DK1475379T3 - Anvendelse af scopinesterderivater til fremstilling af lægemidler - Google Patents

Anvendelse af scopinesterderivater til fremstilling af lægemidler

Info

Publication number: DK1475379T3
Authority: DK; Denmark
Prior art keywords: drugs; manufacture; ester derivatives; scopin ester; scopin
Prior art date: 2001-06-28

Application number

DK04018550T

Other languages

English (en)

Inventor

Rainer Dr Sobotta

Armin Rapp

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-28

Filing date

2002-06-08

Publication date

2007-09-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1475379(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-06-08 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2007-09-03 Application granted granted Critical

2007-09-03 Publication of DK1475379T3 publication Critical patent/DK1475379T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Lock And Its Accessories (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK04018550T 2001-06-28 2002-06-08 Anvendelse af scopinesterderivater til fremstilling af lægemidler DK1475379T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10131200		2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de)	2001-06-28	2002-06-08	Technische syntheseverfahren zur herstellung von tropenol

Publications (1)

Publication Number	Publication Date
DK1475379T3 true DK1475379T3 (da)	2007-09-03

Family

ID=7689774

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK04018550T DK1475379T3 (da)	2001-06-28	2002-06-08	Anvendelse af scopinesterderivater til fremstilling af lægemidler
DK07101821.2T DK1808435T3 (da)	2001-06-28	2002-06-08	Teknisk fremstilling af tiotropiumbromid
DK02727610T DK1404673T3 (da)	2001-06-28	2002-06-08	Teknisk syntesefremgangsmåde til fremstilling af tropenol

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK07101821.2T DK1808435T3 (da)	2001-06-28	2002-06-08	Teknisk fremstilling af tiotropiumbromid
DK02727610T DK1404673T3 (da)	2001-06-28	2002-06-08	Teknisk syntesefremgangsmåde til fremstilling af tropenol

Country Status (41)

Country	Link
US (1)	US6610849B2 (da)
EP (3)	EP1475379B1 (da)
JP (2)	JP4485192B2 (da)
KR (3)	KR100866272B1 (da)
CN (2)	CN1982309B (da)
AR (1)	AR039056A1 (da)
AT (3)	ATE294801T1 (da)
AU (2)	AU2002257820B2 (da)
BG (2)	BG66398B1 (da)
BR (1)	BR0210664B1 (da)
CA (1)	CA2451573C (da)
CO (1)	CO5650166A2 (da)
CY (1)	CY1107681T1 (da)
CZ (1)	CZ296187B6 (da)
DE (2)	DE50209948D1 (da)
DK (3)	DK1475379T3 (da)
EA (2)	EA006393B1 (da)
EC (1)	ECSP034927A (da)
EE (1)	EE05403B1 (da)
EG (1)	EG23203A (da)
ES (3)	ES2374981T3 (da)
HK (2)	HK1068613A1 (da)
HR (2)	HRP20031085B1 (da)
HU (2)	HU230379B1 (da)
IL (2)	IL159239A0 (da)
ME (1)	MEP42608A (da)
MX (1)	MXPA03011516A (da)
MY (1)	MY122932A (da)
NO (1)	NO328154B1 (da)
NZ (2)	NZ530770A (da)
PE (1)	PE20030123A1 (da)
PL (1)	PL209520B1 (da)
PT (2)	PT1404673E (da)
RS (1)	RS50436B (da)
SA (1)	SA02230194B1 (da)
SI (2)	SI1404673T1 (da)
SK (1)	SK288022B6 (da)
TW (1)	TW574220B (da)
UA (2)	UA76761C2 (da)
WO (1)	WO2003002562A1 (da)
ZA (1)	ZA200308895B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10141377A1 (de)	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) *	2002-05-31	2004-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Industrial process for preparing tropenol
US20090162562A1 (en) *	2007-12-24	2009-06-25	Bangalore Aswatha Nagaraj	Methods for Applying Thermal Barrier Coating Systems
CN101918401A (zh) *	2008-01-10	2010-12-15	基因里克斯(英国)有限公司	用于制备东莨菪醇酯的新方法
CN102639531B (zh)	2009-08-07	2016-01-20	基因里克斯(英国)有限公司	噻托溴铵的无水合物
WO2011015884A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Process to prepare scopine esters
CN102351856B (zh) *	2011-08-24	2013-05-01	商丘市韶华药业有限公司	一种α-托品醇的纯化方法
ITRM20110508A1 (it)	2011-09-27	2013-03-28	Lusochimica Spa	Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) *	2011-12-22	2017-05-26	Cerbios-Pharma S A	Processo contínuo para a alquilação de aminas terciárias cíclicas
CN113292574B (zh) *	2020-02-21	2022-05-03	四川大学	一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) *	2020-04-13	2021-09-21	石家庄四药有限公司	异丙托溴铵的合成方法
CN113264929B (zh) *	2021-05-02	2023-10-10	润生药业有限公司	一种噻托溴铵的制备方法
CN115925534B (zh) *	2023-01-03	2025-03-07	绍兴民生医药股份有限公司	高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3931041C2 (de) *	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
PL183025B1 (pl) *	1994-04-19	2002-05-31	Neurosearch As	Pochodne tropanu, sposób ich otrzymywania i zawierające je kompozycje
DE19515625C2 (de) *	1995-04-28	1998-02-19	Boehringer Ingelheim Kg	Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

