[go: up one dir, main page]

DE69628448D1 - Transdermale verabreichungsform von flurbiprofen - Google Patents

Transdermale verabreichungsform von flurbiprofen

Info

Publication number
DE69628448D1
DE69628448D1 DE69628448T DE69628448T DE69628448D1 DE 69628448 D1 DE69628448 D1 DE 69628448D1 DE 69628448 T DE69628448 T DE 69628448T DE 69628448 T DE69628448 T DE 69628448T DE 69628448 D1 DE69628448 D1 DE 69628448D1
Authority
DE
Germany
Prior art keywords
flurbiprofen
transdermal administration
administration form
transdermal
administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69628448T
Other languages
English (en)
Other versions
DE69628448T2 (de
Inventor
J Effing
A Gruhlke
J Godbey
Wolfgang Welsing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Co
Original Assignee
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co
Application granted granted Critical
Publication of DE69628448D1 publication Critical patent/DE69628448D1/de
Publication of DE69628448T2 publication Critical patent/DE69628448T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE69628448T 1995-12-22 1996-12-16 Transdermale verabreichungsform von flurbiprofen Expired - Fee Related DE69628448T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/577,482 US5702720A (en) 1995-12-22 1995-12-22 Transdermal device for the delivery of flurbiprofen
US577482 1995-12-22
PCT/US1996/020006 WO1997023205A1 (en) 1995-12-22 1996-12-16 Transdermal device for the delivery of flurbiprofen

Publications (2)

Publication Number Publication Date
DE69628448D1 true DE69628448D1 (de) 2003-07-03
DE69628448T2 DE69628448T2 (de) 2004-04-08

Family

ID=24308917

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69628448T Expired - Fee Related DE69628448T2 (de) 1995-12-22 1996-12-16 Transdermale verabreichungsform von flurbiprofen
DE69628762T Expired - Fee Related DE69628762T2 (de) 1995-12-22 1996-12-19 Vorrichtung zur verabreichung eines arzneistoffes

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69628762T Expired - Fee Related DE69628762T2 (de) 1995-12-22 1996-12-19 Vorrichtung zur verabreichung eines arzneistoffes

Country Status (22)

