ATE102189T1 - Von kalzium unabhaengiges camp-phosphodiestrerase inhibirendes antidepressivum. - Google Patents

Von kalzium unabhaengiges camp-phosphodiestrerase inhibirendes antidepressivum.

Info

Publication number: ATE102189T1
Authority: AT; Austria
Prior art keywords: phosphodiestrerase; calcium; inhibiting antidepressant; camp; independent
Prior art date: 1986-04-29

Application number

AT87303563T

Other languages

English (en)

Inventor

Nicholas Alex Saccomano

Frederick James Vinick

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-29

Filing date

1987-04-23

Publication date

1994-03-15

1987-04-23 Application filed by Pfizer filed Critical Pfizer

1994-03-15 Application granted granted Critical

1994-03-15 Publication of ATE102189T1 publication Critical patent/ATE102189T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Curing Cements, Concrete, And Artificial Stone (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polymerisation Methods In General (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT87303563T 1986-04-29 1987-04-23 Von kalzium unabhaengiges camp-phosphodiestrerase inhibirendes antidepressivum. ATE102189T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/US1986/000958 WO1987006576A1 (en)	1986-04-29	1986-04-29	Calcium independent camp phosphodiesterase inhibitor antidepressant
EP87303563A EP0247725B1 (de)	1986-04-29	1987-04-23	Von Kalzium unabhängiges Camp-Phosphodiestrerase inhibirendes Antidepressivum

Publications (1)

Publication Number	Publication Date
ATE102189T1 true ATE102189T1 (de)	1994-03-15

Family

ID=22195483

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87303563T ATE102189T1 (de)	1986-04-29	1987-04-23	Von kalzium unabhaengiges camp-phosphodiestrerase inhibirendes antidepressivum.

Country Status (28)

Country	Link
EP (1)	EP0247725B1 (de)
JP (1)	JPH0645602B2 (de)
KR (1)	KR900002064B1 (de)
CN (1)	CN1018827B (de)
AT (1)	ATE102189T1 (de)
AU (1)	AU576448B2 (de)
CA (1)	CA1331606C (de)
CZ (1)	CZ280146B6 (de)
DD (3)	DD280321A5 (de)
DE (1)	DE3789164T2 (de)
DK (1)	DK172033B1 (de)
EG (1)	EG18239A (de)
ES (1)	ES2061492T3 (de)
FI (2)	FI875724A0 (de)
HU (1)	HU215433B (de)
IE (1)	IE63170B1 (de)
IL (1)	IL82342A (de)
IN (1)	IN167587B (de)
MY (2)	MY102842A (de)
NO (2)	NO173138C (de)
NZ (1)	NZ220106A (de)
PH (1)	PH25107A (de)
PL (1)	PL153225B1 (de)
PT (1)	PT84766B (de)
SU (2)	SU1646488A3 (de)
WO (1)	WO1987006576A1 (de)
YU (4)	YU47969B (de)
ZA (1)	ZA873014B (de)

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1986
- 1986-04-29 HU HU111/86A patent/HU215433B/hu not_active IP Right Cessation
- 1986-04-29 FI FI875724A patent/FI875724A0/fi not_active Application Discontinuation
- 1986-04-29 WO PCT/US1986/000958 patent/WO1987006576A1/en active IP Right Grant
1987
- 1987-02-11 IN IN107/DEL/87A patent/IN167587B/en unknown
- 1987-02-16 MY MYPI87000152A patent/MY102842A/en unknown
- 1987-03-22 EG EG170/87A patent/EG18239A/xx active
- 1987-04-22 IE IE103687A patent/IE63170B1/en not_active IP Right Cessation
- 1987-04-23 AT AT87303563T patent/ATE102189T1/de not_active IP Right Cessation
- 1987-04-23 ES ES87303563T patent/ES2061492T3/es not_active Expired - Lifetime
- 1987-04-23 EP EP87303563A patent/EP0247725B1/de not_active Expired - Lifetime
- 1987-04-23 DE DE3789164T patent/DE3789164T2/de not_active Expired - Fee Related
- 1987-04-27 IL IL82342A patent/IL82342A/xx not_active IP Right Cessation
- 1987-04-27 JP JP62104168A patent/JPH0645602B2/ja not_active Expired - Fee Related
- 1987-04-27 CZ CS872989A patent/CZ280146B6/cs not_active IP Right Cessation
- 1987-04-27 NZ NZ220106A patent/NZ220106A/xx unknown
- 1987-04-27 PT PT84766A patent/PT84766B/pt unknown
- 1987-04-27 PL PL1987265397A patent/PL153225B1/pl unknown
- 1987-04-27 CA CA000535594A patent/CA1331606C/en not_active Expired - Fee Related
- 1987-04-28 DD DD87326852A patent/DD280321A5/de not_active IP Right Cessation
- 1987-04-28 YU YU77387A patent/YU47969B/sh unknown
- 1987-04-28 AU AU72142/87A patent/AU576448B2/en not_active Ceased
- 1987-04-28 DD DD87326854A patent/DD280319A5/de not_active IP Right Cessation
- 1987-04-28 ZA ZA873014A patent/ZA873014B/xx unknown
- 1987-04-28 DD DD87302222A patent/DD273773A5/de not_active IP Right Cessation
- 1987-04-28 PH PH35193A patent/PH25107A/en unknown
- 1987-04-28 CN CN87103225A patent/CN1018827B/zh not_active Expired
- 1987-04-28 DK DK215087A patent/DK172033B1/da not_active IP Right Cessation
- 1987-04-28 KR KR1019870004068A patent/KR900002064B1/ko not_active Expired
- 1987-12-22 FI FI875660A patent/FI94341C/fi not_active IP Right Cessation
- 1987-12-28 NO NO87875440A patent/NO173138C/no not_active IP Right Cessation
- 1987-12-28 NO NO1987875441A patent/NO875441D0/no unknown
1988
- 1988-06-14 YU YU115588A patent/YU46915B/sh unknown
- 1988-06-14 YU YU115788A patent/YU46916B/sh unknown
- 1988-06-14 YU YU115688A patent/YU47195B/sh unknown
- 1988-12-12 SU SU884613064A patent/SU1646488A3/ru active
- 1988-12-22 SU SU884613133A patent/SU1653542A3/ru active
1992
- 1992-02-24 MY MYPI92000292A patent/MY106638A/en unknown