2002
- 2002-06-03 US US10/160,702 patent/US6610849B2/en not_active Expired - Lifetime
- 2002-06-08 PL PL366942A patent/PL209520B1/pl unknown
- 2002-06-08 CN CN2006101604057A patent/CN1982309B/zh not_active Expired - Lifetime
- 2002-06-08 HU HU1400554A patent/HU230379B1/hu unknown
- 2002-06-08 KR KR1020037017010A patent/KR100866272B1/ko active IP Right Grant
- 2002-06-08 BR BRPI0210664-7B1A patent/BR0210664B1/pt active IP Right Grant
- 2002-06-08 DK DK04018550T patent/DK1475379T3/da active
- 2002-06-08 MX MXPA03011516A patent/MXPA03011516A/es active IP Right Grant
- 2002-06-08 ES ES07101821T patent/ES2374981T3/es not_active Expired - Lifetime
- 2002-06-08 NZ NZ530770A patent/NZ530770A/en not_active IP Right Cessation
- 2002-06-08 DK DK07101821.2T patent/DK1808435T3/da active
- 2002-06-08 EP EP04018550A patent/EP1475379B1/de not_active Revoked
- 2002-06-08 AT AT02727610T patent/ATE294801T1/de active
- 2002-06-08 SI SI200230153T patent/SI1404673T1/xx unknown
- 2002-06-08 AT AT07101821T patent/ATE527257T1/de active
- 2002-06-08 EE EEP200400045A patent/EE05403B1/xx not_active IP Right Cessation
- 2002-06-08 ME MEP-426/08A patent/MEP42608A/xx unknown
- 2002-06-08 PT PT02727610T patent/PT1404673E/pt unknown
- 2002-06-08 WO PCT/EP2002/006290 patent/WO2003002562A1/de active Application Filing
- 2002-06-08 EP EP02727610A patent/EP1404673B1/de not_active Expired - Lifetime
- 2002-06-08 ES ES02727610T patent/ES2242022T3/es not_active Expired - Lifetime
- 2002-06-08 RS YUP-1011/03A patent/RS50436B/sr unknown
- 2002-06-08 KR KR1020087014692A patent/KR100886342B1/ko active IP Right Grant
- 2002-06-08 ES ES04018550T patent/ES2285318T3/es not_active Expired - Lifetime
- 2002-06-08 CZ CZ20040149A patent/CZ296187B6/cs not_active IP Right Cessation
- 2002-06-08 DE DE50209948T patent/DE50209948D1/de not_active Expired - Lifetime
- 2002-06-08 SK SK66-2004A patent/SK288022B6/sk not_active IP Right Cessation
- 2002-06-08 HU HU0400332A patent/HU230036B1/hu unknown
- 2002-06-08 CN CNB028128672A patent/CN1288154C/zh not_active Expired - Lifetime
- 2002-06-08 EA EA200301292A patent/EA006393B1/ru not_active IP Right Cessation
- 2002-06-08 SI SI200230540T patent/SI1475379T1/sl unknown
- 2002-06-08 EA EA200501081A patent/EA009808B1/ru not_active IP Right Cessation
- 2002-06-08 IL IL15923902A patent/IL159239A0/xx unknown
