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EA200900492A1 - Молекулы антител, которые связываются с il-17a и il-17f - Google Patents

Молекулы антител, которые связываются с il-17a и il-17f

Info

Publication number
EA200900492A1
EA200900492A1 EA200900492A EA200900492A EA200900492A1 EA 200900492 A1 EA200900492 A1 EA 200900492A1 EA 200900492 A EA200900492 A EA 200900492A EA 200900492 A EA200900492 A EA 200900492A EA 200900492 A1 EA200900492 A1 EA 200900492A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibody molecules
associate
methods
specific
therapeutic uses
Prior art date
Application number
EA200900492A
Other languages
English (en)
Other versions
EA029953B1 (ru
Inventor
Ралф Адамс
Эндрью Джордж Попплуэлл
Стивен Эдуард Рейпки
Original Assignee
Юсб Фарма С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юсб Фарма С.А. filed Critical Юсб Фарма С.А.
Publication of EA200900492A1 publication Critical patent/EA200900492A1/ru
Publication of EA029953B1 publication Critical patent/EA029953B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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Abstract

В заявке описаны молекулы антител, обладающих специфичностью в отношении антигенных детерминант как IL-17A, так и IL-17F, терапевтические применения молекул антител и способы получения молекул антител.
EA200900492A 2006-10-18 2007-10-18 Молекулы антител, которые связываются с il-17a и il-17f EA029953B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0620729.4A GB0620729D0 (en) 2006-10-18 2006-10-18 Biological products
PCT/GB2007/003983 WO2008047134A2 (en) 2006-10-18 2007-10-18 Antibody molecules which bind il-17a and il-17f

Publications (2)

Publication Number Publication Date
EA200900492A1 true EA200900492A1 (ru) 2009-10-30
EA029953B1 EA029953B1 (ru) 2018-06-29

Family

ID=37507977

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200900492A EA029953B1 (ru) 2006-10-18 2007-10-18 Молекулы антител, которые связываются с il-17a и il-17f

Country Status (27)

Country Link
US (6) US8303953B2 (ru)
EP (3) EP3524623A1 (ru)
JP (4) JP2010506580A (ru)
KR (1) KR20090078355A (ru)
CN (1) CN101589061B (ru)
AU (1) AU2007311689B2 (ru)
BR (1) BRPI0717768B8 (ru)
CA (1) CA2666458C (ru)
CO (1) CO6180467A2 (ru)
CY (2) CY1117963T1 (ru)
DK (2) DK2076539T3 (ru)
EA (1) EA029953B1 (ru)
ES (2) ES2729064T3 (ru)
GB (1) GB0620729D0 (ru)
HR (2) HRP20161069T1 (ru)
HU (2) HUE029448T2 (ru)
IL (1) IL198061B (ru)
LT (1) LT2514764T (ru)
MX (1) MX2009003973A (ru)
PL (2) PL2514764T3 (ru)
PT (2) PT2076539T (ru)
RS (1) RS55031B1 (ru)
SG (1) SG175652A1 (ru)
SI (2) SI2076539T1 (ru)
TR (1) TR201907599T4 (ru)
WO (1) WO2008047134A2 (ru)
ZA (1) ZA200902460B (ru)

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AU2007226627B2 (en) 2006-03-10 2012-09-20 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
GB0612928D0 (en) 2006-06-29 2006-08-09 Ucb Sa Biological products
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
KR101634890B1 (ko) 2007-04-30 2016-06-29 인터디지탈 테크날러지 코포레이션 Ｍｉｍｏ 무선 통신 시스템에서의 에러 검출 및 검사의 피드백 시그널링
GB0807413D0 (en) * 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
JP2011519911A (ja) * 2008-05-05 2011-07-14 ノヴィミュンヌ エスア 抗ｉｌ１７ａ／ｉｌ−１７ｆ交差反応抗体及びその使用方法
US8790642B2 (en) * 2008-08-29 2014-07-29 Genentech, Inc. Cross-reactive and bispecific anti-IL-17A/F antibodies
US20100093087A1 (en) * 2008-10-07 2010-04-15 Novlmmune S.A. IL-17 Mediated Transfection Methods
RU2015132478A (ru) 2009-03-05 2015-12-10 Эббви Инк. Связывающие il-17 белки
CN104974250A (zh) 2009-05-05 2015-10-14 诺维莫尼公司 抗il-17f抗体及其使用方法
NZ603570A (en) 2010-05-20 2014-12-24 Ablynx Nv Biological materials related to her3
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
AU2012206431B2 (en) 2011-01-14 2015-04-30 UCB Biopharma SRL Antibody molecules which bind IL-17A and IL-17F
EP2673287B1 (de) 2011-02-08 2017-08-30 Merck Patent GmbH Aminostatin-derivate zur behandlung von arthrose
WO2012125680A1 (en) * 2011-03-16 2012-09-20 Novartis Ag Methods of treating vasculitis using an il-17 binding molecule
WO2012138977A1 (en) * 2011-04-06 2012-10-11 Board Of Trustees Of The Leland Stanford Junior University Structural based design of il-17 dominant negative mutants
UA117218C2 (uk) * 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
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