Country Link
US (2) US5702720A (de)
EP (2) EP0869781B1 (de)
JP (2) JP2000503638A (de)
KR (2) KR19990076588A (de)
CN (2) CN1098071C (de)
AR (1) AR005163A1 (de)
AT (2) ATE241350T1 (de)
AU (2) AU701782B2 (de)
CA (2) CA2238400A1 (de)
CO (1) CO4810224A1 (de)
CZ (2) CZ197298A3 (de)
DE (2) DE69628448T2 (de)
HR (1) HRP960608B1 (de)
HU (1) HUP9901991A3 (de)
IL (2) IL124629A (de)
MX (2) MX9804871A (de)
MY (1) MY113685A (de)
NO (2) NO982613L (de)
NZ (2) NZ325659A (de)
TW (1) TW436298B (de)
WO (2) WO1997023205A1 (de)
ZA (1) ZA9610729B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
JP3782834B2 (ja) * 1994-10-26 2006-06-07 株式会社トクホン 鎮痛抗炎症貼付剤
DE19830649C2 (de) 1998-07-09 2003-04-10 Lohmann Therapie Syst Lts Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe
DE19834496B4 (de) 1998-07-31 2004-02-26 Beiersdorf Ag Verbesserte Freisetzung von Ibuprofen aus Heißschmelzklebemassen in wirkstoffhaltigen Pflastern durch Zusatz von pharmazeutischen Hilfsstoffen und Verwendung von Hilfsstoffen zur Verbesserung der Freisetzung von Ibuprofen
WO2000010531A1 (en) 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
DE19840191A1 (de) * 1998-09-03 2000-03-09 Lohmann Therapie Syst Lts Arzneistoffhaltiges Pflaster mit drei funktionalen Schichten
US7052714B1 (en) * 1999-10-13 2006-05-30 Senju Pharmaceutical Co., Ltd Ophthalmic adhesive preparations for percutaneous adsorption
US20020110585A1 (en) 1999-11-30 2002-08-15 Godbey Kristin J. Patch therapeutic agent delivery device having texturized backing
US6455067B1 (en) * 2000-05-24 2002-09-24 Sang-A Pharmaceutical Co., Ltd. Transdermal patch for nonsteroidal antiinflammatory drug(s)
DE10032537A1 (de) * 2000-07-05 2002-01-31 Labtec Gmbh Dermales System, enthaltend 2-(3-Benzophenyl)Propionsäure
DE10049225A1 (de) * 2000-09-28 2002-04-11 Labtec Gmbh Dermales System, enthaltend Diclofenac
AU2002235155A1 (en) * 2000-12-05 2002-06-18 Noven Pharmaceuticals, Inc. Crystallization inhibition of drugs in transdermal drug delivery systems
US7803392B2 (en) * 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
US6479076B2 (en) * 2001-01-12 2002-11-12 Izhak Blank Nicotine delivery compositions
RU2358699C2 (ru) * 2001-06-18 2009-06-20 Ноувен Фамэсьютикэлз, Инк. Композиция для чрескожной доставки лекарственного средства (варианты), способ ее получения и использование
US6805878B2 (en) * 2001-09-13 2004-10-19 Noven Pharmaceuticals, Inc. Transdermal administration of ACE inhibitors
US6951642B2 (en) * 2001-09-28 2005-10-04 3M Innovative Properties Company Water-in-oil emulsions with anionic groups, compositions, and methods
US7030203B2 (en) 2001-09-28 2006-04-18 3M Innovative Properties Company Water-in-oil emulsions with ethylene oxide groups, compositions, and methods
US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
US20030152612A1 (en) * 2002-01-03 2003-08-14 Pugliese Peter T. Method and article to control cellulite
US6838078B2 (en) * 2002-01-16 2005-01-04 3M Innovative Properties Company Film-forming compositions and methods
US7147873B2 (en) 2002-01-16 2006-12-12 3M Innovative Properties Company Antiseptic compositions and methods
DE10212864B4 (de) * 2002-03-22 2005-12-22 Beiersdorf Ag Polymermatrizes umfassend ein Mischsystem zur Löslichkeitsvermittlung von pharmazeutischen Wirkstoffen, Verfahren zu deren Herstellung und deren Verwendung
KR100517101B1 (ko) * 2002-07-31 2005-09-27 한국과학기술연구원 이중 자극 응답성 하이드로젤 및 이의 제조 방법
US20040062794A1 (en) * 2002-09-30 2004-04-01 Lee Shulman 17Beta- estradiol/levonorgestrel transdermal patch for hormone replacement therapy
US7479132B2 (en) 2003-03-10 2009-01-20 Tokuyama Corporation Patch material for ionic medicine administration
CA2529852A1 (en) * 2003-06-20 2004-12-29 Viral Genomix, Inc. Compositions for and methods for treating hiv
US20050065062A1 (en) * 2003-09-24 2005-03-24 3M Innovative Properties Company Method of formulating a pharmaceutical composition
