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EA199900376A1 - Местный анестетик для наружного применения - Google Patents

Местный анестетик для наружного применения

Info

Publication number
EA199900376A1
EA199900376A1 EA199900376A EA199900376A EA199900376A1 EA 199900376 A1 EA199900376 A1 EA 199900376A1 EA 199900376 A EA199900376 A EA 199900376A EA 199900376 A EA199900376 A EA 199900376A EA 199900376 A1 EA199900376 A1 EA 199900376A1
Authority
EA
Eurasian Patent Office
Prior art keywords
skin
isopropyl alcohol
water
local anesthetic
local anesthetics
Prior art date
Application number
EA199900376A
Other languages
English (en)
Other versions
EA001611B1 (ru
Inventor
Тосио Инаги
Акира Мада
Original Assignee
Кова Компани, Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кова Компани, Лтд. filed Critical Кова Компани, Лтд.
Publication of EA199900376A1 publication Critical patent/EA199900376A1/ru
Publication of EA001611B1 publication Critical patent/EA001611B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Cyclones (AREA)

Abstract

Местный анестетик для наружного применения получают путем смешивания а) активного ингредиента, выбранного из лидокаина, прилокаина и их фармацевтически приемлемых солей, б) ускорителя кожного всасывания, в) этанола и/или изопропилового спирта и г) воды, так что отношение смешиваемых этанола и/или изопропилового спирта к воде составляет предпочтительно 0,5-1,2 по весу, а рН предпочтительно регулируется так, чтобы он был равен 6,0-8,5. Таким образом получается местный анестетик для наружного применения с кожным типом всасывания, который удобно использовать, когда он наносится и удаляется, который можно наносить на обширные поверхности кожи и который обладает превосходной кожной всасываемостью, быстрым действием, а также очень хорошей стабильностью.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900376A 1996-10-14 1997-10-06 Местный анестетик для наружного применения EA001611B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27081396 1996-10-14
PCT/JP1997/003567 WO1998016212A1 (en) 1996-10-14 1997-10-06 Local anesthetic for external use

Publications (2)

Publication Number Publication Date
EA199900376A1 true EA199900376A1 (ru) 1999-10-28
EA001611B1 EA001611B1 (ru) 2001-06-25

Family

ID=17491384

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900376A EA001611B1 (ru) 1996-10-14 1997-10-06 Местный анестетик для наружного применения

Country Status (31)

Country Link
US (1) US6429228B1 (ru)
EP (1) EP0957906B1 (ru)
JP (1) JP2001503035A (ru)
KR (1) KR20000049125A (ru)
CN (1) CN1135104C (ru)
AT (1) ATE214599T1 (ru)
AU (1) AU731946B2 (ru)
BG (1) BG103325A (ru)
BR (1) BR9711911A (ru)
CA (1) CA2268535A1 (ru)
CZ (1) CZ129899A3 (ru)
DE (1) DE69711237T2 (ru)
DK (1) DK0957906T3 (ru)
EA (1) EA001611B1 (ru)
EE (1) EE03743B1 (ru)
ES (1) ES2173485T3 (ru)
HU (1) HUP9904109A3 (ru)
ID (1) ID21773A (ru)
IL (1) IL129335A (ru)
LT (1) LT4585B (ru)
MY (1) MY118301A (ru)
NO (1) NO991731L (ru)
NZ (1) NZ335056A (ru)
PL (1) PL332724A1 (ru)
PT (1) PT957906E (ru)
RO (1) RO120604B1 (ru)
SK (1) SK284332B6 (ru)
TR (1) TR199900814T2 (ru)
TW (1) TW450815B (ru)
WO (1) WO1998016212A1 (ru)
YU (1) YU19399A (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration
US6894078B2 (en) * 2001-09-17 2005-05-17 James G. Castillo Alcohol based topical anesthetic formulation and method
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
US20040077593A1 (en) * 2002-10-21 2004-04-22 Marron Susan M. Numbing gel for hair removal
BRPI0408454A (pt) * 2003-03-21 2006-04-04 Nexmed Holdings Inc composição tópica, método de tratar a ejaculação precoce, e, uso da composição
US20050014823A1 (en) * 2003-07-17 2005-01-20 Soderlund Patrick L. Topical anesthetic composition and method of administration
EP1782831B1 (en) * 2004-08-18 2011-10-19 Medrx Co., Ltd. External preparation
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
USRE46397E1 (en) 2007-11-07 2017-05-09 Svip5 Llc Slow release of organic salts of local anesthetics for pain relief
NZ591834A (en) 2008-10-02 2011-12-22 Mylan Inc Method of making a multilayer adhesive laminate
DE102009007152A1 (de) * 2009-02-02 2010-08-05 Müller-Glewe, Gunter Ultraschall-Gel
WO2011121082A1 (en) * 2010-04-01 2011-10-06 Pharmanest Ab Bioadhesive compositions of local anaesthetics
CN102018696B (zh) * 2010-11-22 2013-07-03 北京泰德制药股份有限公司 一种含有利多卡因或其药用盐的皮肤外用制剂
CN103608009B (zh) * 2011-06-20 2015-04-29 久光制药株式会社 含有利多卡因的贴膏剂
FR2983731B1 (fr) * 2011-12-07 2014-04-25 Univ Paris Descartes Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
CN103505791A (zh) * 2012-06-28 2014-01-15 杨德普 透皮吸收局麻无痛注射穿刺酒精棉片
CN103550675A (zh) * 2013-09-04 2014-02-05 赵会霞 一种止痛贴
KR102080860B1 (ko) * 2018-04-11 2020-02-24 숭실대학교산학협력단 미세구조의 피부 흡수 증강제, 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제, 및 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제를 이용한 마취 방법
CN110090197A (zh) * 2019-04-19 2019-08-06 广州芮一生物科技有限公司 一种可成膜的麻醉面膜膏

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954487A (en) * 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
CA1165240A (en) 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
JPS57142913A (en) * 1981-02-27 1982-09-03 Nitto Electric Ind Co Ltd Donor of physiologically active substance
US4748022A (en) 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
JPH03501386A (ja) * 1988-06-09 1991-03-28 アルザ・コーポレーション エタノール及びグリセロールモノオレエートを含む透過促進剤
JPH0755167B2 (ja) * 1988-09-21 1995-06-14 松下電器産業株式会社 移動体
US4892737A (en) * 1988-09-22 1990-01-09 University Of Florida Composition and method for enhancing permeability of topical drugs
GB9101986D0 (en) 1991-01-30 1991-03-13 Smith & Nephew Pharmaceutical compositions
JPH04261119A (ja) * 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤
JP3115625B2 (ja) 1991-03-30 2000-12-11 帝國製薬株式会社 リドカイン含有外用貼付剤
JP2775203B2 (ja) 1991-05-11 1998-07-16 久光製薬株式会社 吸収促進組成物
JPH0640947A (ja) * 1992-07-28 1994-02-15 T T S Gijutsu Kenkyusho:Kk 経皮吸収製剤用組成物および経皮吸収製剤
JPH0694891A (ja) 1992-09-10 1994-04-08 Kawasaki Heavy Ind Ltd 使用済燃料貯蔵・輸送容器
JPH08286701A (ja) 1995-04-11 1996-11-01 Nissan Motor Co Ltd 複数ロボット制御方法およびシステム

Also Published As

Publication number Publication date
ID21773A (id) 1999-07-22
CN1240353A (zh) 2000-01-05
US6429228B1 (en) 2002-08-06
ATE214599T1 (de) 2002-04-15
EP0957906A1 (en) 1999-11-24
IL129335A (en) 2004-08-31
TW450815B (en) 2001-08-21
PL332724A1 (en) 1999-10-11
CA2268535A1 (en) 1998-04-23
BR9711911A (pt) 2000-01-18
NZ335056A (en) 2000-08-25
LT4585B (lt) 1999-12-27
AU4399697A (en) 1998-05-11
EE9900144A (et) 1999-12-15
PT957906E (pt) 2002-07-31
DK0957906T3 (da) 2002-05-27
BG103325A (en) 2000-01-31
HUP9904109A2 (hu) 2000-04-28
IL129335A0 (en) 2000-02-17
EE03743B1 (et) 2002-06-17
TR199900814T2 (xx) 1999-07-21
KR20000049125A (ko) 2000-07-25
NO991731L (no) 1999-06-14
EP0957906B1 (en) 2002-03-20
ES2173485T3 (es) 2002-10-16
CN1135104C (zh) 2004-01-21
HUP9904109A3 (en) 2000-11-28
SK284332B6 (sk) 2005-01-03
EA001611B1 (ru) 2001-06-25
NO991731D0 (no) 1999-04-13
LT99036A (en) 1999-07-26
JP2001503035A (ja) 2001-03-06
YU19399A (sh) 2001-09-28
MY118301A (en) 2004-09-30
WO1998016212A1 (en) 1998-04-23
CZ129899A3 (cs) 1999-09-15
SK48299A3 (en) 2000-01-18
AU731946B2 (en) 2001-04-05
DE69711237T2 (de) 2002-10-17
DE69711237D1 (de) 2002-04-25
RO120604B1 (ro) 2006-05-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU