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MX2022003578A - Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores. - Google Patents

Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores.

Info

Publication number
MX2022003578A
MX2022003578A MX2022003578A MX2022003578A MX2022003578A MX 2022003578 A MX2022003578 A MX 2022003578A MX 2022003578 A MX2022003578 A MX 2022003578A MX 2022003578 A MX2022003578 A MX 2022003578A MX 2022003578 A MX2022003578 A MX 2022003578A
Authority
MX
Mexico
Prior art keywords
immunomodulators
pyrido
pyrimidine compounds
compounds
formula
Prior art date
Application number
MX2022003578A
Other languages
English (en)
Inventor
Liangxing Wu
Jingwei Li
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2022003578A publication Critical patent/MX2022003578A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente descripción hace referencia a compuestos de Fórmula (I): (ver Fórmula) que modulan la interacción proteína/proteína de PD-1/PD-L1, composiciones y métodos para tratar diversas enfermedades, que incluyen enfermedades infecciosas y cáncer.
MX2022003578A 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores. MX2022003578A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962908317P 2019-09-30 2019-09-30
PCT/US2020/053190 WO2021067217A1 (en) 2019-09-30 2020-09-29 Pyrido[3,2-d]pyrimidine compounds as immunomodulators

Publications (1)

Publication Number Publication Date
MX2022003578A true MX2022003578A (es) 2022-05-30

Family

ID=72886166

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022003578A MX2022003578A (es) 2019-09-30 2020-09-29 Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores.

Country Status (19)

Country Link
US (2) US11401279B2 (es)
EP (1) EP4037773A1 (es)
JP (1) JP7559059B2 (es)
KR (1) KR20220075382A (es)
CN (1) CN115175734B (es)
AR (1) AR120109A1 (es)
AU (1) AU2020357514A1 (es)
BR (1) BR112022005826A2 (es)
CA (1) CA3155852A1 (es)
CL (1) CL2022000787A1 (es)
CO (1) CO2022005378A2 (es)
CR (1) CR20220190A (es)
EC (1) ECSP22034236A (es)
IL (1) IL291471B2 (es)
MX (1) MX2022003578A (es)
PE (1) PE20221038A1 (es)
PH (1) PH12022550754A1 (es)
TW (1) TWI879811B (es)
WO (1) WO2021067217A1 (es)

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WO2017205464A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
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EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
MA46045A (fr) 2016-08-29 2021-04-28 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
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ES2934230T3 (es) 2016-12-22 2023-02-20 Incyte Corp Derivados de benzooxazol como inmunomoduladores
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EP4037773A1 (en) 2019-09-30 2022-08-10 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
TW202120504A (zh) 2019-11-11 2021-06-01 美商英塞特公司 Pd-1/pd-l1 抑制劑之鹽及結晶型
EP4174066A4 (en) * 2020-06-17 2024-06-19 Abbisko Therapeutics Co., Ltd. IMMUNOSUPRESSANT AND MANUFACTURING PROCESS AND USE THEREOF
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Pd—1/pd—l1抑制劑之結晶形式
TW202233616A (zh) 2020-11-06 2022-09-01 美商英塞特公司 用於製備pd-1/pd-l1抑制劑以及其鹽及結晶形式之方法
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