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DE69929958D1 - Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie - Google Patents

Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie

Info

Publication number
DE69929958D1
DE69929958D1 DE69929958T DE69929958T DE69929958D1 DE 69929958 D1 DE69929958 D1 DE 69929958D1 DE 69929958 T DE69929958 T DE 69929958T DE 69929958 T DE69929958 T DE 69929958T DE 69929958 D1 DE69929958 D1 DE 69929958D1
Authority
DE
Germany
Prior art keywords
tnf
modulators
receptors
function
receptor family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69929958T
Other languages
English (en)
Other versions
DE69929958T2 (de
Inventor
David Wallach
Andreibeit Clore Kovalenko
S Horwitz
Yongan Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Albert Einstein College of Medicine
Original Assignee
Yeda Research and Development Co Ltd
Albert Einstein College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12375898A external-priority patent/IL123758A0/xx
Application filed by Yeda Research and Development Co Ltd, Albert Einstein College of Medicine filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of DE69929958D1 publication Critical patent/DE69929958D1/de
Publication of DE69929958T2 publication Critical patent/DE69929958T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69929958T 1998-03-19 1999-03-18 Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie Expired - Fee Related DE69929958T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12375898A IL123758A0 (en) 1998-03-19 1998-03-19 Modulators of the function of receptors of the TNF/NGF receptor family and other proteins
IL12375898 1998-03-19
IL12602498A IL126024A0 (en) 1998-03-19 1998-09-01 Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
IL12602498 1998-09-01
PCT/IL1999/000158 WO1999047672A1 (en) 1998-03-19 1999-03-18 Modulators of the function of receptors of the tnf/ngf receptor family and other proteins
CA002323637A CA2323637A1 (en) 1998-03-19 1999-03-18 Modulators of the function of receptors of the tnf/ngf receptor family and other proteins

Publications (2)

Publication Number Publication Date
DE69929958D1 true DE69929958D1 (de) 2006-04-27
DE69929958T2 DE69929958T2 (de) 2006-11-23

Family

ID=39598416

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69929958T Expired - Fee Related DE69929958T2 (de) 1998-03-19 1999-03-18 Modulatoren der funktion von rezeptoren der tnf/ngf rezeptorenfamilie

Country Status (24)

Country Link
US (1) US6734174B1 (de)
EP (1) EP1062336B1 (de)
JP (1) JP4351389B2 (de)
KR (1) KR100748293B1 (de)
CN (1) CN1232641C (de)
AT (1) ATE318310T1 (de)
AU (1) AU760900B2 (de)
BG (2) BG64990B1 (de)
BR (1) BR9909659A (de)
CA (2) CA2625284A1 (de)
DE (1) DE69929958T2 (de)
DK (1) DK1062336T3 (de)
EA (1) EA004062B1 (de)
EE (1) EE200000538A (de)
ES (1) ES2258838T3 (de)
HK (1) HK1034995A1 (de)
HU (1) HUP0101612A3 (de)
IL (1) IL126024A0 (de)
NO (1) NO327854B1 (de)
NZ (2) NZ525566A (de)
PL (1) PL200763B1 (de)
PT (1) PT1062336E (de)
SK (1) SK285804B6 (de)
WO (1) WO1999047672A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189832B1 (en) * 1998-08-20 2007-03-13 The Regents Of The University Of California Gamma subunit of cytokine responsive IκB-alpha kinase complex and methods of using same
US7745579B1 (en) 1998-09-01 2010-06-29 David Wallach Inhibitor of NF-KB activation
DK2270052T3 (en) 2001-06-26 2018-07-02 Amgen Inc Antibodies to OPGL
US7521534B1 (en) * 2003-03-03 2009-04-21 The University Board Of Regents Of Texas System IKK gamma gene products and methods for making and using same
BRPI0414714A (pt) * 2003-09-24 2006-11-21 Pasteur Institut polinucleotìdeo purificado, vetor, célula hospedeira, construto de fusão de polipeptìdeo, métodos de inibir a rota de sinalização de nf-capab, de interromper a oligomerização de nemo, e, de identificar polipeptìdeos que modulam a oligomerização de nemo, e, uso de uma quantidade eficaz de uma composição
EP2492281B1 (de) 2009-10-19 2018-04-11 HanAll Biopharma Co., Ltd. Modifiziertes menschliches tumornekrose-faktor-rezeptor-1-polypeptid oder fragment davon sowie herstellungsverfahren dafür
CN102399819B (zh) * 2011-08-24 2013-06-19 西北农林科技大学 一种质粒型腺病毒载体pAd-NRIP1及其构建方法
DE102011115480A1 (de) * 2011-10-06 2013-04-11 Biostep Gmbh Substrat und Vorrichtung zur Chemilumineszenzdetektion
SG11201704764PA (en) 2014-12-11 2017-07-28 Harvard College Inhibitors of cellular necrosis and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
IL94039A (en) * 1989-08-06 2006-09-05 Yeda Res & Dev Antibodies to tbp - 1 and their use
EP0398327B2 (de) * 1989-05-18 2013-02-20 Yeda Research And Development Co., Ltd. Tumor-Nekrosefaktor-Bindungsprotein II, seine Reinigung und spezifische Antikörper
WO1996025941A1 (en) * 1995-02-22 1996-08-29 Yeda Research And Development Co. Ltd. Modulators of regulatory proteins
US5674734A (en) * 1995-05-18 1997-10-07 President And Fellows Of Harvard College Cell death protein
AU7457796A (en) * 1995-10-23 1997-05-15 Tularik Inc. Rip: novel human protein involved in tumor necrosis factor signal transduction, and screening assays
EP0914338A2 (de) * 1996-05-29 1999-05-12 Genzyme Corporation Zellwachstums regulierungs gene

Also Published As

Publication number Publication date
WO1999047672A1 (en) 1999-09-23
EA200000961A1 (ru) 2001-04-23
PT1062336E (pt) 2006-05-31
HUP0101612A2 (hu) 2004-01-28
IL126024A0 (en) 1999-05-09
DE69929958T2 (de) 2006-11-23
BG109537A (en) 2007-11-30
JP2002506644A (ja) 2002-03-05
BG104769A (en) 2001-04-30
JP4351389B2 (ja) 2009-10-28
CA2323637A1 (en) 1999-09-23
AU760900B2 (en) 2003-05-22
ES2258838T3 (es) 2006-09-01
EP1062336A1 (de) 2000-12-27
PL200763B1 (pl) 2009-02-27
CN1232641C (zh) 2005-12-21
HK1034995A1 (en) 2001-11-09
PL343262A1 (en) 2001-07-30
HUP0101612A3 (en) 2005-03-29
NZ506776A (en) 2003-08-29
NO20004649D0 (no) 2000-09-18
KR20050107527A (ko) 2005-11-11
ATE318310T1 (de) 2006-03-15
EE200000538A (et) 2002-04-15
SK285804B6 (sk) 2007-08-02
BG64990B1 (bg) 2006-11-30
KR100748293B1 (ko) 2007-08-09
AU2954599A (en) 1999-10-11
NZ525566A (en) 2004-12-24
SK13762000A3 (sk) 2001-03-12
CA2625284A1 (en) 1999-09-23
EP1062336B1 (de) 2006-02-22
CN1295614A (zh) 2001-05-16
US6734174B1 (en) 2004-05-11
BG65684B1 (bg) 2009-06-30
DK1062336T3 (da) 2006-05-29
NO327854B1 (no) 2009-10-05
EA004062B1 (ru) 2003-12-25
BR9909659A (pt) 2000-11-21
NO20004649L (no) 2000-10-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee