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FR2962437B1 - Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique - Google Patents

Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2962437B1
FR2962437B1 FR1055475A FR1055475A FR2962437B1 FR 2962437 B1 FR2962437 B1 FR 2962437B1 FR 1055475 A FR1055475 A FR 1055475A FR 1055475 A FR1055475 A FR 1055475A FR 2962437 B1 FR2962437 B1 FR 2962437B1
Authority
FR
France
Prior art keywords
preparing
therapeutic application
imidazopyridine derivatives
imidazopyridine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1055475A
Other languages
English (en)
Other versions
FR2962437A1 (fr
Inventor
Chantal Alcouffe
Reinhard Kirsch
Corentin Herbert
Gilbert Lassale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43383651&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2962437(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR1055475A priority Critical patent/FR2962437B1/fr
Priority to HRP20151309TT priority patent/HRP20151309T1/hr
Priority to CA2804915A priority patent/CA2804915C/fr
Priority to SG2012093464A priority patent/SG186396A1/en
Priority to EP11743633.7A priority patent/EP2590976B1/fr
Priority to SI201130684T priority patent/SI2590976T1/sl
Priority to MA35637A priority patent/MA34450B1/fr
Priority to EA201291414A priority patent/EA022690B1/ru
Priority to PL11743633T priority patent/PL2590976T3/pl
Priority to PE2013000005A priority patent/PE20130651A1/es
Priority to PH1/2013/500041A priority patent/PH12013500041A1/en
Priority to KR1020137002987A priority patent/KR101820548B1/ko
Priority to ES11743633.7T priority patent/ES2556754T3/es
Priority to NZ604973A priority patent/NZ604973A/en
Priority to CN201180042933.1A priority patent/CN103080111B/zh
Priority to MX2012015120A priority patent/MX2012015120A/es
Priority to PT117436337T priority patent/PT2590976E/pt
Priority to JP2013517656A priority patent/JP5889295B2/ja
Priority to BR112013000273-5A priority patent/BR112013000273B1/pt
Priority to AU2011275427A priority patent/AU2011275427B2/en
Priority to DK11743633.7T priority patent/DK2590976T3/en
Priority to PCT/IB2011/052954 priority patent/WO2012004732A1/fr
Priority to HUE11743633A priority patent/HUE025639T2/en
Priority to US13/808,503 priority patent/US8759344B2/en
Priority to ARP110102398A priority patent/AR082112A1/es
Priority to TW100123929A priority patent/TWI520961B/zh
Priority to UY0001033488A priority patent/UY33488A/es
Publication of FR2962437A1 publication Critical patent/FR2962437A1/fr
Application granted granted Critical
Publication of FR2962437B1 publication Critical patent/FR2962437B1/fr
Priority to CR20120643A priority patent/CR20120643A/es
Priority to TNP2012000608A priority patent/TN2012000608A1/en
Priority to ZA2012/09632A priority patent/ZA201209632B/en
Priority to GT201200346A priority patent/GT201200346A/es
Priority to NI201200192A priority patent/NI201200192A/es
Priority to IL223832A priority patent/IL223832A/en
Priority to ECSP13012363 priority patent/ECSP13012363A/es
Priority to CL2013000016A priority patent/CL2013000016A1/es
Priority to CO13001348A priority patent/CO6650360A2/es
Priority to US14/267,272 priority patent/US9452164B2/en
Priority to CY20151101146T priority patent/CY1117374T1/el
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR1055475A 2010-07-06 2010-07-06 Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique Expired - Fee Related FR2962437B1 (fr)

Priority Applications (38)

Application Number Priority Date Filing Date Title
FR1055475A FR2962437B1 (fr) 2010-07-06 2010-07-06 Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique
DK11743633.7T DK2590976T3 (en) 2010-07-06 2011-07-04 Imidazopyridine, MANUFACTURING METHOD THEREOF AND THERAPEUTIC USE THEREOF
PCT/IB2011/052954 WO2012004732A1 (fr) 2010-07-06 2011-07-04 Dérivés de l'imidazopyridine, procédé pour leur préparation, et leur utilisation thérapeutique
US13/808,503 US8759344B2 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for preparation thereof and therapeutic use thereof
EP11743633.7A EP2590976B1 (fr) 2010-07-06 2011-07-04 Dérivés de l'imidazopyridine, procédé pour leur préparation, et leur utilisation thérapeutique
SI201130684T SI2590976T1 (sl) 2010-07-06 2011-07-04 Derivati imidazopiridina, postopek njihove priprave in njihova terapevtska uporaba
MA35637A MA34450B1 (fr) 2010-07-06 2011-07-04 Dérivés de l'imidazopyridine, procédé pour leur préparation, et leur utilisation thérapeutique
EA201291414A EA022690B1 (ru) 2010-07-06 2011-07-04 Имидазопиридиновые производные, способ их получения и терапевтическое использование
PL11743633T PL2590976T3 (pl) 2010-07-06 2011-07-04 Pochodne imidazopirydyny, sposób ich wytwarzania i ich zastosowanie terapeutyczne
PE2013000005A PE20130651A1 (es) 2010-07-06 2011-07-04 Derivados de imidazopiridina y su procedimiento de preparacion
PH1/2013/500041A PH12013500041A1 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
KR1020137002987A KR101820548B1 (ko) 2010-07-06 2011-07-04 이미다조피리딘 유도체, 그의 제조 방법 및 그의 치료 용도
ES11743633.7T ES2556754T3 (es) 2010-07-06 2011-07-04 Derivados de imidazopiridina, procedimiento para la preparación de los mismos y uso terapéutico de los mismos
NZ604973A NZ604973A (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
CN201180042933.1A CN103080111B (zh) 2010-07-06 2011-07-04 咪唑并吡啶衍生物、其制备方法及其治疗用途
MX2012015120A MX2012015120A (es) 2010-07-06 2011-07-04 Derivados de imidazopiridina, su procedimiento de preparación y su uso en terapeutica.
PT117436337T PT2590976E (pt) 2010-07-06 2011-07-04 Derivados da imidazopiridina, seu processo de preparação e sua utilização terapêutica
JP2013517656A JP5889295B2 (ja) 2010-07-06 2011-07-04 イミダゾピリジン誘導体、それらを調製するための方法およびそれらの治療上の使用
BR112013000273-5A BR112013000273B1 (pt) 2010-07-06 2011-07-04 Compostos derivados de imidazopiridina, processo para a preparação dos mesmos e uso terapêutico dos mesmos
AU2011275427A AU2011275427B2 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
HRP20151309TT HRP20151309T1 (hr) 2010-07-06 2011-07-04 Derivati imidazopiridina, postupak za njihovu pripravu i njihova terapeutska upotreba
HUE11743633A HUE025639T2 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, a process for their preparation and their therapeutic use
CA2804915A CA2804915C (fr) 2010-07-06 2011-07-04 Derives de l'imidazopyridine, procede pour leur preparation, et leur utilisation therapeutique
SG2012093464A SG186396A1 (en) 2010-07-06 2011-07-04 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
ARP110102398A AR082112A1 (es) 2010-07-06 2011-07-05 Derivados de imidazopiridina, su procedimiento de preparacion y su aplicacion en terapeutica
TW100123929A TWI520961B (zh) 2010-07-06 2011-07-06 咪唑并吡啶衍生物、其製造方法及其治療用途
UY0001033488A UY33488A (es) 2010-07-06 2011-07-06 Derivados de imidazopiridina, su procedimiento y preparacion y su aplicacion en terapeutica
CR20120643A CR20120643A (es) 2010-07-06 2012-12-17 Derivados de imidazopiridina, su procedimiento de preparaciòn y su aplicaciòn en terapèutica
TNP2012000608A TN2012000608A1 (en) 2010-07-06 2012-12-19 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
ZA2012/09632A ZA201209632B (en) 2010-07-06 2012-12-19 Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof
GT201200346A GT201200346A (es) 2010-07-06 2012-12-20 Derivados de imidazopiridina, su procedimiento de preparaciòn y su aplicaciòn en terapèutica
NI201200192A NI201200192A (es) 2010-07-06 2012-12-20 Derivados de imidazopiridina, su procedimiento de preparación y su aplicación en terapéutica.
IL223832A IL223832A (en) 2010-07-06 2012-12-24 History of imidazopyridine, process for their preparation and medical use
CL2013000016A CL2013000016A1 (es) 2010-07-06 2013-01-03 Compuestos derivados de imidazopiridina; procedimiento de preparacion; composicion farmaceutica y su uso en el tratamiento del cancer.
ECSP13012363 ECSP13012363A (es) 2010-07-06 2013-01-03 Derivados de imidazopiridina, su procedimiento de preparación y su aplicación en terapéutica
CO13001348A CO6650360A2 (es) 2010-07-06 2013-01-04 Derivados de imidazopiridina, su procedimiento de preparació;n y su aplicación en terapéutica
US14/267,272 US9452164B2 (en) 2010-07-06 2014-05-01 Imidazopyridine derivatives, process for preparation thereof and therapeutic use thereof
CY20151101146T CY1117374T1 (el) 2010-07-06 2015-12-15 Παραγωγα ιμιδαζοπυριδινης, διαδικασια για την παρασκευη αυτων και θεραπευτικη χρηση αυτων

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