DE69828193D1 - Hyaluronan synthase gen und seine verwendung - Google Patents

Hyaluronan synthase gen und seine verwendung

Info

Publication number: DE69828193D1
Authority: DE; Germany
Prior art keywords: nucleic acid; hyaluronan synthase; synthase gene; hyaluronan; synthase
Prior art date: 1997-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69828193T

Other languages

English (en)

Other versions

DE69828193T2 (de

Inventor

H Weigel

Kshama Kumari

Paul Deangelis

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Oklahoma

Original Assignee

University of Oklahoma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-31

Filing date

1998-10-30

Publication date

2005-01-20

1998-10-30 Application filed by University of Oklahoma filed Critical University of Oklahoma

2005-01-20 Application granted granted Critical

2005-01-20 Publication of DE69828193D1 publication Critical patent/DE69828193D1/de

2005-12-01 Publication of DE69828193T2 publication Critical patent/DE69828193T2/de

2018-10-31 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

108090000320 Hyaluronan Synthases Proteins 0.000 title abstract 6
102000003918 Hyaluronan Synthases Human genes 0.000 abstract 5
229920002674 hyaluronan Polymers 0.000 abstract 3
150000007523 nucleic acids Chemical group 0.000 abstract 3
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
229960003160 hyaluronic acid Drugs 0.000 abstract 2
108020004707 nucleic acids Proteins 0.000 abstract 2
102000039446 nucleic acids Human genes 0.000 abstract 2
241000701248 Chlorella virus Species 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 abstract 1
229940099552 hyaluronan Drugs 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/839—Bacillus subtilis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Mycology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Oncology (AREA)
Physics & Mathematics (AREA)
Communicable Diseases (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DE69828193T 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung Expired - Lifetime DE69828193T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US6443597P	1997-10-31	1997-10-31
US64435P		1997-10-31
US17885198A	1998-10-26	1998-10-26
US178851		1998-10-26
PCT/US1998/023153 WO1999023227A2 (en)	1997-10-31	1998-10-30	Hyaluronan synthase gene and uses thereof

Publications (2)

Publication Number	Publication Date
DE69828193D1 true DE69828193D1 (de)	2005-01-20
DE69828193T2 DE69828193T2 (de)	2005-12-01

Family

ID=26744517

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69828193T Expired - Lifetime DE69828193T2 (de)	1997-10-31	1998-10-30	Hyaluronan synthase gen und seine verwendung

Country Status (13)

Country	Link
US (10)	US6833264B1 (de)
EP (2)	EP1522579A3 (de)
JP (1)	JP4731013B2 (de)
KR (1)	KR20010031682A (de)
CN (1)	CN1322121C (de)
AT (1)	ATE284954T1 (de)
AU (2)	AU762036B2 (de)
BR (1)	BR9814834B1 (de)
CA (1)	CA2307842C (de)
DE (1)	DE69828193T2 (de)
DK (1)	DK1025211T3 (de)
ES (1)	ES2235378T3 (de)
WO (1)	WO1999023227A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7091008B1 (en)	1994-07-01	2006-08-15	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof in Bacillus hosts
DE69828193T2 (de) *	1997-10-31	2005-12-01	The Board Of Regents Of The University Of Oklahoma, Norman	Hyaluronan synthase gen und seine verwendung
US7060469B2 (en) *	1998-04-02	2006-06-13	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
CN101275143A (zh) *	1998-04-02	2008-10-01	俄克拉何马大学董事会	编码透明质酸合酶的核酸及其应用方法
US7534589B2 (en) *	1999-11-10	2009-05-19	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
US20070020737A1 (en) *	2001-12-03	2007-01-25	Pummill Philip E	Hyaluronan synthases and methods of making and using same
KR100879908B1 (ko)	2001-12-21	2009-01-21	노보자임스 바이오폴리머 에이/에스	재조합체 숙주 세포에서 히알루로난의 제조 방법
AU2008200910C1 (en) *	2001-12-21	2012-11-22	Novozymes A/S	Methods for producing hyaluronan in a recombinant host cell
US9733625B2 (en) *	2006-03-20	2017-08-15	General Electric Company	Trip optimization system and method for a train
KR101023049B1 (ko) *	2002-06-20	2011-03-24	노보자임스 바이오파마 디케이 에이/에스	2가 염을 사용한 응집 방법
BRPI0412582A (pt) *	2003-07-31	2006-09-19	Toyo Boseki	plantas produtoras de ácido hialurÈnico
EP1640457A1 (de) *	2004-09-23	2006-03-29	Bayer CropScience GmbH	Verfahren und Mittel zur Herstellung von Hyaluronan
CA2579592C (en)	2004-09-23	2018-01-02	Bayer Cropscience Gmbh	Plant cells that comprise a nucleic acid encoding hyaluronan synthase, and methods and means for producing hyaluronan
CN101123942A (zh) *	2005-01-03	2008-02-13	诺维信生物聚合物公司	具有保湿和抗皱纹性质的透明质酸级分
JP2006204260A (ja) *	2005-01-31	2006-08-10	Toyobo Co Ltd	ヒアルロン酸合成酵素及びその遺伝子
US8003851B2 (en)	2005-08-25	2011-08-23	Toyo Boseki Kabushiki Kaisha	Plant producing hyaluronic acid
AU2006298961B2 (en) *	2005-10-05	2013-05-02	Bayer Intellectual Property Gmbh	Plants with increased hyaluronan production
WO2007039316A1 (en) *	2005-10-05	2007-04-12	Bayer Cropscience Ag	Improved methods and means for producings hyaluronan
EP1772052A1 (de) *	2005-10-05	2007-04-11	Bayer CropScience GmbH	Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
WO2007039315A1 (de) *	2005-10-05	2007-04-12	Bayer Cropscience Ag	Pflanzen mit gesteigerter produktion von hyaluronan ii
JP2007174957A (ja) *	2005-12-27	2007-07-12	Toyobo Co Ltd	ヒアルロン酸生産酵母
CN101501075B (zh)	2006-08-04	2013-07-10	诺维信生物制药丹麦公司	支化透明质酸和制造方法
EP2140009A2 (de) *	2007-03-29	2010-01-06	CBD Technologies Ltd.	Transgene pflanzen mit löslichen zellwand-polysacchariden
EP2195348A4 (de) *	2007-08-31	2012-11-07	Univ Queensland	Herstellung von hyaluronsäure
JP5523338B2 (ja)	2007-12-19	2014-06-18	エヴォニクゴールドシュミットゲーエムベーハー	エマルジョン中の架橋ヒアルロン酸
US20140155347A1 (en)	2011-05-30	2014-06-05	Novozymes Biopharma Dk A/S	Spray Drying of High Molecular Weight Hyaluronic Acid
CA2847328A1 (en)	2011-09-02	2013-03-07	Novozymes Biopharma Dk A/S	Oral formulations containing hyaluronic acid for sustained drug release
WO2014100837A1 (en)	2012-12-17	2014-06-26	Bui The Duy	Computer aided implantation of body implants
AU2014228022B9 (en) *	2013-03-15	2016-11-03	NuTech Medical, Inc.	Preparations derived from placental materials of making and using same
KR102135044B1 (ko) *	2018-12-10	2020-07-17	대화제약 주식회사	히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법
RU2719140C1 (ru)	2019-07-26	2020-04-17	Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех"	Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии
EP4487863A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya zur verwendung bei der behandlung degenerierter gelenke
WO2025012149A1 (en)	2023-07-07	2025-01-16	Nupep As	Consensus peptides in hya
EP4487834A1 (de)	2023-07-07	2025-01-08	NuPep AS	Konsensuspeptide in hya
CN119020314A (zh) *	2024-09-30	2024-11-26	海南省深海技术创新中心	一种透明质酸合成酶及其应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH624011A5 (de)	1977-08-05	1981-07-15	Battelle Memorial Institute
US4235871A (en)	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
ZA811368B (en)	1980-03-24	1982-04-28	Genentech Inc	Bacterial polypedtide expression employing tryptophan promoter-operator
EP0038776B1 (de)	1980-04-17	1983-09-21	Ciba-Geigy Ag	Phenylharnstoffe
US4517295A (en)	1983-02-18	1985-05-14	Diagnostic, Inc.	Hyaluronic acid from bacterial culture
CA1167797A (en)	1983-06-30	1984-05-22	Herbert E. Gladish	Air conveyor components
JPS6060177A (ja)	1983-09-12	1985-04-06	Hiroyuki Yugawa	冷却用寒剤
US4511478A (en)	1983-11-10	1985-04-16	Genetic Systems Corporation	Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
WO1985002092A1 (en)	1983-11-14	1985-05-23	Bio-Mimetics Inc.	Bioadhesive compositions and methods of treatment therewith
US4983392A (en)	1983-11-14	1991-01-08	Bio-Mimetics, Inc.	Bioadhesive compositions and methods of treatment therewith
NO161573C (no)	1983-11-25	1989-08-30	Miles Inc	Fremgangsmaate til fremstilling av hyaluronsyre.
US4708861A (en)	1984-02-15	1987-11-24	The Liposome Company, Inc.	Liposome-gel compositions
JPS60251898A (ja)	1984-05-25	1985-12-12	Shiseido Co Ltd	醗酵法によるヒアルロン酸の製造方法
DE3531612A1 (de)	1984-09-04	1986-03-27	Chisso Corp., Osaka	Verfahren zur herstellung von hyaluronsaeure
JPS6163294A (ja) *	1984-09-05	1986-04-01	Chisso Corp	発酵法によるヒアルロン酸の製造法
US5171689A (en)	1984-11-08	1992-12-15	Matsushita Electric Industrial Co., Ltd.	Solid state bio-sensor
US4780414A (en)	1985-01-18	1988-10-25	Bio-Technology General Corp.	Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en) *	1985-01-18	1988-11-15	Bio-Technology General Corporation	High molecular weight sodium hyaluronate
