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DE69711237D1 - Lokalanästhetikum zur aüsserlichen anwendung - Google Patents

Lokalanästhetikum zur aüsserlichen anwendung

Info

Publication number
DE69711237D1
DE69711237D1 DE69711237T DE69711237T DE69711237D1 DE 69711237 D1 DE69711237 D1 DE 69711237D1 DE 69711237 T DE69711237 T DE 69711237T DE 69711237 T DE69711237 T DE 69711237T DE 69711237 D1 DE69711237 D1 DE 69711237D1
Authority
DE
Germany
Prior art keywords
local anesthetic
external use
ethanol
water
isopropyl alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69711237T
Other languages
English (en)
Other versions
DE69711237T2 (de
Inventor
Toshio Inagi
Akira Mada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of DE69711237D1 publication Critical patent/DE69711237D1/de
Publication of DE69711237T2 publication Critical patent/DE69711237T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cyclones (AREA)
  • External Artificial Organs (AREA)
DE69711237T 1996-10-14 1997-10-06 Lokalanästhetikum zur aüsserlichen anwendung Expired - Lifetime DE69711237T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27081396 1996-10-14
PCT/JP1997/003567 WO1998016212A1 (en) 1996-10-14 1997-10-06 Local anesthetic for external use

Publications (2)

Publication Number Publication Date
DE69711237D1 true DE69711237D1 (de) 2002-04-25
DE69711237T2 DE69711237T2 (de) 2002-10-17

Family

ID=17491384

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69711237T Expired - Lifetime DE69711237T2 (de) 1996-10-14 1997-10-06 Lokalanästhetikum zur aüsserlichen anwendung

Country Status (31)

Country Link
US (1) US6429228B1 (de)
EP (1) EP0957906B1 (de)
JP (1) JP2001503035A (de)
KR (1) KR20000049125A (de)
CN (1) CN1135104C (de)
AT (1) ATE214599T1 (de)
AU (1) AU731946B2 (de)
BG (1) BG103325A (de)
BR (1) BR9711911A (de)
CA (1) CA2268535A1 (de)
CZ (1) CZ129899A3 (de)
DE (1) DE69711237T2 (de)
DK (1) DK0957906T3 (de)
EA (1) EA001611B1 (de)
EE (1) EE03743B1 (de)
ES (1) ES2173485T3 (de)
HU (1) HUP9904109A3 (de)
ID (1) ID21773A (de)
IL (1) IL129335A (de)
LT (1) LT4585B (de)
MY (1) MY118301A (de)
NO (1) NO991731L (de)
NZ (1) NZ335056A (de)
PL (1) PL332724A1 (de)
PT (1) PT957906E (de)
RO (1) RO120604B1 (de)
SK (1) SK284332B6 (de)
TR (1) TR199900814T2 (de)
TW (1) TW450815B (de)
WO (1) WO1998016212A1 (de)
YU (1) YU19399A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
WO2001054679A2 (en) * 2000-01-27 2001-08-02 Children's Hospital Research Foundation Transdermal composition containing an anesthetic and a vasodilator agent
US6894078B2 (en) * 2001-09-17 2005-05-17 James G. Castillo Alcohol based topical anesthetic formulation and method
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
US20040077593A1 (en) * 2002-10-21 2004-04-22 Marron Susan M. Numbing gel for hair removal
AU2004224329B2 (en) * 2003-03-21 2009-07-09 Nexmed (Holdings), Inc. Compositions and methods for treatment of premature ejaculation
US20050014823A1 (en) * 2003-07-17 2005-01-20 Soderlund Patrick L. Topical anesthetic composition and method of administration
EP1782831B1 (de) * 2004-08-18 2011-10-19 Medrx Co., Ltd. Topisches präparat
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
EP2209450A4 (de) * 2007-11-07 2013-09-25 Svip5 Llc Langsame freisetzung von organischen salzen von lokalanästhetika zur schmerzlinderung
NZ591834A (en) 2008-10-02 2011-12-22 Mylan Inc Method of making a multilayer adhesive laminate
DE102009007152A1 (de) * 2009-02-02 2010-08-05 Müller-Glewe, Gunter Ultraschall-Gel
NZ602540A (en) * 2010-04-01 2014-05-30 Pharmanest Ab Bioadhesive compositions of local anaesthetics
CN102018696B (zh) * 2010-11-22 2013-07-03 北京泰德制药股份有限公司 一种含有利多卡因或其药用盐的皮肤外用制剂
JP5512891B2 (ja) * 2011-06-20 2014-06-04 久光製薬株式会社 リドカイン含有パップ剤
FR2983731B1 (fr) * 2011-12-07 2014-04-25 Univ Paris Descartes Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
CN103505791A (zh) * 2012-06-28 2014-01-15 杨德普 透皮吸收局麻无痛注射穿刺酒精棉片
CN103550675A (zh) * 2013-09-04 2014-02-05 赵会霞 一种止痛贴
KR102080860B1 (ko) * 2018-04-11 2020-02-24 숭실대학교산학협력단 미세구조의 피부 흡수 증강제, 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제, 및 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제를 이용한 마취 방법
CN110090197A (zh) * 2019-04-19 2019-08-06 广州芮一生物科技有限公司 一种可成膜的麻醉面膜膏

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954487A (en) * 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
CA1165240A (en) 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
JPS57142913A (en) * 1981-02-27 1982-09-03 Nitto Electric Ind Co Ltd Donor of physiologically active substance
US4748022A (en) 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
EP0378644A1 (de) * 1988-06-09 1990-07-25 Alza Corporation Ethanol und glycerolmonooleat enthaltende permeabilitätserhöher
JPH0755167B2 (ja) * 1988-09-21 1995-06-14 松下電器産業株式会社 移動体
US4892737A (en) * 1988-09-22 1990-01-09 University Of Florida Composition and method for enhancing permeability of topical drugs
GB9101986D0 (en) 1991-01-30 1991-03-13 Smith & Nephew Pharmaceutical compositions
JPH04261119A (ja) * 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤
JP3115625B2 (ja) * 1991-03-30 2000-12-11 帝國製薬株式会社 リドカイン含有外用貼付剤
JP2775203B2 (ja) 1991-05-11 1998-07-16 久光製薬株式会社 吸収促進組成物
JPH0640947A (ja) * 1992-07-28 1994-02-15 T T S Gijutsu Kenkyusho:Kk 経皮吸収製剤用組成物および経皮吸収製剤
JPH0694891A (ja) 1992-09-10 1994-04-08 Kawasaki Heavy Ind Ltd 使用済燃料貯蔵・輸送容器
JPH08286701A (ja) 1995-04-11 1996-11-01 Nissan Motor Co Ltd 複数ロボット制御方法およびシステム

Also Published As

Publication number Publication date
IL129335A0 (en) 2000-02-17
EP0957906A1 (de) 1999-11-24
LT99036A (en) 1999-07-26
PL332724A1 (en) 1999-10-11
WO1998016212A1 (en) 1998-04-23
EA001611B1 (ru) 2001-06-25
YU19399A (sh) 2001-09-28
BG103325A (en) 2000-01-31
DE69711237T2 (de) 2002-10-17
HUP9904109A2 (hu) 2000-04-28
EE9900144A (et) 1999-12-15
ES2173485T3 (es) 2002-10-16
CZ129899A3 (cs) 1999-09-15
CA2268535A1 (en) 1998-04-23
SK284332B6 (sk) 2005-01-03
ID21773A (id) 1999-07-22
IL129335A (en) 2004-08-31
AU4399697A (en) 1998-05-11
NZ335056A (en) 2000-08-25
CN1240353A (zh) 2000-01-05
EP0957906B1 (de) 2002-03-20
CN1135104C (zh) 2004-01-21
LT4585B (lt) 1999-12-27
ATE214599T1 (de) 2002-04-15
RO120604B1 (ro) 2006-05-30
HUP9904109A3 (en) 2000-11-28
TW450815B (en) 2001-08-21
NO991731D0 (no) 1999-04-13
EA199900376A1 (ru) 1999-10-28
JP2001503035A (ja) 2001-03-06
US6429228B1 (en) 2002-08-06
NO991731L (no) 1999-06-14
PT957906E (pt) 2002-07-31
AU731946B2 (en) 2001-04-05
SK48299A3 (en) 2000-01-18
EE03743B1 (et) 2002-06-17
DK0957906T3 (da) 2002-05-27
KR20000049125A (ko) 2000-07-25
BR9711911A (pt) 2000-01-18
MY118301A (en) 2004-09-30
TR199900814T2 (xx) 1999-07-21

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Legal Events

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