CA2556422A1 (en) 2004-02-17 2005-08-01 Cook Biotech Incorporated Medical devices and methods for applying bolster material
ES2596809T3 (es) * 2004-10-08 2017-01-12 Noven Pharmaceuticals, Inc. Dispositivo de administración transdérmica de fármacos que incluye un refuerzo oclusivo
BRPI0419274B8 (pt) * 2004-11-05 2021-05-25 Lead Chem Co Ltd preparação não aquosa para absorção percutânea contendo analgésico não-esteroidal
KR100663163B1 (ko) 2005-10-24 2007-01-02 (주)아모레퍼시픽 비스테로이드성 소염진통제를 함유하는 경피 투여 제제
CN101541314A (zh) * 2006-06-14 2009-09-23 爱若涂层制品有限公司 向人、动物和植物递送活性成分的装置
KR20080006960A (ko) * 2006-07-14 2008-01-17 (주)아모레퍼시픽 소수성 비스테로이드성 소염진통제를 함유하는 경피 투여제제
US20080039415A1 (en) * 2006-08-11 2008-02-14 Gregory Robert Stewart Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
JP5214223B2 (ja) * 2007-11-15 2013-06-19 船井電機株式会社 プロジェクタ
CA2709808A1 (en) * 2008-05-21 2009-11-26 Teikoku Pharma Usa, Inc. Treatment of dysmenorrhea via transdermal administration of nonsteroidal anti-inflammatory drugs
WO2010077096A2 (ko) * 2008-12-31 2010-07-08 한올바이오파마주식회사 약물전달기구
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
US8850719B2 (en) 2009-02-06 2014-10-07 Nike, Inc. Layered thermoplastic non-woven textile elements
US20100199520A1 (en) * 2009-02-06 2010-08-12 Nike, Inc. Textured Thermoplastic Non-Woven Elements
US8906275B2 (en) 2012-05-29 2014-12-09 Nike, Inc. Textured elements incorporating non-woven textile materials and methods for manufacturing the textured elements
US20100199406A1 (en) 2009-02-06 2010-08-12 Nike, Inc. Thermoplastic Non-Woven Textile Elements
US9682512B2 (en) 2009-02-06 2017-06-20 Nike, Inc. Methods of joining textiles and other elements incorporating a thermoplastic polymer material
CN101502499B (zh) * 2009-03-13 2011-07-27 北京化工大学 一种布洛芬经皮释放贴剂及其制备方法
US9173817B2 (en) 2009-08-24 2015-11-03 Arsenal Medical, Inc. In situ forming hemostatic foam implants
US9044580B2 (en) 2009-08-24 2015-06-02 Arsenal Medical, Inc. In-situ forming foams with outer layer
US20110202016A1 (en) * 2009-08-24 2011-08-18 Arsenal Medical, Inc. Systems and methods relating to polymer foams
US10420862B2 (en) 2009-08-24 2019-09-24 Aresenal AAA, LLC. In-situ forming foams for treatment of aneurysms
EP2504367A4 (de) * 2009-11-23 2015-10-14 Isp Investments Inc Reaktive lösung aus polymerisierbaren polymeren mit polymerisierbaren reaktionsfunktionen sowie verfahren dafür und zusammensetzungen damit
US9034240B2 (en) 2011-01-31 2015-05-19 Arsenal Medical, Inc. Electrospinning process for fiber manufacture
US9194058B2 (en) 2011-01-31 2015-11-24 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US8968626B2 (en) 2011-01-31 2015-03-03 Arsenal Medical, Inc. Electrospinning process for manufacture of multi-layered structures
US8993831B2 (en) 2011-11-01 2015-03-31 Arsenal Medical, Inc. Foam and delivery system for treatment of postpartum hemorrhage
US20130255103A1 (en) 2012-04-03 2013-10-03 Nike, Inc. Apparel And Other Products Incorporating A Thermoplastic Polymer Material
ITMI20121428A1 (it) * 2012-08-10 2014-02-11 Allergosystem S R L Dispositivo per applicazione topica di medicamenti o cosmetici
CN105992596A (zh) * 2014-01-29 2016-10-05 日东电工株式会社 皮肤渗透促进组合物、经皮给药制剂及贴附制剂
IL247927B (en) 2014-05-07 2022-09-01 Boehringer Ingelheim Int Container, nebulizer and use
KR102774558B1 (ko) 2015-12-30 2025-03-04 코리움, 엘엘씨 장기 경피 투여를 위한 시스템 및 방법
WO2018074261A1 (ja) * 2016-10-17 2018-04-26 第一三共株式会社 封入容器の製造方法及び製造装置
CN110114064A (zh) 2016-12-28 2019-08-09 久光制药株式会社 贴剂
US11872320B2 (en) 2021-02-25 2024-01-16 Hisamitsu Pharmaceutical Co., Inc. Method for treating osteoarthritis
CN113648297B (zh) * 2021-08-16 2023-07-14 乐明药业(苏州)有限公司 一种含有氟比洛芬的药物组合物与贴剂
WO2024145319A1 (en) * 2022-12-28 2024-07-04 Corium, Llc Method of preparing transdermal delivery system
WO2024145323A1 (en) * 2022-12-28 2024-07-04 Corium, Llc Pre-mixing method of preparing transdermal delivery system