IT1208514B (it)	1985-03-19	1989-07-10	Eniricerche Spa	Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis.
JPS61267189A (ja)	1985-05-22	1986-11-26	株式会社東芝	結束装置付入金集計機
JPS6232893A (ja)	1985-08-01	1987-02-12	Kyowa Hakko Kogyo Co Ltd	ヒアルロン酸の製造法
US5023175A (en)	1986-05-01	1991-06-11	Kabushiki Kaisha Yakult Honsha	Novel production process of hyaluronic acid and bacterium strain therefor
JPS6394988A (ja)	1986-10-08	1988-04-26	Meiji Seika Kaisha Ltd	ヒアルロン酸の製造法
JPH072117B2 (ja)	1986-10-09	1995-01-18	三菱レイヨン株式会社	ヒアルロン酸の製造法
EP0265578A1 (de)	1986-10-30	1988-05-04	Jan-Olof Eriksson	Zusammensetzung eines nicht abschleifenden Polier- und Reinigungsmittels und Verfahren zu ihrer Herstellung
US4822867A (en)	1987-02-02	1989-04-18	Semih Erhan	Protein polymer grafts
JPH02193818A (ja)	1989-01-23	1990-07-31	Okura Yusoki Co Ltd	パレット荷積み装置
US5015577A (en)	1989-08-29	1991-05-14	Board Of Regents, The University Of Texas System	DNA encoding hyaluronate synthase
FR2652736A1 (fr)	1989-10-06	1991-04-12	Neftel Frederic	Dispositif implantable d'evaluation du taux de glucose.
JP2986519B2 (ja)	1990-07-24	1999-12-06	生化学工業株式会社	燐脂質結合グリコサミノグリカン
JPH04124854A (ja)	1990-09-17	1992-04-24	Nikko Kyodo Co Ltd	半導体装置の製造方法
CA2061703C (en) *	1992-02-20	2002-07-02	Rudolf E. Falk	Formulations containing hyaluronic acid
JPH04134854A (ja)	1990-09-26	1992-05-08	Shimadzu Corp	Ｉｃチップ間配線方法
JPH04158798A (ja)	1990-10-19	1992-06-01	Tdk Corp	酵素活性の測定方法
JPH0630605B2 (ja)	1990-10-23	1994-04-27	チッソ株式会社	ヒアルロン酸ナトリウム水溶液の製造法
IT1250421B (it)	1991-05-30	1995-04-07	Recordati Chem Pharm	Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5217743A (en)	1992-02-07	1993-06-08	Paradigm Biotechnologies Partnership	Biomaterials of enhanced biocompatibility
US5621089A (en)	1992-05-27	1997-04-15	Novo Nordisk Biotech, Inc.	Nucleic acid constructs for the production of a Bacillus alkaline protease
IT1260153B (it) *	1992-06-19	1996-03-28	Michael O'regan	Individuazione di un frammento di dna codificante l'enzima acido ialuronico sintetasi (has) e della sua sequenza nucleotidica
ATE241340T1 (de)	1994-02-17	2003-06-15	New York Blood Ct Inc	Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung
IT1268954B1 (it)	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5473034A (en)	1994-03-18	1995-12-05	Hyogo Prefectural Government	Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
AU2638595A (en)	1994-05-16	1995-12-05	Uab Research Foundation, The	(streptococcus pneumoniae) capsular polysaccharide genes and flanking regions
SE9401806D0 (sv)	1994-05-26	1994-05-26	Pharmacia Ab	Method and means for the production of hyaluronic acid
US7091008B1 (en) *	1994-07-01	2006-08-15	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en)	1994-07-01	2002-09-24	The Board Of Regents Of The University Of Oklahoma	Hyaluronate synthase gene and uses thereof
US6951743B2 (en) *	1997-10-31	2005-10-04	University Of Oklahoma Board Of Regents	Hyaluronan synthase genes and expression thereof in bacillus hosts
JPH0838336A (ja)	1994-08-01	1996-02-13	Matsushita Electric Ind Co Ltd	電気カーペット用カバー
CN1161060A (zh) *	1994-09-12	1997-10-01	M·G·伯杰龙	用于微生物学实验室日常诊断中迅速检测和鉴别临床样品中普通细菌病原体和抗生素抗性基因之特异性和通用性探针及扩增引物
US5831057A (en) *	1995-10-05	1998-11-03	Cold Spring Harbor Laboratory	Associative learning and the linotte gene
EA199800475A1 (ru)	1995-11-28	1998-12-24	Дженвек, Инк.	Векторы и способы для переноса генов в клетки
WO1997020061A1 (en) *	1995-11-30	1997-06-05	The Scripps Research Institute	Synthesis of hyaluronic acid
SE9504304D0 (sv)	1995-11-30	1995-11-30	Sandvik Ab	Coated milling insert
US6423514B1 (en)	1996-04-22	2002-07-23	Millennium Pharmaceuticals, Inc.	Mammalian hyaluronan synthases, nucleic acids and uses thereof
US5610241A (en)	1996-05-07	1997-03-11	Cornell Research Foundation, Inc.	Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6492150B1 (en) *	1996-07-03	2002-12-10	Clear Colutions Biotech, Inc.	Gene encoding hyaluronan synthase
US6602693B1 (en) *	1996-07-03	2003-08-05	Clear Solutions Biotech, Inc.	Gene encoding hyaluronan synthase
CN101113436B (zh)	1997-10-31	2013-02-06	俄克拉何马大学董事会	透明质酸合酶基因及其应用
DE69828193T2 (de)	1997-10-31	2005-12-01	The Board Of Regents Of The University Of Oklahoma, Norman	Hyaluronan synthase gen und seine verwendung
US20060188966A1 (en)	1998-04-02	2006-08-24	Deangelis Paul L	Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en)	1998-04-02	2006-01-17	The Board Of Regents Of The University Of Oklahoma	DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7060469B2 (en)	1998-04-02	2006-06-13	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
US20050272696A1 (en)	1998-04-02	2005-12-08	Board Of Regents Of University Of Oklahoma	Methods of selectively treating diseases with specific glycosaminoglycan polymers
US20080108110A1 (en)	1998-04-02	2008-05-08	Deangelis Paul L	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7223571B2 (en)	1998-04-02	2007-05-29	The Board Of Regents Of The Universtiy Of Oklahoma	Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7094581B2 (en)	1998-10-26	2006-08-22	The Board Of Regents Of The University Of Oklahoma	Hyaluronan synthases and methods of making and using same
US20060105431A1 (en)	1998-11-11	2006-05-18	Deangelis Paul L	Polymer grafting by polysaccharide synthases using artificial sugar acceptors
IL143080A0 (en)	1998-11-11	2002-04-21	Univ Oklahoma	Polymer grafting by polysaccharide synthases
US7534589B2 (en)	1999-11-10	2009-05-19	The Board Of Regents Of The University Of Oklahoma	Polymer grafting by polysaccharide synthases
KR100879908B1 (ko)	2001-12-21	2009-01-21	노보자임스 바이오폴리머 에이/에스	재조합체 숙주 세포에서 히알루로난의 제조 방법

