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DK172033B1 - 5-(4-alkoxy-3-polycycloalkyloxy-phenyl)-hexahydro-2-pyrimidinon-derivater,3-(4-alkoxy-3-polycycloalkyloxy-phenyl)glutaramid-derivater anvendelige som mellemprodukter ved deres fremstilling og farmaceutiske præparater til behandling af depression - Google Patents

5-(4-alkoxy-3-polycycloalkyloxy-phenyl)-hexahydro-2-pyrimidinon-derivater,3-(4-alkoxy-3-polycycloalkyloxy-phenyl)glutaramid-derivater anvendelige som mellemprodukter ved deres fremstilling og farmaceutiske præparater til behandling af depression Download PDF

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Publication number
DK172033B1
DK172033B1 DK215087A DK215087A DK172033B1 DK 172033 B1 DK172033 B1 DK 172033B1 DK 215087 A DK215087 A DK 215087A DK 215087 A DK215087 A DK 215087A DK 172033 B1 DK172033 B1 DK 172033B1
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Prior art keywords
polycycloalkyloxy
alkoxy
phenyl
compounds
formula
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DK215087A
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Danish (da)
English (en)
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DK215087D0 (da
DK215087A (da
Inventor
Nicholas Alex Saccomano
Fredric James Vinick
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Pfizer
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polymerisation Methods In General (AREA)
DK215087A 1986-04-29 1987-04-28 5-(4-alkoxy-3-polycycloalkyloxy-phenyl)-hexahydro-2-pyrimidinon-derivater,3-(4-alkoxy-3-polycycloalkyloxy-phenyl)glutaramid-derivater anvendelige som mellemprodukter ved deres fremstilling og farmaceutiske præparater til behandling af depression DK172033B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1986/000958 WO1987006576A1 (en) 1986-04-29 1986-04-29 Calcium independent camp phosphodiesterase inhibitor antidepressant
US8600958 1986-04-29

Publications (3)

Publication Number Publication Date
DK215087D0 DK215087D0 (da) 1987-04-28
DK215087A DK215087A (da) 1987-10-30
DK172033B1 true DK172033B1 (da) 1997-09-22

Family

ID=22195483

Family Applications (1)

Application Number Title Priority Date Filing Date
DK215087A DK172033B1 (da) 1986-04-29 1987-04-28 5-(4-alkoxy-3-polycycloalkyloxy-phenyl)-hexahydro-2-pyrimidinon-derivater,3-(4-alkoxy-3-polycycloalkyloxy-phenyl)glutaramid-derivater anvendelige som mellemprodukter ved deres fremstilling og farmaceutiske præparater til behandling af depression

Country Status (28)

Country Link
EP (1) EP0247725B1 (fi)
JP (1) JPH0645602B2 (fi)
KR (1) KR900002064B1 (fi)
CN (1) CN1018827B (fi)
AT (1) ATE102189T1 (fi)
AU (1) AU576448B2 (fi)
CA (1) CA1331606C (fi)
CZ (1) CZ280146B6 (fi)
DD (3) DD280321A5 (fi)
DE (1) DE3789164T2 (fi)
DK (1) DK172033B1 (fi)
EG (1) EG18239A (fi)
ES (1) ES2061492T3 (fi)
FI (2) FI94341C (fi)
HU (1) HU215433B (fi)
IE (1) IE63170B1 (fi)
IL (1) IL82342A (fi)
IN (1) IN167587B (fi)
MY (2) MY102842A (fi)
NO (2) NO875441D0 (fi)
NZ (1) NZ220106A (fi)
PH (1) PH25107A (fi)
PL (1) PL153225B1 (fi)
PT (1) PT84766B (fi)
SU (2) SU1646488A3 (fi)
WO (1) WO1987006576A1 (fi)
YU (4) YU47969B (fi)
ZA (1) ZA873014B (fi)

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ZA873014B (en) 1988-12-28
NO875440L (no) 1987-12-28
PT84766A (en) 1987-05-01
PL153225B1 (en) 1991-03-29
DK215087D0 (da) 1987-04-28
PT84766B (pt) 1989-12-29
FI875660A0 (fi) 1987-12-22
NO173138B (no) 1993-07-26
SU1646488A3 (ru) 1991-04-30
CZ280146B6 (cs) 1995-11-15
KR900002064B1 (ko) 1990-03-31
KR870010009A (ko) 1987-11-30
DD273773A5 (de) 1989-11-29
DE3789164D1 (de) 1994-04-07
IE871036L (en) 1987-10-29
YU47969B (sh) 1996-08-13
ATE102189T1 (de) 1994-03-15
YU115788A (en) 1988-10-31
IL82342A (en) 1992-03-29
CZ298987A3 (en) 1995-05-17
YU115688A (en) 1988-10-31
FI94341C (fi) 1995-08-25
DK215087A (da) 1987-10-30
NO173138C (no) 1993-11-03
IN167587B (fi) 1990-11-17
EP0247725B1 (en) 1994-03-02
PH25107A (en) 1991-02-19
SU1653542A3 (ru) 1991-05-30
EG18239A (en) 1992-10-30
EP0247725A3 (en) 1990-01-17
JPS62281864A (ja) 1987-12-07
CN1018827B (zh) 1992-10-28
MY106638A (en) 1995-07-31
CA1331606C (en) 1994-08-23
HUT63150A (en) 1993-07-28
NO875441D0 (no) 1987-12-28
FI875724L (fi) 1987-12-28
DE3789164T2 (de) 1994-06-09
JPH0645602B2 (ja) 1994-06-15
YU46915B (sh) 1994-06-24
YU77387A (en) 1988-10-31
MY102842A (en) 1993-03-31
DD280321A5 (de) 1990-07-04
NO875440D0 (no) 1987-12-28
YU115588A (en) 1988-10-31
NZ220106A (en) 1991-08-27
WO1987006576A1 (en) 1987-11-05
AU7214287A (en) 1987-12-10
FI94341B (fi) 1995-05-15
ES2061492T3 (es) 1994-12-16
IE63170B1 (en) 1995-03-22
EP0247725A2 (en) 1987-12-02
FI875660L (fi) 1987-12-22
PL265397A1 (en) 1988-07-21
CN87103225A (zh) 1987-11-11
AU576448B2 (en) 1988-08-25
YU46916B (sh) 1994-06-24
FI875724A0 (fi) 1987-12-28
YU47195B (sh) 1995-01-31
DD280319A5 (de) 1990-07-04
HU215433B (hu) 2000-05-28

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