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DE69201236D1 - Amide der ge 2270-antibiotika. - Google Patents

Amide der ge 2270-antibiotika.

Info

Publication number
DE69201236D1
DE69201236D1 DE69201236T DE69201236T DE69201236D1 DE 69201236 D1 DE69201236 D1 DE 69201236D1 DE 69201236 T DE69201236 T DE 69201236T DE 69201236 T DE69201236 T DE 69201236T DE 69201236 D1 DE69201236 D1 DE 69201236D1
Authority
DE
Germany
Prior art keywords
antibiotics
amides
amide derivatives
antibiotic
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69201236T
Other languages
English (en)
Other versions
DE69201236T2 (de
Inventor
Paolo Tavecchia
Sergio Lociuro
Romeo Ciabatti
Enrico Selva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naicons SCARL
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Publication of DE69201236D1 publication Critical patent/DE69201236D1/de
Application granted granted Critical
Publication of DE69201236T2 publication Critical patent/DE69201236T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
DE69201236T 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika. Expired - Fee Related DE69201236T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91100123 1991-01-03
PCT/EP1992/000002 WO1992012172A1 (en) 1991-01-03 1992-01-02 Amides of antibiotic ge 2270 factors

Publications (2)

Publication Number Publication Date
DE69201236D1 true DE69201236D1 (de) 1995-03-02
DE69201236T2 DE69201236T2 (de) 1995-06-01

Family

ID=8206281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69201236T Expired - Fee Related DE69201236T2 (de) 1991-01-03 1992-01-02 Amide der ge 2270-antibiotika.

Country Status (18)

Country Link
US (1) US5599791A (de)
EP (2) EP0565567B1 (de)
JP (1) JP3183508B2 (de)
KR (1) KR100225763B1 (de)
CN (1) CN1063110A (de)
AT (1) ATE117320T1 (de)
AU (1) AU662122B2 (de)
CA (1) CA2093219C (de)
DE (1) DE69201236T2 (de)
ES (1) ES2067325T3 (de)
FI (1) FI932944A0 (de)
HU (1) HU224072B1 (de)
IE (1) IE920005A1 (de)
IL (1) IL100572A (de)
MX (1) MX9200015A (de)
NZ (1) NZ241216A (de)
WO (1) WO1992012172A1 (de)
ZA (1) ZA927B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0451486T3 (da) * 1990-03-08 1995-05-08 Lepetit Spa Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
DE69224497T2 (de) * 1991-08-30 1998-07-02 Biosearch Italia Spa Faktor C2a des Antibiotikums CE 2270
US5882900A (en) * 1992-09-10 1999-03-16 Gruppo Lepetit S.P.A. Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
ATE163294T1 (de) * 1992-12-22 1998-03-15 Biosearch Italia Spa Die antibiotika ge 37468 a, b und c
JP2825667B2 (ja) * 1995-02-07 1998-11-18 バイオサーチ・イタリア・ソチエタ・ペル・アチオニ Ｇｅ２２７０及びｇｅ２２７０−様抗生物質の塩基性プロリン−アミド誘導体
PT808326E (pt) * 1995-02-07 2002-02-28 Biosearch Italia Spa Derivados basicos oxazolina-amidas de antibioticos afins de ge 2270 e ge 2270
CA2242067A1 (en) * 1996-02-14 1997-08-21 Versicor Inc. Derivatives of antibiotic ge2270 factors c2a, d2 and e
JPH1059997A (ja) * 1996-08-22 1998-03-03 Microbial Chem Res Found アミチアマイシンアミド誘導体
US20050166498A1 (en) * 1999-12-17 2005-08-04 Oakey David D. Carpet tile with cutout section, method and apparatus for production and method of installation
GB0024200D0 (en) * 2000-10-03 2000-11-15 Smithkline Beecham Sa Component vaccine
SI1553967T1 (sl) * 2002-06-17 2011-07-29 Naicons S C A R L Uporaba amid derivata GE 2270 faktorja A3 za zdravljenje aken
ES2308171T3 (es) 2003-04-30 2008-12-01 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
DE602004015158D1 (de) 2003-12-18 2008-08-28 Morphochem Ag Komb Chemie Oxazolidinon-chinolon hybrid antibiotika
AU2005205188B2 (en) * 2004-01-19 2010-11-11 Genomatica, Inc. Biochemical synthesis of 6-amino caproic acid
AR060977A1 (es) * 2006-05-31 2008-07-23 Novartis Ag Aminotiazoles y sus usos
KR20090082504A (ko) 2006-12-20 2009-07-30 노파르티스 아게 아미노티아졸 마크로사이클, 그의 항균 화합물로서의 용도 및 그의 제조 방법
WO2008091627A2 (en) 2007-01-22 2008-07-31 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
KR101202483B1 (ko) * 2007-06-04 2012-11-16 노파르티스 아게 거대고리 및 그의 용도
WO2009045637A2 (en) 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of acrylic acid and derivatives from fumaric acid
EA201400280A1 (ru) 2007-12-12 2014-08-29 Новартис Аг Аминотиазолы и их применение
EP2245137B1 (de) 2008-01-22 2017-08-16 Genomatica, Inc. Verfahren und organismen zur nutzung von synthesegas oder anderen gasförmigen kohlenstoffquellen und methanol
BRPI0909690A2 (pt) 2008-03-05 2019-02-26 Genomatica Inc organismos produtores de alcoóis primários
CA2719679C (en) 2008-03-27 2018-05-01 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
JP2011519561A (ja) 2008-05-01 2011-07-14 ジェノマティカ， インコーポレイテッド メタクリル酸の産生のための微生物
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
AU2009327490A1 (en) 2008-12-16 2011-07-28 Genomatica, Inc. Microorganisms and methods for conversion of syngas and other carbon sources to useful products
KR101774400B1 (ko) 2009-04-30 2017-09-04 게노마티카 인코포레이티드 1,3-부탄다이올 생산 유기체
KR20120068763A (ko) 2009-04-30 2012-06-27 게노마티카 인코포레이티드 아이소프로판올, ｎ-부탄올 및 아이소부탄올 생산 유기체
KR20200104931A (ko) 2009-05-07 2020-09-04 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
KR20120036851A (ko) 2009-05-15 2012-04-18 게노마티카 인코포레이티드 사이클로헥사논의 제조를 위한 유기체
WO2010144746A2 (en) 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
DK2462221T3 (en) 2009-08-05 2017-05-22 Genomatica Inc SEMISYNTHETIC TEREPHTHALIC ACID BY MICRO-ORGANISMS PRODUCING MUCONIC ACID
CA2773694A1 (en) 2009-09-09 2011-03-17 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
MX2012004291A (es) 2009-10-13 2012-08-17 Genomatica Inc Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos.
KR20120088753A (ko) 2009-10-23 2012-08-08 게노마티카 인코포레이티드 아닐린의 제조를 위한 미생물
CN102753698A (zh) 2009-12-10 2012-10-24 基因组股份公司 合成气或其他气态碳源和甲醇转化为1,3-丁二醇的方法和有机体
AU2011209862A1 (en) 2010-01-29 2012-07-26 Genomatica, Inc. Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
BR112012028049A2 (pt) 2010-05-05 2015-11-24 Genomatica Inc organismo microbiano de ocorrência não natural e método para produzir butadieno, meio de cultura, butadieno biossintetizado, composição, produto químico orgânico, polímero e uso de butadieno biossintetizado
US8715957B2 (en) 2010-07-26 2014-05-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
EP3628676A1 (de) * 2018-09-28 2020-04-01 Université de Montpellier Modifizierte peptide und deren verwendungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2066914T3 (es) * 1989-07-04 1995-03-16 Lepetit Spa Factores a1, a2, a3 y h del antibiotico ge 2270.