Also Published As

Publication number	Publication date
EP0247725B1 (de)	1994-03-02
YU47195B (sh)	1995-01-31
FI875660A0 (fi)	1987-12-22
FI94341B (fi)	1995-05-15
DD280321A5 (de)	1990-07-04
CN87103225A (zh)	1987-11-11
JPH0645602B2 (ja)	1994-06-15
HU215433B (hu)	2000-05-28
MY102842A (en)	1993-03-31
CZ280146B6 (cs)	1995-11-15
FI875724A7 (fi)	1987-12-28
NO875441D0 (no)	1987-12-28
NO173138B (no)	1993-07-26
PT84766B (pt)	1989-12-29
IE871036L (en)	1987-10-29
JPS62281864A (ja)	1987-12-07
YU47969B (sh)	1996-08-13
CN1018827B (zh)	1992-10-28
FI875724L (fi)	1987-12-28
PL153225B1 (en)	1991-03-29
PL265397A1 (en)	1988-07-21
KR900002064B1 (ko)	1990-03-31
DD280319A5 (de)	1990-07-04
DK215087A (da)	1987-10-30
ES2061492T3 (es)	1994-12-16
YU115788A (en)	1988-10-31
YU46916B (sh)	1994-06-24
DE3789164D1 (de)	1994-04-07
DK215087D0 (da)	1987-04-28
DE3789164T2 (de)	1994-06-09
DD273773A5 (de)	1989-11-29
YU115588A (en)	1988-10-31
CA1331606C (en)	1994-08-23
YU77387A (en)	1988-10-31
KR870010009A (ko)	1987-11-30
IL82342A (en)	1992-03-29
NO173138C (no)	1993-11-03
YU46915B (sh)	1994-06-24
PT84766A (en)	1987-05-01
MY106638A (en)	1995-07-31
CZ298987A3 (en)	1995-05-17
NZ220106A (en)	1991-08-27
EP0247725A3 (en)	1990-01-17
FI94341C (fi)	1995-08-25
PH25107A (en)	1991-02-19
AU7214287A (en)	1987-12-10
WO1987006576A1 (en)	1987-11-05
NO875440D0 (no)	1987-12-28
AU576448B2 (en)	1988-08-25
YU115688A (en)	1988-10-31
NO875440L (no)	1987-12-28
HUT63150A (en)	1993-07-28
FI875660L (fi)	1987-12-22
IE63170B1 (en)	1995-03-22
IN167587B (de)	1990-11-17
DK172033B1 (da)	1997-09-22
FI875724A0 (fi)	1987-12-28
EG18239A (en)	1992-10-30
ZA873014B (en)	1988-12-28
SU1653542A3 (ru)	1991-05-30
SU1646488A3 (ru)	1991-04-30
EP0247725A2 (de)	1987-12-02

Publication	Publication Date	Title
ATE102189T1 (de)	1994-03-15	Von kalzium unabhaengiges camp-phosphodiestrerase inhibirendes antidepressivum.
NL971014I2 (nl)	1998-01-05	Heterocyclische verbindingen.
ATE172201T1 (de)	1998-10-15	Morphinan-derivate und medizinische verwendung
FI911980A0 (fi)	1991-04-24	N-(3-fluor-2-fosfonylmetoxipropyl) -derivat av heterocykliska purin- och pyrimidinbaser, deras framstaellning och anvaendning.
DK491089A (da)	1990-04-07	Benzoxazepinon og fremgangsmaade til fremstilling deraf samt mellemprodukt til brug i fremgangsmaaden
NO863647D0 (no)	1986-09-12	Propanolderivater.
SU1624959A1 (ru)	2000-11-27	5-(β-П-МЕТОКСИФЕНИЛ-β-ОКСИЭТИЛ)-2-МЕТИЛТИО-1-МЕТИЛ-4,5,6,7-ТЕТРАГИДРОИ МИДАЗО[4,5-C]ПИРИДИНА ДИГИДРОХЛОРИД, ОБЛАДАЮЩИЙ ГИПОТЕНЗИВНЫМ, АНТИГИПЕРТЕНЗИВНЫМ, СПАЗМОЛИТИЧЕСКИМ И СЕДАТИВНЫМ ДЕЙСТВИЕМ

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