- 2002-06-08 AT AT04018550T patent/ATE359285T1/de active
- 2002-06-08 DE DE50203015T patent/DE50203015D1/de not_active Expired - Lifetime
- 2002-06-08 EP EP07101821A patent/EP1808435B1/de not_active Expired - Lifetime
- 2002-06-08 NZ NZ541395A patent/NZ541395A/en not_active IP Right Cessation
- 2002-06-08 CA CA2451573A patent/CA2451573C/en not_active Expired - Fee Related
- 2002-06-08 AU AU2002257820A patent/AU2002257820B2/en not_active Expired
- 2002-06-08 PT PT04018550T patent/PT1475379E/pt unknown
- 2002-06-08 JP JP2003508943A patent/JP4485192B2/ja not_active Expired - Lifetime
- 2002-06-08 DK DK02727610T patent/DK1404673T3/da active
- 2002-06-25 PE PE2002000553A patent/PE20030123A1/es not_active Application Discontinuation
- 2002-06-26 MY MYPI20022420A patent/MY122932A/en unknown
- 2002-06-26 TW TW91114026A patent/TW574220B/zh not_active IP Right Cessation
- 2002-06-26 EG EG2002060738A patent/EG23203A/xx active
- 2002-06-28 AR ARP020102453A patent/AR039056A1/es active Pending
- 2002-07-10 SA SA2230194A patent/SA02230194B1/ar unknown
- 2002-08-06 UA UA2004010605A patent/UA76761C2/uk unknown
2003
- 2003-03-28 KR KR10-2003-0019708A patent/KR100530661B1/ko not_active IP Right Cessation
- 2003-11-14 ZA ZA200308895A patent/ZA200308895B/en unknown
- 2003-12-08 IL IL159239A patent/IL159239A/en active IP Right Grant
- 2003-12-17 BG BG108462A patent/BG66398B1/bg active Active
- 2003-12-17 NO NO20035633A patent/NO328154B1/no not_active IP Right Cessation
- 2003-12-23 CO CO03112174A patent/CO5650166A2/es active IP Right Grant
- 2003-12-24 HR HR20031085A patent/HRP20031085B1/xx not_active IP Right Cessation
- 2003-12-24 EC EC2003004927A patent/ECSP034927A/es unknown
2005
- 2005-01-29 HK HK05100781A patent/HK1068613A1/xx not_active IP Right Cessation
2006
- 2006-03-09 UA UAA200602562A patent/UA86031C2/ru unknown
2007
- 2007-06-21 CY CY20071100822T patent/CY1107681T1/el unknown
- 2007-10-31 HK HK07111732.3A patent/HK1103404A1/xx not_active IP Right Cessation
2008
- 2008-04-08 AU AU2008201565A patent/AU2008201565B2/en not_active Expired
2009
- 2009-02-23 HR HR20090110A patent/HRP20090110A2/xx not_active Application Discontinuation
- 2009-10-13 JP JP2009236400A patent/JP2010043116A/ja active Pending
2013
- 2013-05-07 BG BG10111461A patent/BG111461A/en active Pending