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US24906A (en) * 1859-07-26 Simeon goodfellow
USRE24906E (en) * 1955-11-18 1960-12-13 Pressure-sensitive adhesive sheet material
US3949128A (en) * 1972-08-22 1976-04-06 Kimberly-Clark Corporation Product and process for producing a stretchable nonwoven material from a spot bonded continuous filament web
US4185100A (en) * 1976-05-13 1980-01-22 Johnson & Johnson Topical anti-inflammatory drug therapy
JPS55139313A (en) * 1979-04-16 1980-10-31 Ota Seiyaku Kk Gel cream composition comprising higher fatty acid ethanol amide, and drug containing it
GB2075837B (en) * 1980-05-14 1984-03-14 Hisamitsu Pharmaceutical Co Topical pharmaceutical gel containing anti-inflammatory analgesic agents
US5445604A (en) * 1980-05-22 1995-08-29 Smith & Nephew Associated Companies, Ltd. Wound dressing with conformable elastomeric wound contact layer
JPS5855411A (ja) * 1981-09-28 1983-04-01 Nitto Electric Ind Co Ltd 基剤組成物および外用医薬組成物
US4473584A (en) * 1982-12-06 1984-09-25 The Upjohn Company Treatment of Type I Herpes virus with flurbiprofen
US4477468A (en) * 1982-12-06 1984-10-16 The Upjohn Company Treatment of type II herpes virus with flurbiprofen
US4701470A (en) * 1982-12-06 1987-10-20 The Upjohn Company Treatment of Type II Herpes virus with ibuprofen
JPS59222409A (ja) * 1983-06-01 1984-12-14 Nippon Redarii Kk 消炎鎮痛ゲル軟膏剤
CH662944A5 (it) * 1984-10-18 1987-11-13 Pier Luigi Prof Dr Luisi Procedimento per la preparazione di biocompatibili di micelle inverse di biocompatibili e loro utilizzazione.
US4751087A (en) * 1985-04-19 1988-06-14 Riker Laboratories, Inc. Transdermal nitroglycerin delivery system
DE3522550A1 (de) * 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab Aufspruehbare pharmazeutische zubereitung fuer die topische anwendung
DE3532562A1 (de) * 1985-09-12 1987-03-12 Dolorgiet Gmbh & Co Kg Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben
GB8701392D0 (en) * 1987-01-22 1987-02-25 Boots Co Plc Therapeutic agents
US5656286A (en) * 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
GB2217595B (en) * 1988-04-21 1991-11-20 American Cyanamid Co Antiinflammatory gel
US5230701A (en) * 1988-05-13 1993-07-27 Minnesota Mining And Manufacturing Company Elastomeric adhesive and cohesive materials
US5266723A (en) * 1989-05-16 1993-11-30 Medice, Ltd., Chem.-Pharm. Fabrik Putter Gmbh & Co. Kg Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids
AU6758990A (en) * 1989-11-06 1991-05-31 Sepracor, Inc. Analgesic composition containing optically pure s(+) flurbiprofen
US5093133A (en) * 1990-01-24 1992-03-03 Mcneil-Ppc, Inc. Method for percutaneous delivery of ibuprofen using hydroalcoholic gel
AU7850491A (en) * 1990-05-18 1991-12-10 Analgesic Associates Prevention or treatment of sunburn using the s(+) isomer of flurbiprofen
DE4028906A1 (de) * 1990-09-12 1992-03-19 Paz Arzneimittelentwicklung Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen
TW218849B (de) * 1991-05-17 1994-01-11 Bristol Myers Squibb Co
ATE176153T1 (de) * 1991-08-30 1999-02-15 Hisamitsu Pharmaceutical Co Entzündungshemmendes, analgetisches pflaster
DE4210711A1 (de) * 1991-10-31 1993-05-06 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Transdermale therapeutische systeme mit kristallisationsinhibitoren
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
EP0695179A1 (de) * 1993-04-22 1996-02-07 Minnesota Mining And Manufacturing Company Transdermale entzuendungshemmende zusammensetzung