Also Published As

Publication number Publication date
ZA927B (en) 1992-09-30
CN1063110A (zh) 1992-07-29
EP0565567B1 (de) 1995-01-18
ATE117320T1 (de) 1995-02-15
ES2067325T3 (es) 1995-03-16
KR100225763B1 (ko) 1999-10-15
KR930703355A (ko) 1993-11-29
NZ241216A (en) 1994-04-27
AU1154492A (en) 1992-08-17
US5599791A (en) 1997-02-04
IL100572A (en) 1997-01-10
JPH06504768A (ja) 1994-06-02
AU662122B2 (en) 1995-08-24
MX9200015A (es) 1992-07-31
FI932944L (fi) 1993-06-24
CA2093219C (en) 2002-04-09
EP0565567A1 (de) 1993-10-20
HU224072B1 (hu) 2005-05-30
IE920005A1 (en) 1992-07-15
JP3183508B2 (ja) 2001-07-09
IL100572A0 (en) 1992-09-06
CA2093219A1 (en) 1992-07-04
FI932944A0 (fi) 1993-06-24
WO1992012172A1 (en) 1992-07-23
HU9301941D0 (en) 1993-09-28
DE69201236T2 (de) 1995-06-01
HUT64085A (en) 1993-11-29
EP0494078A1 (de) 1992-07-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOSEARCH ITALIA S.P.A., GERENZANO, IT

8327 Change in the person/name/address of the patent owner

Owner name: VICURON PHARMACEUTTICALS INC.(N.D.GES.STAATES DELA

8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: NAICONS S.C.A.R.L., MILANO, IT

8339 Ceased/non-payment of the annual fee