DK2089364T3 - Pyridinonforbindelser - Google Patents
PyridinonforbindelserInfo
- Publication number
- DK2089364T3 DK2089364T3 DK07844974.1T DK07844974T DK2089364T3 DK 2089364 T3 DK2089364 T3 DK 2089364T3 DK 07844974 T DK07844974 T DK 07844974T DK 2089364 T3 DK2089364 T3 DK 2089364T3
- Authority
- DK
- Denmark
- Prior art keywords
- pyridinone compounds
- pyridinone
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85754006P | 2006-11-08 | 2006-11-08 | |
| PCT/US2007/084047 WO2008058229A1 (en) | 2006-11-08 | 2007-11-08 | Pyridinone compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2089364T3 true DK2089364T3 (da) | 2013-09-02 |
Family
ID=39048786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07844974.1T DK2089364T3 (da) | 2006-11-08 | 2007-11-08 | Pyridinonforbindelser |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7851489B2 (da) |
| EP (1) | EP2089364B1 (da) |
| JP (1) | JP5276005B2 (da) |
| KR (1) | KR101390076B1 (da) |
| CN (1) | CN101535264B (da) |
| AR (1) | AR063628A1 (da) |
| AU (1) | AU2007317296B2 (da) |
| CA (1) | CA2669266C (da) |
| CL (1) | CL2007003226A1 (da) |
| DK (1) | DK2089364T3 (da) |
| ES (1) | ES2424851T3 (da) |
| HK (1) | HK1131608A1 (da) |
| HR (1) | HRP20130626T1 (da) |
| MX (1) | MX2009004699A (da) |
| NO (1) | NO342395B1 (da) |
| PE (1) | PE20081490A1 (da) |
| PL (1) | PL2089364T3 (da) |
| PT (1) | PT2089364E (da) |
| SI (1) | SI2089364T1 (da) |
| TW (1) | TWI409259B (da) |
| WO (1) | WO2008058229A1 (da) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2531396T3 (es) | 2008-01-23 | 2015-03-13 | Bristol Myers Squibb Co | Proceso para preparar compuestos de piridinona |
| WO2009149188A1 (en) | 2008-06-03 | 2009-12-10 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| EP2563773A1 (en) | 2010-04-29 | 2013-03-06 | Deciphera Pharmaceuticals, LLC | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activites |
| CN102971296B (zh) | 2010-04-30 | 2015-11-25 | 百时美施贵宝公司 | 包含n-(4-(2-氨基-3-氯吡啶-4-基氧基)-3-氟苯基)-4-乙氧基-1-(4-氟苯基)-2-氧代-1，2-二氢吡啶-3-羧酰胺的药物组合物 |
| CN102241625B (zh) * | 2010-05-13 | 2014-10-29 | 中南大学 | 1-(取代芳基)-5-((取代芳胺基)甲基)吡啶-2(1h)酮化合物、制备方法及其用途 |
| CN102070518B (zh) * | 2011-01-24 | 2012-05-02 | 江苏先声药物研究有限公司 | 取代吡啶及氮杂吲哚衍生物的合成 |
| SG194219A1 (en) * | 2011-06-10 | 2013-11-29 | Merck Patent Gmbh | Compositions and methods for the production of pyrimidine and pyridine compounds with btk inhibitory activity |
| SG11201402531XA (en) * | 2011-11-22 | 2014-08-28 | Deciphera Pharmaceuticals Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2014022116A2 (en) | 2012-07-28 | 2014-02-06 | Calitor Sciences, Llc | Substituted pyrazolone compounds and methods of use |
| US8975282B2 (en) | 2012-07-28 | 2015-03-10 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrazolone compounds and methods of use |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX2016012808A (es) | 2014-04-02 | 2017-01-05 | Intermune Inc | Piridinonas anti-fibroticas. |
| ES2928164T3 (es) | 2015-10-19 | 2022-11-15 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| MY199220A (en) | 2015-11-19 | 2023-10-20 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| BR112018012756A2 (pt) | 2015-12-22 | 2018-12-04 | Incyte Corp | compostos heterocíclicos como imunomoduladores |
| TW201808950A (zh) | 2016-05-06 | 2018-03-16 | 英塞特公司 | 作為免疫調節劑之雜環化合物 |
| ES2905980T3 (es) | 2016-05-26 | 2022-04-12 | Incyte Corp | Compuestos heterocíclicos como inmunomoduladores |
| SG10202012828TA (en) | 2016-06-20 | 2021-01-28 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| MA45669A (fr) * | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| EP3504198B1 (en) | 2016-08-29 | 2023-01-25 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| CN110072851B (zh) * | 2016-12-19 | 2023-06-06 | 诺华股份有限公司 | 新的吡啶甲酸衍生物及其作为中间体的用途 |
| IL295660A (en) | 2016-12-22 | 2022-10-01 | Incyte Corp | Benzooxazole derivatives as immunomodulators |
| WO2018119236A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| WO2018136009A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
| WO2018136010A1 (en) | 2017-01-20 | 2018-07-26 | Aslan Pharmaceuticals Pte Ltd | Combination therapy |
| TW201834649A (zh) | 2017-03-02 | 2018-10-01 | 新加坡商亞獅康私人有限公司 | 癌症療法 |
| CN108623568B (zh) * | 2017-03-21 | 2022-04-19 | 南京汇诚制药有限公司 | 9,10二氢菲类丙型肝炎病毒抑制剂的盐型及其制备 |
| WO2018222134A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
| WO2018222135A1 (en) | 2017-06-02 | 2018-12-06 | Aslan Pharmaceuticals Pte Ltd | Cancer therapy |
| WO2019083457A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS MUTATION OF THE BETA-CATENIN PATHWAY |
| WO2019083455A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS PRESENTING HER1, HER2 AND / OR HER3-ACTIVATED HERC-RECEPTOR CANCER CELLS |
| WO2019083458A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR THE TREATMENT OF CANCER TO REDUCE HYPOXIA |
| WO2019083456A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER FOR NORMALIZING ANGIOGENESIS IN A CANCER MASS |
| JP7377798B2 (ja) * | 2017-11-24 | 2023-11-10 | 南京明徳新薬研発有限公司 | ｃ－ＭＥＴ／ＡＸＬ阻害剤としてのウラシル系化合物 |
| JP6955630B2 (ja) | 2018-03-08 | 2021-10-27 | ウェルマーカー・バイオ・カンパニー・リミテッドＷｅｌｌｍａｒｋｅｒ Ｂｉｏ ＣＯ．， Ｌｔｄ． | チエノピリジン誘導体およびそれを含む医薬組成物 |
| EP4212529B1 (en) | 2018-03-30 | 2025-01-29 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP4219492B1 (en) | 2018-05-11 | 2024-11-27 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| US20210379070A1 (en) | 2018-10-09 | 2021-12-09 | Aslan Pharmaceuticals Pte Ltd | Malonate salt of varlitinib |
| JP2022505272A (ja) * | 2018-10-19 | 2022-01-14 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | がん治療のためのトポイソメラーゼｉｉ触媒阻害剤化合物による治療、方法、及び使用 |
| US20220119425A1 (en) * | 2019-01-15 | 2022-04-21 | The Translational Genomics Research Institute | Phosphonate conjugates and uses thereof |
| EP4011885A4 (en) | 2019-08-02 | 2023-01-18 | Wellmarker Bio Co., Ltd. | CONDENSED CYCLE OXO-PYRIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THEM |
| WO2021030162A1 (en) | 2019-08-09 | 2021-02-18 | Incyte Corporation | Salts of a pd-1/pd-l1 inhibitor |
| EP3819300A4 (en) | 2019-09-06 | 2021-11-24 | Wellmarker Bio Co., Ltd. | THERAPEUTIC COMPOSITION BASED ON BIOMARKERS |
| MX2022003578A (es) | 2019-09-30 | 2022-05-30 | Incyte Corp | Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores. |
| IL292524A (en) | 2019-11-11 | 2022-06-01 | Incyte Corp | Salts and crystalline forms of a pd-1/pd-l1 inhibitor |
| CN115003307A (zh) | 2020-02-06 | 2022-09-02 | 伟迈可生物有限公司 | 用于预防或治疗与kras突变相关的癌症的药物组合物 |
| EP4115887A4 (en) | 2020-03-03 | 2024-07-17 | Wellmarker Bio Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER HAVING KRAS MUTATION AND RON ACTIVATION |
| EP4154891A4 (en) | 2020-05-18 | 2023-12-06 | Wellmarker Bio Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF RON MUTATION ASSOCIATED NON-SMALL CELL LUNG CANCER AND METHOD FOR THE USE THEREOF |
| KR20210142553A (ko) | 2020-05-18 | 2021-11-25 | 웰마커바이오 주식회사 | Ron 돌연변이와 관련된 소세포 폐암 예방 또는 치료용 약학 조성물 및 이를 이용한 방법 |
| JP2023526444A (ja) | 2020-05-18 | 2023-06-21 | ウェルマーカー バイオ カンパニー リミテッド | Ｒｏｎ変異が関与する膵臓がんの予防又は治療用医薬組成物及びその使用方法 |
| IL302590A (en) | 2020-11-06 | 2023-07-01 | Incyte Corp | Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof |
| US11760756B2 (en) | 2020-11-06 | 2023-09-19 | Incyte Corporation | Crystalline form of a PD-1/PD-L1 inhibitor |
| US11780836B2 (en) | 2020-11-06 | 2023-10-10 | Incyte Corporation | Process of preparing a PD-1/PD-L1 inhibitor |
| EP4273140A4 (en) * | 2021-02-02 | 2024-06-19 | Lg Chem, Ltd. | NEW COMPOUND USED AS PROTEIN KINASE INHIBITOR |
| KR20220170766A (ko) * | 2021-06-22 | 2022-12-30 | 주식회사 엘지화학 | 단백질 키나아제 억제제로서의 신규한 화합물 |
| US20230257364A1 (en) * | 2022-02-16 | 2023-08-17 | Cmg Pharmaceutical Co., Ltd. | Pyridazinone-based compounds as axl, c-met, and mer inhibitors and methods of use thereof |
| KR20240101434A (ko) * | 2022-12-23 | 2024-07-02 | 주식회사 엘지화학 | Ron 억제제로서 신규한 화합물 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0430885A3 (en) | 1989-12-01 | 1991-11-06 | Ciba-Geigy Ag | Anthelmintical compounds |
| JP4009681B2 (ja) * | 1995-11-07 | 2007-11-21 | キリンファーマ株式会社 | 血小板由来成長因子受容体自己リン酸化を阻害するキノリン誘導体ならびにキナゾリン誘導体およびそれらを含有する薬学的組成物 |
| EP1087937A1 (en) * | 1998-06-17 | 2001-04-04 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| WO2001005769A2 (en) * | 1999-07-20 | 2001-01-25 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| US6355660B1 (en) * | 1999-07-20 | 2002-03-12 | Dow Agrosciences Llc | Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation |
| CA2384291A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
| FR2812633A1 (fr) * | 2000-08-04 | 2002-02-08 | Aventis Cropscience Sa | Derives de phenyl(thio)urees et phenyl(thio)carbamates fongicides |
| SE0102384D0 (sv) * | 2001-07-03 | 2001-07-03 | Pharmacia Ab | New compounds |
| CA2468716A1 (en) * | 2001-11-28 | 2003-06-05 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic amide compounds as apolipoprotein b inhibitors |
| SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| JP2005263787A (ja) * | 2004-02-17 | 2005-09-29 | Ishihara Sangyo Kaisha Ltd | アミド系化合物又はその塩、並びにそれらを含有するサイトカイン産生抑制剤 |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| US7880000B2 (en) * | 2004-05-07 | 2011-02-01 | Amgen Inc. | Protein kinase modulators and method of use |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| US7732613B2 (en) * | 2005-09-14 | 2010-06-08 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| WO2007035428A1 (en) * | 2005-09-15 | 2007-03-29 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US7348325B2 (en) * | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
-
2007
- 2007-11-08 JP JP2009536476A patent/JP5276005B2/ja active Active
- 2007-11-08 TW TW096142253A patent/TWI409259B/zh active
- 2007-11-08 ES ES07844974T patent/ES2424851T3/es active Active
- 2007-11-08 WO PCT/US2007/084047 patent/WO2008058229A1/en active Application Filing
- 2007-11-08 CL CL200703226A patent/CL2007003226A1/es unknown
- 2007-11-08 KR KR1020097009449A patent/KR101390076B1/ko active Active
- 2007-11-08 AU AU2007317296A patent/AU2007317296B2/en active Active
- 2007-11-08 AR ARP070104987A patent/AR063628A1/es active Pending
- 2007-11-08 MX MX2009004699A patent/MX2009004699A/es active IP Right Grant
- 2007-11-08 CN CN2007800414202A patent/CN101535264B/zh active Active
- 2007-11-08 PE PE2007001538A patent/PE20081490A1/es active IP Right Grant
- 2007-11-08 SI SI200731303T patent/SI2089364T1/sl unknown
- 2007-11-08 PL PL07844974T patent/PL2089364T3/pl unknown
- 2007-11-08 PT PT78449741T patent/PT2089364E/pt unknown
- 2007-11-08 CA CA2669266A patent/CA2669266C/en active Active
- 2007-11-08 EP EP07844974.1A patent/EP2089364B1/en active Active
- 2007-11-08 US US11/936,984 patent/US7851489B2/en active Active
- 2007-11-08 DK DK07844974.1T patent/DK2089364T3/da active
-
2009
- 2009-04-22 NO NO20091605A patent/NO342395B1/no unknown
- 2009-11-02 HK HK09110170.2A patent/HK1131608A1/xx unknown
-
2010
- 2010-11-08 US US12/941,419 patent/US8536200B2/en active Active
-
2013
- 2013-07-03 HR HRP20130626TT patent/HRP20130626T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20080114033A1 (en) | 2008-05-15 |
| WO2008058229A1 (en) | 2008-05-15 |
| SI2089364T1 (sl) | 2013-10-30 |
| KR101390076B1 (ko) | 2014-04-29 |
| CN101535264A (zh) | 2009-09-16 |
| CN101535264B (zh) | 2012-11-28 |
| HK1131608A1 (en) | 2010-01-29 |
| CA2669266A1 (en) | 2008-05-15 |
| AR063628A1 (es) | 2009-02-04 |
| AU2007317296B2 (en) | 2012-07-05 |
| NO342395B1 (no) | 2018-05-14 |
| PT2089364E (pt) | 2013-08-26 |
| PL2089364T3 (pl) | 2013-11-29 |
| US20110052583A1 (en) | 2011-03-03 |
| CA2669266C (en) | 2014-04-29 |
| TWI409259B (zh) | 2013-09-21 |
| AU2007317296A1 (en) | 2008-05-15 |
| NO20091605L (no) | 2009-05-27 |
| US8536200B2 (en) | 2013-09-17 |
| ES2424851T3 (es) | 2013-10-09 |
| JP2010509362A (ja) | 2010-03-25 |
| JP5276005B2 (ja) | 2013-08-28 |
| PE20081490A1 (es) | 2008-10-30 |
| TW200829564A (en) | 2008-07-16 |
| KR20090096423A (ko) | 2009-09-10 |
| HRP20130626T1 (en) | 2013-08-31 |
| EP2089364B1 (en) | 2013-06-12 |
| US7851489B2 (en) | 2010-12-14 |
| CL2007003226A1 (es) | 2008-02-08 |
| EP2089364A1 (en) | 2009-08-19 |
| MX2009004699A (es) | 2009-05-15 |
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