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DE69532239T2 - Verfahren und präparate für die prophylaxe und therapie von mit endotoxin verbundenen zuständen - Google Patents

Verfahren und präparate für die prophylaxe und therapie von mit endotoxin verbundenen zuständen Download PDF

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Publication number
DE69532239T2
DE69532239T2 DE69532239T DE69532239T DE69532239T2 DE 69532239 T2 DE69532239 T2 DE 69532239T2 DE 69532239 T DE69532239 T DE 69532239T DE 69532239 T DE69532239 T DE 69532239T DE 69532239 T2 DE69532239 T2 DE 69532239T2
Authority
DE
Germany
Prior art keywords
endotoxin
prophylaxis
preparations
therapy
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69532239T
Other languages
English (en)
Other versions
DE69532239D1 (de
Inventor
Daniel M Levine
Thomas S Parker
Albert L Rubin
Bruce R Gordon
Stuart D Saal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEPSICURE LLC
Original Assignee
SEPSICURE LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26965092&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69532239(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/288,568 external-priority patent/US5506218A/en
Application filed by SEPSICURE LLC filed Critical SEPSICURE LLC
Application granted granted Critical
Publication of DE69532239D1 publication Critical patent/DE69532239D1/de
Publication of DE69532239T2 publication Critical patent/DE69532239T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69532239T 1994-08-10 1995-08-10 Verfahren und präparate für die prophylaxe und therapie von mit endotoxin verbundenen zuständen Expired - Lifetime DE69532239T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/288,568 US5506218A (en) 1992-08-12 1994-08-10 Methods useful in endotoxin based therapy
US08/487,459 US5674855A (en) 1992-08-12 1995-06-07 Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions
PCT/US1995/010189 WO1996004916A1 (en) 1994-08-10 1995-08-10 Methods and compositions useful in prophylaxis and therapy of endotoxin related conditions

Publications (2)

Publication Number Publication Date
DE69532239D1 DE69532239D1 (de) 2004-01-15
DE69532239T2 true DE69532239T2 (de) 2004-10-21

Family

ID=26965092

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532239T Expired - Lifetime DE69532239T2 (de) 1994-08-10 1995-08-10 Verfahren und präparate für die prophylaxe und therapie von mit endotoxin verbundenen zuständen

Country Status (27)