1998
- 1998-10-30 DE DE69828193T patent/DE69828193T2/de not_active Expired - Lifetime
- 1998-10-30 AT AT98957450T patent/ATE284954T1/de active
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- 1998-10-30 DK DK98957450T patent/DK1025211T3/da active
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- 1998-10-30 KR KR1020007004743A patent/KR20010031682A/ko not_active Application Discontinuation
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- 1998-10-30 CN CNB988127733A patent/CN1322121C/zh not_active Expired - Lifetime
1999
- 1999-12-21 US US09/469,200 patent/US6833264B1/en not_active Expired - Lifetime
2001
- 2001-12-11 US US10/011,771 patent/US7109011B2/en not_active Expired - Fee Related
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2003
- 2003-09-19 AU AU2003248204A patent/AU2003248204A1/en not_active Abandoned
2005
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Publication number	Publication date
JP4731013B2 (ja)	2011-07-20
DK1025211T3 (da)	2005-04-04
US7166450B2 (en)	2007-01-23
US20030082780A1 (en)	2003-05-01
BR9814834A (pt)	2001-07-17
US20060216793A1 (en)	2006-09-28
US20060018924A1 (en)	2006-01-26
US6833264B1 (en)	2004-12-21
US20060216808A1 (en)	2006-09-28
US7115405B2 (en)	2006-10-03
US7109011B2 (en)	2006-09-19
US7141409B2 (en)	2006-11-28
WO1999023227A2 (en)	1999-05-14
KR20010031682A (ko)	2001-04-16
BR9814834B1 (pt)	2011-08-23
CA2307842A1 (en)	1999-05-14
CA2307842C (en)	2010-10-19
US6991921B2 (en)	2006-01-31
US20050202540A1 (en)	2005-09-15
EP1522579A2 (de)	2005-04-13
DE69828193T2 (de)	2005-12-01
CN1322121C (zh)	2007-06-20
WO1999023227A3 (en)	1999-08-19
US7060466B2 (en)	2006-06-13
ES2235378T3 (es)	2005-07-01
US20060013829A1 (en)	2006-01-19
EP1522579A3 (de)	2007-11-07
AU762036B2 (en)	2003-06-19
CN1283224A (zh)	2001-02-07
US7504246B2 (en)	2009-03-17
JP2001521741A (ja)	2001-11-13
WO1999023227A9 (en)	2000-07-13
ATE284954T1 (de)	2005-01-15
US20070087416A1 (en)	2007-04-19
EP1025211B1 (de)	2004-12-15
EP1025211A2 (de)	2000-08-09
US7087413B2 (en)	2006-08-08
US20060216794A1 (en)	2006-09-28
AU2003248204A1 (en)	2003-10-30
AU1370699A (en)	1999-05-24
US7153677B2 (en)	2006-12-26
US20030073221A1 (en)	2003-04-17

Publication	Publication Date	Title
ATE284954T1 (de)	2005-01-15	Hyaluronan synthase gen und seine verwendung
DE60033138D1 (de)	2007-03-15	Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
HK1013847A1 (en)	1999-12-10	Gdf-1 and uog-1 proteins
PT101297A (pt)	1994-06-30	Factores mitogenicos gliais, sua preparacao e utilizacao
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NZ510356A (en)	2004-12-24	Molecules designated LDCAM
ATE93272T1 (de)	1993-09-15	Expression von protein c.
DE69333346T2 (de)	2004-10-07	Neuartiges p- selectin ligandenprotein
NO177570B (no)	1995-07-03	Fremgangsmåte ved fremstilling av peptider med fibronektinbindende egenskaper, mikroorganisme og DNA-sekvens som koder for peptider med fibronektinbindende egenskaper
AU2430588A (en)	1989-04-27	Mutant acidic fibroblast growth factor
ES2124694T3 (es)	1999-02-16	Clonacion de la n-metil-hidantoinasa.
AU7357294A (en)	1995-03-21	Recombinant cladosporium herbarum allergens
EP0422217A4 (en)	1992-08-19	Human recombinant placental ribonuclease inhibitor and method of production
DE69828902D1 (de)	2005-03-10	Polypeptide mit 5-aminolevulinsäure synthaseaktivität und deren nukleinsäuren
DK0828004T3 (da)	2007-03-19	Proteindisulfidisomerase-gen afledt af stamme af methylotrof gær
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