EA200200722A1 - Способы детекции амилоидогенных белков - Google Patents
Способы детекции амилоидогенных белковInfo
- Publication number
- EA200200722A1 EA200200722A1 EA200200722A EA200200722A EA200200722A1 EA 200200722 A1 EA200200722 A1 EA 200200722A1 EA 200200722 A EA200200722 A EA 200200722A EA 200200722 A EA200200722 A EA 200200722A EA 200200722 A1 EA200200722 A1 EA 200200722A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- aggregation
- assay
- amyloid
- peptide
- amyloid peptide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000009091 Amyloidogenic Proteins Human genes 0.000 title 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 230000002776 aggregation Effects 0.000 abstract 4
- 238000004220 aggregation Methods 0.000 abstract 4
- 238000003556 assay Methods 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000004847 absorption spectroscopy Methods 0.000 abstract 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
- 238000002983 circular dichroism Methods 0.000 abstract 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 abstract 1
- 230000035557 fibrillogenesis Effects 0.000 abstract 1
- 238000001506 fluorescence spectroscopy Methods 0.000 abstract 1
- 238000010874 in vitro model Methods 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Описан способ/анализ для детекции различных агрегированных форм амилоидного пептида с использованием амилоидоспецифического спектроскопического зонда, такого как конго красный и родственные аналоги. Такой анализ может быть использован для оценки агрегационного состояния данного пептида в присутствии других потенциальных ингибиторов фибриллогенеза, что позволяет получить ценную модель, посредством которой могут быть протестированы ингибиторы агрегации в in vitro-моделях. Результаты такого анализа могут быть использованы для определения стадии, на которой процесс агрегации может быть прекращен для снижения токсичности амилоидного полипептида по отношению к нервным клеткам. В конкретных примерах показано, что для оценки агрегационных форм β-амилоидного пептида может быть использована спектроскопия кругового дихроизма, Уф-абсорбционная спектроскопия и флуоресцентная спектроскопия.Отчет о международном поиске был опубликован 2001.10.18.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/474,970 US6399314B1 (en) | 1999-12-29 | 1999-12-29 | Methods of detection of amyloidogenic proteins |
| PCT/US2000/032693 WO2001050134A2 (en) | 1999-12-29 | 2000-12-01 | Methods of detection of amyloidogenic proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200722A1 true EA200200722A1 (ru) | 2002-12-26 |
| EA005582B1 EA005582B1 (ru) | 2005-04-28 |
Family
ID=23885720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200722A EA005582B1 (ru) | 1999-12-29 | 2000-12-01 | Способы детекции амилоидогенных белков |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6399314B1 (ru) |
| EP (1) | EP1242822B1 (ru) |
| JP (1) | JP2003519383A (ru) |
| KR (1) | KR20020070470A (ru) |
| CN (1) | CN1211661C (ru) |
| AT (1) | ATE399323T1 (ru) |
| AU (1) | AU774377B2 (ru) |
| BR (1) | BR0016883A (ru) |
| CA (1) | CA2395789C (ru) |
| DE (1) | DE60039310D1 (ru) |
| DK (1) | DK1242822T3 (ru) |
| EA (1) | EA005582B1 (ru) |
| ES (1) | ES2309003T3 (ru) |
| HK (1) | HK1046550B (ru) |
| IL (2) | IL150080A0 (ru) |
| MX (1) | MXPA02006362A (ru) |
| NO (1) | NO20023163L (ru) |
| NZ (1) | NZ519612A (ru) |
| PL (1) | PL356813A1 (ru) |
| PT (1) | PT1242822E (ru) |
| WO (1) | WO2001050134A2 (ru) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7179892B2 (en) * | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| US20030147882A1 (en) * | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| DE19923811C1 (de) * | 1999-05-20 | 2000-12-07 | Robert Koch Inst | Verfahren zur Diagnose TSE-induzierter Veränderungen in Geweben mittels Infrarotspektroskopie |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| US6689753B1 (en) * | 1999-11-05 | 2004-02-10 | Axonyx, Inc. | β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide |
| AU8517001A (en) | 2000-08-21 | 2002-03-04 | Gen Hospital Corp | Methods for diagnosing a neurodegenerative condition |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| WO2003018068A1 (en) * | 2001-04-27 | 2003-03-06 | The General Hospital Corporation | Ocular diagnosis of alzheimer's disease |
| US20050026165A1 (en) * | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
| AU2002320045B2 (en) * | 2001-05-31 | 2008-05-08 | Adlyfe, Inc. | Misfolded protein sensor method |
| WO2003059387A2 (en) * | 2001-12-21 | 2003-07-24 | Ilex Oncology, Inc. | Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment for multiple sclerosis |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
| US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
| TWI306458B (en) | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
| US20050048539A1 (en) * | 2003-06-13 | 2005-03-03 | The General Hospital Corporation | Methods to monitor molecule conformation and molecule/molecule proximity |
| SE0401219D0 (sv) * | 2004-05-10 | 2004-05-10 | Biochromix Ab | Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter |
| US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
| CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| AR051800A1 (es) * | 2004-12-15 | 2007-02-07 | Wyeth Corp | Anticuerpos a beta usados en mejorar la cognicion |
| US7625560B2 (en) * | 2004-12-15 | 2009-12-01 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| JP4568840B2 (ja) * | 2004-12-28 | 2010-10-27 | 国立大学法人金沢大学 | アルツハイマー病の検査方法 |
| WO2006069697A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Colorimetrically assessing peptide characteristics |
| ATE528649T1 (de) * | 2005-02-15 | 2011-10-15 | Adlyfe Inc | Verfahren zum nachweis falsch gefalteter proteine und prionen |
| US20090202980A1 (en) * | 2005-03-21 | 2009-08-13 | Crossbeta Biosciences B.V. | Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation |
| US8114832B2 (en) * | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
| BRPI0613525A2 (pt) * | 2005-07-13 | 2011-05-31 | Crossbeta Biosciences Bv | métodos para produzir uma composição imunogênica, para melhorar a imunogenicidade de uma composição, para intensificar a imunogenicidade de uma composição de vacina, e para determinar a quantidade de estruturas beta-cruzadas em uma composição de vacina, usos de estruturas beta-cruzadas, e de uma composição imunogênica, vacina de subunidade, e, composição imunogênica |
| ATE554394T1 (de) * | 2005-07-13 | 2012-05-15 | Crossbeta Biosciences Bv | Cross-beta-struktur-bindende verbindungen |
| US20070015133A1 (en) * | 2005-07-13 | 2007-01-18 | Umc Utrecht Holding B.V. | Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein |
| WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| BRPI0714930A2 (pt) * | 2006-07-28 | 2013-05-21 | Adlyfe Inc | sondas peptÍdicas para fins diagnàsticos e terapÊuticos |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| EP2058001A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Enhancement of immunogenicity of antigens |
| EP2058000A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Immunogenic compositions capable of activating T cells |
| US20100021390A1 (en) * | 2008-03-17 | 2010-01-28 | The Research Foundation Of State University Of New York | Fluorescent Analogs Of The Islet Amyloid Polypeptide |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| RU2509155C1 (ru) * | 2012-10-25 | 2014-03-10 | Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук | Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии |
| GB201303507D0 (en) * | 2013-02-27 | 2013-04-10 | Hollfelder Florian | Assays |
| US9588129B2 (en) * | 2013-03-15 | 2017-03-07 | Amira Medical Technologies Inc. | Methods for analyzing blood to detect diseases associated with abnormal protein aggregation |
| CN104803993B (zh) * | 2015-03-01 | 2017-11-03 | 四川大学 | 一种具有Aβ亲和力的荧光化合物及其用途 |
| CN105651752B (zh) * | 2016-02-26 | 2019-04-12 | 国家纳米科学中心 | 淀粉样蛋白的检测方法 |
| CN105717182B (zh) * | 2016-03-10 | 2018-05-11 | 中南大学 | 一种用于同步检测淀粉样多肽单体和聚集体的生物传感器及其构建方法和应用 |
| US11536731B2 (en) | 2017-01-23 | 2022-12-27 | Rensselaer Polytechnic Institute | Systems and methods for binding amyloid fibrils using fluorescent protein |
| CN108489941B (zh) * | 2018-01-31 | 2021-07-27 | 吉林大学 | 溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用 |
| CN112912732A (zh) * | 2018-08-03 | 2021-06-04 | 香港大学 | 用于淀粉样蛋白原纤维、淀粉样蛋白斑块、rna和核仁的检测和成像的组合物和方法 |
| US12115141B2 (en) | 2018-11-14 | 2024-10-15 | University Of Kentucky Research Foundation | Diagnosis of diabetes by detecting aggregated amylin in erythrocytes |
| CN111504957B (zh) * | 2019-01-31 | 2021-12-03 | 吉林大学 | 一种维多利亚蓝b及其衍生物在制备异构化蛋白的探针或抑制剂中的应用 |
| KR102258048B1 (ko) * | 2019-05-30 | 2021-05-31 | 주식회사 캔티스 | 아밀로이드 베타 올리고머의 검출 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2013396A1 (en) * | 1989-04-05 | 1990-10-05 | Dennis J. Selkoe | Diagnostic method for alzheimer's disease: examination of non-neural tissue |
| US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
| AU6728396A (en) | 1995-08-17 | 1997-03-12 | Ontario Cancer Institute, The | Protein fibril assembly assay |
| JPH0995444A (ja) * | 1995-10-02 | 1997-04-08 | Teijin Ltd | アミロイド蛋白凝集阻害剤 |
| CA2301142A1 (en) | 1997-08-14 | 1999-02-25 | The Regents Of The University Of California | Fluorescent amyloid a.beta. peptides and uses thereof |
| EP1064013A4 (en) * | 1998-03-13 | 2005-05-11 | Univ Washington | TRAINING $ i (IN VITRO) OF MALY CROSS-FORMED AMYLOID PLAINS WITH CONGO RED AFFINITY FOR THE IDENTIFICATION OF ANTI-PLAQUE THERAPEUTIC COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND PRION |
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1999
- 1999-12-29 US US09/474,970 patent/US6399314B1/en not_active Expired - Fee Related
-
2000
- 2000-12-01 CA CA2395789A patent/CA2395789C/en not_active Expired - Fee Related
- 2000-12-01 EA EA200200722A patent/EA005582B1/ru not_active IP Right Cessation
- 2000-12-01 ES ES00980905T patent/ES2309003T3/es not_active Expired - Lifetime
- 2000-12-01 HK HK02108122.2A patent/HK1046550B/en not_active IP Right Cessation
- 2000-12-01 KR KR1020027008505A patent/KR20020070470A/ko not_active Ceased
- 2000-12-01 NZ NZ519612A patent/NZ519612A/en unknown
- 2000-12-01 PT PT00980905T patent/PT1242822E/pt unknown
- 2000-12-01 EP EP00980905A patent/EP1242822B1/en not_active Expired - Lifetime
- 2000-12-01 IL IL15008000A patent/IL150080A0/xx active IP Right Grant
- 2000-12-01 AT AT00980905T patent/ATE399323T1/de not_active IP Right Cessation
- 2000-12-01 BR BR0016883-1A patent/BR0016883A/pt not_active Application Discontinuation
- 2000-12-01 JP JP2001550033A patent/JP2003519383A/ja active Pending
- 2000-12-01 CN CNB008178658A patent/CN1211661C/zh not_active Expired - Fee Related
- 2000-12-01 WO PCT/US2000/032693 patent/WO2001050134A2/en active IP Right Grant
- 2000-12-01 DE DE60039310T patent/DE60039310D1/de not_active Expired - Lifetime
- 2000-12-01 DK DK00980905T patent/DK1242822T3/da active
- 2000-12-01 PL PL00356813A patent/PL356813A1/xx not_active Application Discontinuation
- 2000-12-01 MX MXPA02006362A patent/MXPA02006362A/es active IP Right Grant
- 2000-12-01 AU AU18103/01A patent/AU774377B2/en not_active Ceased
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2002
- 2002-06-06 IL IL150080A patent/IL150080A/en not_active IP Right Cessation
- 2002-06-28 NO NO20023163A patent/NO20023163L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242822A2 (en) | 2002-09-25 |
| EP1242822B1 (en) | 2008-06-25 |
| MXPA02006362A (es) | 2002-11-29 |
| HK1046550A1 (en) | 2003-01-17 |
| CA2395789C (en) | 2010-03-30 |
| KR20020070470A (ko) | 2002-09-09 |
| NO20023163D0 (no) | 2002-06-28 |
| NZ519612A (en) | 2004-04-30 |
| BR0016883A (pt) | 2002-10-01 |
| CA2395789A1 (en) | 2001-07-12 |
| WO2001050134A3 (en) | 2002-06-27 |
| EA005582B1 (ru) | 2005-04-28 |
| CN1415074A (zh) | 2003-04-30 |
| AU774377B2 (en) | 2004-06-24 |
| ES2309003T3 (es) | 2008-12-16 |
| AU1810301A (en) | 2001-07-16 |
| ATE399323T1 (de) | 2008-07-15 |
| IL150080A0 (en) | 2002-12-01 |
| JP2003519383A (ja) | 2003-06-17 |
| PT1242822E (pt) | 2008-09-29 |
| PL356813A1 (en) | 2004-07-12 |
| HK1046550B (en) | 2008-12-19 |
| NO20023163L (no) | 2002-08-27 |
| WO2001050134A2 (en) | 2001-07-12 |
| DK1242822T3 (da) | 2008-09-29 |
| DE60039310D1 (de) | 2008-08-07 |
| CN1211661C (zh) | 2005-07-20 |
| US6399314B1 (en) | 2002-06-04 |
| IL150080A (en) | 2009-02-11 |
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