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DK3102576T3 - Dihydropyrrolopyridininhibitorer af ror-gamma - Google Patents

Dihydropyrrolopyridininhibitorer af ror-gamma Download PDF

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Publication number
DK3102576T3
DK3102576T3 DK15705744.9T DK15705744T DK3102576T3 DK 3102576 T3 DK3102576 T3 DK 3102576T3 DK 15705744 T DK15705744 T DK 15705744T DK 3102576 T3 DK3102576 T3 DK 3102576T3
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DK
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Prior art keywords
ror
gamma
dihydropyrrolopyridine
inhibitors
dihydropyrrolopyridine inhibitors
Prior art date
Application number
DK15705744.9T
Other languages
English (en)
Inventor
David A Claremon
Lawrence Wayne Dillard
Chengguo Dong
Yi Fan
Lanqi Jia
Zhijie Liu
Stephen D Lotesta
Andrew Marcus
Suresh B Singh
Colin M Tice
Jing Yuan
Yajun Zheng
Linghang Zhuang
Wei Zhao
Original Assignee
Vitae Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52544571&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3102576(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vitae Pharmaceuticals Llc filed Critical Vitae Pharmaceuticals Llc
Application granted granted Critical
Publication of DK3102576T3 publication Critical patent/DK3102576T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
DK15705744.9T 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma DK3102576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461935162P 2014-02-03 2014-02-03
US201461970637P 2014-03-26 2014-03-26
PCT/US2015/013699 WO2015116904A1 (en) 2014-02-03 2015-01-30 Dihydropyrrolopyridine inhibitors of ror-gamma

Publications (1)

Publication Number Publication Date
DK3102576T3 true DK3102576T3 (da) 2019-07-22

Family

ID=52544571

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15705744.9T DK3102576T3 (da) 2014-02-03 2015-01-30 Dihydropyrrolopyridininhibitorer af ror-gamma

Country Status (26)

Country Link
US (6) US9266886B2 (da)
EP (2) EP3102576B8 (da)
JP (1) JP6466461B2 (da)
KR (1) KR102408261B1 (da)
CN (1) CN105940002B (da)
AU (1) AU2015210833B2 (da)
CA (1) CA2938311C (da)
CL (1) CL2016001947A1 (da)
DK (1) DK3102576T3 (da)
EA (1) EA031804B1 (da)
EC (1) ECSP16071151A (da)
ES (1) ES2735099T3 (da)
HU (1) HUE045511T2 (da)
IL (1) IL246902B (da)
LT (1) LT3102576T (da)
MX (1) MX371017B (da)
PE (1) PE20161372A1 (da)
PH (1) PH12016501457A1 (da)
PL (1) PL3102576T3 (da)
PT (1) PT3102576T (da)
RS (1) RS59007B1 (da)
SG (1) SG11201606080SA (da)
SI (1) SI3102576T1 (da)
TW (1) TWI658041B (da)
UA (1) UA121309C2 (da)
WO (1) WO2015116904A1 (da)

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* Cited by examiner, † Cited by third party
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CN105940002B (zh) 2014-02-03 2018-09-25 生命医药公司 ROR-γ的二氢吡咯并吡啶抑制剂
JP6749890B2 (ja) 2014-08-12 2020-09-02 モナッシュ ユニバーシティ リンパ指向プロドラッグ
DK3207043T6 (da) * 2014-10-14 2020-01-20 Vitae Pharmaceuticals Llc Dihydropyrrolopyridin-inhibitorer af ror-gamma
RS61853B1 (sr) 2014-10-29 2021-06-30 Bicyclerd Ltd Biciklični peptidni ligandi specifični za mt1-mmp
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
HK1249469A1 (zh) 2015-03-12 2018-11-02 The Regents Of The University Of California 用RORγ抑制剂治疗癌症的方法
PL3294713T4 (pl) 2015-05-15 2021-07-26 Aurigene Discovery Technologies Limited Podstawione związki tetrahydrochinolinonowe jako modulatory ror gamma
CR20170594A (es) 2015-06-09 2018-04-27 Abbvie Inc Moduladores de receptor nuclear
WO2017010399A1 (ja) * 2015-07-10 2017-01-19 塩野義製薬株式会社 ＲＯＲγｔ阻害作用を有する化合物およびそれらを含有する医薬組成物
US10301261B2 (en) 2015-08-05 2019-05-28 Vitae Pharmaceuticals, Llc Substituted indoles as modulators of ROR-gamma
WO2017041139A1 (en) 2015-09-08 2017-03-16 Monash University Lymph directing prodrugs
JP6778259B2 (ja) * 2015-10-01 2020-10-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｒｏｒガンマのモジュレーターとしてのプテリジン誘導体
AU2016355710B2 (en) * 2015-11-20 2021-03-25 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
CA3007893A1 (en) 2015-12-15 2017-06-22 Astrazeneca Ab Isoindole compounds
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN106632313B (zh) * 2016-03-04 2021-04-09 上海贤鼎生物科技有限公司 一种抗癌药帕博昔布重要中间体及合成工艺
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2018011747A1 (en) 2016-07-14 2018-01-18 Cadila Healthcare Limited Polycyclic compounds as ror-gamma modulators
MX2019000276A (es) 2016-07-14 2019-09-09 Cadila Healthcare Ltd Nuevos derivados ciclopropílicos.
WO2018042342A1 (en) * 2016-08-30 2018-03-08 Glenmark Pharmaceuticals S.A. 1,2,3-benzotriazole derivatives as ror gamma t modulators
UY37507A (es) 2016-12-05 2018-06-29 Lead Pharma Holding Bv Moduladores de ror gamma (ror¿)
EP3559018A1 (en) 2016-12-23 2019-10-30 Bicyclerd Limited Peptide derivatives having novel linkage structures
JP2020059651A (ja) * 2016-12-26 2020-04-16 科研製薬株式会社 ピラゾール誘導体及びそれを含有する医薬
US11339144B2 (en) 2017-04-10 2022-05-24 Navitor Pharmaceuticals, Inc. Heteroaryl Rheb inhibitors and uses thereof
EP3615550A1 (en) 2017-04-27 2020-03-04 BicycleTx Limited Bicyclic peptide ligands and uses thereof
TW201900617A (zh) * 2017-05-23 2019-01-01 大陸商江蘇恆瑞醫藥股份有限公司 螺環甲醯胺類衍生物、其製備方法及其在醫藥上的應用
WO2018229155A1 (en) 2017-06-14 2018-12-20 Astrazeneca Ab 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
JP2020142989A (ja) * 2017-06-21 2020-09-10 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 イミダゾール誘導体及びそれを含有する医薬
CN109111418B (zh) * 2017-06-23 2022-10-11 江苏柯菲平医药股份有限公司 一类2，3-二氢-1H-茚-4-磺酰胺RORγ调节剂及其用途
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