DE69225039D1 - Mikroorganismen und Verfahren zur Herstellung von 3-Alpha, 7-Alpha-Dihydroxy-12-Keto-Cholansäure - Google Patents
Mikroorganismen und Verfahren zur Herstellung von 3-Alpha, 7-Alpha-Dihydroxy-12-Keto-CholansäureInfo
- Publication number
- DE69225039D1 DE69225039D1 DE69225039T DE69225039T DE69225039D1 DE 69225039 D1 DE69225039 D1 DE 69225039D1 DE 69225039 T DE69225039 T DE 69225039T DE 69225039 T DE69225039 T DE 69225039T DE 69225039 D1 DE69225039 D1 DE 69225039D1
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- keto
- dihydroxy
- microorganisms
- cholanic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- 229960002997 dehydrocholic acid Drugs 0.000 title 1
- MIHNUBCEFJLAGN-DMMBONCOSA-N 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)C(=O)C1 MIHNUBCEFJLAGN-DMMBONCOSA-N 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03277799A JP3082973B2 (ja) | 1991-10-24 | 1991-10-24 | ３α，７α−ジヒドロキシ−１２−ケト−５β−コラン酸の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69225039D1 true DE69225039D1 (de) | 1998-05-14 |
| DE69225039T2 DE69225039T2 (de) | 1998-07-30 |
Family
ID=17588444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69225039T Expired - Fee Related DE69225039T2 (de) | 1991-10-24 | 1992-10-23 | Mikroorganismen und Verfahren zur Herstellung von 3-Alpha, 7-Alpha-Dihydroxy-12-Keto-Cholansäure |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5451510A (de) |
| EP (1) | EP0539216B1 (de) |
| JP (1) | JP3082973B2 (de) |
| KR (1) | KR0169498B1 (de) |
| AT (1) | ATE164881T1 (de) |
| AU (1) | AU662359B2 (de) |
| CA (1) | CA2081057A1 (de) |
| DE (1) | DE69225039T2 (de) |
| ES (1) | ES2113928T3 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2070720A1 (en) * | 1991-06-12 | 1992-12-13 | Hiromi Kimura | Microorganisms having a conversion ability to bile acids and method for preparing bile acids |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2236574A (en) * | 1937-06-03 | 1941-04-01 | Schering Corp | Biochemical manufacture of ketosteroids |
| US2341110A (en) * | 1939-05-12 | 1944-02-08 | Schering Corp | Process for the manufacture of ketosteroids |
| US2905592A (en) * | 1955-07-27 | 1959-09-22 | Pfizer & Co C | Oxidation of steroids by mycobacteria |
| US2992973A (en) * | 1958-08-12 | 1961-07-18 | Takeda Pharmaceutical | Dehydrogenation of steroids by azotobacter microorganisms |
| US3037914A (en) * | 1960-05-06 | 1962-06-05 | American Cyanamid Co | Bacterial production of triamcinolone by bacterial formulations |
| US3037913A (en) * | 1960-05-06 | 1962-06-05 | American Cyanamid Co | Microbiological dehydrogenation of delta steroids of the pregnene series using bacterium mycoides |
| DE1904544C3 (de) * | 1969-01-27 | 1978-05-18 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur mikrobiologischen Umwandlung von 3 ß-Hydroxy-5,6- epoxysteroiden in 6-Hydroxy-3-KetoA<·4 -Steroide |
| US3801460A (en) * | 1970-12-18 | 1974-04-02 | Merck & Co Inc | Simultaneous steroid oxygenation and 1-dehydrogenation with bacillus cereus |
| JPS578796A (en) * | 1980-06-17 | 1982-01-18 | Kuraray Co Ltd | Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
| JPS578781A (en) * | 1980-12-29 | 1982-01-18 | Kuraray Co Ltd | Microorganism producing 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid |
| DE3241829A1 (de) * | 1982-11-09 | 1984-05-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Biokatalysator |
| JPS59120098A (ja) * | 1982-12-28 | 1984-07-11 | Showa Denko Kk | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造法 |
| JPS6024198A (ja) * | 1983-07-21 | 1985-02-06 | Showa Denko Kk | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造法 |
| JPS61282099A (ja) * | 1985-06-07 | 1986-12-12 | Showa Denko Kk | １２−ケト−３α，７α−ジヒドロキシコラン酸の製造方法 |
| CA2070720A1 (en) * | 1991-06-12 | 1992-12-13 | Hiromi Kimura | Microorganisms having a conversion ability to bile acids and method for preparing bile acids |
-
1991
- 1991-10-24 JP JP03277799A patent/JP3082973B2/ja not_active Expired - Fee Related
-
1992
- 1992-10-20 AU AU27144/92A patent/AU662359B2/en not_active Ceased
- 1992-10-21 CA CA002081057A patent/CA2081057A1/en not_active Abandoned
- 1992-10-21 US US07/964,192 patent/US5451510A/en not_active Expired - Fee Related
- 1992-10-23 KR KR1019920019605A patent/KR0169498B1/ko not_active IP Right Cessation
- 1992-10-23 AT AT92309730T patent/ATE164881T1/de active
- 1992-10-23 DE DE69225039T patent/DE69225039T2/de not_active Expired - Fee Related
- 1992-10-23 ES ES92309730T patent/ES2113928T3/es not_active Expired - Lifetime
- 1992-10-23 EP EP92309730A patent/EP0539216B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2113928T3 (es) | 1998-05-16 |
| EP0539216B1 (de) | 1998-04-08 |
| EP0539216A2 (de) | 1993-04-28 |
| CA2081057A1 (en) | 1993-04-25 |
| KR0169498B1 (ko) | 1999-01-15 |
| AU2714492A (en) | 1993-04-29 |
| US5451510A (en) | 1995-09-19 |
| AU662359B2 (en) | 1995-08-31 |
| EP0539216A3 (en) | 1994-08-17 |
| JPH05111391A (ja) | 1993-05-07 |
| KR930008137A (ko) | 1993-05-21 |
| ATE164881T1 (de) | 1998-04-15 |
| JP3082973B2 (ja) | 2000-09-04 |
| DE69225039T2 (de) | 1998-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MITSUBISHI-TOKYO PHARMACEUTICALS, INC., TOKIO, JP |
|
| 8339 | Ceased/non-payment of the annual fee |