Country Link
US (1) US5674855A (de)
EP (1) EP0767666B1 (de)
JP (1) JP3818660B2 (de)
CN (1) CN1137688C (de)
AP (1) AP782A (de)
AT (1) ATE255415T1 (de)
AU (1) AU703861C (de)
BG (1) BG61967B1 (de)
BR (1) BR9508584A (de)
CA (1) CA2196906C (de)
CY (1) CY2514B1 (de)
CZ (1) CZ287614B6 (de)
DE (1) DE69532239T2 (de)
DK (1) DK0767666T3 (de)
ES (1) ES2211915T3 (de)
FI (1) FI118035B (de)
HK (1) HK1003709A1 (de)
HU (1) HUT77605A (de)
NO (1) NO313786B1 (de)
NZ (1) NZ292315A (de)
OA (2) OA11737A (de)
PL (1) PL182043B1 (de)
PT (1) PT767666E (de)
RO (1) RO115782B1 (de)
RU (1) RU2174839C2 (de)
SK (1) SK282493B6 (de)
WO (1) WO1996004916A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
ES2288847T3 (es) * 1999-03-09 2008-02-01 Anker, Stefan Uso de inhibidores de endotoxina para el tratamiento de la caquexia.
US20030032674A1 (en) * 2001-08-13 2003-02-13 Hwang Daniel H. Use of unsaturated fatty acids to treat severe inflammatory diseases
BR0310099A (pt) 2002-05-17 2007-03-20 Esperion Therapeutics Inc método para tratar dislipidemia ou uma doença associada com a dislipidemia
DK1589834T3 (da) * 2003-02-05 2007-06-18 Nutricia Nv Enteral komposition til forebyggelse og/eller behandling af sepsis
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
PT1758590E (pt) * 2004-05-19 2011-11-15 Univ California Utilização de um detergente para a remoção não cirúrgica de gordura
AP2626A (en) * 2005-08-29 2013-03-26 Sepsicure Llc Method for treatment or prevention of conditions caused by gram-positive bacteria
GB0522942D0 (en) 2005-11-10 2005-12-21 Leigh Steven Dissolution composition
US8163699B2 (en) 2006-06-01 2012-04-24 Montreal Heart Institute Method for the treatment of valvular disease
KR100785656B1 (ko) * 2007-05-14 2007-12-17 재단법인서울대학교산학협력재단 소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체
SI2396017T1 (sl) 2009-02-16 2015-12-31 Cerenis Therapeutics Holding Sa Mimika apolipoproteina A-1
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
US20120237492A1 (en) 2011-02-18 2012-09-20 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
US9023833B2 (en) * 2012-12-18 2015-05-05 Sepsicure, LLC Method for treating sepsis in patients with albumin, cholesterol and HDL levels above minimum thresholds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115313A (en) * 1974-10-08 1978-09-19 Irving Lyon Bile acid emulsions
DE2556592C2 (de) * 1975-12-16 1986-10-09 A. Nattermann & Cie GmbH, 5000 Köln Arzneimittelzubereitungen auf Basis öliger Lösungen von Phospholipiden
US4314997A (en) * 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products
IL63734A (en) * 1981-09-04 1985-07-31 Yeda Res & Dev Lipid fraction,its preparation and pharmaceutical compositions containing same
CA1237671A (en) * 1983-08-01 1988-06-07 Michael W. Fountain Enhancement of pharmaceutical activity
JPS6193111A (ja) * 1984-05-28 1986-05-12 Funayama Seizo 発熱性物質除去方法
US5032585A (en) * 1987-02-17 1991-07-16 Board Of Regents, The University Of Texas System Methods and compositions employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
AU614465B2 (en) * 1989-04-05 1991-08-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Medicinal emulsions
DE4017979A1 (de) * 1990-06-05 1991-12-12 Meyer Lucas Gmbh & Co Lipid- bzw. phospholipid-zusammensetzungen sowie diese enthaltendes mittel zur behandlung von erkrankungen sowie auf die zellmembrane zurueckzufuehrende stoerungen
BR9201168A (pt) * 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas

Also Published As

Publication number Publication date
OA11737A (en) 2005-05-12
AP9700921A0 (en) 1997-01-31
WO1996004916A1 (en) 1996-02-22
AU703861C (en) 2001-12-20
FI970534A0 (fi) 1997-02-07
EP0767666B1 (de) 2003-12-03
FI970534L (fi) 1997-02-07
NZ292315A (en) 1998-10-28
RU2174839C2 (ru) 2001-10-20
EP0767666A1 (de) 1997-04-16
ATE255415T1 (de) 2003-12-15
JP3818660B2 (ja) 2006-09-06
CZ37197A3 (en) 1997-10-15
ES2211915T3 (es) 2004-07-16
AU703861B2 (en) 1999-04-01
CZ287614B6 (en) 2001-01-17
HUT77605A (hu) 1998-06-29
EP0767666A4 (de) 1998-10-07
CN1158087A (zh) 1997-08-27
US5674855A (en) 1997-10-07
AP782A (en) 1999-11-15
BG101288A (en) 1997-09-30
SK17697A3 (en) 1997-09-10
DK0767666T3 (da) 2004-04-05
BG61967B1 (bg) 1998-11-30
PL182043B1 (pl) 2001-10-31
NO970582D0 (no) 1997-02-07
DE69532239D1 (de) 2004-01-15
AU3405295A (en) 1996-03-07
CA2196906C (en) 2004-03-02
RO115782B1 (ro) 2000-06-30
NO970582L (no) 1997-04-07
JPH10504037A (ja) 1998-04-14
OA10598A (en) 2002-07-15
PT767666E (pt) 2004-04-30
PL318593A1 (en) 1997-06-23
CY2514B1 (en) 2005-12-23
NO313786B1 (no) 2002-12-02
HK1003709A1 (en) 1998-11-06
FI118035B (fi) 2007-06-15
CN1137688C (zh) 2004-02-11
SK282493B6 (sk) 2002-02-05
BR9508584A (pt) 1997-10-21
CA2196906A1 (en) 1996-02-22

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