Also Published As

Publication number	Publication date
MXPA03011516A (es)	2004-03-18
ZA200308895B (en)	2004-06-09
TW574220B (en)	2004-02-01
KR100530661B1 (ko)	2005-11-22
KR20040023631A (ko)	2004-03-18
CN1520413A (zh)	2004-08-11
HK1103404A1 (en)	2007-12-21
NO328154B1 (no)	2009-12-21
PL366942A1 (en)	2005-02-07
EE200400045A (et)	2004-04-15
EA200301292A1 (ru)	2004-06-24
JP2004536830A (ja)	2004-12-09
EP1475379B1 (de)	2007-04-11
ATE359285T1 (de)	2007-05-15
CA2451573C (en)	2010-09-21
BG108462A (bg)	2005-01-31
ATE527257T1 (de)	2011-10-15
ECSP034927A (es)	2004-02-26
MEP42608A (en)	2011-02-10
EP1808435A1 (de)	2007-07-18
DE50203015D1 (de)	2005-06-09
DE50209948D1 (de)	2007-05-24
AU2008201565A1 (en)	2008-05-01
SK288022B6 (sk)	2012-12-03
HU230036B1 (hu)	2015-05-28
ATE294801T1 (de)	2005-05-15
PT1475379E (pt)	2007-05-31
CZ296187B6 (cs)	2006-01-11
CZ2004149A3 (cs)	2004-05-12
PL209520B1 (pl)	2011-09-30
CA2451573A1 (en)	2003-01-09
KR20080065313A (ko)	2008-07-11
NO20035633D0 (no)	2003-12-17
DK1404673T3 (da)	2005-06-13
ES2242022T3 (es)	2005-11-01
IL159239A0 (en)	2004-06-01
DK1808435T3 (da)	2012-01-16
PT1404673E (pt)	2005-07-29
SI1475379T1 (sl)	2007-08-31
HUP0400332A3 (en)	2007-06-28
HK1068613A1 (en)	2005-04-29
HRP20031085B1 (en)	2011-12-31
EP1808435B1 (de)	2011-10-05
MY122932A (en)	2006-05-31
HU230379B1 (hu)	2016-03-29
CY1107681T1 (el)	2013-04-18
BR0210664A (pt)	2004-08-10
HRP20090110A2 (en)	2009-04-30
AR039056A1 (es)	2005-02-09
NZ541395A (en)	2007-03-30
ES2285318T3 (es)	2007-11-16
JP2010043116A (ja)	2010-02-25
CO5650166A2 (es)	2006-06-30
HUP0400332A2 (hu)	2004-08-30
EE05403B1 (et)	2011-04-15
EG23203A (en)	2004-07-31
YU101103A (en)	2006-05-25
BG66398B1 (bg)	2013-12-31
UA76761C2 (uk)	2006-09-15
HRP20031085A2 (en)	2004-04-30
UA86031C2 (ru)	2009-03-25
SK662004A3 (en)	2004-06-08
BG111461A (en)	2013-08-30
AU2008201565B2 (en)	2012-03-01
CN1288154C (zh)	2006-12-06
KR100886342B1 (ko)	2009-03-03
EP1404673A1 (de)	2004-04-07
EP1404673B1 (de)	2005-05-04
EA200501081A1 (ru)	2006-06-30
EA009808B1 (ru)	2008-04-28
SI1404673T1 (en)	2005-10-31
US6610849B2 (en)	2003-08-26
BR0210664B1 (pt)	2013-12-03
KR20030078793A (ko)	2003-10-08
RS50436B (sr)	2009-12-31
IL159239A (en)	2010-05-17
JP4485192B2 (ja)	2010-06-16
WO2003002562A1 (de)	2003-01-09
EA006393B1 (ru)	2005-12-29
PE20030123A1 (es)	2003-03-31
US20030022917A1 (en)	2003-01-30
CN1982309B (zh)	2010-06-09
KR100866272B1 (ko)	2008-11-03
ES2374981T3 (es)	2012-02-23
SA02230194B1 (ar)	2008-03-08
CN1982309A (zh)	2007-06-20
NZ530770A (en)	2005-11-25
AU2002257820B2 (en)	2008-05-08
EP1475379A1 (de)	2004-11-10

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