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EA201291414A1 - Имидазопиридиновые производные, способ их получения и терапевтическое использование - Google Patents

Имидазопиридиновые производные, способ их получения и терапевтическое использование

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Publication number
EA201291414A1
EA201291414A1 EA201291414A EA201291414A EA201291414A1 EA 201291414 A1 EA201291414 A1 EA 201291414A1 EA 201291414 A EA201291414 A EA 201291414A EA 201291414 A EA201291414 A EA 201291414A EA 201291414 A1 EA201291414 A1 EA 201291414A1
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EA
Eurasian Patent Office
Prior art keywords
therapeutic use
imidazopiridine
derivatives
production
relates
Prior art date
Application number
EA201291414A
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English (en)
Other versions
EA022690B1 (ru
Inventor
Шанталь Алькуфф
Райнхард Кирш
Корантен Эрбер
Жильбер Лассаль
Original Assignee
Санофи
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Application filed by Санофи filed Critical Санофи
Publication of EA201291414A1 publication Critical patent/EA201291414A1/ru
Publication of EA022690B1 publication Critical patent/EA022690B1/ru

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
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  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к соединениям, соответствующим формуле (I)в которой Rи Rвместе с атомами углерода фенильного ядра, с которыми они связаны, образуют 6-членный азотсодержащий гетероцикл, соответствующий одной из формул (А), (В) и (С), представленных нижев которых волнистые линии представляют собой фенильное ядро; с которым Rи Rсвязаны. Изобретение также относится к способу получения и терапевтическому использованию соединений.
EA201291414A 2010-07-06 2011-07-04 Имидазопиридиновые производные, способ их получения и терапевтическое использование EA022690B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1055475A FR2962437B1 (fr) 2010-07-06 2010-07-06 Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
PCT/IB2011/052954 WO2012004732A1 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof

Publications (2)

Publication Number Publication Date
EA201291414A1 true EA201291414A1 (ru) 2013-05-30
EA022690B1 EA022690B1 (ru) 2016-02-29

Family

ID=43383651

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291414A EA022690B1 (ru) 2010-07-06 2011-07-04 Имидазопиридиновые производные, способ их получения и терапевтическое использование

Country Status (37)

Country Link
US (2) US8759344B2 (ru)
EP (1) EP2590976B1 (ru)
JP (1) JP5889295B2 (ru)
KR (1) KR101820548B1 (ru)
CN (1) CN103080111B (ru)
AR (1) AR082112A1 (ru)
AU (1) AU2011275427B2 (ru)
BR (1) BR112013000273B1 (ru)
CA (1) CA2804915C (ru)
CL (1) CL2013000016A1 (ru)
CO (1) CO6650360A2 (ru)
CR (1) CR20120643A (ru)
CY (1) CY1117374T1 (ru)
DK (1) DK2590976T3 (ru)
EA (1) EA022690B1 (ru)
EC (1) ECSP13012363A (ru)
ES (1) ES2556754T3 (ru)
FR (1) FR2962437B1 (ru)
GT (1) GT201200346A (ru)
HR (1) HRP20151309T1 (ru)
HU (1) HUE025639T2 (ru)
IL (1) IL223832A (ru)
MA (1) MA34450B1 (ru)
MX (1) MX2012015120A (ru)
NI (1) NI201200192A (ru)
NZ (1) NZ604973A (ru)
PE (1) PE20130651A1 (ru)
PH (1) PH12013500041A1 (ru)
PL (1) PL2590976T3 (ru)
PT (1) PT2590976E (ru)
SG (1) SG186396A1 (ru)
SI (1) SI2590976T1 (ru)
TN (1) TN2012000608A1 (ru)
TW (1) TWI520961B (ru)
UY (1) UY33488A (ru)
WO (1) WO2012004732A1 (ru)
ZA (1) ZA201209632B (ru)

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