Richard J. Birch Semiconductor devices having a metallic glass substrate
JPS6391080A (ja) 1986-10-03 1988-04-21 Kanegafuchi Chem Ind Co Ltd ヒト組織プラスミノゲン活性化因子の精製法
GB8902771D0 (en) * 1989-02-08 1989-03-30 Bioprocessing Ltd Improvements in or relating to affinity chromatography
ATE197067T1 (de) 1989-04-07 2000-11-15 Cancerforskningsfonden Af 1989 Plasminogen-aktivator-rezeptor vom urokinasetyp
SU1727839A1 (ru) 1990-05-30 1992-04-23 МГУ им.М.В.Ломоносова Способ получени фибриногена
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
DK82592D0 (da) * 1992-06-23 1992-06-23 Novo Nordisk As Fremstilling af proteiner
US5362859A (en) 1992-07-27 1994-11-08 Sepracor, Inc. High-capacity affinity supports and methods for the preparation and use of same
JPH08225461A (ja) 1995-02-21 1996-09-03 Green Cross Corp:The プラスミノーゲンの精製方法およびプラスミノーゲン製剤
JP3763598B2 (ja) 1995-09-11 2006-04-05 旭電化工業株式会社 トラネキサム酸の製造方法
US6451978B2 (en) * 2000-01-21 2002-09-17 Biovitrum Ab Purification of antithrombin-III-α and β
PL205685B1 (pl) * 2001-05-21 2010-05-31 Omrix Biopharm Sa Sposób in vitro usuwania lub wyodrębniania plazminogenu lub plazminy w obecności fibrynogenu, stałe podłoże powinowactwa do oczyszczania mieszaniny zawierającej fibrynogen i plazminę i/lub plazminogen oraz krioprecypitat

Also Published As

Publication number Publication date
KR100871454B1 (ko) 2008-12-03
HU228899B1 (en) 2013-06-28
DE60215338D1 (de) 2006-11-23
US8563288B2 (en) 2013-10-22
CA2447789C (en) 2012-11-06
PL205685B1 (pl) 2010-05-31
US20090176293A1 (en) 2009-07-09
RU2008130356A (ru) 2010-01-27
KR20040011503A (ko) 2004-02-05
US20030124703A1 (en) 2003-07-03
HUP0600110A2 (en) 2006-05-29
SK14202003A3 (sk) 2004-08-03
US20070092959A1 (en) 2007-04-26
US20040197891A1 (en) 2004-10-07
IL158754A (en) 2009-05-04
EP1390485A1 (en) 2004-02-25
ZA200309030B (en) 2005-06-29
IL158754A0 (en) 2004-05-12
CZ20033097A3 (cs) 2004-06-16
CA2447789A1 (en) 2002-11-28
JP4385097B2 (ja) 2009-12-16
EE200300578A (et) 2004-02-16
SK288005B6 (sk) 2012-10-02
HUP0600110A3 (en) 2010-01-28
WO2002095019A1 (en) 2002-11-28
ATE342353T1 (de) 2006-11-15
RU2344143C2 (ru) 2009-01-20
JP2004528853A (ja) 2004-09-24
RU2003136746A (ru) 2005-05-20
AU2002314081B2 (en) 2007-04-05
RU2458067C2 (ru) 2012-08-10
MXPA03010616A (es) 2004-04-02
EP1390485B1 (en) 2006-10-11
ES2274044T3 (es) 2007-05-16
US7641918B2 (en) 2010-01-05
US7125569B2 (en) 2006-10-24
PL365808A1 (en) 2005-01-10
DE60215338T2 (de) 2007-05-16
HK1060902A1 (en) 2004-08-27

Similar Documents

Publication Publication Date Title
EE05485B1 (et) Plasmi(i)n(ogeen)i eemaldamine valgulahustest
DE59409712D1 (de) Verfahren zur chromatographischen reinigung und trennung von nucleinsäuregemischen
ATE451390T1 (de) Polypeptide zur bindung an das b-lymphozyten- stimulatorische protein (blys)
DE50012021D1 (de) Nucleinsauremoleküle mit spezifischer erkennung von nativem prpsc, herstellung und verwendung
IE64787B1 (en) Peptide boronic acid inhibitors of tryspin-like proteases
DE60019321D1 (de) Verfahren zum screening von inhibitoren von asp2
ATE449104T1 (de) Verfahren zur reinigung von fibrinogen
Lakemeyer et al. Tailored peptide phenyl esters block ClpXP proteolysis by an unusual breakdown into a heptamer–hexamer assembly
ATE417056T1 (de) Verfahren zur proteinreinigung
ID21224A (id) Metode pembuatan obat yang mengandung protein plasma
AU2003260392A1 (en) Method for enriching a prokaryotic dna
AU2126400A (en) Detection of small molecules by use of a piezoelectric sensor
ATE333469T1 (de) Verfahren zur reinigung hochanionischer proteine
ATE246692T1 (de) Verfahren zur reinigung von phosphatidylserin
FR2814744B1 (fr) Cyclopeptides, leur procede de preparation et leur utilisation comme inhibiteur ou activateur de l'angiogenese
Rijkers et al. Prevention of the influence of fibrin and α2-Macroglobulin in the continuous measurement of the thrombin potential: Implications for an endpoint determination of the optical density
DE69433875D1 (de) Verfahren zur präparation von humanem aktiviertem protein c
van Iwaarden et al. Role of high molecular weight kininogen in contact activation
Seya et al. Generation of C3d, g and C3d by urokinase-treated plasma in association with fibrinolysis
WO2007067689A3 (en) Device and methods for preparation of peptides and proteins samples from solution
Harvima et al. Hydrolysis of histones by proteinases
Turner et al. Pharmacology of enkephalinase inhibitors
Mikhailova et al. Effect of calcium ions on enteropeptidase catalysis
Swenson et al. Fibrolase
DE60041985D1 (de) Zusammensetzungen und verfahren zur erfassung von stress induzierten proteinen

Legal Events

Date Code Title Description
MM4A Lapsed by not paying the annual fees

Effective date: 20160517