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EA201291409A1 - Производные индолизина, способ их получения и их терапевтическое применение - Google Patents

Производные индолизина, способ их получения и их терапевтическое применение

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Publication number
EA201291409A1
EA201291409A1 EA201291409A EA201291409A EA201291409A1 EA 201291409 A1 EA201291409 A1 EA 201291409A1 EA 201291409 A EA201291409 A EA 201291409A EA 201291409 A EA201291409 A EA 201291409A EA 201291409 A1 EA201291409 A1 EA 201291409A1
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EA
Eurasian Patent Office
Prior art keywords
indolysine
derivatives
production
therapeutic application
attached
Prior art date
Application number
EA201291409A
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English (en)
Other versions
EA024160B1 (ru
Inventor
Шанталь Алькуфф
Корантен Эрбер
Жильбер Лассалль
Original Assignee
Санофи
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Application filed by Санофи filed Critical Санофи
Publication of EA201291409A1 publication Critical patent/EA201291409A1/ru
Publication of EA024160B1 publication Critical patent/EA024160B1/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Изобретение относится к соединениям, соответствующим формуле (I), где Rи Rобразуют вместе с атомами углерода фенильного ядра, к которому они присоединены, 6-членный азотистый гетероцикл, соответствующий одной из формул (А), (В) и (С), приведенных ниже, где волнистыми линиями обозначено фенильное ядро, к которому присоединены Rи R; способу их получения и терапевтическому применению.
EA201291409A 2010-07-06 2011-07-04 Производные индолизина, способ их получения и их терапевтическое применение EA024160B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1055477A FR2962438B1 (fr) 2010-07-06 2010-07-06 Derives d'indolizines, procedes de preparation et application en therapeutique
PCT/IB2011/052953 WO2012004731A1 (en) 2010-07-06 2011-07-04 Indolizine derivatives, process for the preparation thereof and therapeutic use thereof

Publications (2)

Publication Number Publication Date
EA201291409A1 true EA201291409A1 (ru) 2013-05-30
EA024160B1 EA024160B1 (ru) 2016-08-31

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EA201291409A EA024160B1 (ru) 2010-07-06 2011-07-04 Производные индолизина, способ их получения и их терапевтическое применение

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US (1) US8859544B2 (ru)
EP (1) EP2590975B1 (ru)
JP (1) JP5863788B2 (ru)
KR (1) KR101797795B1 (ru)
CN (1) CN103080112B (ru)
AR (1) AR082768A1 (ru)
AU (1) AU2011275426B2 (ru)
BR (1) BR112013000306A2 (ru)
CA (1) CA2805065C (ru)
CL (1) CL2013000018A1 (ru)
CO (1) CO6650361A2 (ru)
CR (1) CR20130001A (ru)
CY (1) CY1116945T1 (ru)
DK (1) DK2590975T3 (ru)
DO (1) DOP2012000321A (ru)
EA (1) EA024160B1 (ru)
EC (1) ECSP13012362A (ru)
ES (1) ES2552850T3 (ru)
FR (1) FR2962438B1 (ru)
GT (1) GT201300001A (ru)
HR (1) HRP20151162T1 (ru)
HU (1) HUE026067T2 (ru)
IL (1) IL223844A (ru)
MA (1) MA34451B1 (ru)
MX (1) MX2012015306A (ru)
MY (1) MY163202A (ru)
NI (1) NI201200191A (ru)
PE (1) PE20130386A1 (ru)
PH (1) PH12013500005A1 (ru)
PL (1) PL2590975T3 (ru)
PT (1) PT2590975E (ru)
SG (2) SG10201505282YA (ru)
SI (1) SI2590975T1 (ru)
TN (1) TN2012000609A1 (ru)
TW (1) TWI494310B (ru)
UA (1) UA109013C2 (ru)
UY (1) UY33489A (ru)
WO (1) WO2012004731A1 (ru)
ZA (1) ZA201300100B (ru)

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WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
FR2985258A1 (fr) 2011-12-28 2013-07-05 Sanofi Sa Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique
PT3495367T (pt) 2012-06-13 2020-11-12 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
MX393494B (es) 2013-04-19 2025-03-24 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
JP6854776B2 (ja) * 2015-01-08 2021-04-07 インぺティス バイオサイエンス リミテッド 二環式化合物、その組成物および医薬用途
CR20170390A (es) 2015-02-20 2017-10-23 Incyte Holdings Corp Heterociclos biciclicos como inhibidores de fgfr
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
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