Also Published As

Publication number Publication date
DE69628762T2 (de) 2004-04-29
AU714798B2 (en) 2000-01-13
WO1997023205A1 (en) 1997-07-03
NO982613L (no) 1998-08-21
CO4810224A1 (es) 1999-06-30
CA2238400A1 (en) 1997-07-03
EP0869781B1 (de) 2003-05-28
TW436298B (en) 2001-05-28
IL124629A0 (en) 1998-12-06
NO982764D0 (no) 1998-06-15
HRP960608B1 (en) 2001-12-31
AU701782B2 (en) 1999-02-04
CN1098069C (zh) 2003-01-08
CN1098071C (zh) 2003-01-08
US5702720A (en) 1997-12-30
HUP9901991A3 (en) 2001-04-28
CN1205630A (zh) 1999-01-20
NO982764L (no) 1998-06-15
HUP9901991A2 (hu) 1999-10-28
NZ325125A (en) 2000-05-26
CZ197198A3 (cs) 1998-11-11
JP2000502349A (ja) 2000-02-29
AU1422097A (en) 1997-07-17
KR19990076589A (ko) 1999-10-15
MX9804969A (es) 1998-09-30
CN1205631A (zh) 1999-01-20
MY113685A (en) 2002-04-30
IL124629A (en) 2001-10-31
NZ325659A (en) 2000-02-28
NO982613D0 (no) 1998-06-05
DE69628448T2 (de) 2004-04-08
ATE243031T1 (de) 2003-07-15
HRP960608A2 (en) 1997-10-31
KR100452001B1 (ko) 2004-12-30
IL124804A0 (en) 1999-01-26
MX9804871A (es) 1998-10-31
AR005163A1 (es) 1999-04-14
CZ197298A3 (cs) 1999-01-13
EP0868177B1 (de) 2003-06-18
CA2240349A1 (en) 1997-07-03
JP2000503638A (ja) 2000-03-28
US6086911A (en) 2000-07-11
WO1997023206A1 (en) 1997-07-03
DE69628762D1 (de) 2003-07-24
EP0869781A1 (de) 1998-10-14
AU1295097A (en) 1997-07-17
KR19990076588A (ko) 1999-10-15
ZA9610729B (en) 1998-06-19
IL124804A (en) 2001-12-23
EP0868177A1 (de) 1998-10-07
ATE241350T1 (de) 2003-06-15

Similar Documents

Publication Publication Date Title
DE69628448D1 (de) Transdermale verabreichungsform von flurbiprofen
DE69530004D1 (de) Transdermale verabreichung von apomorphin
FI945311L (fi) Oksibutyniinin transdermaalinen annostelu
DE19681287T1 (de) Orale Formulierung von 2-Methylthienobenzodiazepin
DE69431209D1 (de) Transdermale prostaglandin-zusammensetzung
DE69633333D1 (de) Diphosphonatderivate von therapeutischen substanzen
DK42093D0 (da) Administrationsmetode
EE9700241A (et) Farmatseutiline kompositsioon transdermaalseks manustamiseks
DE69631056D1 (de) Zusammensetzungen von süssigkeiten
FI955259L (fi) Estradiolia sisältävä transdermaalinen terapeuttinen systeemi
DE69429359D1 (de) Orale zubereitungen von antimykotika
ATA900296A (de) Verwendung von n-glyoxylprolylesterverbindungen in arzneimitteln
DE69634998D1 (de) Kontrolle von Kanten
FI962932A0 (fi) Ankkuriproteiinifunktion modulaattoreita
FI972542L (fi) Transdermaalijärjestelmä useamman aktiivisen aineen samanaikaista antamista varten
EP0941039A4 (de) Transdermale verabreichung von androgenen
KR970000228A (ko) S-에토돌락의 경구용 제제
NO973471D0 (no) Transdermal formulering
FI962220L (fi) Transdermaalinen terapeuttinen järjestelmä
NO973715D0 (no) Transdermal formulering
DE69628672D1 (de) Transdermale verabreichung von risperidon mit kontrollierter geschwindigkeit
FI973229L (fi) Uusi farmaseuttinen koostumus
DE69325073D1 (de) Borazinderivate von Hydridopolysilazanpolymeren
FI954422L (fi) Ferroseenin käyttö
DE69722623D1 (de) Verabreichungssystem von funktionellen wirkstoffen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee